LOCUS       NM_004673               3543 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens angiopoietin like 1 (ANGPTL1), transcript variant 1,
            mRNA.
ACCESSION   NM_004673
VERSION     NM_004673.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3543)
  AUTHORS   Wang,D., Li,H., Zeng,T., Chen,Q., Huang,W., Huang,Y., Liao,Y. and
            Jiang,Q.
  TITLE     Exosome-transmitted ANGPTL1 suppresses angiogenesis in glioblastoma
            by inhibiting the VEGFA/VEGFR2/Akt/eNOS pathway
  JOURNAL   J Neuroimmunol 387, 578266 (2024)
   PUBMED   38150891
  REMARK    GeneRIF: Exosome-transmitted ANGPTL1 suppresses angiogenesis in
            glioblastoma by inhibiting the VEGFA/VEGFR2/Akt/eNOS pathway.
REFERENCE   2  (bases 1 to 3543)
  AUTHORS   Chang,T.Y., Lan,K.C., Chiu,C.Y., Sheu,M.L. and Liu,S.H.
  TITLE     ANGPTL1 attenuates cancer migration, invasion, and stemness through
            regulating FOXO3a-mediated SOX2 expression in colorectal cancer
  JOURNAL   Clin Sci (Lond) 136 (9), 657-673 (2022)
   PUBMED   35475476
  REMARK    GeneRIF: ANGPTL1 attenuates cancer migration, invasion, and
            stemness through regulating FOXO3a-mediated SOX2 expression in
            colorectal cancer.
REFERENCE   3  (bases 1 to 3543)
  AUTHORS   Wang,T., Sun,W., Wu,H., Cheng,Y., Li,Y., Meng,F. and Ni,C.
  TITLE     Respiratory traits and coal workers' pneumoconiosis: Mendelian
            randomisation and association analysis
  JOURNAL   Occup Environ Med 78 (2), 137-141 (2021)
   PUBMED   33097673
  REMARK    GeneRIF: Respiratory traits and coal workers' pneumoconiosis:
            Mendelian randomisation and association analysis.
REFERENCE   4  (bases 1 to 3543)
  AUTHORS   Jiang,K., Chen,H., Fang,Y., Chen,L., Zhong,C., Bu,T., Dai,S.,
            Pan,X., Fu,D., Qian,Y., Wei,J. and Ding,K.
  TITLE     Exosomal ANGPTL1 attenuates colorectal cancer liver metastasis by
            regulating Kupffer cell secretion pattern and impeding MMP9 induced
            vascular leakiness
  JOURNAL   J Exp Clin Cancer Res 40 (1), 21 (2021)
   PUBMED   33413536
  REMARK    GeneRIF: Exosomal ANGPTL1 attenuates colorectal cancer liver
            metastasis by regulating Kupffer cell secretion pattern and
            impeding MMP9 induced vascular leakiness.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3543)
  AUTHORS   Nian,F., Zhu,J. and Chang,H.
  TITLE     Long non-coding RNA ANGPTL1-3 promotes multiple myeloma bortezomib
            resistance by sponging miR-30a-3p to activate c-Maf expression
  JOURNAL   Biochem Biophys Res Commun 514 (4), 1140-1146 (2019)
   PUBMED   31103265
  REMARK    GeneRIF: The findings demonstrate that
            lnc-ANGPTL1-3/miR-30a-3p/c-Maf axis plays a critical role in
            Multiple Myeloma bortezomib resistance.
REFERENCE   6  (bases 1 to 3543)
  AUTHORS   Kim,I., Moon,S.O., Koh,K.N., Kim,H., Uhm,C.S., Kwak,H.J., Kim,N.G.
            and Koh,G.Y.
  TITLE     Molecular cloning, expression, and characterization of
            angiopoietin-related protein. angiopoietin-related protein induces
            endothelial cell sprouting
  JOURNAL   J Biol Chem 274 (37), 26523-26528 (1999)
   PUBMED   10473614
REFERENCE   7  (bases 1 to 3543)
  AUTHORS   Avram,D., Ishmael,J.E., Nevrivy,D.J., Peterson,V.J., Lee,S.H.,
            Dowell,P. and Leid,M.
  TITLE     Heterodimeric interactions between chicken ovalbumin upstream
            promoter-transcription factor family members ARP1 and ear2
  JOURNAL   J Biol Chem 274 (20), 14331-14336 (1999)
   PUBMED   10318855
REFERENCE   8  (bases 1 to 3543)
  AUTHORS   Valenzuela,D.M., Griffiths,J.A., Rojas,J., Aldrich,T.H.,
            Jones,P.F., Zhou,H., McClain,J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Huang,T., Papadopoulos,N., Maisonpierre,P.C.,
            Davis,S. and Yancopoulos,G.D.
  TITLE     Angiopoietins 3 and 4: diverging gene counterparts in mice and
            humans
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 1904-1909 (1999)
   PUBMED   10051567
REFERENCE   9  (bases 1 to 3543)
  AUTHORS   Kim,I., Kwak,H.J., Ahn,J.E., So,J.N., Liu,M., Koh,K.N. and Koh,G.Y.
  TITLE     Molecular cloning and characterization of a novel angiopoietin
            family protein, angiopoietin-3
  JOURNAL   FEBS Lett 443 (3), 353-356 (1999)
   PUBMED   10025962
REFERENCE   10 (bases 1 to 3543)
  AUTHORS   Lemmens,I., Merregaert,J., Van de Ven,W.J., Kas,K., Zhang,C.X.,
            Giraud,S., Wautot,V., Buisson,N., De Witte,K., Salandre,J.,
            Lenoir,G., Calender,A., Parente,F., Quincey,D., Courseaux,A.,
            Carle,G.F., Gaudray,P., De Wit,M.J., Lips,C.J., Hoppener,J.W.,
            Khodaei,S., Grant,A.L., Weber,G., Kytola,S., Thakker,R.V. et al.
  TITLE     Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13
            encompassing the multiple endocrine neoplasia type 1 (MEN1) gene.
            The European Consortium on MEN1
  JOURNAL   Genomics 44 (1), 94-100 (1997)
   PUBMED   9286704
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX499002.1, AY358278.1,
            BC050640.1, BM710120.1 and AF086266.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004673.3.
            
            Summary: Angiopoietins are members of the vascular endothelial
            growth factor family and the only known growth factors largely
            specific for vascular endothelium. Angiopoietin-1, angiopoietin-2,
            and angiopoietin-4 participate in the formation of blood vessels.
            The protein encoded by this gene is another member of the
            angiopoietin family that is widely expressed in adult tissues with
            mRNA levels highest in highly vascularized tissues. This protein
            was found to be a secretory protein that does not act as an
            endothelial cell mitogen in vitro. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.47398.1, AY358278.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234816.7/ ENSP00000234816.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               BX499002.1         47-487
            442-2333            AY358278.1         417-2308
            2334-2454           BC050640.1         2169-2289
            2455-2837           AY358278.1         2430-2812
            2838-3171           BM710120.1         159-492
            3172-3543           AF086266.1         282-653
FEATURES             Location/Qualifiers
     source          1..3543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..3543
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /note="angiopoietin like 1"
                     /db_xref="GeneID:9068"
                     /db_xref="HGNC:HGNC:489"
                     /db_xref="MIM:603874"
     exon            1..337
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /inference="alignment:Splign:2.1.0"
     exon            338..447
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /inference="alignment:Splign:2.1.0"
     exon            448..1296
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..1949
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /note="angiopoietin 3; angiopoietin Y1; angioarrestin;
                     angiopoietin-related protein 1; dJ595C2.2 (angiopoietin
                     Y1); ANG-3; angiopoietin-like protein 1"
                     /codon_start=1
                     /product="angiopoietin-related protein 1 precursor"
                     /protein_id="NP_004664.1"
                     /db_xref="CCDS:CCDS1327.1"
                     /db_xref="GeneID:9068"
                     /db_xref="HGNC:HGNC:489"
                     /db_xref="MIM:603874"
                     /translation="MKTFTWTLGVLFFLLVDTGHCRGGQFKIKKINQRRYPRATDGKE
                     EAKKCAYTFLVPEQRITGPICVNTKGQDASTIKDMITRMDLENLKDVLSRQKREIDVL
                     QLVVDVDGNIVNEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNSLELSQLENKILN
                     VTTEMLKMATRYRELEVKYASLTDLVNNQSVMITLLEEQCLRIFSRQDTHVSPPLVQV
                     VPQHIPNSQQYTPGLLGGNEIQRDPGYPRDLMPPPDLATSPTKSPFKIPPVTFINEGP
                     FKDCQQAKEAGHSVSGIYMIKPENSNGPMQLWCENSLDPGGWTVIQKRTDGSVNFFRN
                     WENYKKGFGNIDGEYWLGLENIYMLSNQDNYKLLIELEDWSDKKVYAEYSSFRLEPES
                     EFYRLRLGTYQGNAGDSMMWHNGKQFTTLDRDKDMYAGNCAHFHKGGWWYNACAHSNL
                     NGVWYRGGHYRSKHQDGIFWAEYRGGSYSLRAVQMMIKPID"
     exon            1297..1490
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1761
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..3543
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /note="hexamer: AATAAA"
     polyA_site      2454
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /note="major polyA site"
     regulatory      3328..3333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /note="hexamer: AATAAA"
     regulatory      3350..3355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /note="hexamer: ATTAAA"
     polyA_site      3360
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
     polyA_site      3373
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
     regulatory      3515..3520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
                     /note="hexamer: AATAAA"
     polyA_site      3543
                     /gene="ANGPTL1"
                     /gene_synonym="ANG3; ANGPT3; AngY; ARP1; dJ595C2.2;
                     UNQ162"
ORIGIN      
        1 actgtatata caatctgggt cagctgcagc tggttactgc atttctccat gtggcagaca
       61 gagcaaagcc acaacgcttt ctctgctgga ttaaagacgg cccacagacc agaacttcca
      121 ctatactact taaaattaca taggtggctt gtcaaattca attgattagt attgtaaaag
      181 gaaaaagaag ttccttctta cagcttggat tcaacggtcc aaaacaaaaa tgcagctgcc
      241 attaaagtca cagatgaaca aacttctaca ctgattttta aaatcaagaa taagggcagc
      301 aagtttctgg attcactgaa tcaacagaca caaaaagctg gcaatatagc aactatgaag
      361 agaaaagcta ctaataaaat taacccaacg catagaagac ttttttttct cttctaaaaa
      421 caactaagta aagacttaaa tttaaacaca tcattttaca acctcatttc aaaatgaaga
      481 cttttacctg gaccctaggt gtgctattct tcctactagt ggacactgga cattgcagag
      541 gtggacaatt caaaattaaa aaaataaacc agagaagata ccctcgtgcc acagatggta
      601 aagaggaagc aaagaaatgt gcatacacat tcctggtacc tgaacaaaga ataacagggc
      661 caatctgtgt caacaccaag gggcaagatg caagtaccat taaagacatg atcaccagga
      721 tggaccttga aaacctgaag gatgtgctct ccaggcagaa gcgggagata gatgttctgc
      781 aactggtggt ggatgtagat ggaaacattg tgaatgaggt aaagctgctg agaaaggaaa
      841 gccgtaacat gaactctcgt gttactcaac tctatatgca attattacat gagattatcc
      901 gtaagaggga taattcactt gaactttccc aactggaaaa caaaatcctc aatgtcacca
      961 cagaaatgtt gaagatggca acaagataca gggaactaga ggtgaaatac gcttccttga
     1021 ctgatcttgt caataaccaa tctgtgatga tcactttgtt ggaagaacag tgcttgagga
     1081 tattttcccg acaagacacc catgtgtctc ccccacttgt ccaggtggtg ccacaacata
     1141 ttcctaacag ccaacagtat actcctggtc tgctgggagg taacgagatt cagagggatc
     1201 caggttatcc cagagattta atgccaccac ctgatctggc aacttctccc accaaaagcc
     1261 ctttcaagat accaccggta actttcatca atgaaggacc attcaaagac tgtcagcaag
     1321 caaaagaagc tgggcattcg gtcagtggga tttatatgat taaacctgaa aacagcaatg
     1381 gaccaatgca gttatggtgt gaaaacagtt tggaccctgg gggttggact gttattcaga
     1441 aaagaacaga cggctctgtc aacttcttca gaaattggga aaattataag aaagggtttg
     1501 gaaacattga cggagaatac tggcttggac tggaaaatat ctatatgctt agcaatcaag
     1561 ataattacaa gttattgatt gaattagaag actggagtga taaaaaagtc tatgcagaat
     1621 acagcagctt tcgtctggaa cctgaaagtg aattctatag actgcgcctg ggaacttacc
     1681 agggaaatgc aggggattct atgatgtggc ataatggtaa acaattcacc acactggaca
     1741 gagataaaga tatgtatgca ggaaactgcg cccactttca taaaggaggc tggtggtaca
     1801 atgcctgtgc acattctaac ctaaatggag tatggtacag aggaggccat tacagaagca
     1861 agcaccaaga tggaattttc tgggccgaat acagaggcgg gtcatactcc ttaagagcag
     1921 ttcagatgat gatcaagcct attgactgaa gagagacact cgccaattta aatgacacag
     1981 aactttgtac ttttcagctc ttaaaaatgt aaatgttaca tgtatattac ttggcacaat
     2041 ttatttctac acagaaagtt tttaaaatga attttaccgt aactataaaa gggaacctat
     2101 aaatgtagtt tcatctgtcg tcaattactg cagaaaatta tgtgtatcca caacctagtt
     2161 attttaaaaa ttatgttgac taaatacaaa gtttgttttc taaaatgtaa atatttgcca
     2221 caatgtaaag caaatcttag ctatatttta aatcataaat aacatgttca agatacttaa
     2281 caatttattt aaaatctaag attgctctaa cgtctagtga aaaaaatatt tttaaaattt
     2341 cagccaaata atgcatttta tttataaaaa tacagacaga aaattaggga gaaacctcta
     2401 gttttgccaa tagaaaatgc ttcttccatt gaataaaagt tatttcaaat tgaatttgtg
     2461 cctttcacac gtaatgatta aatctgaatt cttaataata tatcctatgc tgattttccc
     2521 aaaacatgac ccatagtatt aaatacatat catttttaaa aataaaaaaa aacccaaaaa
     2581 taatgcatgc ataatttaaa tggtcaattt ataaagacaa atctatgaat gaatttttca
     2641 gtgttatctt catatgatat gctgaacacc aaaatctcca gaaatgcatt ttatgtagtt
     2701 ctaaaatcag caaaatattg gtattacaaa aatgcagaat atttagtgtg ctacagatct
     2761 gaattatagt tctaatttat tattactttt tttctaattt actgatctta ctactacaaa
     2821 gaaaaaaaaa cccaaccaat ctgcaattca aatcagaaag tttggacagc tttacaagta
     2881 ttagtgcatg ctcagaacag gtgggactaa aacaaactca aggaactgtt ggctgttttc
     2941 ccgatactga gaattcaaca gctccagagc agaagccaca ggggcatagc ttagtccaaa
     3001 ctgctaattt cattttacag tgtatgtaac gcttagtctc acagtgtctt taactcatct
     3061 ttgcaatcaa caactttact agtgactttc tggaacaatt tcctttcagg aatacatatt
     3121 cactgcttag aggtgacctt gccttaatat atttgtgaag ttaaaatttt aaagatagct
     3181 catgaaactt ttgcttaagc aaaaagaaaa cctcgaattg aaatgtgtga ggcaaactat
     3241 gcatgggaat agcttaatgt gaagataatc atttggacaa ctcaaatcca tcaacatgac
     3301 caatgttttt catctgccac atctcaaaat aaaacttctg gtgaaacaaa ttaaacaaaa
     3361 tatccaaacc tcatagtggt attattcttt gttttacctg tggtcatctt aaactggttt
     3421 ttcagtccct ctccacttcc ttcagaacca aagaatctgt tataagattc ctggaaggaa
     3481 ctgggcatct aactgttaca ccaaatctta agtgaataaa actttaccaa ggcttctcag
     3541 tta
//
