LOCUS       NM_001378068            4521 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens ankyrin and armadillo repeat containing (ANKAR),
            transcript variant 1, mRNA.
ACCESSION   NM_001378068 XM_011510674
VERSION     NM_001378068.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4521)
  AUTHORS   Liao,M., Shi,J., Huang,L., Gao,Y., Tan,A., Wu,C., Lu,Z., Yang,X.,
            Zhang,S., Hu,Y., Qin,X., Li,J., Chen,G., Xu,J., Mo,Z. and Zhang,H.
  TITLE     Genome-wide association study identifies variants in PMS1
            associated with serum ferritin in a Chinese population
  JOURNAL   PLoS One 9 (8), e105844 (2014)
   PUBMED   25162662
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4521)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 4521)
  AUTHORS   Occhi,G., Olivieri,M., Rampazzo,A. and Danieli,G.A.
  TITLE     Characterization of a novel human gene containing ANK repeats and
            ARM domains
  JOURNAL   Biochem Biophys Res Commun 318 (1), 38-45 (2004)
   PUBMED   15110750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012488.10 and AC013468.12.
            
            On Jan 27, 2020 this sequence version replaced XM_011510674.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AJ549812.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000684021.1/ ENSP00000507233.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC012488.10        70971-71131
            162-797             AC012488.10        72757-73392
            798-1235            AC012488.10        85828-86265
            1236-1399           AC012488.10        88556-88719
            1400-1503           AC012488.10        89375-89478
            1504-1684           AC012488.10        91282-91462
            1685-1904           AC012488.10        92451-92670
            1905-2106           AC012488.10        101324-101525
            2107-2315           AC012488.10        103239-103447
            2316-2420           AC013468.12        3461-3565
            2421-2662           AC013468.12        11984-12225
            2663-2831           AC013468.12        13031-13199
            2832-3073           AC013468.12        20268-20509
            3074-3227           AC013468.12        20679-20832
            3228-3389           AC013468.12        21072-21233
            3390-3496           AC013468.12        22907-23013
            3497-3619           AC013468.12        25519-25641
            3620-3778           AC013468.12        30095-30253
            3779-3896           AC013468.12        30977-31094
            3897-4006           AC013468.12        33754-33863
            4007-4206           AC013468.12        35687-35886
            4207-4253           AC013468.12        37154-37200
            4254-4521           AC013468.12        38792-39059
FEATURES             Location/Qualifiers
     source          1..4521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..4521
                     /gene="ANKAR"
                     /note="ankyrin and armadillo repeat containing"
                     /db_xref="GeneID:150709"
                     /db_xref="HGNC:HGNC:26350"
                     /db_xref="MIM:609803"
     exon            1..161
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            162..797
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..4501
                     /gene="ANKAR"
                     /codon_start=1
                     /product="ankyrin and armadillo repeat-containing protein"
                     /protein_id="NP_001364997.1"
                     /db_xref="CCDS:CCDS33351.2"
                     /db_xref="GeneID:150709"
                     /db_xref="HGNC:HGNC:26350"
                     /db_xref="MIM:609803"
                     /translation="MLRLPKKGLPRFEQVQDEDTYLENLAIQRNASAFFEKYDRSEIQ
                     ELLTTALVSWLSAKEDVRSQVDLPCGIMSQMNNVGFSTAILLTPVDPTALLDYREVHQ
                     MIRELAIGIYCLNQIPSISLEANYDQSSSCQLPPAYYDTRIGQILINIDYMLKALWHG
                     IYMPKEKRARFSELWRAIMDIDPDGKPQTNKDIFSEFSSAGLTDITKDPDFNEIYDED
                     VNEDPTYDPNSPEETAVFMKYAENIMLKLTFSTTQIQQYENVFIFETGYWLTNAIKYN
                     QDYLDICTYQRLQQRLYLQKKIIQKHFEKKKDIRRGIGYLKLICFLIPFLLSLKKKMK
                     VPYLSSLLQPFSDDKVKTERELPPFIYGRDFKCQNFHYKENQYFHVHGGIEFDISTPS
                     IENALEDFQKNLEKIRDCAANTFIEDSGYKEYYSIPVMEFHGKSYYVIYFELETFYQQ
                     LYKTQWWGAINEIVNNLRLKRLPLTDAQLHEQFKKKLGFKRAMKCKSIPFGMKSAVER
                     GLSAVFHTFSRKTSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVT
                     FSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCR
                     KDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLT
                     FHTEVLKYIIKLNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILD
                     AGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPE
                     VHSRCAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNEN
                     NQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVA
                     LFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVA
                     LWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQIC
                     EGNGIAPLVRLLRISTIAEGTLLSVIRAVGSICIGVAHTSNPVSQQLVVDENAFPVLI
                     QLLRNHPSPNIKVEVAFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLR
                     AGYALTLFAFNNRFQQYLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAKVIRD
                     MDHITLSARGVTILVDSLYSVQTSTIVLTGNLIASLAHSRAGIPEAFTTLGTIQRLCY
                     HLYSGIEEVRAACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAF
                     LKEFQMQQTLVGLPSLSLEKNGGPSIIPIFKRGKEHRRKLKPKIQPKDSLTLLPPVTN
                     FMGLFKATKKTKDSHNIFSFSSTITSDITNVSRPRIVCLNQLGKHVQKANPEPAEG"
     exon            798..1235
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1399
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1503
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1684
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1904
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2106
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2315
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2420
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2662
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2831
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3073
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3227
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3389
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3496
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3497..3619
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3778
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3779..3896
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..4006
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4206
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4207..4253
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4521
                     /gene="ANKAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4500..4505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANKAR"
                     /note="hexamer: AATAAA"
     polyA_site      4521
                     /gene="ANKAR"
                     /note="major polyA site"
ORIGIN      
        1 agttccttcc ggtgcgcctc ccgctcgccc ttgcggaggc cctgagggcg gattcaaggc
       61 cccgcgagaa gccatctgag gcggcgacga ctgttctcag ccccacggga acgccgcgga
      121 cgcagcgtcc ctctcccgga caagaaaaca gccattctag aaagcttcaa aaaggacaca
      181 ctagatttaa ttagaaatgt taagattgcc caaaaaagga ttacctagat ttgagcaagt
      241 tcaggatgaa gacacctacc tggaaaattt agcaatacaa agaaatgcat ctgctttttt
      301 tgaaaaatat gatcggagtg aaatacaaga gttactaact actgcactag ttagctggtt
      361 gtctgccaaa gaggatgtgc gctctcaagt agacctccca tgtggaatta tgagtcaaat
      421 gaataacgta ggcttctcca ctgcaatcct actgactccc gtggacccta ctgccctctt
      481 agactataga gaggtccatc aaatgataag agagttggct attggaattt attgcctaaa
      541 tcaaatccct tccatcagtt tagaagctaa ttatgatcag agttcttctt gtcaattacc
      601 tccagcttat tatgatacca gaattgggca aattctgatc aatattgact acatgctgaa
      661 agcactatgg catggaatat atatgcccaa agaaaaacga gctagattct ctgaattgtg
      721 gcgtgccatc atggacattg atcctgatgg aaaacctcaa acaaataaag acattttttc
      781 agagtttagt tcagcaggtt tgactgatat tacaaaggat ccagacttta atgaaatcta
      841 tgatgaagac gtgaatgaag atccaacata tgatcccaac agccctgaag aaacagctgt
      901 atttatgaaa tatgctgaaa atattatgct aaagttaaca ttcagtacca cacaaattca
      961 acagtatgaa aatgtcttta tatttgaaac aggctattgg cttactaatg ctataaaata
     1021 taatcaggat tatcttgata tctgtaccta ccagagacta cagcaaagat tatatcttca
     1081 aaaaaagatt attcaaaaac actttgagaa gaaaaaagat atcagaagag ggataggata
     1141 cctaaagtta atatgttttc tgattccatt tctactgagt ttaaagaaga aaatgaaagt
     1201 tccatattta agtagtctgc ttcagccttt ttcagatgac aaggtcaaga cagagcgaga
     1261 attgcctcca tttatttatg gaagagattt taaatgccag aattttcact acaaagagaa
     1321 tcaatatttt catgttcatg gaggaattga atttgatatc agcacccctt caattgagaa
     1381 tgccttggaa gattttcaga aaaatttaga aaaaatacga gattgtgctg ctaatacatt
     1441 tatagaagat tcaggatata aagaatatta ctcaatacca gtcatggaat ttcatggaaa
     1501 aagctactat gtgatctatt ttgaactaga aactttctat cagcaactat ataagacaca
     1561 gtggtgggga gccataaatg aaatagtgaa caatctgaga ctgaaaagac ttccactgac
     1621 agatgctcaa ttacatgaac aatttaagaa aaagcttggt ttcaaaagag ctatgaaatg
     1681 caagagtatt ccatttggta tgaagtccgc tgttgaaaga gggttgtctg cagttttcca
     1741 cacatttagc cgtaaaacct caagctcaac aatcaatgtt tcagatgaag caggttatac
     1801 tatttttcat catgctgccc tgcacaacag agtttctatt atatgtcaac tgtgcaatgc
     1861 taacttcaag gtcaaccaga ggcgctttgt tacgttcagc caaggtccaa cacctctaca
     1921 ccttgctgca caggcttgct cattagaaac aacagtttgt ctactgtgtt ccaaagctga
     1981 ttacacgctt tctgaaaaaa gaggctggat gccgattcac tttgccgctt tctatgacaa
     2041 cgtttgcatc attattgctc tctgtaggaa ggatcctagt ttgctagaag ctgaggcaac
     2101 agctgagaat cagtgcactc cactgttact tgctgccact tcaggagcac tggacactat
     2161 tcaatacctg ttttctatcg gtgctaactg gagaaaaaca gatattaaag gaaataatat
     2221 aatccattta tcagtgttaa cctttcatac agaggttctc aaatatataa taaaattaaa
     2281 tattcctgaa ctcccagtgt ggaaaacttt ggtagaaatg ttacagtgtg aaagctataa
     2341 acgaaggatg atggccgtca tgtccttgga agtaatttgc ttagcaaatg atcaatactg
     2401 gagatgtatt ttggatgcag gcaccattcc tgccttaatc aatctattaa aaagttccaa
     2461 aataaaactg cagtgcaaaa ctgttgggtt attgagtaat atctcaaccc acaaaagtgc
     2521 agtgcatgct ttggtagaag cgggaggcat tccatctcta atcaacctac tggtttgtga
     2581 tgagcctgaa gtacactctc gctgtgctgt cattctatat gatattgctc aatgtgaaaa
     2641 caaggatgtt attgccaaat ataatggaat cccaagcctg ataaatctat tgaacttaaa
     2701 catagaaaat gtgctagtaa atgtaatgaa ctgtatacgg gtattgtgta taggaaatga
     2761 aaacaatcaa agagctgtga gagaacataa aggcctccca tatcttatca gatttctgag
     2821 ttctgattca gatgtgttga aggctgtatc ttctgctgca attgctgagg ttgggcgtga
     2881 caataaggaa attcaggatg ctatagctat ggagggagcg attcctcctc tggtggctct
     2941 ttttaaaggg aaacaaatta gtgtccaaat gaaaggtgca atggctgtgg aatcactggc
     3001 aagtcacaac gctcttatac agaaagcatt tctggaaaaa tcgttaacta aatatctttt
     3061 aaaactccta aaggcatttc aaatagatgt taaggaacaa ggagctgttg cactttgggc
     3121 cttggcagga caaacactaa aacaacaaaa atatatggca gaacaaattg gatacagctt
     3181 tataataaat atgcttttgt caccatcagc taaaatgcag tatgttggag gtgaagctgt
     3241 catagctcta agtaaggaca gcaggatgca tcaaaatcaa atatgtgaag ggaatggaat
     3301 tgcaccattg gttcgcttac taagaattag tacgattgct gaaggcacac ttctcagtgt
     3361 catcagagca gtgggatcca tttgtattgg tgtagcccat acaagcaatc ctgtcagtca
     3421 acaattggtt gtagatgaaa atgcctttcc agtacttatc caactactaa gaaatcaccc
     3481 ttctcctaac attaaggttg aagtggcatt ttccttggca tgcattgtcc tagggaatga
     3541 tgtgttacag aaagacttac atgaaaatga aggatttgaa tatgctgatg tcctttatct
     3601 tcttcactca acagaaaagg atatttgctt aagagcaggc tatgcattaa cactttttgc
     3661 cttcaataat cgctttcaac aatacttaat attggaaagt ggaataatga ccatatctat
     3721 ttttgaacgt tttcttgaat caacagttga aactgagaag gcaatggcag catttcagat
     3781 tgttgtactg gctaaagtca ttagagatat ggaccatatt actttgtctg caagaggtgt
     3841 tactatttta gttgatagtc tgtattcagt tcagacttct actattgtct tgacagggaa
     3901 tttaatagca agcctggctc attctagagc tggtatccca gaagcattta ccacattagg
     3961 aacaatccaa cggctctgct atcatttgta ctcgggaata gaagaggttc gtgcagcttg
     4021 ttcctctgct cttggctact taacatacaa tgcaaatgct ttccgcatcc tattaaaaga
     4081 atgcaggaat aaacctaatc agttcattcg tataaaaaat aatatcagca gagatgcaag
     4141 tattaaccca gcatttttaa aggaatttca aatgcaacaa acactggtgg gacttccttc
     4201 cttaagtctg gagaagaatg gaggaccatc cataattcct atctttaaaa gagggaagga
     4261 gcaccgaaga aaattaaaac ctaaaattca accaaaagat tctttgactt tattacctcc
     4321 tgtaactaac ttcatgggac tcttcaaagc aacaaaaaag accaaggatt cccataatat
     4381 tttttctttt tcatctacaa ttacatcaga tatcacaaat gtatcaagac caagaatagt
     4441 gtgtttgaac caacttggga aacatgtcca gaaagccaac ccagagcctg cagaaggcta
     4501 ataaaacatt ttagaatgaa a
//
