LOCUS       NM_139314               1872 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens angiopoietin like 4 (ANGPTL4), transcript variant 1,
            mRNA.
ACCESSION   NM_139314
VERSION     NM_139314.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Xie,J., Li,Y., Zeng,T., Fan,T., Shan,H., Shi,G., Zhou,W., Zou,J.
            and Lei,X.
  TITLE     ANGPTL4 plays a paradoxical role in gastric cancer through the
            LGALS7 and Hedgehog pathways
  JOURNAL   Sci Rep 14 (1), 23173 (2024)
   PUBMED   39369030
  REMARK    GeneRIF: ANGPTL4 plays a paradoxical role in gastric cancer through
            the LGALS7 and Hedgehog pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Zhao,J., Zhang,S., Wang,X., Wang,M., Wang,Z., Li,R., Liu,Y., Lu,C.
            and Li,S.
  TITLE     Correlation between serum ANGPTL4 levels and white matter
            hyperintensity and cognitive impairment in patients with cerebral
            small vessel disease
  JOURNAL   Brain Behav 14 (2), e3401 (2024)
   PUBMED   39470400
  REMARK    GeneRIF: Correlation between serum ANGPTL4 levels and white matter
            hyperintensity and cognitive impairment in patients with cerebral
            small vessel disease.
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Grootaert,C., Van de Wiele,T., Verstraete,W., Bracke,M. and
            Vanhoecke,B.
  TITLE     Angiopoietin-like protein 4: health effects, modulating agents and
            structure-function relationships
  JOURNAL   Expert Rev Proteomics 9 (2), 181-199 (2012)
   PUBMED   22462789
  REMARK    GeneRIF: Health issues associated with ANGPTL4 expression,
            including obesity, Type 2 diabetes, cardiovascular diseases and
            cancer. [Review]
            Review article
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Lei,X., Shi,F., Basu,D., Huq,A., Routhier,S., Day,R. and Jin,W.
  TITLE     Proteolytic processing of angiopoietin-like protein 4 by proprotein
            convertases modulates its inhibitory effects on lipoprotein lipase
            activity
  JOURNAL   J Biol Chem 286 (18), 15747-15756 (2011)
   PUBMED   21398697
  REMARK    GeneRIF: the cleavage of ANGPTL4 by these PCs modulates its
            inhibitory effect on LPL activity.
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Yang,Y.H., Wang,Y., Lam,K.S., Yau,M.H., Cheng,K.K., Zhang,J.,
            Zhu,W., Wu,D. and Xu,A.
  TITLE     Suppression of the Raf/MEK/ERK signaling cascade and inhibition of
            angiogenesis by the carboxyl terminus of angiopoietin-like protein
            4
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (5), 835-840 (2008)
   PUBMED   18340008
REFERENCE   6  (bases 1 to 1872)
  AUTHORS   Ito,Y., Oike,Y., Yasunaga,K., Hamada,K., Miyata,K., Matsumoto,S.,
            Sugano,S., Tanihara,H., Masuho,Y. and Suda,T.
  TITLE     Inhibition of angiogenesis and vascular leakiness by
            angiopoietin-related protein 4
  JOURNAL   Cancer Res 63 (20), 6651-6657 (2003)
   PUBMED   14583458
REFERENCE   7  (bases 1 to 1872)
  AUTHORS   Kaneda,A., Kaminishi,M., Yanagihara,K., Sugimura,T. and Ushijima,T.
  TITLE     Identification of silencing of nine genes in human gastric cancers
  JOURNAL   Cancer Res 62 (22), 6645-6650 (2002)
   PUBMED   12438262
REFERENCE   8  (bases 1 to 1872)
  AUTHORS   Zhu,H., Li,J., Qin,W., Yang,Y., He,X., Wan,D. and Gu,J.
  TITLE     [Cloning of a novel gene, ANGPTL4 and the functional study in
            angiogenesis]
  JOURNAL   Zhonghua Yi Xue Za Zhi 82 (2), 94-99 (2002)
   PUBMED   11953136
REFERENCE   9  (bases 1 to 1872)
  AUTHORS   Yoon,J.C., Chickering,T.W., Rosen,E.D., Dussault,B., Qin,Y.,
            Soukas,A., Friedman,J.M., Holmes,W.E. and Spiegelman,B.M.
  TITLE     Peroxisome proliferator-activated receptor gamma target gene
            encoding a novel angiopoietin-related protein associated with
            adipose differentiation
  JOURNAL   Mol Cell Biol 20 (14), 5343-5349 (2000)
   PUBMED   10866690
REFERENCE   10 (bases 1 to 1872)
  AUTHORS   Kim,I., Kim,H.G., Kim,H., Kim,H.H., Park,S.K., Uhm,C.S., Lee,Z.H.
            and Koh,G.Y.
  TITLE     Hepatic expression, synthesis and secretion of a novel
            fibrinogen/angiopoietin-related protein that prevents
            endothelial-cell apoptosis
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 603-610 (2000)
   PUBMED   10698685
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF202636.1 and BP397348.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_139314.2.
            
            Summary: This gene encodes a glycosylated, secreted protein
            containing a C-terminal fibrinogen domain. The encoded protein is
            induced by peroxisome proliferation activators and functions as a
            serum hormone that regulates glucose homeostasis, lipid metabolism,
            and insulin sensitivity. This protein can also act as an apoptosis
            survival factor for vascular endothelial cells and can prevent
            metastasis by inhibiting vascular growth and tumor cell invasion.
            The C-terminal domain may be proteolytically-cleaved from the
            full-length secreted protein. Decreased expression of this gene has
            been associated with type 2 diabetes. Alternative splicing results
            in multiple transcript variants. This gene was previously referred
            to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq,
            Sep 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.23439.1,
                                           SRR3476690.114673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301455.7/ ENSP00000301455.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1833              AF202636.1         6-1838
            1834-1872           BP397348.1         290-328
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1872
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /note="angiopoietin like 4"
                     /db_xref="GeneID:51129"
                     /db_xref="HGNC:HGNC:16039"
                     /db_xref="MIM:605910"
     exon            1..485
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1388
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; fasting-induced adipose factor; hepatic
                     fibrinogen/angiopoietin-related protein; hepatic
                     angiopoietin-related protein; PPARG angiopoietin related
                     protein; peroxisome proliferator-activated receptor (PPAR)
                     gamma induced angiopoietin-related protein;
                     angiopoietin-related protein 4"
                     /codon_start=1
                     /product="angiopoietin-related protein 4 isoform a
                     precursor"
                     /protein_id="NP_647475.1"
                     /db_xref="CCDS:CCDS12200.1"
                     /db_xref="GeneID:51129"
                     /db_xref="HGNC:HGNC:16039"
                     /db_xref="MIM:605910"
                     /translation="MSGAPTAGAALMLCAATAVLLSAQGGPVQSKSPRFASWDEMNVL
                     AHGLLQLGQGLREHAERTRSQLSALERRLSACGSACQGTEGSTDLPLAPESRVDPEVL
                     HSLQTQLKAQNSRIQQLFHKVAQQQRHLEKQHLRIQHLQSQFGLLDHKHLDHEVAKPA
                     RRKRLPEMAQPVDPAHNVSRLHRLPRDCQELFQVGERQSGLFEIQPQGSPPFLVNCKM
                     TSDGGWTVIQRRHDGSVDFNRPWEAYKAGFGDPHGEFWLGLEKVHSITGDRNSRLAVQ
                     LRDWDGNAELLQFSVHLGGEDTAYSLQLTAPVAGQLGATTVPPSGLSVPFSTWDQDHD
                     LRRDKNCAKSLSGGWWFGTCSHSNLNGQYFRSIPQQRQKLKKGIFWKTWRGRYYPLQA
                     TTMLIQPMAAEAAS"
     exon            486..596
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /inference="alignment:Splign:2.1.0"
     exon            597..714
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /inference="alignment:Splign:2.1.0"
     exon            715..828
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /inference="alignment:Splign:2.1.0"
     exon            829..924
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1206
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1872
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1852..1857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /note="hexamer: AATAAA"
     polyA_site      1872
                     /gene="ANGPTL4"
                     /gene_synonym="ARP4; FIAF; HARP; HFARP; NL2; PGAR; pp1158;
                     TGQTL; UNQ171"
                     /note="major polyA site"
ORIGIN      
        1 agaagccgag ctgagcggat cctcacacga ctgtgatccg attctttcca gcggcttctg
       61 caaccaagcg ggtcttaccc ccggtcctcc gcgtctccag tcctcgcacc tggaacccca
      121 acgtccccga gagtccccga atccccgctc ccaggctacc taagaggatg agcggtgctc
      181 cgacggccgg ggcagccctg atgctctgcg ccgccaccgc cgtgctactg agcgctcagg
      241 gcggacccgt gcagtccaag tcgccgcgct ttgcgtcctg ggacgagatg aatgtcctgg
      301 cgcacggact cctgcagctc ggccaggggc tgcgcgaaca cgcggagcgc acccgcagtc
      361 agctgagcgc gctggagcgg cgcctgagcg cgtgcgggtc cgcctgtcag ggaaccgagg
      421 ggtccaccga cctcccgtta gcccctgaga gccgggtgga ccctgaggtc cttcacagcc
      481 tgcagacaca actcaaggct cagaacagca ggatccagca actcttccac aaggtggccc
      541 agcagcagcg gcacctggag aagcagcacc tgcgaattca gcatctgcaa agccagtttg
      601 gcctcctgga ccacaagcac ctagaccatg aggtggccaa gcctgcccga agaaagaggc
      661 tgcccgagat ggcccagcca gttgacccgg ctcacaatgt cagccgcctg caccggctgc
      721 ccagggattg ccaggagctg ttccaggttg gggagaggca gagtggacta tttgaaatcc
      781 agcctcaggg gtctccgcca tttttggtga actgcaagat gacctcagat ggaggctgga
      841 cagtaattca gaggcgccac gatggctcag tggacttcaa ccggccctgg gaagcctaca
      901 aggcggggtt tggggatccc cacggcgagt tctggctggg tctggagaag gtgcatagca
      961 tcacggggga ccgcaacagc cgcctggccg tgcagctgcg ggactgggat ggcaacgccg
     1021 agttgctgca gttctccgtg cacctgggtg gcgaggacac ggcctatagc ctgcagctca
     1081 ctgcacccgt ggccggccag ctgggcgcca ccaccgtccc acccagcggc ctctccgtac
     1141 ccttctccac ttgggaccag gatcacgacc tccgcaggga caagaactgc gccaagagcc
     1201 tctctggagg ctggtggttt ggcacctgca gccattccaa cctcaacggc cagtacttcc
     1261 gctccatccc acagcagcgg cagaagctta agaagggaat cttctggaag acctggcggg
     1321 gccgctacta cccgctgcag gccaccacca tgttgatcca gcccatggca gcagaggcag
     1381 cctcctagcg tcctggctgg gcctggtccc aggcccacga aagacggtga ctcttggctc
     1441 tgcccgagga tgtggccgtt ccctgcctgg gcaggggctc caaggagggg ccatctggaa
     1501 acttgtggac agagaagaag accacgactg gagaagcccc ctttctgagt gcaggggggc
     1561 tgcatgcgtt gcctcctgag atcgaggctg caggatatgc tcagactcta gaggcgtgga
     1621 ccaaggggca tggagcttca ctccttgctg gccagggagt tggggactca gagggaccac
     1681 ttggggccag ccagactggc ctcaatggcg gactcagtca cattgactga cggggaccag
     1741 ggcttgtgtg ggtcgagagc gccctcatgg tgctggtgct gttgtgtgta ggtcccctgg
     1801 ggacacaagc aggcgccaat ggtatctggg cggagctcac agagttcttg gaataaaagc
     1861 aacctcagaa ca
//
