LOCUS       NM_015305               5287 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens angel homolog 1 (ANGEL1), transcript variant 4, mRNA.
ACCESSION   NM_015305
VERSION     NM_015305.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5287)
  AUTHORS   Clemente,P., Calvo-Garrido,J., Pearce,S.F., Schober,F.A.,
            Shigematsu,M., Siira,S.J., Laine,I., Spahr,H., Steinmetzger,C.,
            Petzold,K., Kirino,Y., Wibom,R., Rackham,O., Filipovska,A.,
            Rorbach,J., Freyer,C. and Wredenberg,A.
  TITLE     ANGEL2 phosphatase activity is required for non-canonical
            mitochondrial RNA processing
  JOURNAL   Nat Commun 13 (1), 5750 (2022)
   PUBMED   36180430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5287)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5287)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5287)
  AUTHORS   Gosselin,P., Martineau,Y., Morales,J., Czjzek,M., Glippa,V.,
            Gauffeny,I., Morin,E., Le Corguille,G., Pyronnet,S., Cormier,P. and
            Cosson,B.
  TITLE     Tracking a refined eIF4E-binding motif reveals Angel1 as a new
            partner of eIF4E
  JOURNAL   Nucleic Acids Res 41 (16), 7783-7792 (2013)
   PUBMED   23814182
REFERENCE   5  (bases 1 to 5287)
  AUTHORS   Lipovich,L., Hughes,A.L., King,M.C., Abkowitz,J.L. and Quigley,J.G.
  TITLE     Genomic structure and evolutionary context of the human feline
            leukemia virus subgroup C receptor (hFLVCR) gene: evidence for
            block duplications and de novo gene formation within duplicons of
            the hFLVCR locus
  JOURNAL   Gene 286 (2), 203-213 (2002)
   PUBMED   11943475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF111169.2.
            
            On May 21, 2019 this sequence version replaced NM_015305.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.213226.1,
                                           SRR1803612.152491.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251089.8/ ENSP00000251089.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AF111169.2         41697-41815         c
            120-704             AF111169.2         37992-38576         c
            705-931             AF111169.2         36855-37081         c
            932-1001            AF111169.2         36366-36435         c
            1002-1435           AF111169.2         35349-35782         c
            1436-1562           AF111169.2         32719-32845         c
            1563-1673           AF111169.2         32304-32414         c
            1674-1743           AF111169.2         20230-20299         c
            1744-1907           AF111169.2         19544-19707         c
            1908-5287           AF111169.2         14942-18321         c
FEATURES             Location/Qualifiers
     source          1..5287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..5287
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /note="angel homolog 1"
                     /db_xref="GeneID:23357"
                     /db_xref="HGNC:HGNC:19961"
                     /db_xref="MIM:619537"
     exon            1..119
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2068
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /note="isoform 4 is encoded by transcript variant 4;
                     protein angel homolog 1"
                     /codon_start=1
                     /product="protein angel homolog 1 isoform 4"
                     /protein_id="NP_056120.2"
                     /db_xref="CCDS:CCDS9852.1"
                     /db_xref="GeneID:23357"
                     /db_xref="HGNC:HGNC:19961"
                     /db_xref="MIM:619537"
                     /translation="MIASCLCYLLLPATRLFRALSDAFFTCRKNVLLANSSSPQVEGD
                     FAMAPRGPEQEECEGLLQQWREEGLSQVLSTASEGPLIDKGLAQSSLALLMDNPGEEN
                     AASEDRWSSRQLSDLRAAENLDEPFPEMLGEEPLLEVEGVEGSMWAAIPMQSEPQYAD
                     CAALPVGALATEQWEEDPAVLAWSIAPEPVPQEEASIWPFEGLGQLQPPAVEIPYHEI
                     LWREWEDFSTQPDAQGLKAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWN
                     YRFVNLMQEFQHWDPDILCLQEVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKTDGCAV
                     CYKPTRFRLLCASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLCVANTH
                     ILYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFIRDGE
                     LQYHGMPAWKVSGQEDFSHQLYQRKLQAPLWPSSLGITDCCQYVTSCHPKRSERRKYG
                     RDFLLRFRFCSIACQRPVGLVLMEGVTDTKPERPAGWAESVLEEDASELEPAFSRTVG
                     TIQHCLHLTSVYTHFLPQRGRPEVTTMPLGLGMTVDYIFFSAESCENGNRTDHRLYRD
                     GTLKLLGRLSLLSEEILWAANGLPNPFCSSDHLCLLASFGMEVTAP"
     exon            120..704
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            705..931
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1001
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1435
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1562
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1673
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1743
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1907
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..5287
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4026..4031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /note="hexamer: AATAAA"
     polyA_site      4053
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /note="major polyA site"
     polyA_site      4507
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
     regulatory      5265..5270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /note="hexamer: ATTAAA"
     polyA_site      5287
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
ORIGIN      
        1 gagggaggac ctgctggctg cagtgaggag cggaggcggg cgcgggcggc cggccatgat
       61 cgcgtcgtgc ttgtgttacc tgctgctgcc ggccacgcgc ctcttccgcg ccctctcaga
      121 tgctttcttc acatgtcgaa aaaatgtcct tctggcgaac agctcatccc cccaggtaga
      181 gggcgacttt gccatggccc ctcggggccc tgagcaggag gaatgtgagg gcctgctgca
      241 gcagtggcga gaagaagggt tgagccaggt gctctcaact gcaagtgagg ggccccttat
      301 agataaagga ctagcccaga gcagcctggc acttctgatg gataatcctg gagaagagaa
      361 tgctgcttca gaggacaggt ggtccagcag gcagctgagt gaccttcggg ctgcagagaa
      421 cctggatgag cctttccctg agatgctagg agaggagcca ctgctggagg tggagggggt
      481 ggagggctcc atgtgggcag ctatccccat gcagtcggag ccccagtatg cagactgtgc
      541 tgccctccca gtgggtgccc tggccacaga gcagtgggaa gaggacccag cggtgttggc
      601 ctggagcata gcacctgagc ctgtgcccca ggaagaggct tccatctggc cctttgaggg
      661 cctggggcag ttgcagcctc ccgcagtgga aataccatat catgaaattt tgtggcgaga
      721 atgggaggat ttctccaccc agccagatgc tcagggcctg aaggcaggag atggccctca
      781 gttccagttc actctgatgt cttataacat cctggctcag gacctgatgc agcagagctc
      841 agagctctat ctacattgcc atccagacat cctcaattgg aactatcgct tcgtgaacct
      901 catgcaggaa ttccagcact gggaccctga tatcctgtgt ctccaggaag tccaggaaga
      961 tcattactgg gagcagctgg aaccctctct gcgaatgatg ggctttacct gtttctacaa
     1021 gaggaggact gggtgtaaaa ccgatggctg tgctgtctgc tacaagccta ccagattccg
     1081 cctgctctgt gctagccctg tggagtactt ccggcctggc ttggagctac ttaatcggga
     1141 taatgtgggc ttagtgttgc tactgcaacc actcgtccca gaaggcctgg gacaagtctc
     1201 ggtggccccg ctgtgtgtgg caaataccca tatcctttac aacccacgcc ggggcgatgt
     1261 caagctggcc cagatggcca ttctcctggc ggaagtggac aaggtggcca gactgtcaga
     1321 tggcagccac tgccccatca tcttgtgcgg ggacctaaat tctgtccctg attcacctct
     1381 ctacaacttc atcagggatg gagagctcca gtaccatggg atgccagcct ggaaggtatc
     1441 tggacaggaa gacttctccc atcagcttta ccagaggaag ctgcaggccc cactgtggcc
     1501 cagctccctg ggcatcactg attgctgtca gtatgtcacc tcctgtcacc ccaagagatc
     1561 agagagacgc aagtatggcc gagacttcct gctacgtttc cgcttctgca gcatcgcttg
     1621 tcagcgacca gtaggactgg tccttatgga aggagtgaca gatactaagc cagagcgacc
     1681 tgcgggttgg gctgagtctg tccttgagga agatgcatcg gagcttgagc ctgccttctc
     1741 caggactgta ggtaccatcc agcactgcct ccacctgacg tcagtatata cccacttcct
     1801 gccccagcgt ggccgcccag aggtcactac aatgccattg ggtcttggaa tgacagtaga
     1861 ttacatcttc ttctcagctg agtcctgtga gaatgggaac agaactgatc acaggctgta
     1921 tcgagatgga actctcaagc tcctgggtcg tctctccctt ctctctgaag agatactctg
     1981 ggctgccaat ggcttaccca accccttctg ctcttcagac cacctctgcc tgctagccag
     2041 cttcgggatg gaagtcaccg ccccatgaca gggctcccag gggaagagag cttctcttcc
     2101 agaagagctc actggatcag agactgtgga aaaatcccat gcatctagaa acttagatcc
     2161 aagaaactta catcccctcc cttccccctc ctcgttccct ttttcccacg gttagacttt
     2221 ctccaggcct ggctgcgttc tctgcctgtg gtccttgccc caccccagcc tcttcctaat
     2281 cctgtgccac acactcagtg gccctgggag aggcagaagg ggggctcccc cttccttcca
     2341 tgtatccagc gctccccctt gatttttaat taccagggtt atgggagttc ttgatttcat
     2401 tggttatttg ctttcaggcc gtttcttgat gtaccttctg acctgacctt ttccctgcct
     2461 tcaggacttc tgggcccagc cctcttgcca ggcatgcata tgtgagatat gcatatcatg
     2521 tatgtgtcct cttggggtga gacttctgca cagccatgcc tgcctctgac cagtccactt
     2581 ttcatgttgg ggctgtaggc ctggggcagg ttcagagtct acccaagtac ctatgtatga
     2641 gcaggcagca gcagggcatg gccccatctc tccttttagc ctctgtgttt cattaggcat
     2701 tcatcctgcc aaccagggca ggcccggcgt ctgggctctg ggaacaaatg gggcccacat
     2761 cctggagtgg caaattttgg gggatgcgct acctgtccca gctggccctg tgcctccaac
     2821 ccagagctcc ccacagacct ggtgtaattt cacaagggcc atccctttcc ccaggcttcc
     2881 ctgagggagg cggaagtttg aacccttatg tggggttcat tgggctaggg tagtggtatg
     2941 aggtttaaaa ctatttaagg attaggagga gaaagagtct tcaggaaact cttgtttcac
     3001 tggactctgc agcctgcaga actggggcaa gggtaggagt tccagtaggg gaaggagcag
     3061 gtagactctt cagctgcctc agctgggact gaagacctaa gctgattctc tttcctctcc
     3121 actcctaaga agcaattttc tgttcctctc cttccaccac tttttacttt ctgctatctc
     3181 ccatctcccg cttcccttcc atttcctttc tagaaaaccc tggtatttag ctcaggccaa
     3241 actgcctcag cagaaaggtg gccttggaca aaactggtcc aagaatttga agtggcagta
     3301 cttgcggatt ggctctgtcc agcaaggcct cagctgcttg ttgcgtctgc tttccctccc
     3361 ctaacagaag ggtaccctgg cttattcagg ggactcctta gtccacactg tgtcacctgc
     3421 atgccttaat ctttcattgc tggggtgtgg ccttgggaga tcctgggcca gcccctccac
     3481 acatctccct aagtcagagt ggctgctggc cctggtagat ttgacttgct cttgcctcac
     3541 tcgacctcca aagtgggact gaagacagtg gtcaagagac ttgagttcgg gacagtaagc
     3601 caggggttaa ggttctttcc tttttttgaa agccaaagac ccagtttgca ttgtgctgct
     3661 gcattcatgg ttagaagctt tccatgccta ggttctaggg aatttatttt tctatgtgta
     3721 tatattttca aactttgttt cctgggtact gggcatgtgc ctgtctgagc cccaggtctg
     3781 tctacacccc accattcatt ctgtctgtct gttccctgga cactgcctaa aagggtctca
     3841 agacagtgcc ctgtgggttc ctaggactag ggcccatcac tgttctcttc tgctgggaaa
     3901 tgcagcttta aaatggctaa ccacagcaga gggcagatgc ttgatagatt atcttttcct
     3961 tgctttcttg tttctgtttt gaaagtgaaa tggggtttta aattgttatt taaactcttt
     4021 ttccaaataa aggtttacct tttttccccc caatgttgtt cattttatta ggatcctgaa
     4081 gggattaggt ccttgagaga gggcctgaag aatgaggtgg gcagaggaag agactaagga
     4141 gcttttgatc ttggggtggg gtctcaagac atgaatctag attgagaaat gtgttgtaag
     4201 atctccctct attagctgag gtaaattccc actgctgtga ggcctgggag gaacagggct
     4261 tgagtgaagc ctcctgcctt gacactgctg gggtacagct ttcttctgtc cttcccaagt
     4321 gagagaatga ttctttggac tgcttttcat tcttcctcca tctgctcccc ccatgcctcc
     4381 tcctagtatc ttctgcactt caggagggtc tgtgcaaagt gggataagat gtgtgttttc
     4441 ctgattaaag ctatggcagc tgcatgagac atgatgcggg tggcacatgc ctcttgctga
     4501 gcatctattt ctgatctctt ttgcattctg gagccagggc tgagcagtgg gccatctgtc
     4561 gctggaaaaa tgtctcttcc ttcctaggcc tacctctgtt ggtgcttttg tcttccaacc
     4621 tccctatgta gtaagaccag ccaagcccac atgcccactg ggagccctga aaccagatct
     4681 ggttttctgt cttacctgaa caggttccca gaacccacac caggcctctg aatcagtctc
     4741 tgagaatctg attgatttaa agccacttgg ttgcttccat tgcactacct gggttgcgat
     4801 cccctcaatt gatttagtaa aaagaaaact tagcggccgg gtgcggtggc tcacacctgt
     4861 aatcccagca ctttgggagg ctgaggcggg tggatcacct gaggtcgaga gttccagacc
     4921 agcctgacca acatgaagaa atcccgtctc tactaaaaat acaaaattag ccgggcgtga
     4981 tggcgcatgc ctgtaatccc agctacttgg aggctgaggc aggagaattg cttgaacctg
     5041 ggaagcggag gttgtggtga gccgagatca tgccattgca ctccagcctg gacaacaaga
     5101 gtgaaactcc atctcaaaaa aaaaaaaaga aaagaaaaga aaagaaagaa aactcagcta
     5161 ggaattagaa acatcatttg tcctcttggc ctgttcagct ggtgactgta ggtaagttac
     5221 ttaacctctc tgtatttcag ttcacattcc ttggtgaaat agaaattaaa gttaataatc
     5281 acttcta
//
