LOCUS       NM_031917               1785 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens angiopoietin like 6 (ANGPTL6), transcript variant 1,
            mRNA.
ACCESSION   NM_031917
VERSION     NM_031917.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Wang,W., Zhao,Y., Zhu,P., Jia,X., Wang,C., Zhang,Q., Li,H., Wang,J.
            and Hou,Y.
  TITLE     Differential Proteomic Profiles of Coronary Serum Exosomes in Acute
            Myocardial Infarction Patients with or Without Diabetes Mellitus:
            ANGPTL6 Accelerates Regeneration of Endothelial Cells Treated with
            Rapamycin via MAPK Pathways
  JOURNAL   Cardiovasc Drugs Ther 38 (1), 13-29 (2024)
   PUBMED   35821539
  REMARK    GeneRIF: Differential Proteomic Profiles of Coronary Serum Exosomes
            in Acute Myocardial Infarction Patients with or Without Diabetes
            Mellitus: ANGPTL6 Accelerates Regeneration of Endothelial Cells
            Treated with Rapamycin via MAPK Pathways.
REFERENCE   2  (bases 1 to 1785)
  AUTHORS   Swiderska,M.K., Mostowska,A., Skrypnik,D., Bogdanski,P.,
            Jagodzinski,P.P. and Grzegorzewska,A.E.
  TITLE     Associations of ANGPTL6, DOCK6, FABP1, and PCSK9 single-nucleotide
            variants with hypercholesterolemia in the Polish population: a
            cross-sectional study
  JOURNAL   Pol Arch Intern Med 133 (2) (2023)
   PUBMED   36601873
  REMARK    GeneRIF: Associations of ANGPTL6, DOCK6, FABP1, and PCSK9
            single-nucleotide variants with hypercholesterolemia in the Polish
            population: a cross-sectional study.
REFERENCE   3  (bases 1 to 1785)
  AUTHORS   Valencia-Martinez,A., Schaefer-Graf,U., Amusquivar,E., Herrera,E.
            and Ortega-Senovilla,H.
  TITLE     Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat
            Mass Is Disrupted in Gestational Diabetic Pregnancies
  JOURNAL   J Clin Endocrinol Metab 107 (10), e4078-e4085 (2022)
   PUBMED   35876300
  REMARK    GeneRIF: Relationship of ANGPTL6 With Neonatal Glucose Homeostasis
            and Fat Mass Is Disrupted in Gestational Diabetic Pregnancies.
REFERENCE   4  (bases 1 to 1785)
  AUTHORS   Hu,G., Gao,F., Wang,G., Fang,Y., Guo,Y., Zhou,J., Gu,Y., Zhang,C.,
            Gao,N., Wen,Q. and Qiao,H.
  TITLE     Use of proteomics to identify mechanisms of hepatocellular
            carcinoma with the CYP2D6*10 polymorphism and identification of
            ANGPTL6 as a new diagnostic and prognostic biomarker
  JOURNAL   J Transl Med 19 (1), 359 (2021)
   PUBMED   34412629
  REMARK    GeneRIF: Use of proteomics to identify mechanisms of hepatocellular
            carcinoma with the CYP2D6*10 polymorphism and identification of
            ANGPTL6 as a new diagnostic and prognostic biomarker.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1785)
  AUTHORS   Jang,Y., Heo,J.Y., Lee,M.J., Zhu,J., Seo,C., Go,D.H., Yoon,S.K.,
            Yukari,D., Oike,Y., Sohn,J.W., Shong,M. and Kweon,G.R.
  TITLE     Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the
            Hypothalamus
  JOURNAL   Int J Mol Sci 22 (7), 3443 (2021)
   PUBMED   33810547
  REMARK    GeneRIF: Angiopoietin-Like Growth Factor Involved in Leptin
            Signaling in the Hypothalamus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1785)
  AUTHORS   Zhang,Y., Hu,X., Tian,R., Wei,W., Hu,W., Chen,X., Han,W., Chen,H.
            and Gong,Y.
  TITLE     Angiopoietin-related growth factor (AGF) supports adhesion,
            spreading, and migration of keratinocytes, fibroblasts, and
            endothelial cells through interaction with RGD-binding integrins
  JOURNAL   Biochem Biophys Res Commun 347 (1), 100-108 (2006)
   PUBMED   16806062
  REMARK    GeneRIF: Our results strongly suggest that AGF is an integrin
            ligand as well as a mitogenic growth factor and theoretically
            participates in cutaneous wound healing in a more complex
            mechanism.
REFERENCE   7  (bases 1 to 1785)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   8  (bases 1 to 1785)
  AUTHORS   Oike,Y., Ito,Y., Maekawa,H., Morisada,T., Kubota,Y., Akao,M.,
            Urano,T., Yasunaga,K. and Suda,T.
  TITLE     Angiopoietin-related growth factor (AGF) promotes angiogenesis
  JOURNAL   Blood 103 (10), 3760-3765 (2004)
   PUBMED   14764539
  REMARK    GeneRIF: showed that AGF is a secreted protein, AGF directly
            promotes chemotactic activity of vascular endothelial cells, and
            AGF directly induces a permeability change in the local
            vasculature.
REFERENCE   9  (bases 1 to 1785)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 1785)
  AUTHORS   Oike,Y., Yasunaga,K., Ito,Y., Matsumoto,S., Maekawa,H.,
            Morisada,T., Arai,F., Nakagata,N., Takeya,M., Masuho,Y. and Suda,T.
  TITLE     Angiopoietin-related growth factor (AGF) promotes epidermal
            proliferation, remodeling, and regeneration
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9494-9499 (2003)
   PUBMED   12871997
  REMARK    GeneRIF: findings suggest that AGF affects epidermal proliferation
            and thereby plays a role in the wound healing process
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020931.6.
            
            On Oct 2, 2020 this sequence version replaced NM_031917.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142632.1, AB054064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253109.5/ ENSP00000253109.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC020931.6         88520-88630         c
            112-703             AC020931.6         81934-82525         c
            704-884             AC020931.6         80710-80890         c
            885-1072            AC020931.6         79645-79832         c
            1073-1343           AC020931.6         79301-79571         c
            1344-1785           AC020931.6         78290-78731         c
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1785
                     /gene="ANGPTL6"
                     /gene_synonym="AGF; ARP5"
                     /note="angiopoietin like 6"
                     /db_xref="GeneID:83854"
                     /db_xref="HGNC:HGNC:23140"
                     /db_xref="MIM:609336"
     exon            1..111
                     /gene="ANGPTL6"
                     /gene_synonym="AGF; ARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            112..703
                     /gene="ANGPTL6"
                     /gene_synonym="AGF; ARP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1534
                     /gene="ANGPTL6"
                     /gene_synonym="AGF; ARP5"
                     /note="angiopoietin-related protein 5;
                     angiopoietin-related protein 6; angiopoietin-related
                     growth factor; angiopoietin-like protein 6"
                     /codon_start=1
                     /product="angiopoietin-related protein 6 precursor"
                     /protein_id="NP_114123.2"
                     /db_xref="CCDS:CCDS12224.1"
                     /db_xref="GeneID:83854"
                     /db_xref="HGNC:HGNC:23140"
                     /db_xref="MIM:609336"
                     /translation="MGKPWLRALQLLLLLGASWARAGAPRCTYTFVLPPQKFTGAVCW
                     SGPASTRATPEAANASELAALRMRVGRHEELLRELQRLAAADGAVAGEVRALRKESRG
                     LSARLGQLRAQLQHEAGPGAGPGADLGAEPAAALALLGERVLNASAEAQRAAARFHQL
                     DVKFRELAQLVTQQSSLIARLERLCPGGAGGQQQVLPPPPLVPVVPVRLVGSTSDTSR
                     MLDPAPEPQRDQTQRQQEPMASPMPAGHPAVPTKPVGPWQDCAEARQAGHEQSGVYEL
                     RVGRHVVSVWCEQQLEGGGWTVIQRRQDGSVNFFTTWQHYKAGFGRPDGEYWLGLEPV
                     YQLTSRGDHELLVLLEDWGGRGARAHYDGFSLEPESDHYRLRLGQYHGDAGDSLSWHN
                     DKPFSTVDRDRDSYSGNCALYQRGGWWYHACAHSNLNGVWHHGGHYRSRYQDGVYWAE
                     FRGGAYSLRKAAMLIRPLKL"
     exon            704..884
                     /gene="ANGPTL6"
                     /gene_synonym="AGF; ARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1072
                     /gene="ANGPTL6"
                     /gene_synonym="AGF; ARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1343
                     /gene="ANGPTL6"
                     /gene_synonym="AGF; ARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1785
                     /gene="ANGPTL6"
                     /gene_synonym="AGF; ARP5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1785
                     /gene="ANGPTL6"
                     /gene_synonym="AGF; ARP5"
                     /note="major polyA site"
ORIGIN      
        1 actgccctct ccccgtctct agctcagagg ccccactgga ccctcggctc ttccttggac
       61 ttcttgtgtg ttctgtgagc ttcgctggat tcagggtctt gggcatcaga ggtccgccgc
      121 gatggggaag ccctggctgc gtgcgctaca gctgctgctc ctgctgggcg cgtcgtgggc
      181 gcgggcgggc gccccgcgct gcacctacac cttcgtgctg cccccgcaga agttcacggg
      241 cgctgtgtgc tggagcggcc ccgcatccac gcgggcgacg cccgaggccg ccaacgccag
      301 cgagctggcg gcgctgcgca tgcgcgtcgg ccgccacgag gagctgttac gcgagctgca
      361 gaggctggcg gcggccgacg gcgccgtggc cggcgaggtg cgcgcgctgc gcaaggagag
      421 ccgcggcctg agcgcgcgcc tgggccagtt gcgcgcgcag ctgcagcacg aggcggggcc
      481 cggggcgggc ccgggggcgg atctgggggc ggagcctgcc gcggcgctgg cgctgctcgg
      541 ggagcgcgtg ctcaacgcgt ccgccgaggc tcagcgcgca gccgcccggt tccaccagct
      601 ggacgtcaag ttccgcgagc tggcgcagct cgtcacccag cagagcagtc tcatcgcccg
      661 cctggagcgc ctgtgcccgg gaggcgcggg cgggcagcag caggtcctgc cgccaccccc
      721 actggtgcct gtggttccgg tccgtcttgt gggtagcacc agtgacacca gtaggatgct
      781 ggacccagcc ccagagcccc agagagacca gacccagaga cagcaggagc ccatggcttc
      841 tcccatgcct gcaggtcacc ctgcggtccc caccaagcct gtgggcccgt ggcaggattg
      901 tgcagaggcc cgccaggcag gccatgaaca gagtggagtg tatgaactgc gagtgggccg
      961 tcacgtagtg tcagtatggt gtgagcagca actggagggt ggaggctgga ctgtgatcca
     1021 gcggaggcaa gatggttcag tcaacttctt cactacctgg cagcactata aggcgggctt
     1081 tgggcggcca gacggagaat actggctggg ccttgaaccc gtgtatcagc tgaccagccg
     1141 tggggaccat gagctgctgg ttctcctgga ggactggggg ggccgtggag cacgtgccca
     1201 ctatgatggc ttctccctgg aacccgagag cgaccactac cgcctgcggc ttggccagta
     1261 ccatggtgat gctggagact ctctttcctg gcacaatgac aagcccttca gcaccgtgga
     1321 tagggaccga gactcctatt ctggtaactg tgccctgtac cagcggggag gctggtggta
     1381 ccatgcctgt gcccactcca acctcaacgg tgtgtggcac cacggcggcc actaccgaag
     1441 ccgctaccag gatggtgtct actgggctga gtttcgtggt ggggcatatt ctctcaggaa
     1501 ggccgccatg ctcattcggc ccctgaagct gtgactctgt gttcctctgt cccctaggcc
     1561 ctagaggaca ttggtcagca ggagcccaag ttgttctggc cacaccttct ttgtggctca
     1621 gtgccaatgt gtcccacaga acttcccact gtggatctgt gaccctgggc gctgaaaatg
     1681 ggacccagga atcccccccg tcaatatctt ggcctcagat ggctccccaa ggtcattcat
     1741 atctcggttt gagctcatat cttataataa cacaaagtag ccaca
//
