LOCUS       NM_014495               2926 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens angiopoietin like 3 (ANGPTL3), mRNA.
ACCESSION   NM_014495
VERSION     NM_014495.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2926)
  AUTHORS   Aghasizadeh,M., Ahmadi Hoseini,A., Sahebi,R., Kazemi,T.,
            Asadiyan-Sohan,P., Esmaily,H., Samadi,S., Avan,A., Ferns,G.A.,
            Khosravi,S., Ghazizadeh,H., Miri-Moghaddam,E. and
            Ghayour-Mobarhan,M.
  TITLE     Association of a genetic variant in angiopoietin-like 3 with serum
            HDL-C and risk of cardiovascular disease: A study of the MASHAD
            cohort over 6 years
  JOURNAL   Mol Genet Genomic Med 12 (4), e2418 (2024)
   PUBMED   38634215
  REMARK    GeneRIF: Association of a genetic variant in angiopoietin-like 3
            with serum HDL-C and risk of cardiovascular disease: A study of the
            MASHAD cohort over 6 years.
REFERENCE   2  (bases 1 to 2926)
  AUTHORS   Yang,L., Wang,Y., Xu,Y., Li,K., Yin,R., Zhang,L., Wang,D., Wei,L.,
            Lang,J., Cheng,Y., Wang,L., Ke,J. and Zhao,D.
  TITLE     ANGPTL3 is a novel HDL component that regulates HDL function
  JOURNAL   J Transl Med 22 (1), 263 (2024)
   PUBMED   38462608
  REMARK    GeneRIF: ANGPTL3 is a novel HDL component that regulates HDL
            function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2926)
  AUTHORS   Zhao,Z., Fu,Y., Lian,H., Liu,Y., Liu,J., Sun,L. and Zhang,Y.
  TITLE     Correlation between the serum FABP4, ANGPTL3, and ANGPTL4 levels
            and coronary artery disease
  JOURNAL   Clin Cardiol 47 (3), e24246 (2024)
   PUBMED   38425231
  REMARK    GeneRIF: Correlation between the serum FABP4, ANGPTL3, and ANGPTL4
            levels and coronary artery disease.
REFERENCE   4  (bases 1 to 2926)
  AUTHORS   Schjoldager,K.T., Vester-Christensen,M.B., Bennett,E.P.,
            Levery,S.B., Schwientek,T., Yin,W., Blixt,O. and Clausen,H.
  TITLE     O-glycosylation modulates proprotein convertase activation of
            angiopoietin-like protein 3: possible role of polypeptide
            GalNAc-transferase-2 in regulation of concentrations of plasma
            lipids
  JOURNAL   J Biol Chem 285 (47), 36293-36303 (2010)
   PUBMED   20837471
  REMARK    GeneRIF: ANGPTL3 activation is modulated by O-glycosylation and the
            proprotein undergoes convertase processing for activation.
REFERENCE   5  (bases 1 to 2926)
  AUTHORS   Ono,M., Shimizugawa,T., Shimamura,M., Yoshida,K., Noji-Sakikawa,C.,
            Ando,Y., Koishi,R. and Furukawa,H.
  TITLE     Protein region important for regulation of lipid metabolism in
            angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in
            vivo
  JOURNAL   J Biol Chem 278 (43), 41804-41809 (2003)
   PUBMED   12909640
  REMARK    GeneRIF: the cleavage of ANGPTL3 at two sites is important for the
            activation of ANGPTL3 in vivo
REFERENCE   6  (bases 1 to 2926)
  AUTHORS   Shimamura,M., Matsuda,M., Kobayashi,S., Ando,Y., Ono,M., Koishi,R.,
            Furukawa,H., Makishima,M. and Shimomura,I.
  TITLE     Angiopoietin-like protein 3, a hepatic secretory factor, activates
            lipolysis in adipocytes
  JOURNAL   Biochem Biophys Res Commun 301 (2), 604-609 (2003)
   PUBMED   12565906
  REMARK    GeneRIF: Data show that angiopoietin-like protein 3 (ANGPTL3)
            targets adipose cells and induces lipolysis.
REFERENCE   7  (bases 1 to 2926)
  AUTHORS   Kaplan,R., Zhang,T., Hernandez,M., Gan,F.X., Wright,S.D.,
            Waters,M.G. and Cai,T.Q.
  TITLE     Regulation of the angiopoietin-like protein 3 gene by LXR
  JOURNAL   J Lipid Res 44 (1), 136-143 (2003)
   PUBMED   12518032
  REMARK    GeneRIF: Angptl3 gene is a direct target of the liver X receptor
            (LXR).
REFERENCE   8  (bases 1 to 2926)
  AUTHORS   Camenisch,G., Pisabarro,M.T., Sherman,D., Kowalski,J., Nagel,M.,
            Hass,P., Xie,M.H., Gurney,A., Bodary,S., Liang,X.H., Clark,K.,
            Beresini,M., Ferrara,N. and Gerber,H.P.
  TITLE     ANGPTL3 stimulates endothelial cell adhesion and migration via
            integrin alpha vbeta 3 and induces blood vessel formation in vivo
  JOURNAL   J Biol Chem 277 (19), 17281-17290 (2002)
   PUBMED   11877390
  REMARK    GeneRIF: ANGPTL3 stimulates endothelial cell adhesion and migration
            via integrin alpha vbeta 3 and induces blood vessel formation in
            vivo
            GeneRIF: ANGPTL3 is the first member of the angiopoietin-like
            family of secreted factors binding to integrin alpha(v)beta(3),
            which suggests a possible role in the regulation of angiogenesis.
REFERENCE   9  (bases 1 to 2926)
  AUTHORS   Conklin,D., Gilbertson,D., Taft,D.W., Maurer,M.F., Whitmore,T.E.,
            Smith,D.L., Walker,K.M., Chen,L.H., Wattler,S., Nehls,M. and
            Lewis,K.B.
  TITLE     Identification of a mammalian angiopoietin-related protein
            expressed specifically in liver
  JOURNAL   Genomics 62 (3), 477-482 (1999)
   PUBMED   10644446
REFERENCE   10 (bases 1 to 2926)
  AUTHORS   Burnett,J.R., Hooper,A.J. and Hegele,R.A.
  TITLE     Familial Combined Hypolipidemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
            Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37471510
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007059.1, BC058287.1 and
            AL138847.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_014495.3.
            
            Summary: This gene encodes a member of a family of secreted
            proteins that function in angiogenesis. The encoded protein, which
            is expressed predominantly in the liver, is further processed into
            an N-terminal coiled-coil domain-containing chain and a C-terminal
            fibrinogen chain. The N-terminal chain is important for lipid
            metabolism, while the C-terminal chain may be involved in
            angiogenesis. Mutations in this gene cause familial
            hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058287.1, AK289426.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371129.4/ ENSP00000360170.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1169              BC007059.1         1-1169
            1170-1739           BC058287.1         1174-1743
            1740-2926           AL138847.14        25514-26700
FEATURES             Location/Qualifiers
     source          1..2926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..2926
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /note="angiopoietin like 3"
                     /db_xref="GeneID:27329"
                     /db_xref="HGNC:HGNC:491"
                     /db_xref="MIM:604774"
     exon            1..542
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1430
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /note="angiopoietin 5; angiopoietin-related protein 3"
                     /codon_start=1
                     /product="angiopoietin-related protein 3 preproprotein"
                     /protein_id="NP_055310.1"
                     /db_xref="CCDS:CCDS622.1"
                     /db_xref="GeneID:27329"
                     /db_xref="HGNC:HGNC:491"
                     /db_xref="MIM:604774"
                     /translation="MFTIKLLLFIVPLVISSRIDQDNSSFDSLSPEPKSRFAMLDDVK
                     ILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLQTSEIKEEEKELRRT
                     TYKLQVKNEEVKNMSLELNSKLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPE
                     VTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISLSS
                     KPRAPRTTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDV
                     ISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIE
                     LEDWKDNKHYIEYSFYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTWDHKAKGHF
                     NCPEGYSGGWWWHDECGENNLNGKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKML
                     IHPTDSESFE"
     exon            543..653
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..768
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..882
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..978
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1245
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..2926
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1504..1509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /note="hexamer: ATTAAA"
     polyA_site      1522
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /note="major polyA site"
     regulatory      2374..2379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /note="hexamer: AATAAA"
     regulatory      2378..2383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /note="hexamer: AACAAA"
     polyA_site      2394
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
     polyA_site      2398
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
     regulatory      2749..2754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /note="hexamer: AATAAA"
     regulatory      2761..2766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
                     /note="hexamer: AATAAT"
     polyA_site      2772
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
     polyA_site      2781
                     /gene="ANGPTL3"
                     /gene_synonym="ANG-5; ANGPT5; ANL3; FHBL2"
ORIGIN      
        1 agaagaaaac agttccacgt tgcttgaaat tgaaaatcaa gataaaaatg ttcacaatta
       61 agctccttct ttttattgtt cctctagtta tttcctccag aattgatcaa gacaattcat
      121 catttgattc tctatctcca gagccaaaat caagatttgc tatgttagac gatgtaaaaa
      181 ttttagccaa tggcctcctt cagttgggac atggtcttaa agactttgtc cataagacga
      241 agggccaaat taatgacata tttcaaaaac tcaacatatt tgatcagtct ttttatgatc
      301 tatcgctgca aaccagtgaa atcaaagaag aagaaaagga actgagaaga actacatata
      361 aactacaagt caaaaatgaa gaggtaaaga atatgtcact tgaactcaac tcaaaacttg
      421 aaagcctcct agaagaaaaa attctacttc aacaaaaagt gaaatattta gaagagcaac
      481 taactaactt aattcaaaat caacctgaaa ctccagaaca cccagaagta acttcactta
      541 aaacttttgt agaaaaacaa gataatagca tcaaagacct tctccagacc gtggaagacc
      601 aatataaaca attaaaccaa cagcatagtc aaataaaaga aatagaaaat cagctcagaa
      661 ggactagtat tcaagaaccc acagaaattt ctctatcttc caagccaaga gcaccaagaa
      721 ctactccctt tcttcagttg aatgaaataa gaaatgtaaa acatgatggc attcctgctg
      781 aatgtaccac catttataac agaggtgaac atacaagtgg catgtatgcc atcagaccca
      841 gcaactctca agtttttcat gtctactgtg atgttatatc aggtagtcca tggacattaa
      901 ttcaacatcg aatagatgga tcacaaaact tcaatgaaac gtgggagaac tacaaatatg
      961 gttttgggag gcttgatgga gaattttggt tgggcctaga gaagatatac tccatagtga
     1021 agcaatctaa ttatgtttta cgaattgagt tggaagactg gaaagacaac aaacattata
     1081 ttgaatattc tttttacttg ggaaatcacg aaaccaacta tacgctacat ctagttgcga
     1141 ttactggcaa tgtccccaat gcaatcccgg aaaacaaaga tttggtgttt tctacttggg
     1201 atcacaaagc aaaaggacac ttcaactgtc cagagggtta ttcaggaggc tggtggtggc
     1261 atgatgagtg tggagaaaac aacctaaatg gtaaatataa caaaccaaga gcaaaatcta
     1321 agccagagag gagaagagga ttatcttgga agtctcaaaa tggaaggtta tactctataa
     1381 aatcaaccaa aatgttgatc catccaacag attcagaaag ctttgaatga actgaggcaa
     1441 atttaaaagg caataattta aacattaacc tcattccaag ttaatgtggt ctaataatct
     1501 ggtattaaat ccttaagaga aagcttgaga aatagatttt ttttatctta aagtcactgt
     1561 ctatttaaga ttaaacatac aatcacataa ccttaaagaa taccgtttac atttctcaat
     1621 caaaattctt ataatactat ttgttttaaa ttttgtgatg tgggaatcaa ttttagatgg
     1681 tcacaatcta gattataatc aataggtgaa cttattaaat aacttttcta aataaaaaat
     1741 ttagagactt ttattttaaa aggcatcata tgagctaata tcacaacttt cccagtttaa
     1801 aaaactagta ctcttgttaa aactctaaac ttgactaaat acagaggact ggtaattgta
     1861 cagttcttaa atgttgtagt attaatttca aaactaaaaa tcgtcagcac agagtatgtg
     1921 taaaaatctg taatacaaat ttttaaactg atgcttcatt ttgctacaaa ataatttgga
     1981 gtaaatgttt gatatgattt atttatgaaa cctaatgaag cagaattaaa tactgtatta
     2041 aaataagttc gctgtcttta aacaaatgga gatgactact aagtcacatt gactttaaca
     2101 tgaggtatca ctatacctta tttgttaaaa tatatactgt atacatttta tatattttaa
     2161 cacttaatac tatgaaaaca aataattgta aaggaatctt gtcagattac agtaagaatg
     2221 aacatatttg tggcatcgag ttaaagttta tatttcccct aaatatgctg tgattctaat
     2281 acattcgtgt aggttttcaa gtagaaataa acctcgtaac aagttactga acgtttaaac
     2341 agcctgacaa gcatgtatat atgtttaaaa ttcaataaac aaagacccag tccctaaatt
     2401 atagaaattt aaattattct tgcatgttta tcgacatcac aacagatccc taaatcccta
     2461 aatccctaaa gattagatac aaatttttta ccacagtatc acttgtcaga atttattttt
     2521 aaatatgatt ttttaaaact gccagtaaga aattttaaat taaacccatt tgttaaagga
     2581 tatagtgccc aagttatatg gtgacctacc tttgtcaata cttagcatta tgtatttcaa
     2641 attatccaat atacatgtca tatatatttt tatatgtcac atatataaaa gatatgtatg
     2701 atctatgtga atcctaagta aatattttgt tccagaaaag tacaaaataa taaaggtaaa
     2761 aataatctat aattttcagg accacagact aagctgtcga aattaacgct gattttttta
     2821 gggccagaat accaaaatgg ctcctctctt cccccaaaat tggacaattt caaatgcaaa
     2881 ataattcatt atttaatata tgagttgctt cctctatttg gtttcc
//
