LOCUS       NM_012098               3443 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens angiopoietin like 2 (ANGPTL2), mRNA.
ACCESSION   NM_012098
VERSION     NM_012098.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3443)
  AUTHORS   Liu,P.I., Jiang,Y.J., Chang,A.C., Huang,C.L., Fong,Y.C., Guo,J.H.,
            Liu,C.L., Wang,S.W., Liu,J.F., Chang,S.L. and Tang,C.H.
  TITLE     ANGPTL2 promotes VEGF-A synthesis in human lung cancer and
            facilitates lymphangiogenesis
  JOURNAL   Aging (Albany NY) 15 (5), 1652-1667 (2023)
   PUBMED   36917086
  REMARK    GeneRIF: ANGPTL2 promotes VEGF-A synthesis in human lung cancer and
            facilitates lymphangiogenesis.
REFERENCE   2  (bases 1 to 3443)
  AUTHORS   Jiang,C., Yao,S., Guo,Y., Ma,L., Wang,X., Chen,Y., Zhang,H. and
            Cao,Z.
  TITLE     Angiopoietin-like protein 2 deficiency promotes periodontal
            inflammation and alveolar bone loss
  JOURNAL   J Periodontol 93 (10), 1525-1539 (2022)
   PUBMED   34709660
  REMARK    GeneRIF: Angiopoietin-like protein 2 deficiency promotes
            periodontal inflammation and alveolar bone loss.
REFERENCE   3  (bases 1 to 3443)
  AUTHORS   Thorin-Trescases,N., Labbe,P., Mury,P., Lambert,M. and Thorin,E.
  TITLE     Angptl2 is a Marker of Cellular Senescence: The Physiological and
            Pathophysiological Impact of Angptl2-Related Senescence
  JOURNAL   Int J Mol Sci 22 (22), 12232 (2021)
   PUBMED   34830112
  REMARK    GeneRIF: Angptl2 is a Marker of Cellular Senescence: The
            Physiological and Pathophysiological Impact of Angptl2-Related
            Senescence.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3443)
  AUTHORS   Takeshita,Y., Motohara,T., Kadomatsu,T., Doi,T., Obayashi,K.,
            Oike,Y., Katabuchi,H. and Endo,M.
  TITLE     Angiopoietin-like protein 2 decreases peritoneal metastasis of
            ovarian cancer cells by suppressing anoikis resistance
  JOURNAL   Biochem Biophys Res Commun 561, 26-32 (2021)
   PUBMED   34000514
  REMARK    GeneRIF: Angiopoietin-like protein 2 decreases peritoneal
            metastasis of ovarian cancer cells by suppressing anoikis
            resistance.
REFERENCE   5  (bases 1 to 3443)
  AUTHORS   Xie,P., Wang,H., Fang,J., Du,D., Tian,Z., Zhen,J., Liu,Y., Ding,Y.,
            Fu,B., Liu,F., Huang,D. and Yu,J.
  TITLE     CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through
            ANGPTL2
  JOURNAL   Endocrinology 162 (3) (2021)
   PUBMED   33508120
  REMARK    GeneRIF: CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells
            Through ANGPTL2.
REFERENCE   6  (bases 1 to 3443)
  AUTHORS   Sun,H., Zheng,J.M., Chen,S., Zeng,C.H., Liu,Z.H. and Li,L.S.
  TITLE     Enhanced expression of ANGPTL2 in the microvascular lesions of
            diabetic glomerulopathy
  JOURNAL   Nephron Exp Nephrol 105 (4), e117-e123 (2007)
   PUBMED   17347581
  REMARK    GeneRIF: The upregulation of ANGPTL2 in diabetic glomerulopathy
            shows a close relationship to abnormal microvasculature and
            endothelial inflammation.
REFERENCE   7  (bases 1 to 3443)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 3443)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 3443)
  AUTHORS   Zeng,L., Dai,J., Ying,K., Zhao,E., Jin,W., Ye,Y., Dai,J., Xu,J.,
            Xie,Y. and Mao,Y.
  TITLE     Identification of a novel human angiopoietin-like gene expressed
            mainly in heart
  JOURNAL   J Hum Genet 48 (3), 159-162 (2003)
   PUBMED   12624729
REFERENCE   10 (bases 1 to 3443)
  AUTHORS   Kim,I., Moon,S.O., Koh,K.N., Kim,H., Uhm,C.S., Kwak,H.J., Kim,N.G.
            and Koh,G.Y.
  TITLE     Molecular cloning, expression, and characterization of
            angiopoietin-related protein. angiopoietin-related protein induces
            endothelial cell sprouting
  JOURNAL   J Biol Chem 274 (37), 26523-26528 (1999)
   PUBMED   10473614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL598400.1, BC012368.1,
            AK074726.1 and AL356862.10.
            
            On Nov 22, 2018 this sequence version replaced NM_012098.2.
            
            Summary: Angiopoietins are members of the vascular endothelial
            growth factor family and the only known growth factors largely
            specific for vascular endothelium. Angiopoietin-1, angiopoietin-2,
            and angiopoietin-4 participate in the formation of blood vessels.
            ANGPTL2 protein is a secreted glycoprotein with homology to the
            angiopoietins and may exert a function on endothelial cells through
            autocrine or paracrine action. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.944677.1,
                                           SRR3476690.517902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373425.8/ ENSP00000362524.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AL598400.1         132-452
            322-2159            BC012368.1         325-2162
            2160-3442           AK074726.1         1294-2576
            3443-3443           AL356862.10        81615-81615         c
FEATURES             Location/Qualifiers
     source          1..3443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.3"
     gene            1..3443
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /note="angiopoietin like 2"
                     /db_xref="GeneID:23452"
                     /db_xref="HGNC:HGNC:490"
                     /db_xref="MIM:605001"
     exon            1..321
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /inference="alignment:Splign:2.1.0"
     exon            322..1187
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1852
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /note="angiopoietin-related protein 2; angiopoietin-like
                     protein 2"
                     /codon_start=1
                     /product="angiopoietin-related protein 2 precursor"
                     /protein_id="NP_036230.1"
                     /db_xref="CCDS:CCDS6868.1"
                     /db_xref="GeneID:23452"
                     /db_xref="HGNC:HGNC:490"
                     /db_xref="MIM:605001"
                     /translation="MRPLCVTCWWLGLLAAMGAVAGQEDGFEGTEEGSPREFIYLNRY
                     KRAGESQDKCTYTFIVPQQRVTGAICVNSKEPEVLLENRVHKQELELLNNELLKQKRQ
                     IETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLEN
                     RILNQTADMLQLASKYKDLEHKYQHLATLAHNQSEIIAQLEEHCQRVPSARPVPQPPP
                     AAPPRVYQPPTYNRIINQISTNEIQSDQNLKVLPPPLPTMPTLTSLPSSTDKPSGPWR
                     DCLQALEDGHDTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWE
                     TYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRLEPESEY
                     YKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNG
                     VWYRGGHYRSRYQDGVYWAEFRGGSYSLKKVVMMIRPNPNTFH"
     exon            1188..1381
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1652
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..3443
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /note="hexamer: AATAAA"
     polyA_site      2138
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
     regulatory      3424..3429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /note="hexamer: AATAAA"
     polyA_site      3443
                     /gene="ANGPTL2"
                     /gene_synonym="ARP2; HARP"
                     /note="major polyA site"
ORIGIN      
        1 caaatgaggc tgctgcggac ggcctgagga tggaccccaa gccctggacc tgccgagcgt
       61 ggcactgagg cagcggctga cgctactgtg agggaaagaa ggttgtgagc agccccgcag
      121 gacccctggc cagccctggc cccagcctct gccggagccc tctgtggagg cagagccagt
      181 ggagcccagt gaggcagggc tgcttggcag ccaccggcct gcaactcagg aacccctcca
      241 gaggccatgg acaggctgcc ccgctgacgg ccagggtgaa gcatgtgagg agccgccccg
      301 gagccaagca ggagggaaga ggctttcata gattctattc acaaagaata accaccattt
      361 tgcaaggacc atgaggccac tgtgcgtgac atgctggtgg ctcggactgc tggctgccat
      421 gggagctgtt gcaggccagg aggacggttt tgagggcact gaggagggct cgccaagaga
      481 gttcatttac ctaaacaggt acaagcgggc gggcgagtcc caggacaagt gcacctacac
      541 cttcattgtg ccccagcagc gggtcacggg tgccatctgc gtcaactcca aggagcctga
      601 ggtgcttctg gagaaccgag tgcataagca ggagctagag ctgctcaaca atgagctgct
      661 caagcagaag cggcagatcg agacgctgca gcagctggtg gaggtggacg gcggcattgt
      721 gagcgaggtg aagctgctgc gcaaggagag ccgcaacatg aactcgcggg tcacgcagct
      781 ctacatgcag ctcctgcacg agatcatccg caagcgggac aacgcgttgg agctctccca
      841 gctggagaac aggatcctga accagacagc cgacatgctg cagctggcca gcaagtacaa
      901 ggacctggag cacaagtacc agcacctggc cacactggcc cacaaccaat cagagatcat
      961 cgcgcagctt gaggagcact gccagagggt gccctcggcc aggcccgtcc cccagccacc
     1021 ccccgctgcc ccgccccggg tctaccaacc acccacctac aaccgcatca tcaaccagat
     1081 ctctaccaac gagatccaga gtgaccagaa cctgaaggtg ctgccacccc ctctgcccac
     1141 tatgcccact ctcaccagcc tcccatcttc caccgacaag ccgtcgggcc catggagaga
     1201 ctgcctgcag gccctggagg atggccacga caccagctcc atctacctgg tgaagccgga
     1261 gaacaccaac cgcctcatgc aggtgtggtg cgaccagaga cacgaccccg ggggctggac
     1321 cgtcatccag agacgcctgg atggctctgt taacttcttc aggaactggg agacgtacaa
     1381 gcaagggttt gggaacattg acggcgaata ctggctgggc ctggagaaca tttactggct
     1441 gacgaaccaa ggcaactaca aactcctggt gaccatggag gactggtccg gccgcaaagt
     1501 ctttgcagaa tacgccagtt tccgcctgga acctgagagc gagtattata agctgcggct
     1561 ggggcgctac catggcaatg cgggtgactc ctttacatgg cacaacggca agcagttcac
     1621 caccctggac agagatcatg atgtctacac aggaaactgt gcccactacc agaagggagg
     1681 ctggtggtat aacgcctgtg cccactccaa cctcaacggg gtctggtacc gcgggggcca
     1741 ttaccggagc cgctaccagg acggagtcta ctgggctgag ttccgaggag gctcttactc
     1801 actcaagaaa gtggtgatga tgatccgacc gaaccccaac accttccact aagccagctc
     1861 cccctcctga cctctcgtgg ccattgccag gagcccaccc tggtcacgct ggccacagca
     1921 caaagaacaa ctcctcacca gttcatcctg aggctgggag gaccgggatg ctggattctg
     1981 ttttccgaag tcactgcagc ggatgatgga actgaatcga tacggtgttt tctgtccctc
     2041 ctactttcct tcacaccaga cagcccctca tgtctccagg acaggacagg actacagaca
     2101 actctttctt taaataaatt aagtctctac aataaaaaca caactgcaaa gtaccttcat
     2161 aatatacatg tgtatgagcc tcccttgtgc acgtatgtgt ataccacata tatatgcatt
     2221 tagatataca tcacatgtga tatatctaga tccatatata ggtttgcctt agatacctaa
     2281 atacacatat attcagttct cagatgttga agctgtcacc agcagctttg ctcttaggag
     2341 aaaagcattt cattagtgtt gtattacttg agtctaaggg tagatcacag actgtgtggt
     2401 ctcaactgaa aggatcaccc ttggcatctg tgtgcctgga ttcttccaga atgtctacaa
     2461 tgctaatctc tcacatagag gttcccagct tcttaagaac cccttttggc acctaatcaa
     2521 atttcaaaat ccctcccccc acattttcat acttttcccc attctcagga cttttcacca
     2581 tccatcaccc acttatccct tcatttgaca ccattcatta agtgccttct gtgtgtcagt
     2641 ccctggccac tcactgcagt tcaaggcccc ctttccgctc tgctgtactc ctcgcctacc
     2701 tactccttgc cttttctgtc gcacagcccc ttctttccag gcgagattcc tcagcttctg
     2761 agtaggaaac actccgggct ccaggtttct ggttgggaag ggaaggccag gccaaaagct
     2821 ccaccggccg tatagataat gtactcgcag ttttgtatct tccattcata ctttaaccta
     2881 caggtcattt gagtcttcac acaaataata acctatctgg ccaggagaat tatctcagaa
     2941 cagaagtcat cagatcatca gagcccccag atggctacag accagagatt ccacgctctc
     3001 aggctgacta gagtccgcat ctcatctcca aactacactt ccctggagaa caagtgccac
     3061 aaaaatgaaa acaggccact tctcaggagt tgaataatca ggggtcaccg gaccccttgg
     3121 ttgatgcact gcagcatggt ggctttctga gtcctgttgg ccaccaagtg tcagcctcag
     3181 cactcccggg actattgcca agaaggggca agggatgagt caagaaggtg agacccttcc
     3241 cggtgggcac gtgggccagg ctgtgtgaga tgttggatgt ttggtactgt ccatgtctgg
     3301 gtgtgtgcct attacctcag catttctcac aaagtgtacc atgtagcatg ttttgtgtat
     3361 ataaaaggga gggttttttt aaaaatatat tcccagatta tccttgtaat gacacgaatc
     3421 tgcaataaaa gccatcagtg cta
//
