LOCUS       NM_020319               2489 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ankyrin repeat and MYND domain containing 2 (ANKMY2),
            mRNA.
ACCESSION   NM_020319
VERSION     NM_020319.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2489)
  AUTHORS   Saita,S., Shirane,M., Ishitani,T., Shimizu,N. and Nakayama,K.I.
  TITLE     Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog
            (Shh) signaling pathway
  JOURNAL   J Biol Chem 289 (37), 25639-25654 (2014)
   PUBMED   25077969
REFERENCE   2  (bases 1 to 2489)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC035353.1 and BC015453.1.
            
            On Nov 24, 2018 this sequence version replaced NM_020319.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023704.1, AL050390.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306999.7/ ENSP00000303570.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1401              BC035353.1         20-1420
            1402-2489           BC015453.1         383-1470
FEATURES             Location/Qualifiers
     source          1..2489
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..2489
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /note="ankyrin repeat and MYND domain containing 2"
                     /db_xref="GeneID:57037"
                     /db_xref="HGNC:HGNC:25370"
     exon            1..248
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1507
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /codon_start=1
                     /product="ankyrin repeat and MYND domain-containing
                     protein 2"
                     /protein_id="NP_064715.1"
                     /db_xref="CCDS:CCDS5361.1"
                     /db_xref="GeneID:57037"
                     /db_xref="HGNC:HGNC:25370"
                     /translation="MVHIKKGELTQEEKELLEVIGKGTVQEAGTLLSSKNVRVNCLDE
                     NGMTPLMHAAYKGKLDMCKLLLRHGADVNCHQHEHGYTALMFAALSGNKDITWVMLEA
                     GAETDVVNSVGRTAAQMAAFVGQHDCVTIINNFFPRERLDYYTKPQGLDKEPKLPPKL
                     AGPLHKIITTTNLHPVKIVMLVNENPLLTEEAALNKCYRVMDLICEKCMKQRDMNEVL
                     AMKMHYISCIFQKCINFLKDGENKLDTLIKSLLKGRASDGFPVYQEKIIRESIRKFPY
                     CEATLLQQLVRSIAPVEIGSDPTAFSVLTQAITGQVGFVDVEFCTTCGEKGASKRCSV
                     CKMVIYCDQTCQKTHWFTHKKICKNLKDIYEKQQLEAAKEKRQEENHGKLDVNSNCVN
                     EEQPEAEVGISQKDSNPEDSGEGKKESLESEAELEGLQDAPAGPQVSEE"
     exon            249..313
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            314..452
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            453..551
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            552..712
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            713..927
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1063
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1192
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1322
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..2489
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2465..2470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /note="hexamer: AATAAA"
     polyA_site      2489
                     /gene="ANKMY2"
                     /gene_synonym="ZMYND20"
                     /note="major polyA site"
ORIGIN      
        1 gagctcgccc gctgtccgcc agcccgcggg agggaggaga gaagcgaagc gtttccgcgg
       61 ttggctactc agtgtcttgg tctcaagttg cctcattgcg gctggcgttc ccaatacaga
      121 cgcatcgttt cttttttaat actccctaag aaagggaata accttcaagc tggcgggagc
      181 aatggttcac ataaagaaag gcgagctgac ccaggaggag aaggagctac tggaagtcat
      241 cgggaaaggt actgtccaag aagctggaac attattatcc agcaagaatg ttcgtgtcaa
      301 ctgtttggac gagaatggaa tgactcctct aatgcatgca gcatataaag gaaaactcga
      361 tatgtgcaaa ttactactgc gacatggagc cgatgtaaat tgtcatcagc atgaacatgg
      421 atacacagcc ctcatgtttg ctgcactttc tggtaataaa gacatcacat gggtaatgtt
      481 agaagctggt gctgagacag atgttgtcaa ctctgtggga agaacagcag ctcagatggc
      541 agcctttgtg ggtcaacatg attgtgtgac cataatcaac aatttctttc ctcgagagag
      601 actggattat tacactaagc cccagggact ggataaagag ccaaaactgc ccccaaagtt
      661 ggcaggcccg ctgcacaaaa ttatcaccac aacgaatctt catcctgtca agatcgtgat
      721 gcttgtaaat gagaatcctc tgctgacaga agaagcagcc ctgaataaat gctacagagt
      781 gatggatttg atttgtgaga aatgtatgaa gcaaagagac atgaatgaag tattggctat
      841 gaagatgcat tacataagct gtatctttca gaaatgcatt aacttcttaa aagatggaga
      901 gaataaactg gacaccttga tcaaaagctt gttaaaaggc cgagcttctg atggctttcc
      961 agtgtatcaa gaaaagatca ttagagaaag tatcagaaaa tttccttact gtgaagctac
     1021 actcctccag cagctggttc gaagcattgc tcctgttgaa attggttctg atcccactgc
     1081 attctccgtc cttacccaag ccatcactgg ccaggtgggt tttgtggatg tggaattttg
     1141 cactacctgt ggagaaaagg gagcaagtaa aagatgttca gtttgcaaaa tggtaatata
     1201 ttgtgatcaa acctgccaga aaacacactg gtttactcat aagaaaatct gtaagaatct
     1261 gaaggacatt tacgaaaagc aacagttgga ggctgccaaa gaaaagagac aagaggaaaa
     1321 ccacggcaaa cttgatgtca attctaactg tgttaatgaa gagcaaccag aggctgaagt
     1381 aggtatctct caaaaggatt ccaatcctga agattccggg gaaggaaaga aagaatctct
     1441 tgaaagcgaa gctgagttgg aaggcttaca ggatgctcct gcagggccac aggtgtctga
     1501 ggagtaaaag ccagagcaag tgccagtgtg gatgatcctc accctgcaag aagctggaaa
     1561 actcctagga atgcattgtc ctcaccttgt tatacctgcg tggcaccatg gcaggattcc
     1621 acatttcata gaatacaggt tttcaagcaa acccctgttg accatgccct aatttcctat
     1681 tgatttctgt tctataattg aatggatatt cctatggaaa attttttgtt tcaaaataca
     1741 ggaaaaacat tcctattacc tttctgaggc tggctttcca gcaattgttt caaaggaaaa
     1801 tagatcccct taaagaaaaa atacaggctt tagggaacaa agggacaagc agaacaggtg
     1861 tggaagagag attttcagga agggaaaaat ttatagctac agagggtagt tagaaaaatc
     1921 ataacttata tgtgaataaa atacatataa gcagcattta cggtagtggc attctactta
     1981 ttaagatgca atgaaatgaa gaaaggcttt atgttcaagg acctttgcca tagttcagct
     2041 aattgtagtt ttatatagaa atgatcctga acactctgaa cttgacgtag tcctgcggtg
     2101 atattctatc tgcagtattt gtacctccag aatggcagat ccctcagcag gaacaaaggc
     2161 atattgacgg ttctctcagc gtatgcatta aaaaaggtac ttcctgaaac ttttgattca
     2221 ataatgacta aacatactat gtacacaatt actgtaaggc taattcacgt gccatactcc
     2281 acctgaaagc ctgagttatc ttgctataag cttttcatgg agcacttcct ttccagaaac
     2341 tgatttgtaa ctcatttaga gaatgtcctg gcgtcggttt ttagcatatg tggtatttaa
     2401 acagagctag aatgtgatgt ctgaagataa tgctgcattt ctgggtttct tgtgtggatt
     2461 ttaaaataaa ttgtgcctac aaatataaa
//
