LOCUS       NM_001146               4230 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens angiopoietin 1 (ANGPT1), transcript variant 1, mRNA.
ACCESSION   NM_001146
VERSION     NM_001146.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4230)
  AUTHORS   Markowska,A., de Mezer,M., Kurzawa,P., Bednarek,W., Grybos,A.,
            Krzyzaniak,M., Markowska,J., Grybos,M. and Zurawski,J.
  TITLE     Analysis of Expression of the ANG1, CaSR and FAK Proteins in
            Uterine Fibroids
  JOURNAL   Int J Mol Sci 25 (13), 7164 (2024)
   PUBMED   39000274
  REMARK    GeneRIF: Analysis of Expression of the ANG1, CaSR and FAK Proteins
            in Uterine Fibroids.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4230)
  AUTHORS   Dieter,C., Lemos,N.E., de Faria Correa,N.R., Assmann,T.S.,
            Pellenz,F.M., Canani,L.H., de Almeida Brondani,L., Bauer,A.C. and
            Crispim,D.
  TITLE     Polymorphisms in TIE2 and ANGPT-1 genes are associated with
            protection against diabetic retinopathy in a Brazilian population
  JOURNAL   Arch Endocrinol Metab 67 (5), e000624 (2023)
   PUBMED   37249455
  REMARK    GeneRIF: Polymorphisms in TIE2 and ANGPT-1 genes are associated
            with protection against diabetic retinopathy in a Brazilian
            population.
REFERENCE   3  (bases 1 to 4230)
  AUTHORS   Tsai,T., Alwees,M., Asaad,M.A., Theile,J., Kakkassery,V.,
            Dick,H.B., Schultz,T. and Joachim,S.C.
  TITLE     Increased Angiopoietin-1 and -2 levels in human vitreous are
            associated with proliferative diabetic retinopathy
  JOURNAL   PLoS One 18 (1), e0280488 (2023)
   PUBMED   36662891
  REMARK    GeneRIF: Increased Angiopoietin-1 and -2 levels in human vitreous
            are associated with proliferative diabetic retinopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4230)
  AUTHORS   Ma,D., Liu,P., Hu,C., Zhou,Z., Wang,P., Wang,Y., Zhang,Y., Ran,Y.,
            Li,P., Zhao,J., Wang,J., Zhang,C. and Tang,L.
  TITLE     Intracellular angiopoietin-1 promotes TKI-resistance via activation
            of JAK/STAT5 pathway in chronic myeloid leukemia
  JOURNAL   Oncogene 42 (2), 124-137 (2023)
   PUBMED   36385374
  REMARK    GeneRIF: Intracellular angiopoietin-1 promotes TKI-resistance via
            activation of JAK/STAT5 pathway in chronic myeloid leukemia.
REFERENCE   5  (bases 1 to 4230)
  AUTHORS   Ward,E.G., Grosios,K., Markham,A.F. and Jones,P.F.
  TITLE     Genomic structures of the human angiopoietins show polymorphism in
            angiopoietin-2
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 147-154 (2001)
   PUBMED   11856872
  REMARK    GeneRIF: Genomic structures of the human angiopoietins show
            polymorphism in angiopoietin-2
REFERENCE   6  (bases 1 to 4230)
  AUTHORS   Cheung,A.H., Stewart,R.J. and Marsden,P.A.
  TITLE     Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and
            angiopoietin-2 (ANGPT2): regional localization of the human genes
            to 8q22.3-q23 and 8p23
  JOURNAL   Genomics 48 (3), 389-391 (1998)
   PUBMED   9545648
REFERENCE   7  (bases 1 to 4230)
  AUTHORS   Maisonpierre,P.C., Suri,C., Jones,P.F., Bartunkova,S.,
            Wiegand,S.J., Radziejewski,C., Compton,D., McClain,J.,
            Aldrich,T.H., Papadopoulos,N., Daly,T.J., Davis,S., Sato,T.N. and
            Yancopoulos,G.D.
  TITLE     Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo
            angiogenesis
  JOURNAL   Science 277 (5322), 55-60 (1997)
   PUBMED   9204896
REFERENCE   8  (bases 1 to 4230)
  AUTHORS   Suri,C., Jones,P.F., Patan,S., Bartunkova,S., Maisonpierre,P.C.,
            Davis,S., Sato,T.N. and Yancopoulos,G.D.
  TITLE     Requisite role of angiopoietin-1, a ligand for the TIE2 receptor,
            during embryonic angiogenesis
  JOURNAL   Cell 87 (7), 1171-1180 (1996)
   PUBMED   8980224
REFERENCE   9  (bases 1 to 4230)
  AUTHORS   Davis,S., Aldrich,T.H., Jones,P.F., Acheson,A., Compton,D.L.,
            Jain,V., Ryan,T.E., Bruno,J., Radziejewski,C., Maisonpierre,P.C.
            and Yancopoulos,G.D.
  TITLE     Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by
            secretion-trap expression cloning
  JOURNAL   Cell 87 (7), 1161-1169 (1996)
   PUBMED   8980223
REFERENCE   10 (bases 1 to 4230)
  AUTHORS   Ruegg,C. and Pytela,R.
  TITLE     Sequence of a human transcript expressed in T-lymphocytes and
            encoding a fibrinogen-like protein
  JOURNAL   Gene 160 (2), 257-262 (1995)
   PUBMED   7642106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX648814.1, BC152419.1 and
            AP000428.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001146.4.
            
            Summary: This gene encodes a secreted glycoprotein that belongs to
            the angiopoietin family. Members of this family play important
            roles in vascular development and angiogenesis. All angiopoietins
            bind with similar affinity to an endothelial cell-specific
            tyrosine-protein kinase receptor. The protein encoded by this gene
            is a secreted glycoprotein that activates the receptor by inducing
            its tyrosine phosphorylation. It plays a critical role in mediating
            reciprocal interactions between the endothelium and surrounding
            matrix and mesenchyme and inhibits endothelial permeability. The
            protein also contributes to blood vessel maturation and stability,
            and may be involved in early development of the heart. Mutations in
            this gene are associated with hereditary angioedema. [provided by
            RefSeq, Aug 2020].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648814.1, BC152411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517746.6/ ENSP00000428340.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BX648814.1         139-147
            10-4221             BC152419.1         13-4224
            4222-4230           AP000428.3         157273-157281       c
FEATURES             Location/Qualifiers
     source          1..4230
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1"
     gene            1..4230
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /note="angiopoietin 1"
                     /db_xref="GeneID:284"
                     /db_xref="HGNC:HGNC:484"
                     /db_xref="MIM:601667"
     exon            1..657
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..1857
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ANG-1"
                     /codon_start=1
                     /product="angiopoietin-1 isoform 1 precursor"
                     /protein_id="NP_001137.2"
                     /db_xref="CCDS:CCDS6306.1"
                     /db_xref="GeneID:284"
                     /db_xref="HGNC:HGNC:484"
                     /db_xref="MIM:601667"
                     /translation="MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYT
                     FILPEHDGNCRESTTDQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLEN
                     YIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLE
                     IQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKEN
                     LQGLVTRQTYIIQELEKQLNRATTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGK
                     REEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGS
                     LDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRF
                     HIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFD
                     ACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF"
     exon            658..813
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /inference="alignment:Splign:2.1.0"
     exon            814..935
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1168
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1296
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1398
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1565
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1696
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..4230
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4014..4019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /note="hexamer: AATAAA"
     polyA_site      4035
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
     regulatory      4203..4208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /note="hexamer: AATAAA"
     polyA_site      4230
                     /gene="ANGPT1"
                     /gene_synonym="AGP1; AGPT; AGPT-1; ANG1; HAE5"
                     /note="major polyA site"
ORIGIN      
        1 agcagatctg cagcagatag ggtagaggaa agggtctaga atatgtacac gcagctgact
       61 caggcaggct ccatgctgaa cggtcacaca gagaggaaac aataaatctc agctactatg
      121 caataaatat ctcaagtttt aacgaagaaa aacatcattg cagtgaaata aaaaatttta
      181 aaattttaga acaaagctaa caaatggcta gttttctatg attcttcttc aaacgctttc
      241 tttgaggggg aaagagtcaa acaaacaagc agttttacct gaaataaaga actagtttta
      301 gaggtcagaa gaaaggagca agttttgcga gaggcacgga aggagtgtgc tggcagtaca
      361 atgacagttt tcctttcctt tgctttcctc gctgccattc tgactcacat agggtgcagc
      421 aatcagcgcc gaagtccaga aaacagtggg agaagatata accggattca acatgggcaa
      481 tgtgcctaca ctttcattct tccagaacac gatggcaact gtcgtgagag tacgacagac
      541 cagtacaaca caaacgctct gcagagagat gctccacacg tggaaccgga tttctcttcc
      601 cagaaacttc aacatctgga acatgtgatg gaaaattata ctcagtggct gcaaaaactt
      661 gagaattaca ttgtggaaaa catgaagtcg gagatggccc agatacagca gaatgcagtt
      721 cagaaccaca cggctaccat gctggagata ggaaccagcc tcctctctca gactgcagag
      781 cagaccagaa agctgacaga tgttgagacc caggtactaa atcaaacttc tcgacttgag
      841 atacagctgc tggagaattc attatccacc tacaagctag agaagcaact tcttcaacag
      901 acaaatgaaa tcttgaagat ccatgaaaaa aacagtttat tagaacataa aatcttagaa
      961 atggaaggaa aacacaagga agagttggac accttaaagg aagagaaaga gaaccttcaa
     1021 ggcttggtta ctcgtcaaac atatataatc caggagctgg aaaagcaatt aaacagagct
     1081 accaccaaca acagtgtcct tcagaagcag caactggagc tgatggacac agtccacaac
     1141 cttgtcaatc tttgcactaa agaaggtgtt ttactaaagg gaggaaaaag agaggaagag
     1201 aaaccattta gagactgtgc agatgtatat caagctggtt ttaataaaag tggaatctac
     1261 actatttata ttaataatat gccagaaccc aaaaaggtgt tttgcaatat ggatgtcaat
     1321 gggggaggtt ggactgtaat acaacatcgt gaagatggaa gtctagattt ccaaagaggc
     1381 tggaaggaat ataaaatggg ttttggaaat ccctccggtg aatattggct ggggaatgag
     1441 tttatttttg ccattaccag tcagaggcag tacatgctaa gaattgagtt aatggactgg
     1501 gaagggaacc gagcctattc acagtatgac agattccaca taggaaatga aaagcaaaac
     1561 tataggttgt atttaaaagg tcacactggg acagcaggaa aacagagcag cctgatctta
     1621 cacggtgctg atttcagcac taaagatgct gataatgaca actgtatgtg caaatgtgcc
     1681 ctcatgttaa caggaggatg gtggtttgat gcttgtggcc cctccaatct aaatggaatg
     1741 ttctatactg cgggacaaaa ccatggaaaa ctgaatggga taaagtggca ctacttcaaa
     1801 gggcccagtt actccttacg ttccacaact atgatgattc gacctttaga tttttgaaag
     1861 cgcaatgtca gaagcgatta tgaaagcaac aaagaaatcc ggagaagctg ccaggtgaga
     1921 aactgtttga aaacttcaga agcaaacaat attgtctccc ttccagcaat aagtggtagt
     1981 tatgtgaagt caccaaggtt cttgaccgtg aatctggagc cgtttgagtt cacaagagtc
     2041 tctacttggg gtgacagtgc tcacgtggct cgactataga aaactccact gactgtcggg
     2101 ctttaaaaag ggaagaaact gctgagcttg ctgtgcttca aactactact ggaccttatt
     2161 ttggaactat ggtagccaga tgataaatat ggttaatttc atgtaaaaca gaaaaaaaga
     2221 gtgaaaaaga gaatatacat gaagaataga aacaagcctg ccataatcct ttggaaaaga
     2281 tgtattatac cagtgaaaag gtgttatatc tatgcaaacc tactaacaaa ttatactgtt
     2341 gcacaatttt gataaaaatt tagaacagca ttgtcctctg agttggttaa atgttaatgg
     2401 atttcagaag cctaattcca gtatcatact tactagttga tttctgctta cccatcttca
     2461 aatgaaaatt ccatttttgt aagccataat gaactgtagt acatggacaa taagtgtgtg
     2521 gtagaaacaa actccattac tctgattttt gatacagttt tcagaaaaag aaatgaacat
     2581 aatcaagtaa ggatgtatgt ggtgaaaact taccaccccc atactatggt tttcatttac
     2641 tctaaaaact gattgaatga tatataaata tatttatagc ctgagtaaag ttaaaagaat
     2701 gtaaaatata tcatcaagtt cttaaaataa tatacatgca tttaatattt cctttgatat
     2761 tatacaggaa agcaatattt tggagtatgt taagttgaag taaaagcaag tactctggag
     2821 cagttcattt tacagtatct acttgcatgt gtatacatac atgtaacttc attattttaa
     2881 aaatattttt agaactccaa tactcaccct gttatgtctt gctaatttaa attttgctaa
     2941 ttaactgaaa catgcttacc agattcacac tgttccagtg tctataaaag aaacactttg
     3001 aagtctataa aaaataaaat aattataaat atcattgtac atagcatgtt tatatctgca
     3061 aaaaacctaa tagctaatta atctggaata tgcaacattg tccttaattg atgcaaataa
     3121 cacaaatgct caaagaaatc tactatatcc cttaatgaaa tacatcattc ttcatatatt
     3181 tctccttcag tccattccct taggcaattt ttaattttta aaaattatta tcaggggaga
     3241 aaaattggca aaactattat atgtaaggga aatatataca aaaagaaaat taatcatagt
     3301 cacctgacta agaaattctg actgctagtt gccataaata actcaatgga aatattccta
     3361 tgggataatg tattttaagt gaatttttgg ggtgcttgaa gttactgcat tattttatca
     3421 agaagtcttc tctgcctgta agtgtccaag gttatgacag taaacagttt ttattaaaac
     3481 atgagtcact atgggatgag aaaattgaaa taaagctact gggcctcctc tcataaaaga
     3541 gacagttgtt ggcaaggtag caataccagt ttcaaacttg gtgacttgat ccactatgcc
     3601 ttaatggttt cctccatttg agaaaataaa gctattcaca ttgttaagaa aaatactttt
     3661 taaagtttac catcaagtct tttttatatt tatgtgtctg tattctaccc ctttttgcct
     3721 tacaagtgat atttgcaggt attataccat ttttctattc ttggtggctt cttcatagca
     3781 ggtaagcctc tccttctaaa aacttctcaa ctgttttcat ttaagggaaa gaaaatgagt
     3841 attttgtcct tttgtgttcc tacagacact ttcttaaacc agtttttgga taaagaatac
     3901 tatttccaaa ctcatattac aaaaacaaaa taaaataata aaaaaagaaa gcatgatatt
     3961 tactgttttg ttgtctgggt ttgagaaatg aaatattgtt tccaattatt tataataaat
     4021 cagtataaaa tgttttatga ttgttatgtg tattatgtaa tacgtacatg tttatggcaa
     4081 tttaacatgt gtattctttt aattgtttca gaataggata attaggtatt cgaattttgt
     4141 ctttaaaatt catgtggttt ctatgcaaag ttcttcatat catcacaaca ttatttgatt
     4201 taaataaaat tgaaagtaat atttgtgcaa
//
