LOCUS       NM_020690               8328 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens ANKHD1-EIF4EBP3 readthrough (ANKHD1-EIF4EBP3), mRNA.
ACCESSION   NM_020690
VERSION     NM_020690.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8328)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS ONE 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8328)
  AUTHORS   Santos Duarte Ada S, Traina F, Favaro PM, Basseres DS, de Carvalho
            IC, Medina Sde S, Costa FF and Saad ST.
  TITLE     Characterisation of a new splice variant of MASK-BP3(ARF) and MASK
            human genes, and their expression patterns during haematopoietic
            cell differentiation
  JOURNAL   Gene 363, 113-122 (2005)
   PUBMED   16297570
REFERENCE   3  (bases 1 to 8328)
  AUTHORS   Poulin F, Brueschke A and Sonenberg N.
  TITLE     Gene fusion and overlapping reading frames in the mammalian genes
            for 4E-BP3 and MASK
  JOURNAL   J. Biol. Chem. 278 (52), 52290-52297 (2003)
   PUBMED   14557257
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008438.6, AF521883.1 and
            AC011399.6.
            
            On Aug 13, 2020 this sequence version replaced NM_020690.5.
            
            Summary: The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally
            occurring readthrough transcript of the neighboring ANKHD1 and
            EIF4EBP3 genes. This readthrough transcript encodes a protein
            composed mostly of the multiple ankyrin repeats, single KH-domain
            protein, with its C-terminus encoded in a different reading frame
            from the shared portion of the EIF4EBP3 gene. The significance of
            this readthrough mRNA and the function of its protein product have
            not yet been determined. [provided by RefSeq, Nov 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF521883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 8637, 54882
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC008438.6         60232-60306
            76-3008             AF521883.1         1-2933
            3009-3009           AC011399.6         68743-68743         c
            3010-8177           AF521883.1         2935-8102
            8178-8178           AC011399.6         16465-16465         c
            8179-8321           AF521883.1         8104-8246
            8322-8328           AC011399.6         16315-16321         c
FEATURES             Location/Qualifiers
     source          1..8328
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..8328
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /note="ANKHD1-EIF4EBP3 readthrough"
                     /db_xref="GeneID:404734"
                     /db_xref="HGNC:HGNC:33530"
     exon            1..441
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..7989
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /note="MASK-4E-BP3 alternate reading frame"
                     /codon_start=1
                     /product="ANKHD1-EIF4EBP3 protein"
                     /protein_id="NP_065741.3"
                     /db_xref="CCDS:CCDS4224.1"
                     /db_xref="GeneID:404734"
                     /db_xref="HGNC:HGNC:33530"
                     /translation="MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTV
                     RLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSE
                     VESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLST
                     ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDV
                     NAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL
                     MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDH
                     NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL
                     EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH
                     VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA
                     LTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTA
                     TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG
                     ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTN
                     VVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENS
                     PALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVEETEGKLNELGQRISAIEK
                     AQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQFTKE
                     YLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVDTILFKDNDVDDEQQ
                     SPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQIVGQPQIAITGHD
                     QGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTT
                     SNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG
                     FTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGA
                     NKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP
                     AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM
                     EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV
                     RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV
                     KEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELD
                     LEKSREESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEEN
                     DEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKE
                     TPPTAHLILPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGK
                     SQELNFVMDVNSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPL
                     SSPNIKLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTG
                     AHIDVDKQKDKNGERMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPAS
                     TKSIHANFSSGVGTTAASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSS
                     FPVSLPLAYPHPHFALLAAQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGN
                     TNSSPKHNNTSRLPNQNGTVLPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSV
                     RKQLFACVPKTSPPATVISSVTSTCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQ
                     KMESFSAVPPTKEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTS
                     SNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPR
                     VSHRMQPRGSFYSMVPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVNIMNGSQ
                     MHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFTVQSA
                     FLGNSVLGHLENMHPDNSKAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLASFS
                     GIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSASNSSTSAPPTLGQPKGVSASQDRKI
                     PPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWSFGVNAVSEGLSGWSQSVMGN
                     HPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASGFVDFSKGLPISMYGGTII
                     PSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTDAQQASLLPSVPALKGEIP
                     SPQLTRPKKRIGRPMVASPNQRHQDHLRPKVPAGVQELTHCPDTPLLPPSDSRGHNSS
                     NSPSLQAGGAEGAGDRGRDTR"
     exon            442..595
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            596..752
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            753..900
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1048
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1282
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1377
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1615
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1807
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1917
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2005
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2133
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2277
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2380
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..3139
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3285
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3397
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3543
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3686
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3900
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..4076
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4239
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            4240..4335
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            4336..4452
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            4453..4627
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            4628..5075
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            5076..5222
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            5223..5372
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            5373..6985
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            6986..7162
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            7163..7363
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            7364..7539
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            7540..7704
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            7705..7814
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            7815..7985
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            7986..8328
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8311..8316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /note="hexamer: AGTAAA"
     polyA_site      8328
                     /gene="ANKHD1-EIF4EBP3"
                     /gene_synonym="MASK-BP3; MASK-BP3ARF"
                     /note="major polyA site"
ORIGIN      
        1 agtgagaagt tagtggcgct gctgggacgg gggaaaggag acgcttcttc ctcttgctgc
       61 tcttctcgtt cccgagatca gcggcggcgg tgaccgcgag tgggtcggca ccgtctccgg
      121 ctccgggtgc gaacaatgct gactgatagc ggaggcggcg gcacctcctt tgaggaggac
      181 ctggactctg tggctccgcg atccgcccca gctggggcct cggagccgcc tccgccggga
      241 ggggtcggtc tggggatccg caccgtgagg ctctttgggg aggccgggcc agcgtcggga
      301 gtcggcagca gcggcggcgg cggcagcggc agcggtacgg gcggagggga cgcggcgctg
      361 gatttcaagt tggcggctgc cgtgctgagg accgggggtg gaggtggtgc ctctggcagt
      421 gacgaggacg aagtgtccga ggttgaatca tttattttgg accaagaaga tctggataac
      481 ccagtgctta aaacaacatc agagatattc ttatcaagta ctgcagaagg agcagactta
      541 cgcactgtgg atccagagac acaggcacga ctagaagcat tgctagaagc agcaggaatt
      601 ggcaaattgt caactgctga tggtaaagct tttgcagatc ctgaggtact ccggagactg
      661 acatcctcag ttagttgtgc actggatgaa gctgctgctg cactgacacg gatgaaagca
      721 gaaaacagcc acaatgcagg acaagtggac actcgcagtc tagcagaagc ttgttcagat
      781 ggggatgtta atgctgttcg taaattgcta gatgaaggca gaagtgtaaa tgaacataca
      841 gaagaaggag aaagcctgct gtgtttggct tgttcagcag ggtattatga attagcacaa
      901 gtattgcttg ctatgcatgc taatgttgaa gatcgaggga ataaaggaga cataactccc
      961 ctgatggcag cttccagtgg aggttactta gatattgtga aattattact tcttcatgat
     1021 gctgatgtca actcccagtc tgcaacagga aacactgcgc taacttatgc atgtgctgga
     1081 ggatttgttg acattgttaa agtgctcctt aatgaaggtg caaatataga agatcataat
     1141 gaaaatggac atactccctt aatggaagca gccagtgcag gtcatgtgga agttgcaaga
     1201 gttcttttag atcatggtgc aggcatcaac actcattcta atgaattcaa agaaagtgct
     1261 ctaacacttg cttgctacaa aggccatttg gatatggttc gctttctact tgaagctggt
     1321 gcagatcaag agcacaaaac agatgagatg cacactgcct taatggaggc ctgcatggat
     1381 ggacatgtag aggtggcacg tttgcttttg gatagtggtg ctcaagtgaa catgcctgca
     1441 gattcatttg aatctccatt gacgctagct gcctgtggag gacatgttga attggcagct
     1501 ctacttattg aaaggggagc aaatcttgaa gaagttaatg atgaaggata cactcccttg
     1561 atggaagctg cccgggaagg acatgaagaa atggtggcac tactcttagc acaaggagca
     1621 aatataaatg cccagacaga agaaactcaa gaaactgctc ttactttggc ttgctgtgga
     1681 ggattttctg aagttgcaga ctttcttatt aaggcagggg ctgatataga acttggctgc
     1741 tccacacctc tgatggaggc atctcaggag ggacacctgg aattggttaa atatttgctg
     1801 gcttctggcg ctaatgtgca tgctacaaca gcaacaggag acacagcctt aacctatgct
     1861 tgtgaaaatg gacatacgga tgttgcagat gttttacttc aagcaggggc tgatttagaa
     1921 catgaatctg aaggtggaag aacacctttg atgaaagctg caagagctgg tcatttgtgc
     1981 actgtgcagt ttcttattag caaaggtgcc aatgttaaca gggctacagc caataatgat
     2041 catacagtag tgtcgctggc atgtgcagga ggccacctgg cagttgttga gcttctcttg
     2101 gctcatgggg ctgaccctac tcatcgactc aaggatggtt caacaatgct cattgaagct
     2161 gcaaagggtg gccatactaa tgtagtttct tatctgttgg attatccaaa taatgttctg
     2221 tcagttccca ccacagatgt gtctcagctc cctccacctt ctcaagatca gtctcaggtg
     2281 ccacgtgtgc caacgcatac acttgccatg gttgtacctc cccaggaacc tgacagaact
     2341 tcacaggaga actctcctgc ccttttagga gtgcaaaaag gtacatccaa gcagaagtcc
     2401 agttccctcc aggtagcaga tcaggaccta ctgccatctt ttcacccata ccagcctttg
     2461 gagtgcatag tagaggagac tgaaggcaag ctgaatgaac tgggacaaag aattagtgct
     2521 attgaaaaag cacagcttaa gtcactggag ttaattcaag gtgaacctct gaacaaagat
     2581 aagatagaag aacttaaaaa gaacagagaa gagcaagtcc agaagaagaa gaaaatattg
     2641 aaagaactgc agaaagtgga aaggcagttg cagatgaaaa cacagcagca atttaccaaa
     2701 gaatacttgg aaaccaaagg tcagaaagac acagtgtctc tacaccaaca gtgctctcat
     2761 agaggagtct tcccagaagg ggaaggagat ggtagtctcc cagaggatca cttttcagag
     2821 ttacctcagg ttgacacaat cttatttaaa gataatgatg ttgatgatga gcaacagtct
     2881 ccaccatcgg cagaacagat tgattttgtc ccagtccagc ctttatcatc tccacagtgt
     2941 aacttttcca gtgacttagg ttctaatggg acaaattctc ttgaacttca gaaagtatca
     3001 ggtaatcagc agattgtagg acagcctcag attgctatta ctggacatga tcaggggctg
     3061 ttagttcaag aaccagatgg actaatggtt gcaactccag ctcagacgct taccgacact
     3121 cttgatgacc tgatagcagc tgtgagtacc agagtgccca ctggttccaa cagttcttct
     3181 cagaccacag agtgtcttac acctgaatcc tgttcgcaga ctacaagcaa tgtggcttcc
     3241 caatcgatgc ctcctgtgta tccttcagtt gacattgatg cacatactga gagcaatcat
     3301 gacacagcat taacactagc ttgtgcaggt ggtcatgaag aacttgtatc tgtgctcatt
     3361 gcacgggatg ccaaaattga acacagagac aaaaaaggtt tcacaccact aatcctggca
     3421 gcaacagcag ggcatgttgg agttgttgaa atccttttgg ataaaggtgg agatatagaa
     3481 gcacagtctg aacgaactaa ggatactccg ctttcattgg catgttctgg tggacgtcag
     3541 gaggtggtag acttgctgct ggctcgaggt gcaaataaag aacataggaa cgtatctgat
     3601 tatacaccac tgagtctagc tgcgtctgga ggatatgtta atatcattaa gattctgctt
     3661 aatgctgggg cagaaattaa ttcaaggact gggagtaaac taggtatttc tcccctgatg
     3721 ttggctgcaa tgaatggaca tgttcctgca gtaaaattgc tgctcgatat gggttcagac
     3781 attaatgccc aaatagagac caatcggaac acggctctca ccctggcctg tttccagggc
     3841 cgagcagaag tagtgagttt gcttctggac cgaaaagcca atgttgaaca tagggcaaag
     3901 acgggtctta cccccttgat ggaagcagct tctggagggt atgcagaggt tggaagagtt
     3961 cttcttgata aaggagcaga tgttaatgct ccccctgtgc cttcctcaag agatactgct
     4021 ttaacaatag cagcagacaa aggtcactac aaattttgtg aactcctgat tcatagggga
     4081 gcccacattg atgttcgtaa caaaaaggga aatacgccac tttggctggc atccaatgga
     4141 ggtcattttg atgttgtgca gttgctagtg caagcaggtg ctgatgtgga tgcagcagat
     4201 aaccggaaaa tcacacctct tatgtcagca tttcgcaagg gtcatgtaaa agttgttcaa
     4261 tatttggtaa aggaagtaaa tcagttccct tctgatatag aatgcatgag atacatagca
     4321 acaattacag ataaggaact gttgaaaaaa tgtcatcaat gtgtcgaaac cattgtgaag
     4381 gctaaagacc agcaagctgc agaagcaaat aagaatgcga gtattctttt aaaggaactt
     4441 gatctggaaa agtcaagaga agagagcaga aagcaggctc ttgctgctaa aagagaaaaa
     4501 agaaaagaaa agagaaaaaa gaaaaaagag gaacagaaaa ggaaacagga agaagatgaa
     4561 gaaaacaaac ctaaggagaa ttcggaacta ccagaggatg aagatgaaga ggagaatgat
     4621 gaagatgtgg agcaagaagt tcccatagaa cctcctagtg caaccaccac cactacgatt
     4681 ggaatctctg caacatctgc aacattcaca aatgtgtttg ggaaaaaaag ggccaatgtg
     4741 gtgacaactc ccagcaccaa tcggaaaaat aagaagaaca aaacaaaaga aacccctcct
     4801 acagcacatt taattttacc agaacaacat atgtctttag cccaacaaaa ggcagataaa
     4861 aataaaataa atggagaacc tagaggtggt ggtgcaggtg ggaatagtga ttcagataac
     4921 ttggacagca cagactgcaa cagtgagagt agcagtggtg gtaaaagcca agagttaaat
     4981 tttgtgatgg atgtgaattc ctctaaatac ccctcactgc tccttcattc ccaagaagaa
     5041 aagacaagta ctgctacttc caaaactcag acacgacttg aaggtgaagt gactcctaat
     5101 tccttgtcaa ccagctacaa gacagtgtca ttgccattaa gctctccaaa cataaagctg
     5161 aatctcacta gccctaaaag gggtcagaaa agagaagaag ggtggaaaga agttgtacga
     5221 aggtcaaaga aattgtctgt tccagcctca gtggtgtcga ggataatggg aagaggagga
     5281 tgcaacatca ctgcaataca ggatgttact ggtgcccata ttgatgtgga taaacaaaaa
     5341 gataagaatg gcgagagaat gatcacaata aggggtggca cagaatcaac aagatatgca
     5401 gttcaactaa tcaatgcact cattcaagat cctgctaagg aactggaaga cttgattcct
     5461 aaaaatcata tcagaacacc tgccagcacc aaatcaattc atgctaactt ctcatctgga
     5521 gtaggtacca cagcagcttc cagtaaaaat gcatttcctt tgggtgctcc aactcttgta
     5581 acttcacagg caacaacgtt atctacgttc cagcccgcta ataaacttaa taagaatgtt
     5641 ccaacaaatg tacgttcttc tttcccagtt tctctaccct tagcttatcc tcaccctcat
     5701 tttgccctgc tggctgctca aactatgcaa cagattcggc atcctcgctt acccatggcc
     5761 cagtttggag gaaccttctc accttctcct aacacatggg gaccattccc agtgagacct
     5821 gtgaatcctg gcaacacaaa tagctctcca aagcataata acacaagccg tctacctaac
     5881 cagaacggga ctgttttacc ctcagagtct gctggactag ctactgccag ttgtcctatc
     5941 actgtctctt ctgtagttgc tgccagtcag caactgtgtg tcactaatac ccggactcct
     6001 tcatcagtca gaaagcagtt gtttgcctgt gtgcctaaga caagtcctcc agcaacagtg
     6061 atttcttctg tgacaagcac ttgtagttcc ctgccttctg tctcctctgc acctatcact
     6121 agcgggcaag ctcccaccac atttctacct gcaagtactt ctcaagcaca gctttcttca
     6181 caaaagatgg agtctttctc tgctgtgcca cccaccaaag agaaagtgtc cacacaggac
     6241 cagcccatgg caaacctatg taccccatct tcaactgcaa acagttgcag tagctctgcc
     6301 agcaacaccc cgggagctcc agaaactcac ccatccagta gtcccactcc tacttccagt
     6361 aacacacaag aggaggcaca gccatccagt gtgtctgatt taagtcctat gtcaatgcct
     6421 tttgcatcta actcagaacc tgctccattg actttgacat cacccagaat ggttgctgct
     6481 gataatcagg acaccagtaa tttacctcag ttagctgtac cagcacctcg agtttctcat
     6541 cgaatgcagc ccagaggttc tttttactcc atggtaccaa atgcaactat tcaccaggat
     6601 ccccagtcta tttttgttac gaatccagtt actttaacac cacctcaagg cccaccagct
     6661 gcagtgcagc tttcttcagc tgtgaacatt atgaatggtt ctcagatgca cataaaccca
     6721 gcaaataagt ctttgccacc tacatttggc ccagccacac ttttcaatca cttcagcagt
     6781 ctttttgata gtagtcaggt gccagctaac cagggctggg gagatggtcc actgtcctca
     6841 cgagttgcta cagatgcctc tttcactgtt cagtcagcgt tcctgggtaa ctcagtgctt
     6901 ggacacttgg aaaacatgca ccctgataac tcaaaggcac ctggcttcag accaccttcc
     6961 cagcgagttt ctactagtcc agttgggtta ccatccattg acccatcagg cagctcccca
     7021 tcttcctctt ctgctcctct ggcaagtttt tccggcatac caggaacaag ggttttcctg
     7081 caagggccag ctcctgttgg gactcctagt ttcaacagac aacatttttc tccccatcct
     7141 tggacaagcg cctcaaactc atccacttct gccccaccaa cgttgggcca accaaaagga
     7201 gtcagtgcca gtcaagatcg aaagatacct cccccaattg gaacagagag actggcccga
     7261 attcggcaag gagggtctgt tgcacaagcc ccggcgggga ccagttttgt cgctcccgtt
     7321 ggacacagtg gaatctggtc atttggtgtc aatgctgtgt cagaaggctt atcaggttgg
     7381 tcgcaatctg tgatggggaa ccatccaatg catcaacaat tatcagaccc aagcacattc
     7441 tcccaacatc agccaatgga gagagatgat tctggaatgg tagccccctc taacattttt
     7501 catcagccta tggcaagtgg ttttgtggat ttttctaaag gtctgccaat ttccatgtat
     7561 ggaggcacca taataccctc tcatcctcag cttgctgatg ttccaggagg ccctctgttt
     7621 aatggacttc acaatccaga tcctgcttgg aaccctatga taaaagttat ccaaaattca
     7681 actgaatgca ctgatgccca gcaggccagt ctgcttcctt cagtccctgc tctcaaaggg
     7741 gaaatcccat cacctcagct aaccagaccg aagaagagaa ttggacggcc gatggtggcc
     7801 tctcctaacc agaggcacca ggatcatcta cgaccgaaag ttcctgctgg agtgcaagaa
     7861 ctcacccatt gcccggacac ccccctgctg cctccctcag attcccgggg tcacaactcc
     7921 tccaacagcc cctctctcca agctggagga gctgaaggag caggagacag aggaagagat
     7981 acccgatgac gcacaatttg aaatggacat ctaatccagt gcagatgacc tggcatgtgg
     8041 agttacagag ggatccctca tgccactgct gccaccacct cttcctgggg catccaaagg
     8101 ccagctggcc tcatctaatc tggaagggag tgacttgtta gttccaggcc tcctttagtt
     8161 ctgaggcagc tagaccaggg ataggagtgg gcaacttgcc aagcccttaa ctctacttcc
     8221 tcttcagtct gtggtactcc tcctaaccct aaaccctcta tgctcagggg ctggaactgg
     8281 ggaatggagt aagtcacctt ctgactgctt agtaaacatt caaagaaa
//
