LOCUS       NM_019004               6340 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ankyrin repeat and IBR domain containing 1 (ANKIB1),
            mRNA.
ACCESSION   NM_019004 XM_377955 XM_380018 XM_940258
VERSION     NM_019004.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6340)
  AUTHORS   Liu,W., Yuan,C., Fu,B., Xie,J., Li,W., Zhang,G., Ma,Z. and Jiao,P.
  TITLE     E3 ubiquitin ligase ANKIB1 attenuates antiviral immune responses by
            promoting K48-linked polyubiquitination of MAVS
  JOURNAL   Cell Rep 43 (9), 114687 (2024)
   PUBMED   39213157
  REMARK    GeneRIF: E3 ubiquitin ligase ANKIB1 attenuates antiviral immune
            responses by promoting K48-linked polyubiquitination of MAVS.
REFERENCE   2  (bases 1 to 6340)
  AUTHORS   Piras,R., Ko,E.Y., Barrett,C., De Simone,M., Lin,X., Broz,M.T.,
            Tessaro,F.H.G., Castillo-Martin,M., Cordon-Cardo,C.,
            Goodridge,H.S., Di Vizio,D., Batish,M., Lawrenson,K., Chen,Y.G.,
            Chan,K.S. and Guarnerio,J.
  TITLE     circCsnk1g3- and circAnkib1-regulated interferon responses in
            sarcoma promote tumorigenesis by shaping the immune
            microenvironment
  JOURNAL   Nat Commun 13 (1), 7243 (2022)
   PUBMED   36433954
  REMARK    GeneRIF: circCsnk1g3- and circAnkib1-regulated interferon responses
            in sarcoma promote tumorigenesis by shaping the immune
            microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6340)
  AUTHORS   Miyamoto-Sato,E., Fujimori,S., Ishizaka,M., Hirai,N., Masuoka,K.,
            Saito,R., Ozawa,Y., Hino,K., Washio,T., Tomita,M., Yamashita,T.,
            Oshikubo,T., Akasaka,H., Sugiyama,J., Matsumoto,Y. and Yanagawa,H.
  TITLE     A comprehensive resource of interacting protein regions for
            refining human transcription factor networks
  JOURNAL   PLoS One 5 (2), e9289 (2010)
   PUBMED   20195357
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6340)
  AUTHORS   Miller,S.L., Malotky,E. and O'Bryan,J.P.
  TITLE     Analysis of the role of ubiquitin-interacting motifs in ubiquitin
            binding and ubiquitylation
  JOURNAL   J Biol Chem 279 (32), 33528-33537 (2004)
   PUBMED   15155768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC000120.1, AB037807.1, BC063861.1 and AC007566.2.
            
            On Nov 22, 2018 this sequence version replaced NM_019004.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.78146.1,
                                           SRR1803613.260847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265742.8/ ENSP00000265742.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC000120.1         137611-137870
            261-284             AB037807.1         1-24
            285-4305            BC063861.1         1-4021
            4306-6340           AC007566.2         15093-17127
FEATURES             Location/Qualifiers
     source          1..6340
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..6340
                     /gene="ANKIB1"
                     /note="ankyrin repeat and IBR domain containing 1"
                     /db_xref="GeneID:54467"
                     /db_xref="HGNC:HGNC:22215"
                     /db_xref="MIM:620069"
     exon            1..546
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..824
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             637..3906
                     /gene="ANKIB1"
                     /EC_number="2.3.2.31"
                     /codon_start=1
                     /product="ankyrin repeat and IBR domain-containing protein
                     1"
                     /protein_id="NP_061877.1"
                     /db_xref="CCDS:CCDS47639.1"
                     /db_xref="GeneID:54467"
                     /db_xref="HGNC:HGNC:22215"
                     /db_xref="MIM:620069"
                     /translation="MGNTTTKFRKALINGDENLACQIYENNPQLKESLDPNTSYGEPY
                     QHNTPLHYAARHGMNKILGTFLGRDGNPNKRNVHNETSMHLLCMGPQIMISEGALHPR
                     LARPTEDDFRRADCLQMILKWKGAKLDQGEYERAAIDAVDNKKNTPLHYAAASGMKAC
                     VELLVKHGGDLFAENENKDTPCDCAEKQHHKDLALNLESQMVFSRDPEAEEIEAEYAA
                     LDKREPYEGLRPQDLRRLKDMLIVETADMLQAPLFTAEALLRAHDWDREKLLEAWMSN
                     PENCCQRSGVQMPTPPPSGYNAWDTLPSPRTPRTTRSSVTSPDEISLSPGDLDTSLCD
                     ICMCSISVFEDPVDMPCGHDFCRGCWESFLNLKIQEGEAHNIFCPAYDCFQLVPVDII
                     ESVVSKEMDKRYLQFDIKAFVENNPAIKWCPTPGCDRAVRLTKQGSNTSGSDTLSFPL
                     LRAPAVDCGKGHLFCWECLGEAHEPCDCQTWKNWLQKITEMKPEELVGVSEAYEDAAN
                     CLWLLTNSKPCANCKSPIQKNEGCNHMQCAKCKYDFCWICLEEWKKHSSSTGGYYRCT
                     RYEVIQHVEEQSKEMTVEAEKKHKRFQELDRFMHYYTRFKNHEHSYQLEQRLLKTAKE
                     KMEQLSRALKETEGGCPDTTFIEDAVHVLLKTRRILKCSYPYGFFLEPKSTKKEIFEL
                     MQTDLEMVTEDLAQKVNRPYLRTPRHKIIKAACLVQQKRQEFLASVARGVAPADSPEA
                     PRRSFAGGTWDWEYLGFASPEEYAEFQYRRRHRQRRRGDVHSLLSNPPDPDEPSESTL
                     DIPEGGSSSRRPGTSVVSSASMSVLHSSSLRDYTPASRSENQDSLQALSSLDEDDPNI
                     LLAIQLSLQESGLALDEETRDFLSNEASLGAIGTSLPSRLDSVPRNTDSPRAALSSSE
                     LLELGDSLMRLGAENDPFSTDTLSSHPLSEARSDFCPSSSDPDSAGQDPNINDNLLGN
                     IMAWFHDMNPQSIALIPPATTEISADSQLPCIKDGSEGVKDVELVLPEDSMFEDASVS
                     EGRGTQIEENPLEENILAGEAASQAGDSGNEAANRGDGSDVSSQTPQTSSDWLEQVHL
                     V"
     exon            825..1122
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1305
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1423
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1632
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1721
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1866
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2033
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2122
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2253
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2388
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2475
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2542
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2688
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2867
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2919
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3031
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3168
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..6340
                     /gene="ANKIB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6317..6322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKIB1"
                     /note="hexamer: ATTAAA"
     polyA_site      6340
                     /gene="ANKIB1"
                     /note="major polyA site"
ORIGIN      
        1 gggtcggcgg ccgggctgct gccgttcctg ctccttttca ctggacctgc agtctctcag
       61 gggctggtgg caggcgacta ggagactagg gtggtggcgg tgggggtgcc agcggctgag
      121 ccggagccgg agccggaggc gggggagggg aagagggcgg ccggggctgc gagcgcgcaa
      181 ggctggaaca tgagccgggc ttgaccgcga ggcggaggca agagccaccg ccccctcttc
      241 ccctcccccg agtgaggcgg cgcagcggcc ggagagggat ggggggcgcc cacccagtct
      301 gagcctcgcc gcgggcgcct tcggctcacg cagcgcttcc cgcgggccgc cagtgcgcac
      361 cctcggccac atcagcctcc gcctggcggg tgcacccggg ccggcgagga aggggcaacc
      421 gtccgggtgg gtggggcggg ctgggtacct gaggtcacca gctcggctgt agaggcaggg
      481 gcggcggagg cggaactgcg gagttgctgg gtccaccgac ccttaccctc agcgagagaa
      541 gtaaccaatg tgaaagatgt tgcagaagtg ttccagaagt ggctgaagat agaaggaaaa
      601 aagtgccact gcctatcaga aaaaacaaaa caaaacatgg gaaatacaac caccaaattc
      661 cgtaaagcac tcatcaatgg tgatgaaaac ctggcctgcc aaatatatga aaacaatcct
      721 cagctaaaag aatctcttga tccaaataca tcttatgggg agccctacca gcacaatact
      781 ccattacatt atgctgctag acatggaatg aataaaatat tagggacttt tcttggtaga
      841 gatggaaatc caaataaacg gaatgtgcac aatgaaacat ctatgcattt gttgtgtatg
      901 ggacctcaaa ttatgatatc tgaaggagcc cttcatcctc gcttggcacg ccccacagaa
      961 gatgatttca gaagagcaga ttgtctgcag atgatcttaa aatggaaagg agcaaaactt
     1021 gaccagggtg aatatgagag agcagctatt gatgctgttg ataacaaaaa aaacacaccc
     1081 ttgcactatg ctgctgcctc agggatgaaa gcctgtgtag agcttttagt aaaacatgga
     1141 ggagacttgt ttgctgagaa tgaaaataaa gatactcctt gtgattgtgc tgaaaagcaa
     1201 caccacaaag atttggccct caatctggaa tctcaaatgg tattctcacg ggatcccgag
     1261 gctgaagaaa tagaagctga atatgctgca ttagacaaac gagagccata tgaaggatta
     1321 aggcctcagg atcttcgtag actaaaagat atgcttattg tggaaactgc agacatgctt
     1381 caggctcctc tctttactgc tgaagcttta cttcgagctc atgactggga cagggagaaa
     1441 ttacttgaag cttggatgtc caacccggag aactgctgcc aacgatcagg tgttcaaatg
     1501 ccaactccac caccaagtgg gtataatgcc tgggacacgc tcccatctcc aagaactcca
     1561 aggactacac gctcttctgt cacctcccca gatgaaatca gcttatctcc tggggattta
     1621 gacaccagtt tgtgtgacat ttgtatgtgc agtatctctg tatttgaaga ccctgtggat
     1681 atgccctgtg gacatgactt ttgtagagga tgttgggagt cgtttttgaa tctgaaaatt
     1741 caagaaggtg aagctcacaa cattttttgc cctgcatatg attgcttcca acttgtacct
     1801 gtggatatca tagaaagtgt agtttcaaag gagatggaca aacgatacct acagtttgat
     1861 attaaggcct ttgttgaaaa taatcctgcc attaaatggt gtcctactcc aggctgtgac
     1921 agagcagtaa gactaacgaa acaagggtca aatacatctg gatctgatac actcagcttc
     1981 ccattgctga gagctcctgc tgttgattgt ggaaaaggac acctcttctg ctgggagtgc
     2041 cttggtgaag cacatgagcc ttgtgactgc caaacatgga agaattggct gcaaaaaata
     2101 accgaaatga aaccagaaga acttgtggga gttagtgaag cctacgagga tgccgccaat
     2161 tgtctctggt tattaactaa ctccaagcct tgtgccaact gtaagtctcc aatacagaag
     2221 aatgaaggct gcaatcacat gcagtgtgct aagtgcaagt atgacttttg ctggatttgc
     2281 cttgaagagt ggaaaaaaca tagttcgtcc actggaggtt attacagatg tactcgctat
     2341 gaagtcattc aacacgtgga ggagcaatcc aaggaaatga ctgtggaggc tgagaaaaaa
     2401 cacaaacgat ttcaggaact tgacagattt atgcactatt atacaagatt taaaaaccat
     2461 gagcatagtt atcagctaga acaacgcctt cttaaaacag ccaaagaaaa gatggagcaa
     2521 ttgagcagag ctctcaaaga aactgaagga ggctgtccag ataccacttt cattgaagat
     2581 gcagttcatg tgctcttaaa aactcggcgc attctcaagt gttcttatcc atatggattt
     2641 ttcttggaac ctaaaagcac aaagaaagaa atttttgaac taatgcaaac agacctagaa
     2701 atggtcactg aagaccttgc ccagaaagtc aataggcctt accttcgcac accccgccac
     2761 aagatcatca aagcagcatg ccttgtacag cagaagaggc aagaattcct ggcatctgtg
     2821 gctcggggag tagctcctgc agactcacca gaagctccaa ggcgcagctt tgctggtgga
     2881 acatgggatt gggaatattt aggatttgca tcaccagagg aatatgctga atttcagtat
     2941 cggaggaggc acagacaacg tcgtcgagga gatgttcaca gtctactcag taatcctcca
     3001 gaccctgatg agccaagtga aagcacttta gatattccag aaggcggcag cagcagccgc
     3061 aggcctggca catccgtggt aagttctgca tctatgagtg tgctgcacag ctcttccctg
     3121 cgtgactaca cccctgccag tcgctctgaa aaccaggact ctcttcaggc tctgagttcc
     3181 ttggatgaag acgatcccaa tatacttctt gcaatacagt tatcactgca agagtctggg
     3241 ctggccctcg atgaagaaac tagagacttc ctcagtaatg aagcatcctt aggtgcgata
     3301 ggcacttctt taccttccag gctggactct gtccccagaa atacagatag ccctcgggct
     3361 gcattgagca gctctgagct tttggaactt ggtgacagcc tcatgagact aggagcagag
     3421 aatgacccat tttcaactga caccctgagc tcacaccctc tcagtgaggc aagaagtgat
     3481 ttctgtccct catctagtga tcctgactca gctggccagg accccaacat caatgacaat
     3541 cttctcggca acatcatggc ttggtttcat gacatgaacc ctcagagtat tgccctgatt
     3601 cctccagcaa ctacagaaat cagtgcagat tcccagctcc cctgtatcaa agatgggtca
     3661 gaaggtgtga aggatgtgga actggtgctg ccagaagatt caatgtttga agatgccagt
     3721 gtcagtgaag gtagaggaac ccagatagaa gaaaatcctt tggaagaaaa tattctggcg
     3781 ggggaagcag catctcaagc tggtgacagt ggtaacgagg cagccaacag aggagatggt
     3841 tcagatgttt caagtcaaac acctcaaacc tcaagtgact ggcttgaaca agtacattta
     3901 gtgtgaactg cacacatctg ggctctaaat gaattacagg tacagatggt atgctaggtg
     3961 gagtatgctt gatagagact ttgattcact taattccaac tcagtgataa accactgaca
     4021 ttagggttga atacagagaa gttcccttga atggtagctt cattttttat tttaacctta
     4081 cagggaattt cctttgtact taattgaata gcttttcccc tttttgctga caaaaagaag
     4141 agcaagagaa agagaaacaa aaatgaaata aataagttgt attccacact ctaagaaaat
     4201 gcagtcctct atttagccta ggcttgacaa tacttaaatt gaacatttaa actaaaggct
     4261 tactccctaa tctttgggtg gctttccttt aaaaaaaaaa aaaaagtttt cttcattcta
     4321 gaaatttatt ttggataaat ccgataacat atatgtcctc aatctctttg tgctcttcca
     4381 taacttactt cctttttgtc tgagcaatgt gaattgaagt ctctttagta ccacatctac
     4441 catagtgtaa ttagttttaa ttttcacatg aatcaaaggt ttcctttcat gtctatttac
     4501 agtccaattg tgccaaactc ttacttgtgt gctgactaac aaggcattta ggtgtgcagc
     4561 atcctagagt gctccagggc agtgtcagcg ttctcgggag taaaaggtgc cacttggtag
     4621 caatgatatt ccagaattaa atgggttttt gttgccatgg agactgcatt tatataaatg
     4681 tagcctgtag cttaagttaa ctaaacctaa tgctgctgtt aaaaacagtt tattttaata
     4741 ttaaaataca gttgattagc aacagcggtg ctgtatttta agagacactt tattggaagt
     4801 gcaatcatag ttatttgttt tcacaatttt acagtgcatt ctaattactg atgggtgcaa
     4861 ttacttttaa tcgtgtttta taaaatagaa aaaaagtgga gttttcatga gttatagtaa
     4921 atcccacgat tattaagaaa ttcagtaaaa catcctgcgc aacatgttac cgtgcctttg
     4981 cctaacctaa atggatagtt gccagttaaa taagtgagta attcaaattt caatgtctct
     5041 tctgaagtaa ctatgctatg aattgcaaag acctccataa aaccacccat ggccttgctt
     5101 ttacactaac tataacaact aaatgttcaa tcagtttgtt tgcctaacta gcaaatgctg
     5161 acatgtgttt gttctactgc gcaatactca tttgctgtgt gattactgtt tagtgttgaa
     5221 aaaaatcaac ttcctagtta tcagtgtctt actgtgaaga aaatactggt cttagttgta
     5281 attaggatac aatggtacag tgtgtaatta aaactagagt aaactgttgg aatggctgtt
     5341 ttacttaaat attatcaaaa ctagcataac ataagcaaaa tagataagta caacactcca
     5401 tttagtgttt tgccagattg ttaccagaag tctacagata ccaaactttc agttctgagt
     5461 ttgtacaggc aagtcctggg ctgggtaaaa agttatatta atattgttat ccacaagaga
     5521 tgtgattatg ggttttgatt actttttttt tttccaaacc ctgcttttga aatatccttg
     5581 tacttaaaat tcatattgct aagacactgt attagaatat ttaatattcc ccagatcctc
     5641 ttaggataaa ctgtgggaat cctcctatgc catggatatc aaaggtccac attagttttt
     5701 atttctccag tgatcagaaa cattgatatc aatccctatt aaattagtgg ggggaatatt
     5761 aactttatct acagtgtatt actgtatatt aaactgaaat agtccattaa aggatttttt
     5821 tataaattta ttttggatta aaaatatcaa caccaataag tttttagacc aagttgtaat
     5881 ttttccaata tagagtcttt gcatcacact gaggcatctt gcacagctgc agttaaggtg
     5941 agaaagaatg ctctgtgtga agacagtgta cacaatgggt tccggtttcc ttgcaccttg
     6001 tgcagtatcc tttatttctg tgctgttctc tcctgagcat gaaaaatgat cattatccaa
     6061 tttgtatttc cttggtacat attttaaaaa caacacagtc attgacttta caattcagta
     6121 atgaagtttg gcaaagccta ttttgtaaac aagttaattt tataatgtaa aaaaaaaaag
     6181 ttaatctaac cttgacttgt tatttgcact ttcatagtct atacttgata cattcccact
     6241 ttatatacag taggattcta caaacgtgta gatgtttggc caaatgaatg ctgttaataa
     6301 tatgtaaaat tctttgatta aacatttatt acttaaacta
//
