LOCUS       NM_018687                872 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens angiopoietin like 8 (ANGPTL8), mRNA.
ACCESSION   NM_018687
VERSION     NM_018687.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 872)
  AUTHORS   Chen,S.M., Huang,T.Y., Lee,W.J., Chuang,L.M. and Chang,T.J.
  TITLE     Positive correlation of ANGPTL8 expression in human visceral
            adipose tissue with body mass index
  JOURNAL   J Formos Med Assoc 123 (8), 860-865 (2024)
   PUBMED   38191275
  REMARK    GeneRIF: Positive correlation of ANGPTL8 expression in human
            visceral adipose tissue with body mass index.
REFERENCE   2  (bases 1 to 872)
  AUTHORS   Mohammedsaeed,W. and Binjawhar,D.
  TITLE     The correlations between angiopoietin like 8 and cardiometabolic
            risk factors in Saudi women with type 2 diabetes mellitus: A pilot
            study
  JOURNAL   Diab Vasc Dis Res 21 (3), 14791641241259792 (2024)
   PUBMED   38843864
  REMARK    GeneRIF: The correlations between angiopoietin like 8 and
            cardiometabolic risk factors in Saudi women with type 2 diabetes
            mellitus: A pilot study.
REFERENCE   3  (bases 1 to 872)
  AUTHORS   Wen,Y., Chen,Y.Q. and Konrad,R.J.
  TITLE     Angiopoietin-like protein 8: a multifaceted protein instrumental in
            regulating triglyceride metabolism
  JOURNAL   Curr Opin Lipidol 35 (2), 58-65 (2024)
   PUBMED   37962908
  REMARK    GeneRIF: Angiopoietin-like protein 8: a multifaceted protein
            instrumental in regulating triglyceride metabolism.
            Review article
REFERENCE   4  (bases 1 to 872)
  AUTHORS   Abu-Farha,M., Madhu,D., Hebbar,P., Mohammad,A., Channanath,A.,
            Kavalakatt,S., Alam-Eldin,N., Alterki,F., Taher,I., Alsmadi,O.,
            Shehab,M., Arefanian,H., Ahmad,R., Thanaraj,T.A., Al-Mulla,F. and
            Abubaker,J.
  TITLE     The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating
            Inflammation through NF-kappaB Signaling Pathway under TNFalpha
            Stimulation
  JOURNAL   Cells 12 (21), 2563 (2023)
   PUBMED   37947641
  REMARK    GeneRIF: The Proinflammatory Role of ANGPTL8 R59W Variant in
            Modulating Inflammation through NF-kappaB Signaling Pathway under
            TNFalpha Stimulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 872)
  AUTHORS   AlMajed,H.T., Abu-Farha,M., Alshawaf,E., Devarajan,S.,
            Alsairafi,Z., Elhelaly,A., Cherian,P., Al-Khairi,I., Ali,H.,
            Jose,R.M., Thanaraj,T.A., Al-Ozairi,E., Al-Mulla,F., Al Attar,A.
            and Abubaker,J.
  TITLE     Increased Levels of Circulating IGFBP4 and ANGPTL8 with a
            Prospective Role in Diabetic Nephropathy
  JOURNAL   Int J Mol Sci 24 (18), 14244 (2023)
   PUBMED   37762544
  REMARK    GeneRIF: Increased Levels of Circulating IGFBP4 and ANGPTL8 with a
            Prospective Role in Diabetic Nephropathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 872)
  AUTHORS   Fu,Z., Yao,F., Abou-Samra,A.B. and Zhang,R.
  TITLE     Lipasin, thermoregulated in brown fat, is a novel but atypical
            member of the angiopoietin-like protein family
  JOURNAL   Biochem Biophys Res Commun 430 (3), 1126-1131 (2013)
   PUBMED   23261442
  REMARK    GeneRIF: Lipasin, ANGPTL3 and ANGPTL4 are within the same branch
            based on phylogenetic analysis of all ANGPTL members, and therefore
            Lipasin is a novel but atypical member of the ANGPTL family.
            Lipasin is abundant in brown fat, in which its expression is
            induced by cold exposure.  Lipasin and ANGPTL4 expressions show
            opposite changes in response to fasting and cold exposure.
REFERENCE   7  (bases 1 to 872)
  AUTHORS   Quagliarini,F., Wang,Y., Kozlitina,J., Grishin,N.V., Hyde,R.,
            Boerwinkle,E., Valenzuela,D.M., Murphy,A.J., Cohen,J.C. and
            Hobbs,H.H.
  TITLE     Atypical angiopoietin-like protein that regulates ANGPTL3
  JOURNAL   Proc Natl Acad Sci U S A 109 (48), 19751-19756 (2012)
   PUBMED   23150577
REFERENCE   8  (bases 1 to 872)
  AUTHORS   Zhang,R.
  TITLE     Lipasin, a novel nutritionally-regulated liver-enriched factor that
            regulates serum triglyceride levels
  JOURNAL   Biochem Biophys Res Commun 424 (4), 786-792 (2012)
   PUBMED   22809513
  REMARK    GeneRIF: Lipasin is highly enriched in the liver, where its
            expression is suppressed by fasting and induced by obesity.
            Adenovirus-mediated overexpression of Lipasin increases serum
            triglyceride levels in mice. Lipasin therefore is a
            nutritionally-regulated liver-enriched factor that regulates serum
            triglyceride levels.
REFERENCE   9  (bases 1 to 872)
  AUTHORS   Ren,G., Kim,J.Y. and Smas,C.M.
  TITLE     Identification of RIFL, a novel adipocyte-enriched insulin target
            gene with a role in lipid metabolism
  JOURNAL   Am J Physiol Endocrinol Metab 303 (3), E334-E351 (2012)
   PUBMED   22569073
  REMARK    GeneRIF: RIFL is an important new regulator of lipid metabolism.
REFERENCE   10 (bases 1 to 872)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP316755.1, AY358356.1 and BF511595.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018687.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358356.1, ERR279834.8726.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252453.12/ ENSP00000252453.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BP316755.1         2-17
            17-868              AY358356.1         1-852
            869-872             BF511595.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..872
                     /gene="ANGPTL8"
                     /gene_synonym="C19orf80; PRO1185; PVPA599; RIFL; TD26"
                     /note="angiopoietin like 8"
                     /db_xref="GeneID:55908"
                     /db_xref="HGNC:HGNC:24933"
                     /db_xref="MIM:616223"
     exon            1..316
                     /gene="ANGPTL8"
                     /gene_synonym="C19orf80; PRO1185; PVPA599; RIFL; TD26"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..616
                     /gene="ANGPTL8"
                     /gene_synonym="C19orf80; PRO1185; PVPA599; RIFL; TD26"
                     /note="hepatocellular carcinoma-associated protein TD26;
                     hepatocellular carcinoma-associated gene TD26; lipasin;
                     angiopoietin-like protein 8; refeeding-induced fat and
                     liver protein"
                     /codon_start=1
                     /product="angiopoietin-like protein 8 precursor"
                     /protein_id="NP_061157.3"
                     /db_xref="CCDS:CCDS54220.1"
                     /db_xref="GeneID:55908"
                     /db_xref="HGNC:HGNC:24933"
                     /db_xref="MIM:616223"
                     /translation="MPVPALCLLWALAMVTRPASAAPMGGPELAQHEELTLLFHGTLQ
                     LGQALNGVYRTTEGRLTKARNSLGLYGRTIELLGQEVSRGRDAAQELRASLLETQMEE
                     DILQLQAEATAEVLGEVAQAQKVLRDSVQRLEVQLRSAWLGPAYREFEVLKAHADKQS
                     HILWALTGHVQRQRREMVAQQHRLRQIQERLHTAALPA"
     exon            317..478
                     /gene="ANGPTL8"
                     /gene_synonym="C19orf80; PRO1185; PVPA599; RIFL; TD26"
                     /inference="alignment:Splign:2.1.0"
     exon            479..588
                     /gene="ANGPTL8"
                     /gene_synonym="C19orf80; PRO1185; PVPA599; RIFL; TD26"
                     /inference="alignment:Splign:2.1.0"
     exon            589..872
                     /gene="ANGPTL8"
                     /gene_synonym="C19orf80; PRO1185; PVPA599; RIFL; TD26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      848..853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL8"
                     /gene_synonym="C19orf80; PRO1185; PVPA599; RIFL; TD26"
                     /note="hexamer: ATTAAA"
     polyA_site      872
                     /gene="ANGPTL8"
                     /gene_synonym="C19orf80; PRO1185; PVPA599; RIFL; TD26"
                     /note="major polyA site"
ORIGIN      
        1 ataccttaga ccctcagtca tgccagtgcc tgctctgtgc ctgctctggg ccctggcaat
       61 ggtgacccgg cctgcctcag cggcccccat gggcggccca gaactggcac agcatgagga
      121 gctgaccctg ctcttccatg ggaccctgca gctgggccag gccctcaacg gtgtgtacag
      181 gaccacggag ggacggctga caaaggccag gaacagcctg ggtctctatg gccgcacaat
      241 agaactcctg gggcaggagg tcagccgggg ccgggatgca gcccaggaac ttcgggcaag
      301 cctgttggag actcagatgg aggaggatat tctgcagctg caggcagagg ccacagctga
      361 ggtgctgggg gaggtggccc aggcacagaa ggtgctacgg gacagcgtgc agcggctaga
      421 agtccagctg aggagcgcct ggctgggccc tgcctaccga gaatttgagg tcttaaaggc
      481 tcacgctgac aagcagagcc acatcctatg ggccctcaca ggccacgtgc agcggcagag
      541 gcgggagatg gtggcacagc agcatcggct gcgacagatc caggagagac tccacacagc
      601 ggcgctccca gcctgaatct gcctggatgg aactgaggac caatcatgct gcaaggaaca
      661 cttccacgcc ccgtgaggcc cctgtgcagg gaggagctgc ctgttcactg ggatcagcca
      721 gggcgccggg ccccacttct gagcacagag cagagacaga cgcaggcggg gacaaaggca
      781 gaggatgtag ccccattggg gaggggtgga ggaaggacat gtaccctttc atgcctacac
      841 acccctcatt aaagcagagt cgtggcatct ca
//
