LOCUS       NM_001118887            5268 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens angiopoietin 2 (ANGPT2), transcript variant 2, mRNA.
ACCESSION   NM_001118887
VERSION     NM_001118887.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5268)
  AUTHORS   Pastura,P., McDaniel,C.G., Alharbi,S., Fox,D., Coleman,B.,
            Malik,P., Adams,D.M. and Le Cras,T.D.
  TITLE     NRASQ61R mutation drives elevated angiopoietin-2 expression in
            human endothelial cells and a genetic mouse model
  JOURNAL   Pediatr Blood Cancer 71 (7), e31032 (2024)
   PUBMED   38711167
  REMARK    GeneRIF: NRAS[Q61R] mutation drives elevated angiopoietin-2
            expression in human endothelial cells and a genetic mouse model.
REFERENCE   2  (bases 1 to 5268)
  AUTHORS   Meder,L., Orschel,C.I., Otto,C.J., Koker,M., Bragelmann,J.,
            Ercanoglu,M.S., Dahling,S., Compes,A., Selenz,C., Nill,M.,
            Dietlein,F., Florin,A., Eich,M.L., Borchmann,S., Odenthal,M.,
            Blazquez,R., Hilberg,F., Klein,F., Hallek,M., Buttner,R.,
            Reinhardt,H.C. and Ullrich,R.T.
  TITLE     Blocking the angiopoietin-2-dependent integrin beta-1 signaling
            axis abrogates small cell lung cancer invasion and metastasis
  JOURNAL   JCI Insight 9 (10), e166402 (2024)
   PUBMED   38775153
  REMARK    GeneRIF: Blocking the angiopoietin-2-dependent integrin beta-1
            signaling axis abrogates small cell lung cancer invasion and
            metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5268)
  AUTHORS   Wang,X., Huang,J., Liu,J., Sun,Y., Feng,X., Jin,Y. and Zhou,W.
  TITLE     Silencing ANGPT2 alleviates ulcerative colitis by regulating
            autophagy-mediated NLRP3 inflammasome inactivation via the mTOR
            signaling pathway
  JOURNAL   Braz J Med Biol Res 57, e13379 (2024)
   PUBMED   38808888
  REMARK    GeneRIF: Silencing ANGPT2 alleviates ulcerative colitis by
            regulating autophagy-mediated NLRP3 inflammasome inactivation via
            the mTOR signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5268)
  AUTHORS   Smadja,D.M., Guerin,C.L., Chocron,R., Yatim,N., Boussier,J.,
            Gendron,N., Khider,L., Hadjadj,J., Goudot,G., Debuc,B., Juvin,P.,
            Hauw-Berlemont,C., Augy,J.L., Peron,N., Messas,E., Planquette,B.,
            Sanchez,O., Charbit,B., Gaussem,P., Duffy,D., Terrier,B.,
            Mirault,T. and Diehl,J.L.
  TITLE     Angiopoietin-2 as a marker of endothelial activation is a good
            predictor factor for intensive care unit admission of COVID-19
            patients
  JOURNAL   Angiogenesis 23 (4), 611-620 (2020)
   PUBMED   32458111
REFERENCE   5  (bases 1 to 5268)
  AUTHORS   Akwii,R.G., Sajib,M.S., Zahra,F.T. and Mikelis,C.M.
  TITLE     Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology
  JOURNAL   Cells 8 (5), 471 (2019)
   PUBMED   31108880
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5268)
  AUTHORS   Scholz,A., Plate,K.H. and Reiss,Y.
  TITLE     Angiopoietin-2: a multifaceted cytokine that functions in both
            angiogenesis and inflammation
  JOURNAL   Ann N Y Acad Sci 1347, 45-51 (2015)
   PUBMED   25773744
  REMARK    Review article
REFERENCE   7  (bases 1 to 5268)
  AUTHORS   Fagiani,E. and Christofori,G.
  TITLE     Angiopoietins in angiogenesis
  JOURNAL   Cancer Lett 328 (1), 18-26 (2013)
   PUBMED   22922303
  REMARK    Review article
REFERENCE   8  (bases 1 to 5268)
  AUTHORS   Witzenbichler,B., Maisonpierre,P.C., Jones,P., Yancopoulos,G.D. and
            Isner,J.M.
  TITLE     Chemotactic properties of angiopoietin-1 and -2, ligands for the
            endothelial-specific receptor tyrosine kinase Tie2
  JOURNAL   J Biol Chem 273 (29), 18514-18521 (1998)
   PUBMED   9660821
REFERENCE   9  (bases 1 to 5268)
  AUTHORS   Cheung,A.H., Stewart,R.J. and Marsden,P.A.
  TITLE     Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and
            angiopoietin-2 (ANGPT2): regional localization of the human genes
            to 8q22.3-q23 and 8p23
  JOURNAL   Genomics 48 (3), 389-391 (1998)
   PUBMED   9545648
REFERENCE   10 (bases 1 to 5268)
  AUTHORS   Maisonpierre,P.C., Suri,C., Jones,P.F., Bartunkova,S.,
            Wiegand,S.J., Radziejewski,C., Compton,D., McClain,J.,
            Aldrich,T.H., Papadopoulos,N., Daly,T.J., Davis,S., Sato,T.N. and
            Yancopoulos,G.D.
  TITLE     Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo
            angiogenesis
  JOURNAL   Science 277 (5322), 55-60 (1997)
   PUBMED   9204896
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA829327.1, BC126200.1,
            BC022490.1 and AC018398.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001118887.1.
            
            Summary: This gene belongs to the angiopoietin family of growth
            factors. The protein encoded by this gene is an antagonist of
            angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are
            ligands for the endothelial TEK receptor tyrosine kinase.
            Angiopoietin 2 is upregulated in multiple inflammatory diseases and
            is implicated in the direct control of inflammation-related
            signaling pathways. The encoded protein affects angiogenesis during
            embryogenesis and tumorigenesis, disrupts the vascular remodeling
            ability of angiopoietin 1, and may induce endothelial cell
            apoptosis. This gene serves a prognostic biomarker for acute
            respiratory distress syndrome. [provided by RefSeq, Aug 2020].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site compared to variant 1, resulting in an isoform (b) that
            lacks an internal aa compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075219.1, SRR1660809.51371.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000629816.3/ ENSP00000486858.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-538               DA829327.1         19-556
            539-1045            BC126200.1         285-791
            1046-1696           BC022490.1         932-1582
            1697-5249           AC018398.10        101528-105080
            5250-5268           AC018398.10        105081-105099
FEATURES             Location/Qualifiers
     source          1..5268
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..5268
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /note="angiopoietin 2"
                     /db_xref="GeneID:285"
                     /db_xref="HGNC:HGNC:485"
                     /db_xref="MIM:601922"
     exon            1..599
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1799
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; angiopoietin-2a; Tie2-ligand; angiopoietin-2B"
                     /codon_start=1
                     /product="angiopoietin-2 isoform b precursor"
                     /protein_id="NP_001112359.1"
                     /db_xref="CCDS:CCDS47762.1"
                     /db_xref="GeneID:285"
                     /db_xref="HGNC:HGNC:485"
                     /db_xref="MIM:601922"
                     /translation="MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYT
                     FLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQ
                     DNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQL
                     LEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQV
                     LVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSKDPTVAKEE
                     QISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDF
                     QRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLS
                     SEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACG
                     PSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF"
     exon            600..755
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /inference="alignment:Splign:2.1.0"
     exon            756..877
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1110
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1238
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1340
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1507
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1638
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..5268
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /note="hexamer: AATACA"
     polyA_site      2182
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /note="major polyA site"
     regulatory      2582..2587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /note="hexamer: ATTAAA"
     polyA_site      2604
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
     regulatory      4813..4818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /note="hexamer: AATAAA"
     polyA_site      4835
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /note="major polyA site"
     regulatory      5227..5232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
                     /note="hexamer: AATAAA"
     polyA_site      5268
                     /gene="ANGPT2"
                     /gene_synonym="AGPT2; ANG2; LMPHM10"
ORIGIN      
        1 actgacactg taggatctgg ggagagagga acaaaggacc gtgaaagctg ctctgtaaaa
       61 gctgacacag ccctcccaag tgagcaggac tgttcttccc actgcaatct gacagtttac
      121 tgcatgcctg gagagaacac agcagtaaaa accaggtttg ctactggaaa aagaggaaag
      181 agaagacttt cattgacgga cccagccatg gcagcgtagc agccctgcgt tttagacggc
      241 agcagctcgg gactctggac gtgtgtttgc cctcaagttt gctaagctgc tggtttatta
      301 ctgaagaaag aatgtggcag attgttttct ttactctgag ctgtgatctt gtcttggccg
      361 cagcctataa caactttcgg aagagcatgg acagcatagg aaagaagcaa tatcaggtcc
      421 agcatgggtc ctgcagctac actttcctcc tgccagagat ggacaactgc cgctcttcct
      481 ccagccccta cgtgtccaat gctgtgcaga gggacgcgcc gctcgaatac gatgactcgg
      541 tgcagaggct gcaagtgctg gagaacatca tggaaaacaa cactcagtgg ctaatgaagc
      601 ttgagaatta tatccaggac aacatgaaga aagaaatggt agagatacag cagaatgcag
      661 tacagaacca gacggctgtg atgatagaaa tagggacaaa cctgttgaac caaacagcgg
      721 agcaaacgcg gaagttaact gatgtggaag cccaagtatt aaatcagacc acgagacttg
      781 aacttcagct cttggaacac tccctctcga caaacaaatt ggaaaaacag attttggacc
      841 agaccagtga aataaacaaa ttgcaagata agaacagttt cctagaaaag aaggtgctag
      901 ctatggaaga caagcacatc atccaactac agtcaataaa agaagagaaa gatcagctac
      961 aggtgttagt atccaagcaa aattccatca ttgaagaact agaaaaaaaa atagtgactg
     1021 ccacggtgaa taattcagtt cttcagaagc agcaacatga tctcatggag acagttaata
     1081 acttactgac tatgatgtcc acatcaaact ctaaggaccc cactgttgct aaagaagaac
     1141 aaatcagctt cagagactgt gctgaagtat tcaaatcagg acacaccacg aatggcatct
     1201 acacgttaac attccctaat tctacagaag agatcaaggc ctactgtgac atggaagctg
     1261 gaggaggcgg gtggacaatt attcagcgac gtgaggatgg cagcgttgat tttcagagga
     1321 cttggaaaga atataaagtg ggatttggta acccttcagg agaatattgg ctgggaaatg
     1381 agtttgtttc gcaactgact aatcagcaac gctatgtgct taaaatacac cttaaagact
     1441 gggaagggaa tgaggcttac tcattgtatg aacatttcta tctctcaagt gaagaactca
     1501 attataggat tcaccttaaa ggacttacag ggacagccgg caaaataagc agcatcagcc
     1561 aaccaggaaa tgattttagc acaaaggatg gagacaacga caaatgtatt tgcaaatgtt
     1621 cacaaatgct aacaggaggc tggtggtttg atgcatgtgg tccttccaac ttgaacggaa
     1681 tgtactatcc acagaggcag aacacaaata agttcaacgg cattaaatgg tactactgga
     1741 aaggctcagg ctattcgctc aaggccacaa ccatgatgat ccgaccagca gatttctaaa
     1801 catcccagtc cacctgagga actgtctcga actattttca aagacttaag cccagtgcac
     1861 tgaaagtcac ggctgcgcac tgtgtcctct tccaccacag agggcgtgtg ctcggtgctg
     1921 acgggaccca catgctccag attagagcct gtaaacttta tcacttaaac ttgcatcact
     1981 taacggacca aagcaagacc ctaaacatcc ataattgtga ttagacagaa cacctatgca
     2041 aagatgaacc cgaggctgag aatcagactg acagtttaca gacgctgctg tcacaaccaa
     2101 gaatgttatg tgcaagttta tcagtaaata actggaaaac agaacactta tgttatacaa
     2161 tacagatcat cttggaactg cattcttctg agcactgttt atacactgtg taaataccca
     2221 tatgtcctga attcaccatc actatcacaa ttaaaaggaa gaaaaaaact ctctaagcca
     2281 taaaaagaca tattcaggga tattctgaga aggggttact agaagtttaa tatttggaaa
     2341 aacagttagt gcatttttac tccatctctt aggtgcttta aatttttatt tcaaaaacag
     2401 cgtatttaca tttatgttga cagcttagtt ataagttaat gctcaaatac gtatttcaaa
     2461 tttatatggt agaaacttcc agaatctctg aaattatcaa cagaaacgtg ccattttagt
     2521 ttatatgcag accgtactat ttttttctgc ctgattgtta aatatgaagg tatttttagt
     2581 aattaaatat aacttattag gggatatgcc tatgtttaac ttttatgata atatttacaa
     2641 ttttataatt tgtttccaaa agacctaatt gtgccttgtg ataaggaaac ttcttacttt
     2701 taatgatgag gaaaattata catttcattc tatgacaaag aaactttact atcttctcac
     2761 tattctaaaa cagaggtctg ttttctttcc tagtaagata tatttttata gaactagact
     2821 acaatttaat ttctggttga gaaaagcctt ctatttaaga aatttacaaa gctatatgtc
     2881 tcaagattca cccttaaatt tacttaagga aaaaaataat tgacactagt aagttttttt
     2941 atgtcaatca gcaaactgaa aaaaaaaaaa gggtttcaaa gtgcaaaaac aaaatctgat
     3001 gttcataata tatttaaata tttaccaaaa atttgagaac acagggctgg gcgcagtggc
     3061 tcacacctat aatcccagta cattggtagg caaggtgggc agatcacctg aggtcaggag
     3121 ttcaagacca gcctggacaa catggtgaaa ccctgtctct actaaataat acaaaaatta
     3181 gccaggcgtg ctggcgggca cctgtaatcc cagctactcg ggaggctgag gcagggagaa
     3241 ttgcttgcac cagggaggta gaggttgcag tgagccaaga tcgcaccact gcactccagc
     3301 cggggcaaca gagcaagact ccatctcaaa aaaaaaaaaa aaaaaagaaa gaaaagaaaa
     3361 tttgagaaca cagctttata ctcgggacta caaaaccata aactcctgga gttttaactc
     3421 cttttgaaat tttcatagta caattaatac taatgaacat ttgtgtaaag ctttataatt
     3481 taaaggcaat ttctcatata ttcttttctg aatcatttgc aaggaagttc agagtccagt
     3541 ctgtaactag catctactat atgtctgtct tcaccttaca gtgttctacc attatttttt
     3601 ctttattcca tttcaaaatc taatttattt taccccaact tctccccacc acttgacgta
     3661 gttttagaac acacaggtgt tgctacatat ttggagtcaa tgatggactc tggcaaagtc
     3721 aaggctctgt tttatttcca ccaaggtgca cttttccaac aactatttaa ctagttaaga
     3781 acctccctat cttagaactg tatctacttt atatttaaga aggttttatg aattcaacaa
     3841 cggtatcatg gccttgtatc aagttgaaaa acaactgaaa ataagaaaat ttcacagcct
     3901 cgaaagacaa caacaagttt ctaggatatc tcaatgacaa gagtgatgga tacttaggta
     3961 gggaaacgct aatgcaggaa aaactggcaa caacacaatt tatatcaatt ctctttgtag
     4021 gcaggtgata aaaaattcaa ggacaaatct cattatgtca ttgtgcatca tatataatct
     4081 cttatgagcg agaatggggg gaatttgtgt ttttacttta cacttcaatt ccttacacgg
     4141 tatttcaaac aaacagtttt gctgagagga gcttttgtct ctccttaaga aaatgtttat
     4201 aaagctgaaa ggaaatcaaa cagtaatctt aaaaatgaaa acaaaacaac ccaacaacct
     4261 agataactac agtgatcagg gagcacagtt caactccttg ttatgtttta gtcatatggc
     4321 ctactcaaac agctaaataa caacaccagt ggcagataaa aatcaccatt tatctttcag
     4381 ctattaatct tttgaatgaa taaactgtga caaacaaatt aacatttttg aacatgaaag
     4441 gcaacttctg cacaatcctg tatccaagca aactttaaat tatccactta attattactt
     4501 aatcttaaaa aaaattagaa cccagaactt ttcaatgaag catttgaaag ttgaagtgga
     4561 atttaggaaa gccataaaaa tataaatact gttatcacag caccagcaag ccataatctt
     4621 tatacctatc agttctattt ctattaacag taaaaacatt aagcaagata taagactacc
     4681 tgcccaagaa ttcagtcttt tttcattttt gtttttctca gttctgagga tgttaatcgt
     4741 caaattttct ttggactgca ttcctcacta ctttttgcac aatggtctca cgttctcaca
     4801 tttgttctcg cgaataaatt gataaaaggt gttaagttct gtgaatgtct ttttaattat
     4861 gggcataatt gtgcttgact ggataaaaac ttaagtccac ccttatgttt ataataattt
     4921 cttgagaaca gcaaactgca tttaccatcg taaaacaaca tctgacttac gggagctgca
     4981 gggaagtggt gagacagttc gaacggctcc tcagaaatcc agtgacccaa ttctaaagac
     5041 catagcacct gcaagtgaca caacaagcag atttattata catttattag ccttagcagg
     5101 caataaacca agaatcactt tgaagacaca gcaaaaagtg atacactccg cagatctgaa
     5161 atagatgtgt tctcagacaa caaagtccct tcagaatctt catgttgcat aaatgttatg
     5221 aatattaata aaaagttgat tgagaaaaag tctcacgata acaagaaa
//
