LOCUS       NM_001097577             748 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens angiogenin (ANG), transcript variant 2, mRNA.
ACCESSION   NM_001097577
VERSION     NM_001097577.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 748)
  AUTHORS   Loveland,A.B., Koh,C.S., Ganesan,R., Jacobson,A. and
            Korostelev,A.A.
  TITLE     Structural mechanism of angiogenin activation by the ribosome
  JOURNAL   Nature 630 (8017), 769-776 (2024)
   PUBMED   38718836
  REMARK    GeneRIF: Structural mechanism of angiogenin activation by the
            ribosome.
REFERENCE   2  (bases 1 to 748)
  AUTHORS   Dewangan,D., Joshi,A. and Padhi,A.K.
  TITLE     Long-timescale atomistic simulations uncover loss-of-function
            mechanisms of uncharacterized Angiogenin mutants associated with
            ALS
  JOURNAL   Arch Biochem Biophys 756, 110000 (2024)
   PUBMED   38621442
  REMARK    GeneRIF: Long-timescale atomistic simulations uncover
            loss-of-function mechanisms of uncharacterized Angiogenin mutants
            associated with ALS.
REFERENCE   3  (bases 1 to 748)
  AUTHORS   Hu,A., Nussbaum,Y.I., Mitchem,J. and Yoo,J.
  TITLE     Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced
            Angiogenin Expression and Signaling via the PLXNB2 Receptor
  JOURNAL   J Surg Res 296, 273-280 (2024)
   PUBMED   38295715
  REMARK    GeneRIF: Colorectal Cancer-Associated Myofibroblasts Exhibit
            Enhanced Angiogenin Expression and Signaling via the PLXNB2
            Receptor.
REFERENCE   4  (bases 1 to 748)
  AUTHORS   Ferguson,R., van Es,M.A., van den Berg,L.H. and Subramanian,V.
  TITLE     Neural stem cell homeostasis is affected in cortical organoids
            carrying a mutation in Angiogenin
  JOURNAL   J Pathol 262 (4), 410-426 (2024)
   PUBMED   38180358
  REMARK    GeneRIF: Neural stem cell homeostasis is affected in cortical
            organoids carrying a mutation in Angiogenin.
REFERENCE   5  (bases 1 to 748)
  AUTHORS   Hooper,L.V., Stappenbeck,T.S., Hong,C.V. and Gordon,J.I.
  TITLE     Angiogenins: a new class of microbicidal proteins involved in
            innate immunity
  JOURNAL   Nat Immunol 4 (3), 269-273 (2003)
   PUBMED   12548285
  REMARK    GeneRIF: Human angiogenin has antimicrobial activity against C.
            albicans and S. pneumoniae.
REFERENCE   6  (bases 1 to 748)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
REFERENCE   7  (bases 1 to 748)
  AUTHORS   Saxena,S.K., Rybak,S.M., Davey,R.T. Jr., Youle,R.J. and
            Ackerman,E.J.
  TITLE     Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase
            A superfamily
  JOURNAL   J Biol Chem 267 (30), 21982-21986 (1992)
   PUBMED   1400510
REFERENCE   8  (bases 1 to 748)
  AUTHORS   Weremowicz,S., Fox,E.A., Morton,C.C. and Vallee,B.L.
  TITLE     The placental ribonuclease inhibitor (RNH) gene is located on
            chromosome subband 11p15.5
  JOURNAL   Genomics 8 (4), 717-721 (1990)
   PUBMED   2276743
REFERENCE   9  (bases 1 to 748)
  AUTHORS   Weremowicz,S., Fox,E.A., Morton,C.C. and Vallee,B.L.
  TITLE     Localization of the human angiogenin gene to chromosome band 14q11,
            proximal to the T cell receptor alpha/delta locus
  JOURNAL   Am J Hum Genet 47 (6), 973-981 (1990)
   PUBMED   1978563
REFERENCE   10 (bases 1 to 748)
  AUTHORS   Shapiro,R., Riordan,J.F. and Vallee,B.L.
  TITLE     Characteristic ribonucleolytic activity of human angiogenin
  JOURNAL   Biochemistry 25 (12), 3527-3532 (1986)
   PUBMED   2424496
  REMARK    Erratum:[Biochemistry 1986 Oct 21;25(21):6730]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL163636.7.
            
            On Jun 2, 2019 this sequence version replaced NM_001097577.2.
            
            Summary: The protein encoded by this gene is a member of the RNase
            A superfamily though it has relatively weak ribonucleolytic
            activity. This protein is a potent mediator of new blood vessel
            formation and thus, in addition to the name RNase5, is commonly
            called angiogenin. This protein induces angiogenesis after binding
            to actin on the surface of endothelial cells. This protein also
            accumulates at the nucleolus where it stimulates ribosomal
            transcription. Under stress conditions this protein translocates to
            the cytosol where it hydrolyzes cellular tRNAs and influences
            protein synthesis. A signal peptide is cleaved from the precursor
            protein to produce a mature protein which contains a nuclear
            localization signal, a cell binding motif, and a catalytic domain.
            This protein has been shown to be both neurotrophic and
            neuroprotective and the mature protein has antimicrobial activity
            against some bacteria and fungi, including S. pneumoniae and C.
            albicans. Due to its effect on rRNA production and angiogenesis
            this gene plays important roles in cell growth and tumor
            progression. Mutations in this gene are associated with progression
            of amyotrophic lateral sclerosis (ALS). This gene and the
            neighboring RNase4 gene share promoters and 5' exons though each
            gene then splices to a distinct 3' exon containing the complete
            coding region of each gene. Alternative splicing results in
            multiple transcript variants encoding the same protein. [provided
            by RefSeq, Jul 2020].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.115939.1,
                                           SRR5189664.11749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000397990.5/
                                                  ENSP00000381077.4
            Protein has antimicrobial activity :: PMID: 12548285
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AL163636.7         120852-120860
            10-111              AL163636.7         120861-120962
            112-748             AL163636.7         125635-126271
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..748
                     /gene="ANG"
                     /gene_synonym="ALS9; HEL168; RAA1; RNASE4; RNASE5"
                     /note="angiogenin"
                     /db_xref="GeneID:283"
                     /db_xref="HGNC:HGNC:483"
                     /db_xref="MIM:105850"
     exon            1..111
                     /gene="ANG"
                     /gene_synonym="ALS9; HEL168; RAA1; RNASE4; RNASE5"
                     /inference="alignment:Splign:2.1.0"
     exon            112..748
                     /gene="ANG"
                     /gene_synonym="ALS9; HEL168; RAA1; RNASE4; RNASE5"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..573
                     /gene="ANG"
                     /gene_synonym="ALS9; HEL168; RAA1; RNASE4; RNASE5"
                     /EC_number="3.1.27.-"
                     /note="epididymis luminal protein 168; RNase 5;
                     ribonuclease 5; ribonuclease A A1; angiogenin,
                     ribonuclease, RNase A family, 5; ribonuclease A family
                     member 5; Homo sapiens epididymis luminal protein 168"
                     /codon_start=1
                     /product="angiogenin precursor"
                     /protein_id="NP_001091046.1"
                     /db_xref="CCDS:CCDS9554.1"
                     /db_xref="GeneID:283"
                     /db_xref="HGNC:HGNC:483"
                     /db_xref="MIM:105850"
                     /translation="MVMGLGVLLLVFVLGLGLTPPTLAQDNSRYTHFLTQHYDAKPQG
                     RDDRYCESIMRRRGLTSPCKDINTFIHGNKRSIKAICENKNGNPHRENLRISKSSFQV
                     TTCKLHGGSPWPPCQYRATAGFRNVVVACENGLPVHLDQSIFRRP"
     regulatory      724..729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANG"
                     /gene_synonym="ALS9; HEL168; RAA1; RNASE4; RNASE5"
                     /note="hexamer: AATAAA"
     polyA_site      748
                     /gene="ANG"
                     /gene_synonym="ALS9; HEL168; RAA1; RNASE4; RNASE5"
                     /note="major polyA site"
ORIGIN      
        1 ggagaggcct ccaggttcac acaactggaa cccatctcca ggaacaaaca gctggaaccc
       61 atctcccgtt gaagggaaac tgccagattt ttgtaagatt cttcctcctg ggagcctgtg
      121 ttggaagaga tggtgatggg cctgggcgtt ttgttgttgg tcttcgtgct gggtctgggt
      181 ctgaccccac cgaccctggc tcaggataac tccaggtaca cacacttcct gacccagcac
      241 tatgatgcca aaccacaggg ccgggatgac agatactgtg aaagcatcat gaggagacgg
      301 ggcctgacct caccctgcaa agacatcaac acatttattc atggcaacaa gcgcagcatc
      361 aaggccatct gtgaaaacaa gaatggaaac cctcacagag aaaacctaag aataagcaag
      421 tcttctttcc aggtcaccac ttgcaagcta catggaggtt ccccctggcc tccatgccag
      481 taccgagcca cagcggggtt cagaaacgtt gttgttgctt gtgaaaatgg cttacctgtc
      541 cacttggatc agtcaatttt ccgtcgtccg taaccagcgg gcccctggtc aagtgctggc
      601 tctgctgtcc ttgccttcca tttcccctct gcacccagaa cagtggtggc aacattcatt
      661 gccaagggcc caaagaaaga gctacctgga ccttttgttt tctgtttgac aacatgttta
      721 ataaataaaa atgtcttgat atcagtaa
//
