LOCUS       NM_054027               8207 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ANKH inorganic pyrophosphate transport regulator
            (ANKH), mRNA.
ACCESSION   NM_054027 NM_019847 XM_939587 XM_944214 XM_944218 XM_944222
            XM_944225 XM_944228
VERSION     NM_054027.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8207)
  AUTHORS   Szeri,F., Niaziorimi,F., Donnelly,S., Fariha,N., Tertyshnaia,M.,
            Patel,D., Lundkvist,S. and van de Wetering,K.
  TITLE     The Mineralization Regulator ANKH Mediates Cellular Efflux of ATP,
            Not Pyrophosphate
  JOURNAL   J Bone Miner Res 37 (5), 1024-1031 (2022)
   PUBMED   35147247
  REMARK    GeneRIF: The Mineralization Regulator ANKH Mediates Cellular Efflux
            of ATP, Not Pyrophosphate.
REFERENCE   2  (bases 1 to 8207)
  AUTHORS   Yang,J., Zhang,M., Yang,D., Ma,Y., Tang,Y., Xing,M., Li,L.,
            Chen,L., Jin,Y. and Ma,C.
  TITLE     m6A-mediated upregulation of AC008 promotes osteoarthritis
            progression through the miR-328-3p-AQP1/ANKH axis
  JOURNAL   Exp Mol Med 53 (11), 1723-1734 (2021)
   PUBMED   34737423
  REMARK    GeneRIF: m(6)A-mediated upregulation of AC008 promotes
            osteoarthritis progression through the miR-328-3pAQP1/ANKH axis.
REFERENCE   3  (bases 1 to 8207)
  AUTHORS   Krzyzanowska,A.K., Frawley,R.J., Damle,S., Chen,T., Otero,M. and
            Cunningham,M.E.
  TITLE     Activation of nuclear factor-kappa B by TNF promotes nucleus
            pulposus mineralization through inhibition of ANKH and ENPP1
  JOURNAL   Sci Rep 11 (1), 8271 (2021)
   PUBMED   33859255
  REMARK    GeneRIF: Activation of nuclear factor-kappa B by TNF promotes
            nucleus pulposus mineralization through inhibition of ANKH and
            ENPP1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8207)
  AUTHORS   Szeri,F., Lundkvist,S., Donnelly,S., Engelke,U.F.H., Rhee,K.,
            Williams,C.J., Sundberg,J.P., Wevers,R.A., Tomlinson,R.E.,
            Jansen,R.S. and van de Wetering,K.
  TITLE     The membrane protein ANKH is crucial for bone mechanical
            performance by mediating cellular export of citrate and ATP
  JOURNAL   PLoS Genet 16 (7), e1008884 (2020)
   PUBMED   32639996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8207)
  AUTHORS   Vijen,S., Hawes,C., Runions,J., Russell,R.G.G., Wordsworth,B.P.,
            Carr,A.J., Pink,R.C. and Zhang,Y.
  TITLE     Differences in intracellular localisation of ANKH mutants that
            relate to mechanisms of calcium pyrophosphate deposition disease
            and craniometaphyseal dysplasia
  JOURNAL   Sci Rep 10 (1), 7408 (2020)
   PUBMED   32366894
  REMARK    GeneRIF: Differences in intracellular localisation of ANKH mutants
            that relate to mechanisms of calcium pyrophosphate deposition
            disease and craniometaphyseal dysplasia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8207)
  AUTHORS   Rojas,K., Serrano de la Pena,L., Gallardo,T., Simmons,A., Nyce,K.,
            McGrath,R., Considine,E., Vasko,A.J., Peterson,E., Grady,D.,
            Cox,R., Andrew,L.J., Lovett,M., Overhauser,J. and Williams,C.J.
  TITLE     Physical map and characterization of transcripts in the candidate
            interval for familial chondrocalcinosis at chromosome 5p15.1
  JOURNAL   Genomics 62 (2), 177-183 (1999)
   PUBMED   10610710
REFERENCE   7  (bases 1 to 8207)
  AUTHORS   Andrew,L.J., Brancolini,V., de la Pena,L.S., Devoto,M., Caeiro,F.,
            Marchegiani,R., Reginato,A., Gaucher,A., Netter,P., Gillet,P.,
            Loeuille,D., Prockop,D.J., Carr,A., Wordsworth,B.F., Lathrop,M.,
            Butcher,S., Considine,E., Everts,K., Nicod,A., Walsh,S. and
            Williams,C.J.
  TITLE     Refinement of the chromosome 5p locus for familial calcium
            pyrophosphate dihydrate deposition disease
  JOURNAL   Am J Hum Genet 64 (1), 136-145 (1999)
   PUBMED   9915952
REFERENCE   8  (bases 1 to 8207)
  AUTHORS   Nurnberg,P., Tinschert,S., Mrug,M., Hampe,J., Muller,C.R.,
            Fuhrmann,E., Braun,H.S. and Reis,A.
  TITLE     The gene for autosomal dominant craniometaphyseal dysplasia maps to
            chromosome 5p and is distinct from the growth hormone-receptor gene
  JOURNAL   Am J Hum Genet 61 (4), 918-923 (1997)
   PUBMED   9382103
REFERENCE   9  (bases 1 to 8207)
  AUTHORS   Hughes,A.E., McGibbon,D., Woodward,E., Dixey,J. and Doherty,M.
  TITLE     Localisation of a gene for chondrocalcinosis to chromosome 5p
  JOURNAL   Hum Mol Genet 4 (7), 1225-1228 (1995)
   PUBMED   8528213
REFERENCE   10 (bases 1 to 8207)
  AUTHORS   Reichenberger,E. and Chen,I.P.
  TITLE     Craniometaphyseal Dysplasia, Autosomal Dominant
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301634
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU193060.1, DA126651.1,
            BC009835.2, AC010491.4 and BQ008340.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_054027.5.
            
            Summary: This gene encodes a multipass transmembrane protein that
            is expressed in joints and other tissues and controls pyrophosphate
            levels in cultured cells. Progressive ankylosis-mediated control of
            pyrophosphate levels has been suggested as a possible mechanism
            regulating tissue calcification and susceptibility to arthritis in
            higher animals. Mutations in this gene have been associated with
            autosomal dominant craniometaphyseal dysplasia. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046801.1, AY358503.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284268.8/ ENSP00000284268.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               BU193060.1         1-259
            260-376             DA126651.1         223-339
            377-1943            BC009835.2         302-1868
            1944-7889           AC010491.4         97792-103737        c
            7890-8207           BQ008340.1         18-335              c
FEATURES             Location/Qualifiers
     source          1..8207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.2"
     gene            1..8207
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /note="ANKH inorganic pyrophosphate transport regulator"
                     /db_xref="GeneID:56172"
                     /db_xref="HGNC:HGNC:15492"
                     /db_xref="MIM:605145"
     exon            1..427
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1810
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /note="progressive ankylosis protein homolog; ATP carrier
                     protein ANKH; ankylosis, progressive homolog; solute
                     carrier family 62, member 1"
                     /codon_start=1
                     /product="mineralization regulator ANKH"
                     /protein_id="NP_473368.1"
                     /db_xref="CCDS:CCDS3885.1"
                     /db_xref="GeneID:56172"
                     /db_xref="HGNC:HGNC:15492"
                     /db_xref="MIM:605145"
                     /translation="MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKED
                     AVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRTKAVLCMVVAGAIAAVFHT
                     LIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFL
                     VGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYKNIHD
                     IIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAV
                     AILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLVSTSNTVTAAHIKKFTFVCMAL
                     SLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVVPLRIFSFFPVPVTVRAHLTGWLM
                     TLKKTFVLAPSSVLRIIVLIASLVVLPYLGVHGATLGVGSLLAGFVGESTMVAIAACY
                     VYRKQKKKMENESATEGEDSAMTDMPPTEEVTDIVEMREENE"
     exon            428..644
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..763
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..847
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1018
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1153
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1246
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1342
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1472
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1596
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1696
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..8207
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /note="hexamer: AATGAA"
     polyA_site      1943
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /note="major polyA site"
     regulatory      3170..3175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /note="hexamer: AATAAA"
     polyA_site      3190
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /note="major polyA site"
     regulatory      3738..3743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /note="hexamer: ATTAAA"
     polyA_site      3756
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
     regulatory      5272..5277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /note="hexamer: AATAAA"
     polyA_site      5297
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
     regulatory      8177..8182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
                     /note="hexamer: AGTAAA"
     polyA_site      8207
                     /gene="ANKH"
                     /gene_synonym="ANK; CCAL2; CMDJ; CPPDD; HANK; MANK;
                     SLC62A1"
ORIGIN      
        1 agagcgctta taatggagcc gctgtcagca gaaccttctg ccgccgccgc cgccgccgcc
       61 gtccctcctc ttttttttcc cggcagatct ttgttgtgtg ggagggcagc agggatggac
      121 ttgagcttgc ggatcccctg ctagagcagc cgcgctcgga gaaggcgccg cagccgcgag
      181 gaggagccgc cgccgccgcg cccgaggccc cgccgcccgc ggcctctgtc ggcccgcgcc
      241 ccgctcgccc cgtcgccccg tcgcccctcg cctccccgca gagtcccctc gcggcagcag
      301 atgtgtgtgg ggtcagccca cggcggggac tatggtgaaa ttcccggcgc tcacgcacta
      361 ctggcccctg atccggttct tggtgcccct gggcatcacc aacatagcca tcgacttcgg
      421 ggagcaggcc ttgaaccggg gcattgctgc tgtcaaggag gatgcagtcg agatgctggc
      481 cagctacggg ctggcgtact ccctcatgaa gttcttcacg ggtcccatga gtgacttcaa
      541 aaatgtgggc ctggtgtttg tgaacagcaa gagagacagg accaaagccg tcctgtgtat
      601 ggtggtggca ggggccatcg ctgccgtctt tcacacactg atagcttata gtgatttagg
      661 atactacatt atcaataaac tgcaccatgt ggacgagtcg gtggggagca agacgagaag
      721 ggccttcctg tacctcgccg cctttccttt catggacgca atggcatgga cccatgctgg
      781 cattctctta aaacacaaat acagtttcct ggtgggatgt gcctcaatct cagatgtcat
      841 agctcaggtt gtttttgtag ccattttgct tcacagtcac ctggaatgcc gggagcccct
      901 gctcatcccg atcctctcct tgtacatggg cgcacttgtg cgctgcacca ccctgtgcct
      961 gggctactac aagaacattc acgacatcat ccctgacaga agtggcccgg agctgggggg
     1021 agatgcaaca ataagaaaga tgctgagctt ctggtggcct ttggctctaa ttctggccac
     1081 acagagaatc agtcggccta ttgtcaacct ctttgtttcc cgggaccttg gtggcagttc
     1141 tgcagccaca gaggcagtgg cgattttgac agccacatac cctgtgggtc acatgccata
     1201 cggctggttg acggaaatcc gtgctgtgta tcctgctttc gacaagaata accccagcaa
     1261 caaactggtg agcacgagca acacagtcac ggcagcccac atcaagaagt tcaccttcgt
     1321 ctgcatggct ctgtcactca cgctctgttt cgtgatgttt tggacaccca acgtgtctga
     1381 gaaaatcttg atagacatca tcggagtgga ctttgccttt gcagaactct gtgttgttcc
     1441 tttgcggatc ttctccttct tcccagttcc agtcacagtg agggcgcatc tcaccgggtg
     1501 gctgatgaca ctgaagaaaa ccttcgtcct tgcccccagc tctgtgctgc ggatcatcgt
     1561 cctcatcgcc agcctcgtgg tcctacccta cctgggggtg cacggtgcga ccctgggcgt
     1621 gggctccctc ctggcgggct ttgtgggaga atccaccatg gtcgccatcg ctgcgtgcta
     1681 tgtctaccgg aagcagaaaa agaagatgga gaatgagtcg gccacggagg gggaagactc
     1741 tgccatgaca gacatgcctc cgacagagga ggtgacagac atcgtggaaa tgagagagga
     1801 gaatgaataa ggcacgggac gccatgggca ctgcagggac agtcagtcag gatgacactt
     1861 cggcatcatc tcttccctct cccatcgtat tttgttccct tttttttgtt ttgttttggt
     1921 aatgaaagag gccttgattt aaaggtttcg tgtcaattct ctagcatact gggtatgctc
     1981 acactgacgg ggggacctag tgaatggtct ttactgttgc tatgtaaaaa caaacgaaac
     2041 aactgacttc atacccctgc ctcacgaaaa cccaaaagac acagctgcct cacggttgac
     2101 gttgtgtcct cctcccctgg acaatctcct cttggaacca aaggactgca gctgtgccat
     2161 cgcgcctcgg tcaccctgca cagcaggcca cagactctcc tgtccccctt catcgctctt
     2221 aagaatcaac aggttaaaac tcggcttcct ttgatttgct tcccagtcac atggccgtac
     2281 aaagagatgg agccccggtg gcctcttaaa tttcccttcc gccacggagt tcgaaaccat
     2341 ctactccaca catgcaggag gcgggtggca cgctgcagcc cggagtcccc gttcacactg
     2401 aggaacggag acctgtgacc acagcaggct gacagatgga cagaatctcc cgtagaaagg
     2461 tttggtttga aatgccccgg gggcagcaaa ctgacatggt tgaatgatag catttcactc
     2521 tgcgttctcc tagatctgag caagctgtca gttctcaccc ccaccgtgta tatacatgag
     2581 ctaacttttt taaattgtca caaaagcgca tctccagatt ccagaccctg ccgcatgact
     2641 tttcctgaag gcttgctttt ccctcgcctt tcctgaaggt cgcattagag cgagtcacat
     2701 ggagcatcct aactttgcat tttagttttt acagtgaact gaagctttaa gtctcatcca
     2761 gcattctaat gccaggttgc tgtagggtaa cttttgaagt agatatatta cctggttctg
     2821 ctatccttag tcataactct gcggtacagg taattgagaa tgtactacgg tacttccctc
     2881 ccacaccata cgataaagca agacatttta taacgatacc agagtcacta tgtggtcctc
     2941 cctgaaataa cgcattcgaa atccatgcag tgcagtatat ttttctaagt tttggaaagc
     3001 aggttttttc ctttaaaaaa attatagaca cggttcacta aattgattta gtcagaattc
     3061 ctagactgaa agaacctaaa aaaaaaaata ttttaaagat ataaatatat gctgtatatg
     3121 ttatgtaatt tattttaggc tataatacat ttcctatttt cgcattttca ataaaatgtc
     3181 tctaatacaa tacggtgatt gcttgtgtgc tcaacatacc tgcagttgaa acgtattgta
     3241 tcaatgaaca ttgtacctta ttggcagcag ttttataaag tccgtcattt gcatttgaat
     3301 gtaaggctca gtaaatgaca gaactatttt tcattatggg taactgggga ataaatgggt
     3361 cactggagta ggaatagaag tgcaagctgg aaaggcaaaa atgagaaaga aaaaggcagg
     3421 ccctttgtgt ctaccgtttt cagtgctgtg tgatcatatt gttcctcaca gcaaaaaaga
     3481 atgcaagggc ataatgttag ctgtgaacat gccagggttg cattcacatt cctgggtacc
     3541 cagtgctgat ggggtgtgcc cacgtgggga catgtccttg gcgtgcttcc tcagagtggc
     3601 ttttcctcca ttaatacata tatgagtact gaaaaattaa gttgcatagc tgctttgcag
     3661 tggtttcaga ggcagatctg agaagattaa aaaaaaatct caatgtatca gcttttttta
     3721 aaggacatta ctagaaaatt aaacagtatt ttttaacatg tgtgactttc atgcttctgg
     3781 ggttggagct taaagatcca aactgagaaa gcaggccggg catggtggct catgcctgta
     3841 atcccaacac tttgggaggc caaggagggt ggatcactta aggtcaggag tttgagacca
     3901 gcctggccaa catggcaaaa ccctgtctct actaaaaaca taaaaattag ctgggggtgg
     3961 tagcacatac ctgtaatccc agctactcag gaggctgagg caggagaatt tgcttgatcc
     4021 tgggaggcag aggttgtagt gagccgagat cgcgccatcg cactccagcc tgggtgacaa
     4081 gagcaaaact ccatctcaaa aaaaaaaaaa atcctttccc tctaaatcca ggaaggatca
     4141 gcaagggcct cctcattatg agatgaggaa atacaactcc agagattcct tcagtgatca
     4201 agatcagtgg gccataatat ttggttagag tttctgagaa cacaggaagc aatgccacac
     4261 tcaggccacc acaatggagc tgatttggca ggacttgttc aaacctttca ccttaaagca
     4321 cgtgatcctt cttcgtacat tttcttcact tgggctgctt aagtcacagc ctaacaactt
     4381 tgaggcaaaa ctgagaactg gcatattctc ctgcgtttct tctaatcgag tcccatcatc
     4441 cagctagaca tgagagatca aaccagggag ggtgaccttt ctccttccca cttttcagag
     4501 tcattggggc aactttttga cttttgtgac caaagaaaca ttcccccaaa acatttattt
     4561 ttcattgtag ggcattcagc tgacagctgc attttagaaa gttaccatgc ctgtgagatt
     4621 ctcatgtcaa agaccaggga aagaccaggt gtgactttct ccaaaactga gtgattgctt
     4681 gtggatgaat acaatctaaa aatacaaggc catgaagtag tttttcattt agatgctgag
     4741 aaataatagg tttgggcagc tcaaagcata ggaaatagta agggttttct agagctcctc
     4801 ctttggtggc ctgtttgagt agcacaaggg acgtcatcct aaatgtgcag ttgccatttg
     4861 ttctgtagtg acttacaggg atctcagtgg caaagggcgt cagtgagaca acaactgagc
     4921 aaaaagaact agacgaggct tgcgcttgga aagtcacggt aggattggac ctgccggcca
     4981 catggctcag ggagtattga cggatttgca cattggcagg aaactctccc gtttgggatt
     5041 ctttaaatgg ggcacagaag gccacttgtt tgcatttctg ggtaaaaaac agtcatcccc
     5101 catgactgcc tgcatcgggt ttgtcttgtg ccaaagttac tcttcctttg tttttacttt
     5161 gccttgattt ttagcattag ctggtagttt ggcttggaaa tgtcctggat agccgattcc
     5221 ctaagaaact gaaacattta atattggctt aggatgtatc agatggggcc aaataaagct
     5281 tctttacaat agtaaaagca ctttatactt cactctctga gtcttcccaa taaataacct
     5341 tgggaggtgc agggggtggg gggcccagga tggggaggcc tgggagctcc cagggtagtg
     5401 acagagttgg gctgagttct ccagacgcca ggatgcgtcg cagcggggcc agctcaggag
     5461 tgctcactcc cagccctctg gatctctctc ctggttggaa taatcattac atatcgtaac
     5521 tctcaaaatt tattcactta tattttcaga ataagaagtg tgaaatgtta acagctctct
     5581 gctctcttac ttgttcccca tttggggatc ttctggaggg aaggggcagg gggagagtaa
     5641 cttttctata tccttggttt ctaggaacac atcgatttga agactcagta gctgactggt
     5701 tttttttttt cccccttcaa actgaagtgc gagtgtgcgt gtgttccaca aaatagcaag
     5761 tatttatagt gttgtaatta catttccttg agaaatattt tcttgtattt aaaaatcttt
     5821 ctacttcagt aactcccagc agaacagtgc ccaggacagc atgtgccggt tagtaccagc
     5881 tttgcaggtg agctgacttc taaacttagg acgacgtctt catcaatcaa actagtgcac
     5941 agtccagaaa aaggggtcct ttatcttcta agttctgctc ctcacctttc tttggaacca
     6001 aaattgcagt ggagtgtgag gaagagcttt gaaagacgtg gagtgttgag atgtctgcat
     6061 tgcacattca gccggttcaa agccagcagc tcctgcctgc attctgtaga catcgccctc
     6121 acacacagtc ctctgatggc tctcatataa agcactcaaa ccgtaggaaa gcatgttttt
     6181 gagcaacgtg tctgggatac tcctctgtgt ggttattttg aatctctatt tctgtcattg
     6241 aagcagcaaa aaacatcatg tgactcatca actgatctaa tcacacttaa aacaggatgt
     6301 agagaaaaat ctgatgagaa acgtaaaagg gcctgttgcc tgccctttta aaggcaaaat
     6361 gtctaaaatc atgcaaatgt tcaaaatgag agaaattgca ttgtggaatc aaaataaccc
     6421 aaactccact cagaaaagtc acaaatatat agtatactat ctgatctcaa aagggaaaaa
     6481 cgagatgata agaccttaag tttagacttt attttcttct caagagtgga cattaaatct
     6541 attaacttgc aactttctgc tgggaagagc atcaaaggtg ggcctcctaa atcatttttg
     6601 aaaaacctct gtcaagtcca agtggttcca ggagaattat agccagtatc ttttaaaata
     6661 tttcatttta gtgataatgt ttttctctgc ttcatttgca atcaaccagg atctctaaaa
     6721 gactgcataa gatatatgca cttttatagg tggctgtcag ctacacatag attcagcaaa
     6781 ttttttttat atagtacctg tttttaagtt aggctacata acttaaagtg cactttacta
     6841 acaagacttg acattagcgt ctacaatatg tatatgtaaa caaaagcaca caagaactag
     6901 gcaccctttc tctctccaag agtttaagtg gtttccttag gttaaagaag gggacagacc
     6961 agctaaaaat ggttgtacca ctcactgtac aacctcatgg aaattctcac tataagattt
     7021 agaggcaatg ttccctagct ataagccagg gcaagaaatg gcgcctctgg agttggggaa
     7081 cattagggga acattacaac cgggtagatg ctggttccct gaagtgtggg gccatgaaca
     7141 tgcagggacc cacggtttga atgaaacagc tactgaaagc taagttcaaa ccacccttgc
     7201 gtaacaaagg agtacagggt acacatcaac accaatcacc cagcacccca cagcgatggt
     7261 catgtcaccg tgcagcaggt cccttacccc agggctgcca catccacaag ccttgcagtg
     7321 gcaaatacgc tgctccttgg atttaatgag atattttggt tgcttaatga tgtactgatc
     7381 agggaactgt ctaaagctag tagggccaag gagttaatca aagggcttcg ggaaagtgga
     7441 caagagccac acacgtgatt ctgttccatg ccgacactca ttcatttaag aagtgtattc
     7501 aagctggagg cttccatatc actcacgctt cttggcctca ccttgctcat ctgtccaatg
     7561 ggaggcttga gccattattg ctaaggcccc ttcctgatct aacattctgt ttatgatcta
     7621 ggatttagaa cgtcgtatga gatcctacaa tggaagaata aaatcacctc attcttcatt
     7681 tcagatctga acattagcag tgatctagat tttttttttt ttaaacaaaa ttaagtgtgc
     7741 ttagagtcat tcctctacat gggctgtggc tgtcagccca taggtttgtc agtttcacat
     7801 caaaactgtg ggtataaact gttgaaacca atcacattaa aatatttagc tgggcacagt
     7861 ggtgtgcatc tgtagtccca gctacttggg aggctgaggc aggaggatcg cttaagcaca
     7921 ggagttggaa tccagcctga gcaacagagc aaaaccccgt ctctaaaata caaataaaat
     7981 atttgtgtag tttttgatta aaattgacta cagcggtcag tataaaatac atgtcgcttt
     8041 taaggaagtg ctctttatgt atctaacaga tggaagtttt tgcattggta agagcattta
     8101 tatatgcttt gtttcagggt ttatggattt gtattcatat attgtcaaat aggtttcata
     8161 ctctaatttt actttaagta aagcttaaac acttggcata caactga
//
