LOCUS       NM_016238               3023 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens anaphase promoting complex subunit 7 (ANAPC7),
            transcript variant 1, mRNA.
ACCESSION   NM_016238
VERSION     NM_016238.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3023)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
  REMARK    GeneRIF: APC7 mediates ubiquitin signaling in constitutive
            heterochromatin in the developing mammalian brain.
REFERENCE   2  (bases 1 to 3023)
  AUTHORS   Wild,T., Budzowska,M., Hellmuth,S., Eibes,S., Karemore,G.,
            Barisic,M., Stemmann,O. and Choudhary,C.
  TITLE     Deletion of APC7 or APC16 Allows Proliferation of Human Cells
            without the Spindle Assembly Checkpoint
  JOURNAL   Cell Rep 25 (9), 2317-2328 (2018)
   PUBMED   30485802
  REMARK    GeneRIF: the contribution of the anaphase-promoting
            complex/cyclosome subunits APC7 and APC16 to APC/C composition and
            function in human cells.
REFERENCE   3  (bases 1 to 3023)
  AUTHORS   Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
            Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
            and Rape,M.
  TITLE     Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
            and Protein Quality Control
  JOURNAL   Cell 171 (4), 918-933 (2017)
   PUBMED   29033132
REFERENCE   4  (bases 1 to 3023)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3023)
  AUTHORS   Zhang,S., Chang,L., Alfieri,C., Zhang,Z., Yang,J., Maslen,S.,
            Skehel,M. and Barford,D.
  TITLE     Molecular mechanism of APC/C activation by mitotic phosphorylation
  JOURNAL   Nature 533 (7602), 260-264 (2016)
   PUBMED   27120157
REFERENCE   6  (bases 1 to 3023)
  AUTHORS   Sudakin,V., Chan,G.K. and Yen,T.J.
  TITLE     Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
            complex of BUBR1, BUB3, CDC20, and MAD2
  JOURNAL   J Cell Biol 154 (5), 925-936 (2001)
   PUBMED   11535616
REFERENCE   7  (bases 1 to 3023)
  AUTHORS   Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
   PUBMED   10500174
REFERENCE   8  (bases 1 to 3023)
  AUTHORS   Chan,G.K., Jablonski,S.A., Sudakin,V., Hittle,J.C. and Yen,T.J.
  TITLE     Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E
            functions at kinetochores and binds the cyclosome/APC
  JOURNAL   J Cell Biol 146 (5), 941-954 (1999)
   PUBMED   10477750
REFERENCE   9  (bases 1 to 3023)
  AUTHORS   Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
            Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J Biol Chem 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   10 (bases 1 to 3023)
  AUTHORS   Yu,H., Peters,J.M., King,R.W., Page,A.M., Hieter,P. and
            Kirschner,M.W.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC144548.8 and BC098362.1.
            
            On Jul 10, 2020 this sequence version replaced NM_016238.2.
            
            Summary: This gene encodes a tetratricopeptide repeat containing
            component of the anaphase promoting complex/cyclosome (APC/C), a
            large E3 ubiquitin ligase that controls cell cycle progression by
            targeting a number of cell cycle regulators such as B-type cyclins
            for 26S proteasome-mediated degradation through ubiquitination. The
            encoded protein is required for proper protein ubiquitination
            function of APC/C and for the interaction of APC/C with certain
            transcription coactivators. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141848.1, SRR1660809.138278.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455511.9/ ENSP00000394394.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC144548.8         52003-52084
            83-1779             BC098362.1         1-1697
            1780-3023           AC144548.8         81568-82811
FEATURES             Location/Qualifiers
     source          1..3023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..3023
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="anaphase promoting complex subunit 7"
                     /db_xref="GeneID:51434"
                     /db_xref="HGNC:HGNC:17380"
                     /db_xref="MIM:606949"
     exon            1..182
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1779
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="isoform a is encoded by transcript variant 1;
                     cyclosome subunit 7"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 7 isoform a"
                     /protein_id="NP_057322.3"
                     /db_xref="CCDS:CCDS9145.3"
                     /db_xref="GeneID:51434"
                     /db_xref="HGNC:HGNC:17380"
                     /db_xref="MIM:606949"
                     /translation="MNVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPPQKYQ
                     LLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEI
                     EVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKE
                     VLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNS
                     RAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDV
                     YGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQL
                     NSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREA
                     MVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAE
                     LLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPND
                     QKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ"
     exon            183..369
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            370..489
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            490..601
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            602..755
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            756..898
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1016
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1213
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1438
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1589
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..3023
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2423..2428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="hexamer: AATAAA"
     polyA_site      2445
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="major polyA site"
     regulatory      2482..2487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="hexamer: AATAGA"
     polyA_site      2514
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
     polyA_site      3014
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
     polyA_site      3023
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
ORIGIN      
        1 attttggagt cttccctaag gatcctctac cggcttttcg agtcagtgct gccgccgctg
       61 cccgcggctt tgcagagcag gatgaatgtg atagaccacg tgcgggacat ggcggccgcg
      121 gggctgcact ccaacgtgcg gctcctcagc agcttgttac ttacaatgag taataacaac
      181 cctgagttat tctccccacc tcagaagtac cagcttttgg tgtatcatgc agattctctc
      241 tttcatgata aggaatatcg gaatgctgtg agtaagtata ccatggcttt acagcagaag
      301 aaagcgctaa gtaaaacttc aaaagtgaga ccttcaactg gaaattctgc atctactcca
      361 caaagtcagt gtcttccatc tgaaattgaa gtgaaataca aaatggctga atgttataca
      421 atgctaaaac aagataaaga tgccattgct atacttgatg ggatcccttc aagacaaaga
      481 actcccaaaa taaacatgat gctggcaaac ctgtacaaga aggctggtca ggagcgccct
      541 tcagtcacca gctataagga ggtgctgagg cagtgcccat tagcccttga tgccattcta
      601 ggcttgttgt ccctttctgt aaaaggggca gaggtggcat ccatgacaat gaatgtgatc
      661 caaaccgtgc ctaacttgga ctggctctct gtgtggatca aagcgtatgc ttttgtgcac
      721 actggtgaca actcaagagc aatcagtacc atctgttcac tagagaaaaa atccttattg
      781 cgagataacg tggacctatt gggaagcttg gcagatctgt acttcagagc tggagacaat
      841 aaaaactctg tcctcaagtt tgaacaggca cagatgttgg atccttatct gataaaagga
      901 atggatgtat atggctacct actggcacga gaagggcggc tagaggatgt tgagaacctt
      961 ggatgccgcc ttttcaatat ctctgatcag catgcagaac cgtgggtggt ttctggctgt
     1021 cacagcttct atagcaaacg ctactcccgg gccctctatt taggagccaa ggccattcag
     1081 ctgaacagta atagtgttca agctctgcta cttaagggag cagcacttag gaacatgggc
     1141 agagtccaag aagcaataat ccactttcgg gaggccatac ggctcgcacc ttgtcgctta
     1201 gattgttatg aaggtcttat cgaatgttac ttagcctcca acagtattcg agaagcaatg
     1261 gtaatggcta acaacgttta caaaactctg ggagcaaatg cacagaccct taccctttta
     1321 gccaccgttt gtcttgaaga cccagtgaca caggagaaag ccaaaacatt attagataaa
     1381 gccctgaccc aaaggccaga ttacattaag gctgtggtga aaaaagcaga actacttagc
     1441 agagaacaga aatatgaaga tggaattgct ttgctgagga acgcactggc taatcagagt
     1501 gactgtgtcc tgcatcggat cctaggagat ttccttgtag ctgtcaatga gtatcaggag
     1561 gcaatggacc agtatagtat agcactaagt ttggacccca atgaccagaa gtctctagag
     1621 gggatgcaga agatggagaa ggaggagagt cccacggatg ccactcagga ggaggatgtg
     1681 gacgacatgg aagggagtgg ggaagaaggg gacctggagg gcagcgacag tgaggcggcc
     1741 cagtgggctg accaggagca gtggttcggc atgcagtgag ggggcggcag ctccatggcc
     1801 gcagtggcct gccctgctct gagcacttcc gtggactgaa ggaaccgtag gagcctgctc
     1861 tcagaaggac aatgattcag catgtgattg cagcaggggt ctctgccccc tcgctcccaa
     1921 ttcctagtcg tgacttcatt tctaaaacag agcctgacca accttccatg tatctccatc
     1981 ctcccctgct ccagccaggg aggactgagg gagtgccccg agacccacgc acatgttggg
     2041 gcttctgggc caagagtact ttttatataa ctaatttcta aatccaaaag ctcaaggaat
     2101 agacagtgtt ctgtgacatg gattggtttg aaggagttac ccaccatccc agcacgataa
     2161 tgtcatctcc caagttggat ggcagcacga tctggcccta gggagcttcc tgttcccaga
     2221 agtcattgtc ctgggctatc cagatgtccc tagtaaatct tgcttccttc tgcaatgtta
     2281 gtaatgcctt aagctgacag ttgctatttt gcagaacagt tttcctcttt gcttagctag
     2341 taacttgcct ctgagcctgg gctgatctga gaaacaggtg tgacaagagc atgaaccaga
     2401 ggtgcacctg gggcagttcc ctaataaaac tggtttgtac agtcatggtg ttggggtgat
     2461 cagaatggaa gcccttttca aaatagactc ttagtatttt tgtcttattc gcaatgcatt
     2521 gattcagccc cagaattatt tgccagaaat agactttctt cccctggtgt tgggagccag
     2581 gagggttgga aagctcagga accctgagct ggttcatctg tttgcatatt gggtaggtta
     2641 atttccctgg agcctgagag tctttggcca gatttcagct gcgtctgcct ggctcttttg
     2701 ctgcagctgt gagattgggg tctggttcca gcagtctgtc actggtcagc ctgagtatca
     2761 caccctgagc tctggggctg ggagtttctt cccacaccct ctcccttgtg ccttaagttg
     2821 cgatggctct gagtatacaa ttaatcggag gtgaggggtg ggtgtcacag ctaatcccaa
     2881 attcaaaaat tagtccaagg tgctgcaaaa tataaatttg atgtcagtag aaagtcgtat
     2941 cctaaaatgt aaaaactgta agtgtacagt agttaatgag ctcagaacat ctgataactg
     3001 caatttaaaa tgggcaaaaa gtt
//
