LOCUS       NM_001370748            2491 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens angel homolog 1 (ANGEL1), transcript variant 3, mRNA.
ACCESSION   NM_001370748
VERSION     NM_001370748.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2491)
  AUTHORS   Clemente,P., Calvo-Garrido,J., Pearce,S.F., Schober,F.A.,
            Shigematsu,M., Siira,S.J., Laine,I., Spahr,H., Steinmetzger,C.,
            Petzold,K., Kirino,Y., Wibom,R., Rackham,O., Filipovska,A.,
            Rorbach,J., Freyer,C. and Wredenberg,A.
  TITLE     ANGEL2 phosphatase activity is required for non-canonical
            mitochondrial RNA processing
  JOURNAL   Nat Commun 13 (1), 5750 (2022)
   PUBMED   36180430
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2491)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2491)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2491)
  AUTHORS   Gosselin,P., Martineau,Y., Morales,J., Czjzek,M., Glippa,V.,
            Gauffeny,I., Morin,E., Le Corguille,G., Pyronnet,S., Cormier,P. and
            Cosson,B.
  TITLE     Tracking a refined eIF4E-binding motif reveals Angel1 as a new
            partner of eIF4E
  JOURNAL   Nucleic Acids Res 41 (16), 7783-7792 (2013)
   PUBMED   23814182
REFERENCE   5  (bases 1 to 2491)
  AUTHORS   Lipovich,L., Hughes,A.L., King,M.C., Abkowitz,J.L. and Quigley,J.G.
  TITLE     Genomic structure and evolutionary context of the human feline
            leukemia virus subgroup C receptor (hFLVCR) gene: evidence for
            block duplications and de novo gene formation within duplicons of
            the hFLVCR locus
  JOURNAL   Gene 286 (2), 203-213 (2002)
   PUBMED   11943475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF111169.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AF111169.2         41697-41815         c
            120-704             AF111169.2         37992-38576         c
            705-931             AF111169.2         36855-37081         c
            932-1001            AF111169.2         36366-36435         c
            1002-1435           AF111169.2         35349-35782         c
            1436-1562           AF111169.2         32719-32845         c
            1563-1673           AF111169.2         32304-32414         c
            1674-1743           AF111169.2         20230-20299         c
            1744-1907           AF111169.2         19544-19707         c
            1908-2491           AF111169.2         14942-15525         c
FEATURES             Location/Qualifiers
     source          1..2491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2491
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /note="angel homolog 1"
                     /db_xref="GeneID:23357"
                     /db_xref="HGNC:HGNC:19961"
                     /db_xref="MIM:619537"
     exon            1..119
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2131
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /note="isoform 3 is encoded by transcript variant 3;
                     protein angel homolog 1"
                     /codon_start=1
                     /product="protein angel homolog 1 isoform 3"
                     /protein_id="NP_001357677.1"
                     /db_xref="GeneID:23357"
                     /db_xref="HGNC:HGNC:19961"
                     /db_xref="MIM:619537"
                     /translation="MIASCLCYLLLPATRLFRALSDAFFTCRKNVLLANSSSPQVEGD
                     FAMAPRGPEQEECEGLLQQWREEGLSQVLSTASEGPLIDKGLAQSSLALLMDNPGEEN
                     AASEDRWSSRQLSDLRAAENLDEPFPEMLGEEPLLEVEGVEGSMWAAIPMQSEPQYAD
                     CAALPVGALATEQWEEDPAVLAWSIAPEPVPQEEASIWPFEGLGQLQPPAVEIPYHEI
                     LWREWEDFSTQPDAQGLKAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWN
                     YRFVNLMQEFQHWDPDILCLQEVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKTDGCAV
                     CYKPTRFRLLCASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLCVANTH
                     ILYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFIRDGE
                     LQYHGMPAWKVSGQEDFSHQLYQRKLQAPLWPSSLGITDCCQYVTSCHPKRSERRKYG
                     RDFLLRFRFCSIACQRPVGLVLMEGVTDTKPERPAGWAESVLEEDASELEPAFSRTVG
                     TIQHCLHLTSVYTHFLPQRGRPEVTTMPLGLGMTVDYIFFSAESCENGNRTGSQNPHQ
                     ASESVSENLIDLKPLGCFHCTTWVAIPSIDLVKRKLSGRVRWLTPVIPALWEAEAGGS
                     PEVESSRPA"
     exon            120..704
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            705..931
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1001
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1435
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1562
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1673
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1743
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1907
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2491
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2469..2474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /note="hexamer: ATTAAA"
     polyA_site      2491
                     /gene="ANGEL1"
                     /gene_synonym="Ccr4e; KIAA0759"
                     /note="major polyA site"
ORIGIN      
        1 gagggaggac ctgctggctg cagtgaggag cggaggcggg cgcgggcggc cggccatgat
       61 cgcgtcgtgc ttgtgttacc tgctgctgcc ggccacgcgc ctcttccgcg ccctctcaga
      121 tgctttcttc acatgtcgaa aaaatgtcct tctggcgaac agctcatccc cccaggtaga
      181 gggcgacttt gccatggccc ctcggggccc tgagcaggag gaatgtgagg gcctgctgca
      241 gcagtggcga gaagaagggt tgagccaggt gctctcaact gcaagtgagg ggccccttat
      301 agataaagga ctagcccaga gcagcctggc acttctgatg gataatcctg gagaagagaa
      361 tgctgcttca gaggacaggt ggtccagcag gcagctgagt gaccttcggg ctgcagagaa
      421 cctggatgag cctttccctg agatgctagg agaggagcca ctgctggagg tggagggggt
      481 ggagggctcc atgtgggcag ctatccccat gcagtcggag ccccagtatg cagactgtgc
      541 tgccctccca gtgggtgccc tggccacaga gcagtgggaa gaggacccag cggtgttggc
      601 ctggagcata gcacctgagc ctgtgcccca ggaagaggct tccatctggc cctttgaggg
      661 cctggggcag ttgcagcctc ccgcagtgga aataccatat catgaaattt tgtggcgaga
      721 atgggaggat ttctccaccc agccagatgc tcagggcctg aaggcaggag atggccctca
      781 gttccagttc actctgatgt cttataacat cctggctcag gacctgatgc agcagagctc
      841 agagctctat ctacattgcc atccagacat cctcaattgg aactatcgct tcgtgaacct
      901 catgcaggaa ttccagcact gggaccctga tatcctgtgt ctccaggaag tccaggaaga
      961 tcattactgg gagcagctgg aaccctctct gcgaatgatg ggctttacct gtttctacaa
     1021 gaggaggact gggtgtaaaa ccgatggctg tgctgtctgc tacaagccta ccagattccg
     1081 cctgctctgt gctagccctg tggagtactt ccggcctggc ttggagctac ttaatcggga
     1141 taatgtgggc ttagtgttgc tactgcaacc actcgtccca gaaggcctgg gacaagtctc
     1201 ggtggccccg ctgtgtgtgg caaataccca tatcctttac aacccacgcc ggggcgatgt
     1261 caagctggcc cagatggcca ttctcctggc ggaagtggac aaggtggcca gactgtcaga
     1321 tggcagccac tgccccatca tcttgtgcgg ggacctaaat tctgtccctg attcacctct
     1381 ctacaacttc atcagggatg gagagctcca gtaccatggg atgccagcct ggaaggtatc
     1441 tggacaggaa gacttctccc atcagcttta ccagaggaag ctgcaggccc cactgtggcc
     1501 cagctccctg ggcatcactg attgctgtca gtatgtcacc tcctgtcacc ccaagagatc
     1561 agagagacgc aagtatggcc gagacttcct gctacgtttc cgcttctgca gcatcgcttg
     1621 tcagcgacca gtaggactgg tccttatgga aggagtgaca gatactaagc cagagcgacc
     1681 tgcgggttgg gctgagtctg tccttgagga agatgcatcg gagcttgagc ctgccttctc
     1741 caggactgta ggtaccatcc agcactgcct ccacctgacg tcagtatata cccacttcct
     1801 gccccagcgt ggccgcccag aggtcactac aatgccattg ggtcttggaa tgacagtaga
     1861 ttacatcttc ttctcagctg agtcctgtga gaatgggaac agaactggtt cccagaaccc
     1921 acaccaggcc tctgaatcag tctctgagaa tctgattgat ttaaagccac ttggttgctt
     1981 ccattgcact acctgggttg cgatcccctc aattgattta gtaaaaagaa aacttagcgg
     2041 ccgggtgcgg tggctcacac ctgtaatccc agcactttgg gaggctgagg cgggtggatc
     2101 acctgaggtc gagagttcca gaccagcctg accaacatga agaaatcccg tctctactaa
     2161 aaatacaaaa ttagccgggc gtgatggcgc atgcctgtaa tcccagctac ttggaggctg
     2221 aggcaggaga attgcttgaa cctgggaagc ggaggttgtg gtgagccgag atcatgccat
     2281 tgcactccag cctggacaac aagagtgaaa ctccatctca aaaaaaaaaa aagaaaagaa
     2341 aagaaaagaa agaaaactca gctaggaatt agaaacatca tttgtcctct tggcctgttc
     2401 agctggtgac tgtaggtaag ttacttaacc tctctgtatt tcagttcaca ttccttggtg
     2461 aaatagaaat taaagttaat aatcacttct a
//
