LOCUS       NM_144567               4690 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens angel homolog 2 (ANGEL2), transcript variant 1, mRNA.
ACCESSION   NM_144567
VERSION     NM_144567.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4690)
  AUTHORS   Clemente,P., Calvo-Garrido,J., Pearce,S.F., Schober,F.A.,
            Shigematsu,M., Siira,S.J., Laine,I., Spahr,H., Steinmetzger,C.,
            Petzold,K., Kirino,Y., Wibom,R., Rackham,O., Filipovska,A.,
            Rorbach,J., Freyer,C. and Wredenberg,A.
  TITLE     ANGEL2 phosphatase activity is required for non-canonical
            mitochondrial RNA processing
  JOURNAL   Nat Commun 13 (1), 5750 (2022)
   PUBMED   36180430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4690)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 4690)
  AUTHORS   Pinto,P.H., Kroupova,A., Schleiffer,A., Mechtler,K., Jinek,M.,
            Weitzer,S. and Martinez,J.
  TITLE     ANGEL2 is a member of the CCR4 family of deadenylases with
            2',3'-cyclic phosphatase activity
  JOURNAL   Science 369 (6503), 524-530 (2020)
   PUBMED   32732418
  REMARK    GeneRIF: ANGEL2 is a member of the CCR4 family of deadenylases with
            2',3'-cyclic phosphatase activity.
REFERENCE   4  (bases 1 to 4690)
  AUTHORS   Yi,X., Hong,M., Gui,B., Chen,Z., Li,L., Xie,G., Liang,J., Wang,X.
            and Shang,Y.
  TITLE     RNA processing and modification protein, carbon catabolite
            repression 4 (Ccr4), arrests the cell cycle through p21-dependent
            and p53-independent pathway
  JOURNAL   J Biol Chem 287 (25), 21045-21057 (2012)
   PUBMED   22547059
REFERENCE   5  (bases 1 to 4690)
  AUTHORS   Wagner,E., Clement,S.L. and Lykke-Andersen,J.
  TITLE     An unconventional human Ccr4-Caf1 deadenylase complex in nuclear
            cajal bodies
  JOURNAL   Mol Cell Biol 27 (5), 1686-1695 (2007)
   PUBMED   17178830
REFERENCE   6  (bases 1 to 4690)
  AUTHORS   Lipovich,L., Hughes,A.L., King,M.C., Abkowitz,J.L. and Quigley,J.G.
  TITLE     Genomic structure and evolutionary context of the human feline
            leukemia virus subgroup C receptor (hFLVCR) gene: evidence for
            block duplications and de novo gene formation within duplicons of
            the hFLVCR locus
  JOURNAL   Gene 286 (2), 203-213 (2002)
   PUBMED   11943475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC395916.1, AF510741.1, AL079275.1, BC016966.1, BC047469.1,
            AK022855.1, BX103687.1 and AI658922.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144567.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.273818.1,
                                           SRR1660803.81945.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366962.8/ ENSP00000355929.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                DC395916.1         9-76
            69-255              AF510741.1         28-214
            256-321             AL079275.1         217-282
            322-908             BC016966.1         74-660
            909-1825            AL079275.1         875-1791
            1826-2004           BC047469.1         1424-1602
            2005-2023           AL079275.1         1972-1990
            2024-3374           BC047469.1         1623-2973
            3375-3916           AK022855.1         1374-1915
            3917-4456           BX103687.1         30-569
            4457-4690           AI658922.1         20-253              c
FEATURES             Location/Qualifiers
     source          1..4690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..4690
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /note="angel homolog 2"
                     /db_xref="GeneID:90806"
                     /db_xref="HGNC:HGNC:30534"
                     /db_xref="MIM:619001"
     exon            1..255
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1831
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /note="isoform a is encoded by transcript variant 1;
                     protein angel homolog 2"
                     /codon_start=1
                     /product="protein angel homolog 2 isoform a"
                     /protein_id="NP_653168.2"
                     /db_xref="CCDS:CCDS1512.1"
                     /db_xref="GeneID:90806"
                     /db_xref="HGNC:HGNC:30534"
                     /db_xref="MIM:619001"
                     /translation="MEAWRCVRKGYGHCVVGRGRYPMFPHHSRSLGRDWTTPWENLQR
                     CCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPCLFESRTQFQYCNWRPDNLSQ
                     TSLIHLSSYVMNAEGDEPSSKRRKHQGVIKRNWEYICSHDKEKTKILGDKNVDPKCED
                     SENKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCL
                     QEVQEDHYGAEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFFRP
                     DISLLDRDNVGLVLLLQPKIPYAACPAICVANTHLLYNPRRGDIKLTQLAMLLAEISS
                     VAHQKDGSFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLPIGKVSGQEQSSRGQRIL
                     SIPIWPPNLGISQNCVYEVQQVPKVEKTDSDLTQTQLKQTEVLVTAEKLSSNLQHHFS
                     LSSVYSHYFPDTGIPEVTTCHSRSAITVDYIFYSAEKEDVAGHPGAEVALVGGLKLLA
                     RLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL"
     exon            256..581
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /inference="alignment:Splign:2.1.0"
     exon            582..838
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /inference="alignment:Splign:2.1.0"
     exon            839..908
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1330
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1457
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1515
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1679
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..4690
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4388..4393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /note="hexamer: ATTAAA"
     polyA_site      4416
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
     regulatory      4671..4676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /note="hexamer: AATAAA"
     polyA_site      4690
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /note="major polyA site"
ORIGIN      
        1 attcagggac tctgactgcg caagatggag tgtaggccgg ccggcgagac tgcacctccc
       61 agcatgcctt gcagccagga ctggagtcgg tacttaagag tgatggggtt ccctagatac
      121 tttaggccgt cgcatcgatt atagagattg aggtggaacc cggggcctgg gaactggacg
      181 cacgcggagg gcgaagatgg aagcctggcg ctgtgtgagg aagggctacg gccactgtgt
      241 ggtgggaaga ggccgatacc ccatgtttcc ccatcactcg aggagtctgg gcagagactg
      301 gactacaccg tgggagaatc tgcaaaggtg ttgctggaac agacatattt ctagttgtat
      361 gaggtggcct ggacattact ctcgagctcc ttacccatac ttcagtagta ggcatttttc
      421 actaaattgg agaccaccct gtttgtttga gtctagaact cagttccagt actgtaactg
      481 gagacctgac aacctgagcc agacatcttt gattcatctc tctagttacg tcatgaacgc
      541 tgagggagat gagccttcat caaaacgaag aaaacaccaa ggtgtgataa agcggaattg
      601 ggaatatata tgtagccatg ataaagaaaa aacgaagatc ctaggagaca aaaatgttga
      661 tcccaaatgt gaagacagtg agaacaagtt tgacttttca gtgatgtcct ataatatact
      721 ttcacaagat ttactggaag ataactctca cctttataga cattgccggc ggccagtatt
      781 acactggagt tttaggtttc ccaatattct gaaagaaatt aaacattttg atgcagacgt
      841 actttgtttg caagaagttc aagaagatca ttatggagca gagatcaggc caagtttgga
      901 atcactgggt tatcactgtg aatataagat gcggacagga aggaaacctg atggctgtgc
      961 tatttgcttc aaacattcca aattttcact cttgtcagtg aacccagtgg aattcttccg
     1021 ccctgatatt tctctgttgg acagagacaa tgttggatta gttttactct tacagcccaa
     1081 aattccatat gctgcctgcc ctgcaatctg cgtagcaaat acgcatctgt tgtataatcc
     1141 aaggcgaggt gatattaagc tgacgcaatt ggcaatgcta ctggcagaga tttccagtgt
     1201 tgcccaccag aaagatggca gcttctgccc tattgttatg tgtggtgact ttaattctgt
     1261 tcctggttct ccactatata gtttcataaa ggaaggaaaa ttgaattatg aaggacttcc
     1321 cataggaaag gtatctggcc aggaacagtc ttcacgggga caaagaattt tatctattcc
     1381 aatttggccc ccaaacctag gtatctcaca gaactgtgtg tatgaggtac agcaggtacc
     1441 aaaagtagaa aagacagaca gtgatctgac acaaacacag ctgaagcaaa cagaggtcct
     1501 agtgacagct gaaaaattgt cttcaaattt acagcaccat ttcagtttgt catctgttta
     1561 ttcacattac tttcctgaca ctggaattcc agaagtgacc acctgtcatt cccgaagtgc
     1621 cataactgtg gattatattt tctactctgc agaaaaggaa gatgttgctg ggcacccagg
     1681 agctgaagtt gctttggttg gtggcttgaa acttctagct agactgtcac ttcttacaga
     1741 acaagactta tggactgtta atggacttcc aaacgaaaat aactcttcag atcatctgcc
     1801 tttattggca aagttcagac ttgagctctg actctctttg atcacatact aattttcttt
     1861 ccaatttgta ttgtttttca aagaatgtaa agttcttaag tgtatgcatg ttgtttattt
     1921 ttgcactgtg gagattctga agcggttatg ttagatgctt tgaaactcca tatcagaaga
     1981 aataacttta taacaatttt ttttaataat gaaaaatatt ttcgtgacaa gtgagctcta
     2041 aattctcttt attgtaaaag agatgtaaag gttttatatt ctaaatccta gtaaaattga
     2101 cagtgatttt taaatataat gcatcttcct ttgtctgctt agtaaaaaat ttcatttcat
     2161 aattttggca agctctgtag tggatccaaa gtatctttga gttcttgcaa actacaagtt
     2221 gtttcctttc cagaaggctt gatttcatta ggagacccct ctattgagtt ctaaatagtt
     2281 tatcttagaa agccttgggt cattcacagg tatccaacca gccattgttt agtttgtttt
     2341 tgaaggggtt tgataatgct ttttaagttg tacagaatgc ttaatccatc ttattactgt
     2401 cctgagccat gtaatatgcc tgcatcgtgt tggggaaatg tttgggaaat ataagccagc
     2461 ataacgtgta aagctcactc tttcaccctg gaacagacaa gaggtgggct taatagaggc
     2521 agagactggg gatatacctt tgtttcccta gcatttttat ttatttattt ttattttatt
     2581 ttattttttg agatggagtt tcactcttgt tgcccaggct gggggtgcaa tggcgcaatc
     2641 tttgctcact gcaacccctg cctcccgggc tcaagcgatt ctcctgcctc agcctctcga
     2701 gtagctggga ttacaggcat gcgtcaccac tcccagctaa ttttgtattt tcagtagaga
     2761 cagggtttcc ccatgttggt taggctggtc tcgaactccc aacctcaggt gatccgccca
     2821 cctcagctct caaagtgctg ggattacagg cgggagccac tgcacatggc agcatttttt
     2881 aaaaattcag ttttaagatc tctggtttag gggagagatt ttattttact gaaccagttc
     2941 tatagaaatt tattttatta ggaaatttgt ctttggaaca aagtggcagc tataaaatta
     3001 tttttgttaa gcctcagaaa tatgaggaag cctgtaaaac tctagtgggg agatattaac
     3061 ttggagacct aatgctctgt aaatagtcat ttaaactgtt ggttttagtg gttttgtttc
     3121 taaaatgttt tcttttaccg tgatgcacca gtatgagatg gtgctgacac tttctatgaa
     3181 gtggttatga gcaggtttaa taaatcctct atacaagtgt ttgaatcaat tttaaaacat
     3241 aaaaagtgga aatttccttt tttgtagaca gtaggaacaa ggaattatat gcatttttac
     3301 taagtagtaa ttttacactg aattgtaaat gtttttacag tgagttttat taatagaatg
     3361 cttcacctta aattggaaaa caataatagt cttggactaa gtctttgtac taaagcattt
     3421 gctataatta tttttaaaaa aacaaacaga tgaaaacctc agagaaggca tgtggattat
     3481 aagatttgtc tagtaaaaat tgtaattgaa tatgtttaaa tatttaattt ctcattttgg
     3541 ggggttttta tttttttatt ttttagatgg tgtctcacgc tatcgcccag gctggagtgc
     3601 agtggcgcga actcggctca ctgcaacctc cgcctcctgg gttcaagcaa ttctccttcc
     3661 tcagcctccc aagtagctgg gattacaggc atgcaccacc atgcccagct aatttttgta
     3721 tttttagtag agatggaatt ttgccatgtt ggccaggctg gtcttgaact cctgacctca
     3781 ggggtgatcc acccgcctcg ggctcccaaa gtgctgtgat tacaggcatg agccaccatg
     3841 cctggccttt ggggggattt taattacagt attaattata gttctaggat ttcccacatt
     3901 ttatagtagt agtttgcagg atattatgtg ccctaattag cagatataga cattatcaaa
     3961 ttataatgat agtataatta tcccttttta atattgggga aagaaaaatg aaaattcatt
     4021 agttaattac tgctttgtgt tgtgtgaatt tattaacaaa taacattatt acatataggt
     4081 cattgttaac aaacaaacat ccctgaaaac ctctgtgaaa atttaatttt ttatatcctg
     4141 attaatatat tgtgacttta ggcccatttt tcatgtgctt cactttgata gagttaatcc
     4201 ataaaattgc tctttacttt agcttatcaa atgaagtatt attttgtgga ctggaggcca
     4261 aaaagtcaat gtgagcttct cacaggtttt taaagctcca ctaaaaataa ttatccactt
     4321 gtctttactt ttgttgacca gaatagttgg taactctgcc agagcctgta cttacctgcc
     4381 aaaaacaatt aaatctggtt aatgcctgaa accaaatctc tcagtctcaa gtgttatact
     4441 atccaagttt taaatggaaa ggtaaactgt ggagtaatga aattttggtt ttactgtacc
     4501 ttttgctatc aagataatat tcatgtttga aatcttgtct ttatttggaa tttagttact
     4561 gtctgctttt aacctttgct ttcctaaaga aagtttgaga tccagagagt tcaagggatt
     4621 ggggaaagag aggcgtcaag tcatttgcac tttgtacctg taagttaggt aataaactat
     4681 tatactcgta
//
