LOCUS       NM_178127               2368 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens angiopoietin like 5 (ANGPTL5), mRNA.
ACCESSION   NM_178127 XM_005271496
VERSION     NM_178127.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2368)
  AUTHORS   Liu,C., Yi,X., Lyu,Y., Ren,W., Zhou,Y., Feng,G., Wan,W. and
            Jiang,X.J.
  TITLE     Elevated Plasma Angiopoietinlike Protein 5 (ANGPTL5) Is More
            Positively Associated with Glucose Metabolism Disorders in Patients
            with Metabolic Syndrome
  JOURNAL   Med Sci Monit 27, e929626 (2021)
   PUBMED   33486501
  REMARK    GeneRIF: Elevated Plasma Angiopoietinlike Protein 5 (ANGPTL5) Is
            More Positively Associated with Glucose Metabolism Disorders in
            Patients with Metabolic Syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2368)
  AUTHORS   Hammad,M.M., Abu-Farha,M., Al-Taiar,A., Alam-Eldin,N., Al-Sabah,R.,
            Shaban,L., Al-Mulla,F., Abubaker,J. and Rahman,A.
  TITLE     Correlation of circulating ANGPTL5 levels with obesity, high
            sensitivity C-reactive protein and oxidized low-density lipoprotein
            in adolescents
  JOURNAL   Sci Rep 10 (1), 6330 (2020)
   PUBMED   32286392
  REMARK    GeneRIF: Correlation of circulating ANGPTL5 levels with obesity,
            high sensitivity C-reactive protein and oxidized low-density
            lipoprotein in adolescents.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2368)
  AUTHORS   Deng,M., Lu,Z., Zheng,J., Wan,X., Chen,X., Hirayasu,K., Sun,H.,
            Lam,Y., Chen,L., Wang,Q., Song,C., Huang,N., Gao,G.F., Jiang,Y.,
            Arase,H. and Zhang,C.C.
  TITLE     A motif in LILRB2 critical for Angptl2 binding and activation
  JOURNAL   Blood 124 (6), 924-935 (2014)
   PUBMED   24899623
REFERENCE   4  (bases 1 to 2368)
  AUTHORS   Cobb,J., Cule,E., Moncrieffe,H., Hinks,A., Ursu,S., Patrick,F.,
            Kassoumeri,L., Flynn,E., Bulatovic,M., Wulffraat,N., van Zelst,B.,
            de Jonge,R., Bohm,M., Dolezalova,P., Hirani,S., Newman,S.,
            Whitworth,P., Southwood,T.R., De Iorio,M., Wedderburn,L.R. and
            Thomson,W.
  CONSRTM   Childhood Arthritis Response to Medication Study (CHARMS);
            Childhood Arthritis Prospective Study (CAPS); BSPAR study group
  TITLE     Genome-wide data reveal novel genes for methotrexate response in a
            large cohort of juvenile idiopathic arthritis cases
  JOURNAL   Pharmacogenomics J 14 (4), 356-364 (2014)
   PUBMED   24709693
REFERENCE   5  (bases 1 to 2368)
  AUTHORS   Zheng,J., Umikawa,M., Cui,C., Li,J., Chen,X., Zhang,C., Huynh,H.,
            Kang,X., Silvany,R., Wan,X., Ye,J., Canto,A.P., Chen,S.H.,
            Wang,H.Y., Ward,E.S. and Zhang,C.C.
  TITLE     Inhibitory receptors bind ANGPTLs and support blood stem cells and
            leukaemia development
  JOURNAL   Nature 485 (7400), 656-660 (2012)
   PUBMED   22660330
  REMARK    Erratum:[Nature. 2012 Aug 30;488(7413):684. Hyunh, Hoangdinh
            [corrected to Huynh, HoangDinh]]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2368)
  AUTHORS   Drake,A.C., Khoury,M., Leskov,I., Iliopoulou,B.P., Fragoso,M.,
            Lodish,H. and Chen,J.
  TITLE     Human CD34+ CD133+ hematopoietic stem cells cultured with growth
            factors including Angptl5 efficiently engraft adult NOD-SCID
            Il2rgamma-/- (NSG) mice
  JOURNAL   PLoS One 6 (4), e18382 (2011)
   PUBMED   21559522
  REMARK    GeneRIF: CD34+ CD133+ hematopoietic stem cells cultured with growth
            factors including Angptl5 efficiently engraft adult NOD-SCID
            Il2rgamma-/- (NSG) mice
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2368)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 2368)
  AUTHORS   Zeng,L., Dai,J., Ying,K., Zhao,E., Jin,W., Ye,Y., Dai,J., Xu,J.,
            Xie,Y. and Mao,Y.
  TITLE     Identification of a novel human angiopoietin-like gene expressed
            mainly in heart
  JOURNAL   J Hum Genet 48 (3), 159-162 (2003)
   PUBMED   12624729
  REMARK    GeneRIF: Maps to 11q22, mainly expressed in adult human heart.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049170.1, AP003383.2 and AK291523.1.
            
            On May 17, 2019 this sequence version replaced NM_178127.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053957.1, DRR138524.126642.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178, SAMEA2153980
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334289.7/ ENSP00000335255.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BC049170.1         4-80
            78-78               AP003383.2         44683-44683         c
            79-1169             BC049170.1         82-1172
            1170-1170           AP003383.2         28755-28755         c
            1171-1174           BC049170.1         1174-1177
            1175-2166           AK291523.1         639-1630
            2167-2368           BC049170.1         2170-2371
FEATURES             Location/Qualifiers
     source          1..2368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.1"
     gene            1..2368
                     /gene="ANGPTL5"
                     /note="angiopoietin like 5"
                     /db_xref="GeneID:253935"
                     /db_xref="HGNC:HGNC:19705"
                     /db_xref="MIM:607666"
     exon            1..504
                     /gene="ANGPTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            505..692
                     /gene="ANGPTL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             597..1763
                     /gene="ANGPTL5"
                     /note="angiopoietin-related protein 5; angiopoietin-like
                     protein 5"
                     /codon_start=1
                     /product="angiopoietin-related protein 5 precursor"
                     /protein_id="NP_835228.2"
                     /db_xref="CCDS:CCDS8312.1"
                     /db_xref="GeneID:253935"
                     /db_xref="HGNC:HGNC:19705"
                     /db_xref="MIM:607666"
                     /translation="MMSPSQASLLFLNVCIFICGEAVQGNCVHHSTDSSVVNIVEDGS
                     NAKDESKSNDTVCKEDCEESCDVKTKITREEKHFMCRNLQNSIVSYTRSTKKLLRNMM
                     DEQQASLDYLSNQVNELMNRVLLLTTEVFRKQLDPFPHRPVQSHGLDCTDIKDTIGSV
                     TKTPSGLYIIHPEGSSYPFEVMCDMDYRGGGRTVIQKRIDGIIDFQRLWCDYLDGFGD
                     LLGEFWLGLKKIFYIVNQKNTSFMLYVALESEDDTLAYASYDNFWLEDETRFFKMHLG
                     RYSGNAGDAFRGLKKEDNQNAMPFSTSDVDNDGCRPACLVNGQSVKSCSHLHNKTGWW
                     FNECGLANLNGIHHFSGKLLATGIQWGTWTKNNSPVKIKSVSMKIRRMYNPYFK"
     exon            693..837
                     /gene="ANGPTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            838..941
                     /gene="ANGPTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1035
                     /gene="ANGPTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1136
                     /gene="ANGPTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1257
                     /gene="ANGPTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1443
                     /gene="ANGPTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..2368
                     /gene="ANGPTL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2341..2346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL5"
                     /note="hexamer: AATAAA"
     polyA_site      2368
                     /gene="ANGPTL5"
                     /note="major polyA site"
ORIGIN      
        1 gatgagagga actagaagca gctattgcaa gctaccattt tgagaacctg cccaaagaaa
       61 gaaaagactg aagggatgga agattgcaga aagcatgatc ggagaagaga tattttactt
      121 ttagtgaagc tctatacaca tttgtcttcc tcactagatt tgtatcccta gaacctagaa
      181 cagagtcagc caaagagcag gcactcaata caaattgttg acttgctgct aaaattgtaa
      241 cagagtacaa agaacatcct agaaattgga gacaaagggg ataagaaaac agagttaact
      301 tggaaagaga agacactcat ctctgacaag actgaagatg attacacaac accatcattg
      361 ccaaccaagt cctttgggaa tacaaaggtt aaatcctaat catcacaaca gtctctaaag
      421 gaataaacct gatttacaga ttttgataac aaaatacttc tcctctttcc attttctaca
      481 atgcaaccaa cagcaacatc aaagaggttt ttaactgaag actctatgct ctgtagttct
      541 ttccacaaag agctgactga tatttgaaga agtgttttca tctatccaag aaaaatatga
      601 tgtctccatc ccaagcctca ctcttattct taaatgtatg tatttttatt tgtggagaag
      661 ctgtacaagg taactgtgta catcattcta cggactcttc agtagttaac attgtagaag
      721 atggatctaa tgcaaaagat gaaagtaaaa gtaatgatac tgtttgtaag gaagactgtg
      781 aggaatcatg tgatgttaaa actaaaatta cacgagaaga aaaacatttc atgtgtagaa
      841 atttgcaaaa ttctattgtt tcctacacaa gaagtaccaa aaaactacta aggaatatga
      901 tggatgagca acaagcttcc ttggattatt tatctaatca ggttaacgag ctcatgaata
      961 gagttctcct tttgactaca gaagttttta gaaaacagct ggatcctttt cctcacagac
     1021 ctgttcagtc acatggttta gattgcactg atattaagga taccattggc tctgtcacca
     1081 aaacaccgag tggtttatac ataattcacc cagaaggatc tagctaccca tttgaggtaa
     1141 tgtgtgacat ggattacaga ggaggtggac ggactgtgat acagaaaaga attgatggga
     1201 taattgattt ccagaggttg tggtgtgatt atctggatgg atttggagat cttctaggag
     1261 aattttggct aggactgaaa aagatttttt atatagtaaa tcagaaaaat accagtttta
     1321 tgctgtatgt ggctttggaa tctgaagatg acactcttgc ttatgcatca tatgataatt
     1381 tttggctaga ggatgaaacg agatttttta aaatgcactt aggacggtat tcaggaaatg
     1441 ctggtgatgc attccggggt ctcaaaaaag aagataatca aaatgcaatg ccttttagca
     1501 catcagatgt tgataatgat gggtgtcgcc ctgcatgcct ggtcaatggt cagtctgtga
     1561 agagctgcag tcacctccat aacaagaccg gctggtggtt taacgagtgt ggtctagcaa
     1621 atctaaatgg cattcatcac ttctctggaa aattgcttgc aactggaatt caatggggca
     1681 cgtggaccaa aaacaactca cctgtcaaga ttaaatctgt ttcaatgaaa attagaagaa
     1741 tgtacaatcc atattttaaa taatctcatt taacattgta atgcaagttc tacaatgata
     1801 atatattaaa gatttttaaa agtttatctt ttcacttagt gtttcaaaca tattaggcaa
     1861 aatttaactg tagatggcat ttagatgtta tgagtttaat tagaaaactt caattttgta
     1921 gtattctata aaagaaaaca tggcttattg tatgttttta cttctgacta tattaacaat
     1981 atacaatgaa atttgtttca agtgaactac aacttgtctt cctaaaattt atagtgattt
     2041 taaaggattt tgccttttct ttgaagcatt tttaaaccat aatatgttgt aaggaaaatt
     2101 gaagggaata ttttacttat ttttatactt tatatgatta tataatctac agataatttc
     2161 tactgaagac agttacaata aataacttta tgcagattaa tatataagct acacatgatg
     2221 taaaaacctt actatttcta ggtgatgcca taccatttta aaagtagtaa gagtttgctg
     2281 cccaaatagt ttttcttgtt ttcatatcta atcatggtta actattttgt tattgtttgt
     2341 aataaatata tgtactttta tatcctga
//
