LOCUS       NP_653168                544 aa            linear   PRI 20-SEP-2024
DEFINITION  protein angel homolog 2 isoform a [Homo sapiens].
ACCESSION   NP_653168
VERSION     NP_653168.2
DBSOURCE    REFSEQ: accession NM_144567.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 544)
  AUTHORS   Clemente,P., Calvo-Garrido,J., Pearce,S.F., Schober,F.A.,
            Shigematsu,M., Siira,S.J., Laine,I., Spahr,H., Steinmetzger,C.,
            Petzold,K., Kirino,Y., Wibom,R., Rackham,O., Filipovska,A.,
            Rorbach,J., Freyer,C. and Wredenberg,A.
  TITLE     ANGEL2 phosphatase activity is required for non-canonical
            mitochondrial RNA processing
  JOURNAL   Nat Commun 13 (1), 5750 (2022)
   PUBMED   36180430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 544)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (residues 1 to 544)
  AUTHORS   Pinto,P.H., Kroupova,A., Schleiffer,A., Mechtler,K., Jinek,M.,
            Weitzer,S. and Martinez,J.
  TITLE     ANGEL2 is a member of the CCR4 family of deadenylases with
            2',3'-cyclic phosphatase activity
  JOURNAL   Science 369 (6503), 524-530 (2020)
   PUBMED   32732418
  REMARK    GeneRIF: ANGEL2 is a member of the CCR4 family of deadenylases with
            2',3'-cyclic phosphatase activity.
REFERENCE   4  (residues 1 to 544)
  AUTHORS   Yi,X., Hong,M., Gui,B., Chen,Z., Li,L., Xie,G., Liang,J., Wang,X.
            and Shang,Y.
  TITLE     RNA processing and modification protein, carbon catabolite
            repression 4 (Ccr4), arrests the cell cycle through p21-dependent
            and p53-independent pathway
  JOURNAL   J Biol Chem 287 (25), 21045-21057 (2012)
   PUBMED   22547059
REFERENCE   5  (residues 1 to 544)
  AUTHORS   Wagner,E., Clement,S.L. and Lykke-Andersen,J.
  TITLE     An unconventional human Ccr4-Caf1 deadenylase complex in nuclear
            cajal bodies
  JOURNAL   Mol Cell Biol 27 (5), 1686-1695 (2007)
   PUBMED   17178830
REFERENCE   6  (residues 1 to 544)
  AUTHORS   Lipovich,L., Hughes,A.L., King,M.C., Abkowitz,J.L. and Quigley,J.G.
  TITLE     Genomic structure and evolutionary context of the human feline
            leukemia virus subgroup C receptor (hFLVCR) gene: evidence for
            block duplications and de novo gene formation within duplicons of
            the hFLVCR locus
  JOURNAL   Gene 286 (2), 203-213 (2002)
   PUBMED   11943475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC395916.1, AF510741.1, AL079275.1, BC016966.1, BC047469.1,
            AK022855.1, BX103687.1 and AI658922.1.
            
            On Sep 26, 2003 this sequence version replaced NP_653168.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.273818.1,
                                           SRR1660803.81945.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366962.8/ ENSP00000355929.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     Protein         1..544
                     /product="protein angel homolog 2 isoform a"
                     /note="protein angel homolog 2"
                     /calculated_mol_wt=62208
     Region          23..159
                     /region_name="ANGEL2_N"
                     /note="Protein angel homolog 2 N-terminal; pfam19339"
                     /db_xref="CDD:466047"
     Region          169..542
                     /region_name="EEP"
                     /note="Exonuclease-Endonuclease-Phosphatase (EEP) domain
                     superfamily; cl00490"
                     /db_xref="CDD:469791"
     Site            order(173,220,310,351,353,479,532..533)
                     /site_type="active"
                     /note="putative catalytic site [active]"
                     /db_xref="CDD:197331"
     Site            order(220,532)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:197331"
     Site            order(310,353,533)
                     /site_type="other"
                     /note="putative phosphate binding site [ion binding]"
                     /db_xref="CDD:197331"
     CDS             1..544
                     /gene="ANGEL2"
                     /gene_synonym="Ccr4d; KIAA0759L"
                     /coded_by="NM_144567.5:197..1831"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS1512.1"
                     /db_xref="GeneID:90806"
                     /db_xref="HGNC:HGNC:30534"
                     /db_xref="MIM:619001"
ORIGIN      
        1 meawrcvrkg yghcvvgrgr ypmfphhsrs lgrdwttpwe nlqrccwnrh isscmrwpgh
       61 ysrapypyfs srhfslnwrp pclfesrtqf qycnwrpdnl sqtslihlss yvmnaegdep
      121 sskrrkhqgv ikrnweyics hdkektkilg dknvdpkced senkfdfsvm synilsqdll
      181 ednshlyrhc rrpvlhwsfr fpnilkeikh fdadvlclqe vqedhygaei rpsleslgyh
      241 ceykmrtgrk pdgcaicfkh skfsllsvnp veffrpdisl ldrdnvglvl llqpkipyaa
      301 cpaicvanth llynprrgdi kltqlamlla eissvahqkd gsfcpivmcg dfnsvpgspl
      361 ysfikegkln yeglpigkvs gqeqssrgqr ilsipiwppn lgisqncvye vqqvpkvekt
      421 dsdltqtqlk qtevlvtaek lssnlqhhfs lssvyshyfp dtgipevttc hsrsaitvdy
      481 ifysaekedv aghpgaeval vgglkllarl sllteqdlwt vnglpnenns sdhlpllakf
      541 rlel
//
