LOCUS       NM_001148              14215 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ankyrin 2 (ANK2), transcript variant 1, mRNA.
ACCESSION   NM_001148
VERSION     NM_001148.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14215)
  AUTHORS   Martin-Lagos,J., Bernal-Robledano,A., Perez-Carpena,P., Lamolda,M.,
            Escalera-Balsera,A., Frejo,L. and Lopez-Escamez,J.A.
  TITLE     Phenotypic spectrum of tinnitus patients bearing rare ANK2 gene
            variants
  JOURNAL   Eur Arch Otorhinolaryngol 281 (8), 4071-4080 (2024)
   PUBMED   38507076
  REMARK    GeneRIF: Phenotypic spectrum of tinnitus patients bearing rare ANK2
            gene variants.
REFERENCE   2  (bases 1 to 14215)
  AUTHORS   Teunissen,M.W.A., Lewerissa,E., van Hugte,E.J.H., Wang,S.,
            Ockeloen,C.W., Koolen,D.A., Pfundt,R., Marcelis,C.L.M.,
            Brilstra,E., Howe,J.L., Scherer,S.W., Le Guillou,X., Bilan,F.,
            Primiano,M., Roohi,J., Piton,A., de Saint Martin,A., Baer,S.,
            Seiffert,S., Platzer,K., Jamra,R.A., Syrbe,S., Doering,J.H.,
            Lakhani,S., Nangia,S., Gilissen,C., Vermeulen,R.J., Rouhl,R.P.W.,
            Brunner,H.G., Willemsen,M.H. and Nadif Kasri,N.
  TITLE     ANK2 loss-of-function variants are associated with epilepsy, and
            lead to impaired axon initial segment plasticity and hyperactive
            network activity in hiPSC-derived neuronal networks
  JOURNAL   Hum Mol Genet 32 (14), 2373-2385 (2023)
   PUBMED   37195288
  REMARK    GeneRIF: ANK2 loss-of-function variants are associated with
            epilepsy, and lead to impaired axon initial segment plasticity and
            hyperactive network activity in hiPSC-derived neuronal networks.
REFERENCE   3  (bases 1 to 14215)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 14215)
  AUTHORS   Sharma,N., Bham,K. and Senapati,S.
  TITLE     Human ankyrins and their contribution to disease biology: An update
  JOURNAL   J Biosci 45 (2020)
   PUBMED   33410423
  REMARK    GeneRIF: Human ankyrins and their contribution to disease biology:
            An update.
            Review article
REFERENCE   5  (bases 1 to 14215)
  AUTHORS   Scotland,P., Zhou,D., Benveniste,H. and Bennett,V.
  TITLE     Nervous system defects of AnkyrinB (-/-) mice suggest functional
            overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB
            in premyelinated axons
  JOURNAL   J Cell Biol 143 (5), 1305-1315 (1998)
   PUBMED   9832558
REFERENCE   6  (bases 1 to 14215)
  AUTHORS   Schott,J.J., Charpentier,F., Peltier,S., Foley,P., Drouin,E.,
            Bouhour,J.B., Donnelly,P., Vergnaud,G., Bachner,L., Moisan,J.P. et
            al.
  TITLE     Mapping of a gene for long QT syndrome to chromosome 4q25-27
  JOURNAL   Am J Hum Genet 57 (5), 1114-1122 (1995)
   PUBMED   7485162
REFERENCE   7  (bases 1 to 14215)
  AUTHORS   Chan,W., Kordeli,E. and Bennett,V.
  TITLE     440-kD ankyrinB: structure of the major developmentally regulated
            domain and selective localization in unmyelinated axons
  JOURNAL   J Cell Biol 123 (6 Pt 1), 1463-1473 (1993)
   PUBMED   8253844
REFERENCE   8  (bases 1 to 14215)
  AUTHORS   Groffen,A.J., Bikker,H. and Christiaans,I.
  TITLE     Long QT Syndrome Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301308
REFERENCE   9  (bases 1 to 14215)
  AUTHORS   Tse,W.T., Menninger,J.C., Yang-Feng,T.L., Francke,U., Sahr,K.E.,
            Lux,S.E., Ward,D.C. and Forget,B.G.
  TITLE     Isolation and chromosomal localization of a novel nonerythroid
            ankyrin gene
  JOURNAL   Genomics 10 (4), 858-866 (1991)
   PUBMED   1833308
REFERENCE   10 (bases 1 to 14215)
  AUTHORS   Otto,E., Kunimoto,M., McLaughlin,T. and Bennett,V.
  TITLE     Isolation and characterization of cDNAs encoding human brain
            ankyrins reveal a family of alternatively spliced genes
  JOURNAL   J Cell Biol 114 (2), 241-253 (1991)
   PUBMED   1830053
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093879.3, AC004057.1 and
            AC093900.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001148.5.
            
            Summary: This gene encodes a member of the ankyrin family of
            proteins that link the integral membrane proteins to the underlying
            spectrin-actin cytoskeleton. Ankyrins play key roles in activities
            such as cell motility, activation, proliferation, contact and the
            maintenance of specialized membrane domains. Most ankyrins are
            typically composed of three structural domains: an amino-terminal
            domain containing multiple ankyrin repeats; a central region with a
            highly conserved spectrin binding domain; and a carboxy-terminal
            regulatory domain which is the least conserved and subject to
            variation. The protein encoded by this gene is required for
            targeting and stability of Na/Ca exchanger 1 in cardiomyocytes.
            Mutations in this gene cause long QT syndrome 4 and cardiac
            arrhythmia syndrome. Multiple transcript variants encoding
            different isoforms have been described. [provided by RefSeq, Dec
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z26634.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357077.9/ ENSP00000349588.4
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC093879.3         126262-126421
            161-262             AC004057.1         135684-135785       c
            263-361             AC004057.1         113735-113833       c
            362-460             AC004057.1         111092-111190       c
            461-559             AC004057.1         77942-78040         c
            560-745             AC004057.1         73029-73214         c
            746-769             AC004057.1         72579-72602         c
            770-868             AC004057.1         69618-69716         c
            869-967             AC004057.1         67992-68090         c
            968-1066            AC004057.1         60339-60437         c
            1067-1264           AC004057.1         54269-54466         c
            1265-1363           AC004057.1         52053-52151         c
            1364-1462           AC004057.1         51790-51888         c
            1463-1561           AC004057.1         45206-45304         c
            1562-1759           AC004057.1         35552-35749         c
            1760-1858           AC004057.1         32266-32364         c
            1859-1957           AC004057.1         31643-31741         c
            1958-2155           AC004057.1         27329-27526         c
            2156-2254           AC004057.1         22498-22596         c
            2255-2353           AC004057.1         21715-21813         c
            2354-2452           AC004057.1         17687-17785         c
            2453-2551           AC004057.1         16663-16761         c
            2552-2624           AC004057.1         7362-7434           c
            2625-2769           AC093900.3         3049-3193
            2770-2872           AC093900.3         9501-9603
            2873-2976           AC093900.3         10311-10414
            2977-3201           AC093900.3         22040-22264
            3202-3300           AC093900.3         23766-23864
            3301-3455           AC093900.3         24848-25002
            3456-3667           AC093900.3         27640-27851
            3668-3872           AC093900.3         28371-28575
            3873-3969           AC093900.3         31020-31116
            3970-4198           AC093900.3         33482-33710
            4199-4324           AC093900.3         34811-34936
            4325-4447           AC093900.3         37694-37816
            4448-4480           AC093900.3         40070-40102
            4481-4502           AC093900.3         42022-42043
            4503-10757          AC093900.3         44839-51093
            10758-10832         AC093900.3         52617-52691
            10833-10964         AC093900.3         55132-55263
            10965-11108         AC093900.3         56833-56976
            11109-11394         AC093900.3         59360-59645
            11395-11686         AC093900.3         61308-61599
            11687-11770         AC093900.3         64884-64967
            11771-11935         AC093900.3         65079-65243
            11936-14215         AC093900.3         73251-75530
FEATURES             Location/Qualifiers
     source          1..14215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25-q26"
     gene            1..14215
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /note="ankyrin 2"
                     /db_xref="GeneID:287"
                     /db_xref="HGNC:HGNC:493"
                     /db_xref="MIM:106410"
     exon            1..160
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..11950
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin B; ankyrin 2, neuronal; ankyrin, brain; ankyrin-2,
                     nonerythrocytic; non-erythroid ankyrin"
                     /codon_start=1
                     /product="ankyrin-2 isoform 1"
                     /protein_id="NP_001139.3"
                     /db_xref="CCDS:CCDS3702.1"
                     /db_xref="GeneID:287"
                     /db_xref="HGNC:HGNC:493"
                     /db_xref="MIM:106410"
                     /translation="MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNL
                     DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALH
                     IASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT
                     EDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA
                     DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR
                     GNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS
                     PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPN
                     ARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL
                     LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG
                     KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP
                     LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA
                     TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL
                     DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN
                     VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL
                     AIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTG
                     DGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHAS
                     YLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSF
                     MVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRL
                     IEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALR
                     GKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRD
                     FPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSE
                     LVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLC
                     SITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYRE
                     IICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEG
                     KPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKS
                     TRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNE
                     VPVLASPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIV
                     ERVKEDLEKVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLE
                     ITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEA
                     LAVGRSSEKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKA
                     ELKKGSSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGR
                     SKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERH
                     PPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTER
                     HPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTE
                     KHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSA
                     KQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIG
                     VKKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKEKMADEQGDMDLQISPDRKT
                     STDFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPA
                     LSLQSGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLS
                     FSPKKSEEQTGETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDSETSTES
                     FQKEATLGSPKDTSPKRQDDCTGSCSVALAKETPTGLTEEAACDEGQRTFGSSAHKTQ
                     TDSEVQESTATSDETKALPLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLS
                     AVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKA
                     GIFPSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSP
                     DTPSSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIK
                     MFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVT
                     SESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQP
                     VVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPK
                     ICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELD
                     VSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENL
                     PKDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKT
                     QTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQEST
                     LWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVK
                     EEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAID
                     MTKRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVD
                     DEADLLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIP
                     PLSGVKQISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPM
                     ENVPFTESKSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPV
                     KVPLQRVEQQLSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTR
                     SYTETETESRERAEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSPTKESKEH
                     FFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESSSALEVSVIENLPPVET
                     EHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQERIEERLAYIADHLGF
                     SWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKI
                     NRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQA
                     VSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGK
                     MQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQT
                     PTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGD
                     DMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNI
                     EEGDGYSKVIKRVVLKSDTEQSEDNNE"
     exon            161..262
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            263..361
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            362..460
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            461..559
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            560..745
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            746..769
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            770..868
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            869..967
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1066
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1264
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1363
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1462
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1561
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1759
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1858
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1957
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2155
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2254
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2353
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2452
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2551
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2624
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2769
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2872
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2976
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3201
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3300
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3455
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3667
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3872
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..3969
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            3970..4198
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            4199..4324
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4447
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            4448..4480
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            4481..4502
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            4503..10757
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            10758..10832
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            10833..10964
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            10965..11108
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            11109..11394
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            11395..11686
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            11687..11770
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            11771..11935
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     exon            11936..14215
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      13684
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
     regulatory      14190..14195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /note="hexamer: AATAAA"
     polyA_site      14215
                     /gene="ANK2"
                     /gene_synonym="ANK-2; brank-2; CFAP87; FAP87; LQT4"
                     /note="major polyA site"
ORIGIN      
        1 aagtgcatac ccgctagtgg tctgtacagg cggcacggtt tgatggcaga gatattttct
       61 ttccaaactg ttcaaaatga tgaacgaaga tgcagctcag aaaagcgaca gtggagagaa
      121 gttcaacggc agtagtcaga ggagaaaaag acccaagaag tctgacagca atgcaagctt
      181 cctccgtgct gccagagcag gcaacctgga caaagttgtg gaatatctga aggggggcat
      241 agacatcaat acctgcaatc agaatggact caacgctctc catctggctg ccaaggaagg
      301 ccacgtgggg ctggtgcagg agctgctggg aagagggtcc tctgtggatt ctgccactaa
      361 gaagggaaat accgctcttc acattgcatc tttggctgga caagcagaag ttgtcaaagt
      421 tcttgttaag gaaggagcca atattaatgc acagtctcag aatggcttta ctcctttata
      481 catggctgcc caagagaatc acattgatgt tgtaaaatat ttgctggaaa atggagctaa
      541 tcagagcact gctacagagg atggctttac tcctctagct gtggcactcc agcaaggaca
      601 caaccaggcg gtggccatcc tcttggagaa tgacaccaaa gggaaagtga ggctgccagc
      661 tctgcatatt gccgctagga aagacgacac caaatctgcc gcacttctgc ttcagaatga
      721 ccacaatgct gacgtacaat ccaagatgat ggtgaatagg acaactgaga gtggttttac
      781 ccctttgcac atagctgcac attacggaaa tgtcaacgtg gcaactcttc ttctaaaccg
      841 gggagctgct gtggacttca cagccaggaa tggaatcact cctctgcatg tggcttccaa
      901 aagaggaaat acaaacatgg tgaagctctt actggatcga ggcggtcaga tcgatgccaa
      961 aactagggat gggttgacac cacttcactg tgctgcacga agtgggcatg accaagtggt
     1021 ggaacttctg ttggaacggg gtgccccctt gctggcaagg actaagaatg ggctgtctcc
     1081 actacacatg gctgcccagg gagaccacgt ggaatgtgtg aagcacctgt tacagcacaa
     1141 ggcacctgtt gatgatgtca ccctagacta cctgacagcc ctccacgttg ctgcgcactg
     1201 tggccactac cgtgtaacca aactcctttt agacaagaga gccaatccga acgccagagc
     1261 cctgaatggt tttactccac tgcacattgc ctgcaagaaa aaccgcatca aagtcatgga
     1321 actgctggtg aaatatgggg cttcaatcca agctataaca gagtctggcc tcacaccaat
     1381 acatgtggct gccttcatgg gccacttgaa cattgtcctc cttctgctgc agaacggagc
     1441 ctctccagat gtcactaaca ttcgtggtga gacggcacta cacatggcag cccgagccgg
     1501 gcaggtggaa gtggtccgat gcctcctgag aaatggtgcc cttgttgatg ccagagccag
     1561 ggaggaacag acacctttac atattgcctc ccgcctgggt aagacagaaa ttgtccagct
     1621 gcttctacaa catatggctc atccagatgc ggccactaca aatgggtaca caccactgca
     1681 catctctgcc cgggagggcc aggtggatgt ggcatcagtc ctattggaag caggagcagc
     1741 ccactcctta gctaccaaga agggttttac tcccctgcat gtagcagcca agtatggaag
     1801 cctggatgtg gcaaaacttc tcttgcaacg ccgtgctgcc gcagattctg cagggaagaa
     1861 cggccttacc ccgctccatg ttgctgctca ttatgacaac cagaaggtgg cgctgctgtt
     1921 actggagaag ggtgcttccc ctcatgccac tgccaagaat ggctatactc cgttacatat
     1981 tgctgccaag aagaatcaaa tgcagatagc ttccacactc ctgaactatg gagcagagac
     2041 aaacattgtg acaaagcaag gagtaactcc actccatctg gcctcgcagg aggggcacac
     2101 agatatggtt accttgcttc tggataaggg agccaatatc cacatgtcaa ctaagagtgg
     2161 actcacatcc ttacaccttg cagcccagga agataaagtg aatgttgctg atattctcac
     2221 caagcatgga gctgatcagg atgctcatac aaagcttggt tacacacctt taattgtggc
     2281 ctgtcactat ggaaatgtga aaatggtcaa ctttcttctg aagcagggag caaatgttaa
     2341 cgcaaaaacc aagaacggct acacgccttt gcaccaggcc gctcagcagg gtcacacgca
     2401 catcatcaac gtcctgctcc agcatggggc caagcccaac gccaccactg cgaatggcaa
     2461 cactgccttg gcgattgcta agcgtctggg ctacatctcc gtggtcgaca ccctgaaggt
     2521 tgtgactgag gaggtcacca ccaccaccac aactattaca gaaaaacaca aactaaatgt
     2581 acctgagacg atgactgagg ttcttgatgt ttctgatgaa gagggtgatg acacaatgac
     2641 tggtgatggg ggagaatacc ttaggcctga ggacctaaaa gaactgggtg atgactcact
     2701 acccagcagt cagttcctgg atggtatgaa ttacctgcga tacagcttgg agggaggacg
     2761 atctgacagc cttcgatcct tcagttccga caggtctcac actctgagcc atgcctccta
     2821 cctgagggac agtgccgtga tggatgactc agttgtgatt cccagtcacc aggtgtcaac
     2881 tctagccaag gaggcagaaa ggaattctta tcgcctaagc tggggcactg agaacttaga
     2941 caacgtggct ctttcttcta gtcctattca ttcaggtttc ctggttagtt ttatggtgga
     3001 tgcccgaggt ggtgctatgc gaggatgcag acacaatggg ctccgaatca ttattccacc
     3061 tcggaaatgt actgctccaa cgcgagtcac ctgccgactg gtcaagcgcc acagactggc
     3121 aacaatgcct ccaatggtgg aaggagaagg cctggccagt cgcctgatcg aagttggacc
     3181 ttctggtgct cagttccttg gtaaacttca cctgccaacg gctcctcccc cacttaatga
     3241 gggagaaagt ttggtcagcc gcattcttca gctggggcct cctggaacca aattccttgg
     3301 gcctgtgatc gtggagatcc ctcactttgc ggcccttcga ggaaaggaaa gggaactggt
     3361 ggtcctgcgc agtgagaatg gggacagctg gaaagagcat ttctgtgact acactgaaga
     3421 tgaattgaat gaaattctta acggcatgga tgaagtactg gatagcccag aagacctaga
     3481 aaagaaacga atctgccgca tcatcacccg agacttccca cagtactttg cagtggtgtc
     3541 tcgtatcaaa caggacagca atctgattgg cccagaagga ggtgtactga gcagcacagt
     3601 ggtgccccag gtgcaggccg tcttcccaga gggggcactc accaagcgga tccgcgtagg
     3661 cctgcaggct caacctatgc acagtgagct ggttaagaag atcctaggca acaaagctac
     3721 cttcagccct atagtcactt tggaacctag aagaagaaaa ttccacaaac caattaccat
     3781 gaccattcct gtccccaaag cttcaagtga tgtcatgttg aatggttttg ggggagatgc
     3841 accaacctta agattactat gcagcataac aggtggaacc acccctgccc agtgggaaga
     3901 tattacagga actacgccat taacatttgt caatgaatgt gtttccttta caacaaacgt
     3961 gtctgccagg ttctggctga tagattgtcg acagatccag gaatccgtta cttttgcatc
     4021 acaagtatac agagaaatta tctgcgtacc ttatatggcc aaatttgtag tgtttgccaa
     4081 atcacatgac cccattgaag ccaggttgag gtgtttctgc atgactgatg ataaagtgga
     4141 taagaccctt gaacaacaag aaaattttgc tgaggtggcc agaagcaggg atgtggaggt
     4201 gttagaagga aaacccatct acgttgattg tttcggcaac ttggtaccat taactaaaag
     4261 tggccagcat catatattca gtttttttgc cttcaaagaa aatagacttc ctctatttgt
     4321 caaggtacgc gatacgactc aggaaccttg cggacgacta tcatttatga aggagccaaa
     4381 atccacgaga ggcctggtgc atcaagctat ttgcaactta aacatcactt tgccgattta
     4441 tacaaaggaa tcagagtcag atcaagaaca ggaggaagag atcgatatga catcagaaaa
     4501 aaatgatgag acagaatcta cagaaacatc tgtcctgaaa agtcacctgg ttaatgaagt
     4561 tcctgtccta gcaagtccgg acttgctctc tgaagtttct gagatgaaac aagatttgat
     4621 caaaatgacc gccatcttga ccacagatgt gtctgataag gcaggttcta ttaaagtgaa
     4681 ggagctggtg aaggctgctg aggaagagcc aggagagcct tttgaaatcg ttgaaagagt
     4741 taaagaggac ttagagaaag tgaatgaaat cctgagaagt ggaacctgca caagagatga
     4801 aagcagtgtg cagagctctc ggtctgagag aggattagtt gaagaggaat gggttattgt
     4861 cagtgatgag gaaatagaag aggctaggca aaaagcacct ttagaaatca ctgaatatcc
     4921 atgtgtagaa gttagaatag ataaagagat caaaggaaaa gtagagaaag actcaactgg
     4981 gctagtgaac taccttactg atgatctgaa tacctgtgtg cctcttccca aagagcagct
     5041 gcagacagtt caagataagg cagggaagaa atgtgaggct ctggctgttg gcaggagctc
     5101 tgaaaaggaa gggaaagaca tacccccaga tgagacacag agtacacaga aacagcacaa
     5161 accaagcttg ggaataaaga agccagtaag aaggaaatta aaagaaaagc agaaacaaaa
     5221 agaggaaggt ttacaagcta gtgcagagaa agctgaactt aaaaaaggta gttcagaaga
     5281 gtcattaggt gaagacccag gtttagcccc tgaacccctt cccactgtca aggccacatc
     5341 tcctttgata gaagaaactc ccattggttc cataaaggac aaagtaaagg cccttcagaa
     5401 gcgagtggaa gatgaacaga aaggtcgaag caagttgccc atcagagtca aaggcaagga
     5461 ggacgtgcca aaaaagacca cccacaggcc acatccagct gcgtcaccct ctctgaagtc
     5521 agagagacat gcgccagggt ctccctcccc taaaacagaa agacactcta ctctttcctc
     5581 ttccgcaaaa actgaaaggc accctccagt atcaccatca agtaaaactg agaaacactc
     5641 acctgtgtca ccctctgcaa aaacggaaag acattcacct gcgtcatcat cgagtaaaac
     5701 tgagaaacac tcacctgtat caccctcgac aaaaactgaa aggcactctc ctgtgtcatc
     5761 tacaaaaaca gaaagacacc cacctgtttc gccttcaggc aaaacagaca aacgtccacc
     5821 tgtatcgccc tccgggagga cagaaaaaca cccgccagta tcgcctggga gaacagaaaa
     5881 acgcttgcct gtttcaccct ccggaagaac ggacaagcac caacctgtat caacagctgg
     5941 gaaaactgag aagcacctgc ctgtgtcacc ttctggcaaa acagaaaagc aaccacctgt
     6001 atcccccact tcaaaaacag agaggattga ggaaaccatg tctgttcggg agctgatgaa
     6061 ggctttccag tcaggtcagg acccttctaa acataaaact ggactctttg agcacaaatc
     6121 agcaaaacaa aagcagccac aagagaaagg taaagttcgg gtagaaaaag aaaaggggcc
     6181 gatactaacc cagagagaag ctcagaaaac agagaatcag acaatcaaac gaggccagag
     6241 actcccggta acgggcacag cagaatccaa aagaggagtt cgtgtttcct ccataggagt
     6301 taagaaagaa gatgcagctg gaggaaagga gaaagttctc agccacaaaa tacctgaacc
     6361 tgttcagtca gtgcctgaag aagaaagcca cagagagagc gaagtgccca aagaaaagat
     6421 ggctgatgag cagggagaca tggatctaca gatcagccca gataggaaaa cctccactga
     6481 cttctctgag gtcattaagc aagagttgga agacaatgac aaataccaac aattccgcct
     6541 gagtgaggag acagaaaagg cacagcttca cttagaccaa gtactcacta gtcctttcaa
     6601 cacaacattt ccactcgact acatgaaaga tgagttcctt ccagctctgt ctttacaaag
     6661 cggtgcttta gatggcagtt ctgaaagcct aaagaatgag ggggtagccg gctctccgtg
     6721 tggcagcctg atggagggga cccctcagat tagttcagaa gaaagctata agcatgaagg
     6781 cctagcagag acccctgaga cgagcccaga aagcctttct ttctcaccaa agaaaagtga
     6841 ggagcaaact ggggaaacaa aggaaagcac caagacagaa accaccacag aaattcgttc
     6901 agaaaaagag catcccacga ccaaagacat tactggtggc tctgaagagc gaggtgccac
     6961 agtcactgag gactcagaga cctctactga gagttttcag aaagaggcca ctctaggctc
     7021 tcccaaagac acaagcccta aaagacaaga tgattgcaca ggcagctgta gtgtagcatt
     7081 agctaaagag acacctacag gactgactga ggaggcagcc tgtgatgaag gtcaacgtac
     7141 ctttggtagt tcagcccaca agacacaaac tgatagtgag gttcaagaat ccacagccac
     7201 ctcagacgag acaaaggcct tgccgctgcc tgaggcttct gtaaagacag atacaggaac
     7261 tgaatcaaaa cctcagggag tcattagaag tccccaaggg ttagaacttg cactccctag
     7321 ccgagatagc gaagtcctca gcgctgtggc tgatgactca ttagcagtga gccacaaaga
     7381 ctctctggaa gccagccctg tgctagaaga taactcttca cacaaaaccc ctgattctct
     7441 ggagccaagt cctctgaaag aatccccttg ccgtgactct ctggaaagca gccctgttga
     7501 accaaagatg aaggctggaa tttttccaag tcactttcct cttcctgcag ctgttgccaa
     7561 aacagaactc ttgacggaag tggcctctgt gcggtcccgg ctactccgag accctgatgg
     7621 cagtgctgag gatgacagtc ttgagcagac atcgctcatg gagagctcag ggaagagccc
     7681 cctttctcct gacaccccca gctctgaaga agtcagctat gaggttacac ccaaaaccac
     7741 agatgtaagt acaccaaaac cagctgtgat tcatgaatgt gcagaggagg atgattcaga
     7801 aaacggggag aaaaagaggt tcacacctga agaggagatg tttaaaatgg taaccaaaat
     7861 caaaatgttt gatgaacttg aacaagaagc aaagcagaaa agggactaca aaaaagaacc
     7921 caaacaagaa gaatcttctt catcttctga cccagatgct gactgttcag tagatgtgga
     7981 tgaaccaaaa catacaggca gtggggagga tgaaagtggt gtccctgtgt tagtaacttc
     8041 ggagagcagg aaggtgtctt cctcctcaga aagtgaacct gagttggcac agcttaaaaa
     8101 aggtgctgac tcaggccttt taccagaacc agtgattcga gtacaacctc cttctccact
     8161 tccatcaagc atggactcca attccagtcc agaagaagta caattccagc ctgtcgtttc
     8221 caaacaatat actttcaaga tgaatgaaga tactcaggaa gagccaggca aatcagaaga
     8281 agaaaaagat tctgaatccc atttagctga agaccgtcat gctgtttcca ctgaggctga
     8341 agacaggtct tatgataagc taaacagaga cactgatcag ccaaaaatct gtgatggcca
     8401 tggatgtgag gccatgagtc ctagcagctc agctgctcct gtctcttcag gtctacagag
     8461 tccgactggt gatgatgttg atgaacagcc agtcatctat aaagaatcat tagctctcca
     8521 aggcactcat gaaaaagaca cagagggaga agagcttgat gtttctagag cagaatctcc
     8581 acaagcagat tgccccagtg aaagcttttc atcttcatcc tctttgcctc attgtttggt
     8641 atctgaagga aaagaattag atgaagacat atctgccaca tcttctattc aaaaaacaga
     8701 ggtcacaaaa actgatgaaa catttgagaa cttaccaaag gactgcccct ctcaagactc
     8761 atccattact actcaaacag atagattttc catggatgtt cccgtgtctg acctagctga
     8821 gaatgatgaa atctatgatc cacaaatcac tagcccttat gaaaatgtcc cttcccaatc
     8881 ttttttctct agtgaagaaa gcaaaaccca aacagatgca aatcacacca caagttttca
     8941 ctcttctgaa gtgtattctg ttaccatcac atcccctgtt gaagacgttg tagtggcaag
     9001 ctcctctagt ggaactgttt taagcaaaga atctaatttt gagggccagg acataaaaat
     9061 ggaatcccaa caggaaagta ccttgtggga aatgcaatca gacagtgtct cttcatcttt
     9121 cgagcctact atgtccgcta caacaacagt tgttggtgaa caaataagca aagtcatcat
     9181 cacaaaaact gatgtggatt ctgattcttg gagtgaaatt cgggaagacg atgaagcctt
     9241 tgaggctcgt gtgaaagagg aagaacaaaa gatatttggt ttgatggtag acagacaatc
     9301 acagggtacc acccctgaca ccactcctgc taggacccca actgaagagg ggaccccaac
     9361 aagtgagcaa aacccatttc tgtttcagga aggaaaattg tttgaaatga cccgaagtgg
     9421 tgccattgat atgaccaaaa ggtcctatgc agatgaaagt tttcactttt tccaaattgg
     9481 tcaagaatcc agggaagaga ctctctctga agatgtgaaa gaaggggcta ctggggctga
     9541 tcccctaccg ctggagacat cagctgaatc actagcactt tcagaatcaa aagaaacagt
     9601 ggatgatgag gcagacttac ttccagatga cgtgagtgag gaagtagagg aaatacctgc
     9661 ttcggatgct caacttaact cccaaatggg gatttcagcc tccactgaaa cacctacaaa
     9721 agaagctgtt agtgtaggga ccaaggacct ccccaccgtg caaacgggtg atatacctcc
     9781 tctctctggt gtaaagcaga tatcctgccc cgactcttct gaaccagctg tacaagtcca
     9841 gttagatttt tccacactca ccaggtctgt ttattcagat aggggtgatg attctcccga
     9901 ttcttcccca gaagaacaga aatcagtaat cgagattcct actgcaccca tggagaatgt
     9961 gccttttact gaaagcaaat ccaaaattcc tgtaaggact atgcccactt ccaccccagc
    10021 acctccatct gcagagtatg agagttcagt ttctgaagat tttctatcca gtgtagatga
    10081 ggaaaataag gcggatgaag caaaaccaaa gtccaaactc cctgtcaaag tacccctcca
    10141 aagagttgaa cagcagctct cagatctaga cacctctgtc cagaagacag tggctcctca
    10201 gggacaggac atggcaagca tcgcaccaga taatagaagc aaatctgaat ctgatgctag
    10261 ttctttggat tcaaagacca aatgcccagt aaaaacccga agttacactg agacagaaac
    10321 agagagcaga gagagggccg aggaacttga gttagaatca gaagaagggg ccacaagacc
    10381 aaagatactt acatcccgat tgccagttaa gagcagaagc actacatctt cctgcagggg
    10441 gggcacgagc cccacaaaag aaagtaagga gcatttcttt gacctttaca gaaattccat
    10501 agaattcttt gaggagatta gtgatgaggc ttccaaatta gtggataggc tgacacagtc
    10561 agagagggag caggaaatag tttcagacga tgaaagtagt agtgccctgg aagtatcagt
    10621 aattgaaaat ctgccacctg ttgagaccga gcactcagtt cctgaggaca tctttgacac
    10681 aaggcccatt tgggatgagt ctattgagac tctgattgaa cgcatccctg atgaaaatgg
    10741 ccatgaccat gctgaagatc cacaggatga gcaggaacgg atcgaggaaa ggctggctta
    10801 tattgctgat caccttggct tcagctggac agaattagca agagaactgg atttcactga
    10861 ggagcaaatt catcaaattc gaattgaaaa tcccaactct cttcaagacc agagtcatgc
    10921 actgttgaag tactggctag agagggatgg gaaacatgct acagatacca acctcgttga
    10981 atgtctcacc aagatcaacc gaatggatat tgttcatctc atggagacca acacagaacc
    11041 tctccaggag cgcatcagtc atagttatgc agaaattgaa cagaccatta cactggatca
    11101 tagtgaaggg ttctcggtac ttcaagagga gttatgcact gcacagcaca agcagaaaga
    11161 ggagcaagct gtttctaaag aaagtgagac ctgcgatcac cctcctatcg tctcagagga
    11221 agacatttct gttggttatt ccacttttca ggatggcgtc cccaaaactg agggggacag
    11281 ctcagcaaca gcactctttc cccaaactca caaggagcaa gttcaacagg atttctcagg
    11341 gaaaatgcaa gacctgcctg aagagtcatc tctggaatat cagcaggaat attttgtgac
    11401 aactccagga acagaaacat cagagactca gaaggctatg atagtaccca gctctcccag
    11461 caagacacct gaggaagtta gcacccctgc agaggaggag aagctgtacc tccagacccc
    11521 aacatccagc gagcggggag gctctcccat catacaagaa cccgaagagc cctcagagca
    11581 cagagaggag agctctccgc ggaaaaccag cctcgtaata gtggagtctg ccgataacca
    11641 gcctgagacc tgtgaaagac tcgatgaaga tgcagctttt gaaaagggag acgatatgcc
    11701 tgaaataccc ccagaaacag tcacagaaga agaatacatt gatgagcatg gacacaccgt
    11761 ggtaaagaag gttactagga aaatcattag gcggtatgta tcctctgaag gcacagagaa
    11821 agaagagatt atggtgcagg gaatgccaca ggaacctgtc aacatcgagg aaggggatgg
    11881 ctattccaaa gttataaagc gtgttgtatt gaagagtgac accgagcagt cagaggacaa
    11941 caatgagtaa agccatcaca cagaagaggg ctgtggtgaa ggaccagcat ggaaaacgca
    12001 ttgacttgga gcacctggag gatgtaccag aagcactaga ccaggacgac ctccagcgcg
    12061 atctccagca gctccttcgg catttctgca aggaggactt gaagcaagag gccaagtgag
    12121 gggctgccca gttctcacac cagaaaccac acattcactc aatatgcagc ttcctgtttc
    12181 agtaggggag tgacctaact ggcctaatta atgggatacc ccgacatttc cactgttagc
    12241 aaatatacgg cattttgctt tagttttccc ccatcctctt taactataaa gctaatttgt
    12301 gaccaaagat ggcatccttc atactggatg ctgtatccaa tactttgttg tgtctgtgct
    12361 aacctgggaa ctggccacct ccattgttct ttgcttctgc acaagatcca tgaaaatcca
    12421 ttgatcagaa gaacttcacc tgcagacctc ttcaagtgac actatgtagg aatccttcca
    12481 aggaatatct atgtacaatg tatatagctg aaatgctcag atgaacaaca tattaaaatt
    12541 aaaaccactg cctattgtaa ctacactggg catcagaata aaaggcctct agaaattgct
    12601 gaacaatggt taattaagat attgctaaca caatcgagtg ataatacagt tttactgcaa
    12661 aagaagcact tcaaacctat tatgtcctta gaacttccag agtagccact gctcccagtt
    12721 aaaggtgggt cagtagcctt gcagaactgt cctgagaagt tattgctggt gctggccagc
    12781 catggcttag gactccaaca gccactctga gggaggggag aagggagcag aggccacgca
    12841 gaatgaaccg atggggtatt cagttgctgg cagctacatt gtgtggcatt ctagcatctt
    12901 caggtcttta gatcttggac aagttggcag ggtattttaa aagctataac tactgtagtt
    12961 ttccagtttt cattgctgct ttagcaaacc acgctgtctt acagtggtac tttcttctgg
    13021 ccactgcact gtagataatt cattggaaac aagatttacc cactacataa aaggttaaac
    13081 tccttcagta tgttggagtg gtttcttttt ttttttcttt ctttcttttt tttcttcagg
    13141 tttatatctt ctctaatacc tgcatgtggc gtttaaaaat caagaccacg gtcaaacccc
    13201 tcttctaatc acattaattg tttccattct ttttaccctg agtgagcact tttcactttc
    13261 cagctaggtc tgtttttcag cttgcagaca agattgagaa atccttgaaa atttggtttt
    13321 ggttaaaatt tttggtttat ttatttgaaa tccacactcc cttggaaact cttaagtgca
    13381 tttgtgcact tctgtttgtt tgtctcaaag aagggactgt aacaatctga gtaatttcca
    13441 tgtcctcttc cttattcctc tagtggttga agctgtgtag cattttaaca tatatatatt
    13501 cacaaatata ttcatataaa cagtatacat tttgaatcag tcatttgtta aagaaaagta
    13561 tattcaatga agatgaaatt taaataaaaa aggacagagt ctatcctcca gggattgaac
    13621 attttccaat tatctggtct tttcctgttg tgcaaaaatg actcattgct ccgaatgtca
    13681 aaaacaaatg cgacaaacaa tggcacttca tcatttaaag taatgttgcc aagagaaaaa
    13741 atttcctggg agggaggttt cccacaagcc aaatctccta agcctcaaat gctagcactt
    13801 tttggcagtt ggataggaaa tgagacattc tttggcagcc aaaataagag aggccgatgg
    13861 tgaaactttt tgagacaccc tatggccttc ttgtcaaaac cttcactgga gctcaagaaa
    13921 agcatttctg ttgtgttatt tgcagtgcag atgatgtctg tgtaacaaca taatggttat
    13981 tcaccttttt ttgattttga tttttgctgt gttatcaaaa acttgaatac tgtgagaaga
    14041 agtgaatttt cagttgacga atcagcatct tgttcccatg gtgataacac taattgaata
    14101 tatctatgag ggcatgtatt agttaatgga aaaaaaaata caacactaac aatacatagc
    14161 tgcaatgtgt acaatggctg atttaattaa ataaaatgta caagtgttaa atgtg
//
