LOCUS       NM_152363               2962 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ankyrin repeat and LEM domain containing 1 (ANKLE1),
            transcript variant 1, mRNA.
ACCESSION   NM_152363
VERSION     NM_152363.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2962)
  AUTHORS   Freeman,A.D.J., Declais,A.C., Wilson,T.J. and Lilley,D.M.J.
  TITLE     Biochemical and mechanistic analysis of the cleavage of branched
            DNA by human ANKLE1
  JOURNAL   Nucleic Acids Res 51 (11), 5743-5754 (2023)
   PUBMED   37216589
  REMARK    GeneRIF: Biochemical and mechanistic analysis of the cleavage of
            branched DNA by human ANKLE1.
REFERENCE   2  (bases 1 to 2962)
  AUTHORS   Kaspers,M.S., Pogenberg,V., Pett,C., Ernst,S., Ecker,F.,
            Ochtrop,P., Groll,M., Hedberg,C. and Itzen,A.
  TITLE     Dephosphocholination by Legionella effector Lem3 functions through
            remodelling of the switch II region of Rab1b
  JOURNAL   Nat Commun 14 (1), 2245 (2023)
   PUBMED   37076474
  REMARK    GeneRIF: Dephosphocholination by Legionella effector Lem3 functions
            through remodelling of the switch II region of Rab1b.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2962)
  AUTHORS   Jiang,H., Kong,N., Liu,Z., West,S.C. and Chan,Y.W.
  TITLE     Human Endonuclease ANKLE1 Localizes at the Midbody and Processes
            Chromatin Bridges to Prevent DNA Damage and cGAS-STING Activation
  JOURNAL   Adv Sci (Weinh) 10 (12), e2204388 (2023)
   PUBMED   36825683
  REMARK    GeneRIF: Human Endonuclease ANKLE1 Localizes at the Midbody and
            Processes Chromatin Bridges to Prevent DNA Damage and cGAS-STING
            Activation.
REFERENCE   4  (bases 1 to 2962)
  AUTHORS   Martini,R., Chen,Y., Jenkins,B.D., Elhussin,I.A., Cheng,E.,
            Hoda,S.A., Ginter,P.S., Hanover,J., Zeidan,R.B., Oppong,J.K.,
            Adjei,E.K., Jibril,A., Chitale,D., Bensenhaver,J.M., Awuah,B.,
            Bekele,M., Abebe,E., Kyei,I., Aitpillah,F.S., Adinku,M.O.,
            Ankomah,K., Osei-Bonsu,E.B., Nathansan,S.D., Jackson,L., Jiagge,E.,
            Petersen,L.F., Proctor,E., Nikolinakos,P., Gyan,K.K., Yates,C.,
            Kittles,R., Newman,L.A. and Davis,M.B.
  TITLE     Investigation of triple-negative breast cancer risk alleles in an
            International African-enriched cohort
  JOURNAL   Sci Rep 11 (1), 9247 (2021)
   PUBMED   33927264
  REMARK    GeneRIF: Investigation of triple-negative breast cancer risk
            alleles in an International African-enriched cohort.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2962)
  AUTHORS   Song,J., Freeman,A.D.J., Knebel,A., Gartner,A. and Lilley,D.M.J.
  TITLE     Human ANKLE1 Is a Nuclease Specific for Branched DNA
  JOURNAL   J Mol Biol 432 (21), 5825-5834 (2020)
   PUBMED   32866453
  REMARK    GeneRIF: Human ANKLE1 Is a Nuclease Specific for Branched DNA.
REFERENCE   6  (bases 1 to 2962)
  AUTHORS   Brachner,A., Braun,J., Ghodgaonkar,M., Castor,D., Zlopasa,L.,
            Ehrlich,V., Jiricny,J., Gotzmann,J., Knasmuller,S. and Foisner,R.
  TITLE     The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA
            cleavage in vivo
  JOURNAL   J Cell Sci 125 (Pt 4), 1048-1057 (2012)
   PUBMED   22399800
  REMARK    GeneRIF: Ankle1 is conserved in metazoans and contains a unique
            C-terminal GIY-YIG motif that confers endonuclease activity in
            vitro and in vivo
REFERENCE   7  (bases 1 to 2962)
  AUTHORS   Bolton,K.L., Tyrer,J., Song,H., Ramus,S.J., Notaridou,M., Jones,C.,
            Sher,T., Gentry-Maharaj,A., Wozniak,E., Tsai,Y.Y., Weidhaas,J.,
            Paik,D., Van Den Berg,D.J., Stram,D.O., Pearce,C.L., Wu,A.H.,
            Brewster,W., Anton-Culver,H., Ziogas,A., Narod,S.A., Levine,D.A.,
            Kaye,S.B., Brown,R., Paul,J., Flanagan,J., Sieh,W., McGuire,V.,
            Whittemore,A.S., Campbell,I., Gore,M.E., Lissowska,J., Yang,H.P.,
            Medrek,K., Gronwald,J., Lubinski,J., Jakubowska,A., Le,N.D.,
            Cook,L.S., Kelemen,L.E., Brooks-Wilson,A., Massuger,L.F.,
            Kiemeney,L.A., Aben,K.K., van Altena,A.M., Houlston,R.,
            Tomlinson,I., Palmieri,R.T., Moorman,P.G., Schildkraut,J.,
            Iversen,E.S., Phelan,C., Vierkant,R.A., Cunningham,J.M.,
            Goode,E.L., Fridley,B.L., Kruger-Kjaer,S., Blaeker,J., Hogdall,E.,
            Hogdall,C., Gross,J., Karlan,B.Y., Ness,R.B., Edwards,R.P.,
            Odunsi,K., Moyisch,K.B., Baker,J.A., Modugno,F., Heikkinenen,T.,
            Butzow,R., Nevanlinna,H., Leminen,A., Bogdanova,N., Antonenkova,N.,
            Doerk,T., Hillemanns,P., Durst,M., Runnebaum,I., Thompson,P.J.,
            Carney,M.E., Goodman,M.T., Lurie,G., Wang-Gohrke,S., Hein,R.,
            Chang-Claude,J., Rossing,M.A., Cushing-Haugen,K.L., Doherty,J.,
            Chen,C., Rafnar,T., Besenbacher,S., Sulem,P., Stefansson,K.,
            Birrer,M.J., Terry,K.L., Hernandez,D., Cramer,D.W., Vergote,I.,
            Amant,F., Lambrechts,D., Despierre,E., Fasching,P.A.,
            Beckmann,M.W., Thiel,F.C., Ekici,A.B., Chen,X., Johnatty,S.E.,
            Webb,P.M., Beesley,J., Chanock,S., Garcia-Closas,M., Sellers,T.,
            Easton,D.F., Berchuck,A., Chenevix-Trench,G., Pharoah,P.D. and
            Gayther,S.A.
  CONSRTM   Australian Ovarian Cancer Study Group; Australian Cancer Study
            (Ovarian Cancer); Ovarian Cancer Association Consortium
  TITLE     Common variants at 19p13 are associated with susceptibility to
            ovarian cancer
  JOURNAL   Nat Genet 42 (10), 880-884 (2010)
   PUBMED   20852633
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[Nat Genet. 2016 Jan;48(1):101. doi: 10.1038/ng0116-101b..
            Brook-Wilson, Angela [corrected to Brooks-Wilson, Angela]. PMID:
            26711112]
REFERENCE   8  (bases 1 to 2962)
  AUTHORS   Antoniou,A.C., Wang,X., Fredericksen,Z.S., McGuffog,L., Tarrell,R.,
            Sinilnikova,O.M., Healey,S., Morrison,J., Kartsonaki,C.,
            Lesnick,T., Ghoussaini,M., Barrowdale,D., Peock,S., Cook,M.,
            Oliver,C., Frost,D., Eccles,D., Evans,D.G., Eeles,R., Izatt,L.,
            Chu,C., Douglas,F., Paterson,J., Stoppa-Lyonnet,D., Houdayer,C.,
            Mazoyer,S., Giraud,S., Lasset,C., Remenieras,A., Caron,O.,
            Hardouin,A., Berthet,P., Hogervorst,F.B., Rookus,M.A., Jager,A.,
            van den Ouweland,A., Hoogerbrugge,N., van der Luijt,R.B.,
            Meijers-Heijboer,H., Gomez Garcia,E.B., Devilee,P., Vreeswijk,M.P.,
            Lubinski,J., Jakubowska,A., Gronwald,J., Huzarski,T., Byrski,T.,
            Gorski,B., Cybulski,C., Spurdle,A.B., Holland,H., Goldgar,D.E.,
            John,E.M., Hopper,J.L., Southey,M., Buys,S.S., Daly,M.B.,
            Terry,M.B., Schmutzler,R.K., Wappenschmidt,B., Engel,C., Meindl,A.,
            Preisler-Adams,S., Arnold,N., Niederacher,D., Sutter,C.,
            Domchek,S.M., Nathanson,K.L., Rebbeck,T., Blum,J.L., Piedmonte,M.,
            Rodriguez,G.C., Wakeley,K., Boggess,J.F., Basil,J., Blank,S.V.,
            Friedman,E., Kaufman,B., Laitman,Y., Milgrom,R., Andrulis,I.L.,
            Glendon,G., Ozcelik,H., Kirchhoff,T., Vijai,J., Gaudet,M.M.,
            Altshuler,D., Guiducci,C., Loman,N., Harbst,K., Rantala,J.,
            Ehrencrona,H., Gerdes,A.M., Thomassen,M., Sunde,L., Peterlongo,P.,
            Manoukian,S., Bonanni,B., Viel,A., Radice,P., Caldes,T., de la
            Hoya,M., Singer,C.F., Fink-Retter,A., Greene,M.H., Mai,P.L.,
            Loud,J.T., Guidugli,L., Lindor,N.M., Hansen,T.V., Nielsen,F.C.,
            Blanco,I., Lazaro,C., Garber,J., Ramus,S.J., Gayther,S.A.,
            Phelan,C., Narod,S., Szabo,C.I., Benitez,J., Osorio,A.,
            Nevanlinna,H., Heikkinen,T., Caligo,M.A., Beattie,M.S., Hamann,U.,
            Godwin,A.K., Montagna,M., Casella,C., Neuhausen,S.L., Karlan,B.Y.,
            Tung,N., Toland,A.E., Weitzel,J., Olopade,O., Simard,J., Soucy,P.,
            Rubinstein,W.S., Arason,A., Rennert,G., Martin,N.G.,
            Montgomery,G.W., Chang-Claude,J., Flesch-Janys,D., Brauch,H.,
            Severi,G., Baglietto,L., Cox,A., Cross,S.S., Miron,P., Gerty,S.M.,
            Tapper,W., Yannoukakos,D., Fountzilas,G., Fasching,P.A.,
            Beckmann,M.W., Dos Santos Silva,I., Peto,J., Lambrechts,D.,
            Paridaens,R., Rudiger,T., Forsti,A., Winqvist,R., Pylkas,K.,
            Diasio,R.B., Lee,A.M., Eckel-Passow,J., Vachon,C., Blows,F.,
            Driver,K., Dunning,A., Pharoah,P.P., Offit,K., Pankratz,V.S.,
            Hakonarson,H., Chenevix-Trench,G., Easton,D.F. and Couch,F.J.
  CONSRTM   EMBRACE; GEMO Study Collaborators; HEBON; kConFab; SWE-BRCA; MOD
            SQUAD; GENICA
  TITLE     A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation
            carriers and is associated with hormone receptor-negative breast
            cancer in the general population
  JOURNAL   Nat Genet 42 (10), 885-892 (2010)
   PUBMED   20852631
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association and gene-gene interaction. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2962)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2962)
  AUTHORS   Lee,K.K. and Wilson,K.L.
  TITLE     All in the family: evidence for four new LEM-domain proteins Lem2
            (NET-25), Lem3, Lem4 and Lem5 in the human genome
  JOURNAL   Symp Soc Exp Biol (56), 329-339 (2004)
   PUBMED   15565891
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK303628.1, AK096688.1 and AC010463.6.
            
            On Nov 9, 2018 this sequence version replaced NM_152363.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.280551.1,
                                           SRR1163657.66042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404085.7/ ENSP00000384008.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1140              AK303628.1         257-1396
            1141-1994           AK096688.1         366-1219
            1995-2962           AC010463.6         86844-87811         c
FEATURES             Location/Qualifiers
     source          1..2962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2962
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /note="ankyrin repeat and LEM domain containing 1"
                     /db_xref="GeneID:126549"
                     /db_xref="HGNC:HGNC:26812"
                     /db_xref="MIM:619348"
     exon            1..82
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1868
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /note="isoform 1 is encoded by transcript variant 1; LEM
                     domain containing 6; ankyrin repeat and LEM
                     domain-containing protein 1; LEM-domain containing 3;
                     ankyrin repeat domain-containing protein 41"
                     /codon_start=1
                     /product="ankyrin repeat and LEM domain-containing protein
                     1 isoform 1"
                     /protein_id="NP_689576.6"
                     /db_xref="CCDS:CCDS12354.4"
                     /db_xref="GeneID:126549"
                     /db_xref="HGNC:HGNC:26812"
                     /db_xref="MIM:619348"
                     /translation="MCSEARLARRLRDALREEEPWAVEELLRCGADPNLVLEDGAAAV
                     HLAAGARHPRGLRCLGALLRQGGDPNARSVEALTPLHVAAAWGCRRGLELLLSQGADP
                     ALRDQDGLRPLDLALQQGHLECARVLQDLDTRTRTRTRIGAETQEPEPAPGTPGLSGP
                     TDETLDSIALQKQPCRGDNRDIGLEADPGPPSLPVPLETVDKHGSSASPPGHWDYSSD
                     ASFVTAVEVSGAEDPASDTPPWAGSLPPTRQGLLHVVHANQRVPRSQGTEAELNARLQ
                     ALTLTPPNAAGFQSSPSSMPLLDRSPAHSPPRTPTPGASDCHCLWEHQTSIDSDMATL
                     WLTEDEASSTGGREPVGPCRHLPVSTVSDLELLKGLRALGENPHPITPFTRQLYHQQL
                     EEAQIAPGPEFSGHSLELAAALRTGCIPDVQADEDALAQQFEQPDPARRWREGVVKSS
                     FTYLLLDPRETQDLPARAFSLTPAERLQTFIRAIFYVGKGTRARPYVHLWEALGHHGR
                     SRKQPHQACPKVRQILDIWASGCGVVSLHCFQHVVAVEAYTREACIVEALGIQTLTNQ
                     KQGHCYGVVAGWPPARRRRLGVHLLHRALLVFLAEGERQLHPQDIQARG"
     exon            83..235
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            236..341
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            342..480
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1218
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1396
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1556
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1695
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..2962
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2942..2947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /note="hexamer: AATAAA"
     polyA_site      2962
                     /gene="ANKLE1"
                     /gene_synonym="ANKRD41; LEM3; LEMD6"
                     /note="major polyA site"
ORIGIN      
        1 gcttcggacc cagccagggc atgtgctcgg aggcccgcct ggctcgcagg ttgcgggatg
       61 cgctgcggga ggaggagccg tgggcagtag aggagctgct gcgctgcggc gcggacccta
      121 atttggtgct agaggacggc gcagcggctg tgcacttggc ggccggagcc cggcacccgc
      181 gcggcctgcg ttgcctcggg gccctactgc gccaaggcgg ggaccccaac gctcgatctg
      241 tcgaggcact gacgccgctg catgtggccg ccgcgtgggg ctgccgccgc ggcctggagc
      301 tgctgctgag ccaaggagcg gacccggcgc tgcgcgacca ggacggactc cggccgctgg
      361 acctggccct gcagcaggga cacctggagt gcgcgcgagt cctgcaggat ctcgacacgc
      421 ggaccaggac ccggacccgg atcggggcag agactcagga gcccgagcct gcacctggca
      481 ccccaggcct ctctggacct accgatgaga cgctggactc catagcactc caaaagcagc
      541 catgcagagg tgacaacagg gacattggct tggaggctga cccaggaccc cccagcctcc
      601 ctgttcccct tgaaactgtg gacaaacatg ggagctcggc gtcccctcca gggcactggg
      661 attacagctc agacgcctct ttcgtcacag cggttgaggt ctctggagct gaggacccag
      721 cctcggacac tcccccctgg gctgggtcat tgccaccgac caggcaggga cttctgcatg
      781 ttgtccatgc caaccagagg gtacctaggt ctcagggcac ggaggcagaa ctgaatgccc
      841 gtctgcaggc cctgactctg accccaccaa atgctgctgg cttccagtcc tccccttcct
      901 ccatgcctct cctggacagg agtccagctc atagcccccc acggacacca acccctggag
      961 cttctgactg ccactgcctg tgggagcacc agacatccat tgatagtgac atggccacgc
     1021 tctggctgac agaggatgag gcaagctcta caggtggcag ggaacctgtc ggcccttgcc
     1081 ggcacctgcc agtctccact gtgtctgact tggagttgct gaagggactc cgagcacttg
     1141 gtgagaatcc tcaccccatc acacccttca ccaggcagtt gtaccaccag cagctggaag
     1201 aagcccagat tgctcctggc ccagagtttt cagggcacag cctagaactg gctgcagccc
     1261 tgcggacggg ctgtattcca gatgtccagg cagatgaaga cgcgctggcc cagcagtttg
     1321 agcagccaga tcctgccagg aggtggcggg agggggtcgt gaagtctagc ttcacctatc
     1381 tgctgctgga ccccagggag actcaggacc tgccagcccg agccttctca ctgaccccag
     1441 ctgagcgcct tcagactttc atccgtgcca tcttctacgt gggcaaaggg acgagggccc
     1501 ggccatatgt ccacctctgg gaggcccttg gtcaccatgg gcggtcaaga aaacagcccc
     1561 accaggcctg ccccaaggtg cgtcagatct tggacatctg ggccagtggt tgcggtgttg
     1621 tgtccctaca ttgcttccag cacgtggtcg ctgtggaggc ttatacacgg gaggcgtgta
     1681 ttgtggaagc cctagggatc cagacgctca ccaaccagaa gcaagggcac tgctatggag
     1741 tggtggcagg ctggccacct gctcgtcgcc ggcgcttggg ggtgcacctg ctgcaccgtg
     1801 ccctccttgt cttcctggct gaaggcgagc gacagcttca tccccaggac atccaggccc
     1861 ggggctgagt gctggggagt tggccatcca gcctggggag aaatgtttga atgttccagc
     1921 tgccccatgc tgacagcagc ccccatctct ggtttcagaa ggggtgtgtg tgtgtgtgtg
     1981 tgtgtgtgtg tgtgtgtgtg tgtgtgtttg tgtgtgtgtg tgtgtgtgta gggagcaccc
     2041 aggcagatct cccccaggct gagagaggac tttgttacag atggtactgc tggagaggta
     2101 gtaagtagtg agctccccat cgtgggagga ggacaagaag ggaagcagaa ggtgctttgg
     2161 aacagtccgg tgcttctgta agaggcgttt gaacctgggc aactccacct ggaataggag
     2221 ctgggtaaaa tgaggctgaa acctactggg ctgcattccc agatggttaa agcattctaa
     2281 gtcacgggat caggtaggag gtcagcacaa gataacgggt cataaagaac ctgctgataa
     2341 aacaggttgc agtaaagaag ccggccaaaa cccaccaata ccaagatggc gacaagagtg
     2401 acctctggtc gtcctcattg ctacactccc accagcgcca tgacagttta caaatgccat
     2461 ggctggccag gcgcggtggc tcacgcctgt aatcctagca ttttgggagg ccaaggaggg
     2521 cagatcacct aaggtcagga gttcaagacc agcgtggcca acgtggcgaa accctatctc
     2581 tactaaaaat accaaaatta gctgggcatg gtggcgcgtg cctgtaatcc cagctactag
     2641 gggggctgag gcaggaggat cgcttgaacc caggaggtgg aggttgcagt gagctgagat
     2701 tgtaccattg cactccagcc tgggcaacag agcgagagtc tgtctcaaac aaacaaacaa
     2761 aaaaacaaat gccacatcaa catcaggacg ttaaccttta gaccctatat ggtctaaaaa
     2821 ggggaggcat gaataatcca ccccttgttt agcatatcat caagaaataa ccataaaaat
     2881 gggcaaccag cagccctgcc ctgtctatgg agtagccatt cttttattcc tttagtttct
     2941 taataaattt gctttcactg ta
//
