LOCUS       NM_021146               2224 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens angiopoietin like 7 (ANGPTL7), mRNA.
ACCESSION   NM_021146
VERSION     NM_021146.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2224)
  AUTHORS   Brown,S.F., Nguyen,H., Mzyk,P., De Ieso,M.L., Unser,A.M., Brown,I.,
            Ramesh,P., Afzaal,H., Ahmed,F., Torrejon,K.Y., Nhan,A.,
            Markrush,D., Daly,T., Knecht,E., McConaughy,W., Halmos,S.,
            Liu,Z.L., Rennard,R., Peterson,A. and Stamer,W.D.
  TITLE     ANGPTL7 and Its Role in IOP and Glaucoma
  JOURNAL   Invest Ophthalmol Vis Sci 65 (3), 22 (2024)
   PUBMED   38497513
  REMARK    GeneRIF: ANGPTL7 and Its Role in IOP and Glaucoma.
REFERENCE   2  (bases 1 to 2224)
  AUTHORS   Fei,M.Y., Wang,Y., Chang,B.H., Xue,K., Dong,F., Huang,D., Li,X.Y.,
            Li,Z.J., Hu,C.L., Liu,P., Wu,J.C., Yu,P.C., Hong,M.H., Chen,S.B.,
            Xu,C.H., Chen,B.Y., Jiang,Y.L., Liu,N., Zhao,C., Jin,J.C., Hou,D.,
            Chen,X.C., Ren,Y.Y., Deng,C.H., Zhang,J.Y., Zong,L.J., Wang,R.J.,
            Gao,F.F., Liu,H., Zhang,Q.L., Wu,L.Y., Yan,J., Shen,S., Chang,C.K.,
            Sun,X.J. and Wang,L.
  TITLE     The non-cell-autonomous function of ID1 promotes AML progression
            via ANGPTL7 from the microenvironment
  JOURNAL   Blood 142 (10), 903-917 (2023)
   PUBMED   37319434
  REMARK    GeneRIF: The non-cell-autonomous function of ID1 promotes AML
            progression via ANGPTL7 from the microenvironment.
REFERENCE   3  (bases 1 to 2224)
  AUTHORS   Aboobakar,I.F., Collantes,E.R.A., Hauser,M.A., Stamer,W.D. and
            Wiggs,J.L.
  TITLE     Rare protective variants and glaucoma-relevant cell stressors
            modulate Angiopoietin-like 7 expression
  JOURNAL   Hum Mol Genet 32 (15), 2523-2531 (2023)
   PUBMED   37220876
  REMARK    GeneRIF: Rare protective variants and glaucoma-relevant cell
            stressors modulate Angiopoietin-like 7 expression.
REFERENCE   4  (bases 1 to 2224)
  AUTHORS   Yamamoto,A., Huang,Y., Krajina,B.A., McBirney,M., Doak,A.E., Qu,S.,
            Wang,C.L., Haffner,M.C. and Cheung,K.J.
  TITLE     Metastasis from the tumor interior and necrotic core formation are
            regulated by breast cancer-derived angiopoietin-like 7
  JOURNAL   Proc Natl Acad Sci U S A 120 (10), e2214888120 (2023)
   PUBMED   36853945
  REMARK    GeneRIF: Metastasis from the tumor interior and necrotic core
            formation are regulated by breast cancer-derived angiopoietin-like
            7.
REFERENCE   5  (bases 1 to 2224)
  AUTHORS   Praveen,K., Patel,G.C., Gurski,L., Ayer,A.H., Persaud,T.,
            Still,M.D., Miloscio,L., Van Zyl,T., Di Gioia,S.A., Brumpton,B.,
            Krebs,K., Asvold,B.O., Chen,E., Chavali,V.R.M., Fury,W.,
            Gudiseva,H.V., Hyde,S., Jorgenson,E., Lefebvre,S., Li,D., Li,A.,
            Mclninch,J., Patel,B., Rabinowitz,J.S., Salowe,R., Schurmann,C.,
            Seidelin,A.S., Stahl,E., Sun,D., Teslovich,T.M.,
            Tybjaerg-Hansen,A., Willer,C., Waldron,S., Walley,S., Yang,H.,
            Zaveri,S., Hu,Y., Hveem,K., Melander,O., Milani,L., Stender,S.,
            O'Brien,J.M., Jones,M.B., Abecasis,G.R., Cantor,M.N., Weyne,J.,
            Karalis,K., Economides,A., Della Gatta,G., Ferreira,M.A.,
            Yancopoulos,G.D., Baras,A., Romano,C. and Coppola,G.
  CONSRTM   Regeneron Genetics Center; GHS-RGC DiscovEHR Collaboration;
            Estonian Biobank Research Team
  TITLE     ANGPTL7, a therapeutic target for increased intraocular pressure
            and glaucoma
  JOURNAL   Commun Biol 5 (1), 1051 (2022)
   PUBMED   36192519
  REMARK    GeneRIF: ANGPTL7, a therapeutic target for increased intraocular
            pressure and glaucoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2224)
  AUTHORS   Peek,R., Kammerer,R.A., Frank,S., Otte-Holler,I. and Westphal,J.R.
  TITLE     The angiopoietin-like factor cornea-derived transcript 6 is a
            putative morphogen for human cornea
  JOURNAL   J Biol Chem 277 (1), 686-693 (2002)
   PUBMED   11682471
REFERENCE   7  (bases 1 to 2224)
  AUTHORS   Stover,C., Endo,Y., Takahashi,M., Lynch,N.J., Constantinescu,C.,
            Vorup-Jensen,T., Thiel,S., Friedl,H., Hankeln,T., Hall,R.,
            Gregory,S., Fujita,T. and Schwaeble,W.
  TITLE     The human gene for mannan-binding lectin-associated serine
            protease-2 (MASP-2), the effector component of the lectin route of
            complement activation, is part of a tightly linked gene cluster on
            chromosome 1p36.2-3
  JOURNAL   Genes Immun 2 (3), 119-127 (2001)
   PUBMED   11426320
REFERENCE   8  (bases 1 to 2224)
  AUTHORS   Peek,R., van Gelderen,B.E., Bruinenberg,M. and Kijlstra,A.
  TITLE     Molecular cloning of a new angiopoietinlike factor from the human
            cornea
  JOURNAL   Invest Ophthalmol Vis Sci 39 (10), 1782-1788 (1998)
   PUBMED   9727400
REFERENCE   9  (bases 1 to 2224)
  AUTHORS   Lim,Y.S., Cha,M.K., Kim,H.K. and Kim,I.H.
  TITLE     The thiol-specific antioxidant protein from human brain: gene
            cloning and analysis of conserved cysteine regions
  JOURNAL   Gene 140 (2), 279-284 (1994)
   PUBMED   8144038
REFERENCE   10 (bases 1 to 2224)
  AUTHORS   Shau,H., Butterfield,L.H., Chiu,R. and Kim,A.
  TITLE     Cloning and sequence analysis of candidate human natural
            killer-enhancing factor genes
  JOURNAL   Immunogenetics 40 (2), 129-134 (1994)
   PUBMED   8026862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC001881.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021146.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001881.1, AY358301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376819.4/ ENSP00000366015.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2224              BC001881.1         15-2238
FEATURES             Location/Qualifiers
     source          1..2224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..2224
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /note="angiopoietin like 7"
                     /db_xref="GeneID:10218"
                     /db_xref="HGNC:HGNC:24078"
                     /db_xref="MIM:618517"
     exon            1..601
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1266
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /note="angiopoietin-related protein 7; angiopoietin-like
                     factor (CDT6); angiopoietin-like protein 7; cornea-derived
                     transcript 6 protein"
                     /codon_start=1
                     /product="angiopoietin-related protein 7 precursor"
                     /protein_id="NP_066969.1"
                     /db_xref="CCDS:CCDS128.1"
                     /db_xref="GeneID:10218"
                     /db_xref="HGNC:HGNC:24078"
                     /db_xref="MIM:618517"
                     /translation="MLKKPLSAVTWLCIFIVAFVSHPAWLQKLSKHKTPAQPQLKAAN
                     CCEEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSKRMESRLTDAESKY
                     SEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEV
                     FCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTR
                     LRVEMEDWEGNLRYAEYSHFVLGNELNSYRLFLGNYTGNVGNDALQYHNNTAFSTKDK
                     DNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSTYSLKR
                     VEMKIRPEDFKP"
     exon            602..702
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..897
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1096
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..2224
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2151..2156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /note="major polyA site"
     regulatory      2203..2208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /note="hexamer: AATAAA"
     polyA_site      2224
                     /gene="ANGPTL7"
                     /gene_synonym="AngX; CDT6; dJ647M16.1"
                     /note="major polyA site"
ORIGIN      
        1 gggcttggaa ggaaagctat aggctaccca ttcagctccc ctgtcagaga ctcaagcttt
       61 gagaaaggct agcaaagagc aaggaaagag agaaaacaac aaagtggcga ggccctcaga
      121 gtgaaagcgt aaggttcagt cagcctgctg cagctttgca gacctcagct gggcatctcc
      181 agactcccct gaaggaagag ccttcctcac ccaaacccac aaaagatgct gaaaaagcct
      241 ctctcagctg tgacctggct ctgcattttc atcgtggcct ttgtcagcca cccagcgtgg
      301 ctgcagaagc tctctaagca caagacacca gcacagccac agctcaaagc ggccaactgc
      361 tgtgaggagg tgaaggagct caaggcccaa gttgccaacc ttagcagcct gctgagtgaa
      421 ctgaacaaga agcaggagag ggactgggtc agcgtggtca tgcaggtgat ggagctggag
      481 agcaacagca agcgcatgga gtcgcggctc acagatgctg agagcaagta ctccgagatg
      541 aacaaccaaa ttgacatcat gcagctgcag gcagcacaga cggtcactca gacctccgca
      601 gatgccatct acgactgctc ttccctctac cagaagaact accgcatctc tggagtgtat
      661 aagcttcctc ctgatgactt cctgggcagc cctgaactgg aggtgttctg tgacatggag
      721 acttcaggcg gaggctggac catcatccag agacgaaaaa gtggccttgt ctccttctac
      781 cgggactgga agcagtacaa gcagggcttt ggcagcatcc gtggggactt ctggctgggg
      841 aacgaacaca tccaccggct ctccagacag ccaacccggc tgcgtgtaga gatggaggac
      901 tgggagggca acctgcgcta cgctgagtat agccactttg ttttgggcaa tgaactcaac
      961 agctatcgcc tcttcctggg gaactacact ggcaatgtgg ggaacgacgc cctccagtat
     1021 cataacaaca cagccttcag caccaaggac aaggacaatg acaactgctt ggacaagtgt
     1081 gcacagctcc gcaaaggtgg ctactggtac aactgctgca cagactccaa cctcaatgga
     1141 gtgtactacc gcctgggtga gcacaataag cacctggatg gcatcacctg gtatggctgg
     1201 catggatcta cctactccct caaacgggtg gagatgaaaa tccgcccaga agacttcaag
     1261 ccttaaaagg aggctgccgt ggagcacgga tacagaaact gagacacgtg gagactggat
     1321 gagggcagat gaggacagga agagagtgtt agaaagggta ggactgagaa acagcctata
     1381 atctccaaag aaagaataag tctccaagga gcacaaaaaa atcatatgta ccaaggatgt
     1441 tacagtaaac aggatgaact atttaaaccc actgggtcct gccacatcct tctcaaggtg
     1501 gtagactgag tggggtctct ctgcccaaga tccctgacat agcagtagct tgtcttttcc
     1561 acatgatttg tctgtgaaag aaaataattt tgagatcgtt ttatctattt tctctacggc
     1621 ttaggctatg tgagggcaaa acacaaatcc ctttgctaaa aagaaccata ttattttgat
     1681 tctcaaagga taggcctttg agtgttagag aaaggagtga aggaggcagg tgggaaatgg
     1741 tatttctatt tttaaatcca gtgaaattat cttgagtcta cacattattt ttaaaacaca
     1801 aaaattgttc ggctggaact gacccaggct ggacttgcgg ggaggaaact ccagggcact
     1861 gcatctggcg atcagactct gagcactgcc cctgctcgcc ttggtcatgt acagcactga
     1921 aaggaatgaa gcaccagcag gaggtggaca gagtctctca tggatgccgg cacaaaactg
     1981 ccttaaaata ttcatagtta atacaggtat atctattttt atttactttg taagaaacaa
     2041 gctcaaggag cttcctttta aattttgtct gtaggaaatg gttgaaaact gaaggtagat
     2101 ggtgttatag ttaataataa atgctgtaaa taagcatctc actttgtaaa aataaaatat
     2161 tgtggttttg ttttaaacat tcaacgtttc ttttccttct acaataaaca ctttcaaaat
     2221 gtga
//
