LOCUS       NM_001385211            2798 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens anaphase promoting complex subunit 7 (ANAPC7),
            transcript variant 6, mRNA.
ACCESSION   NM_001385211 XM_017019425
VERSION     NM_001385211.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2798)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
  REMARK    GeneRIF: APC7 mediates ubiquitin signaling in constitutive
            heterochromatin in the developing mammalian brain.
REFERENCE   2  (bases 1 to 2798)
  AUTHORS   Wild,T., Budzowska,M., Hellmuth,S., Eibes,S., Karemore,G.,
            Barisic,M., Stemmann,O. and Choudhary,C.
  TITLE     Deletion of APC7 or APC16 Allows Proliferation of Human Cells
            without the Spindle Assembly Checkpoint
  JOURNAL   Cell Rep 25 (9), 2317-2328 (2018)
   PUBMED   30485802
  REMARK    GeneRIF: the contribution of the anaphase-promoting
            complex/cyclosome subunits APC7 and APC16 to APC/C composition and
            function in human cells.
REFERENCE   3  (bases 1 to 2798)
  AUTHORS   Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
            Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
            and Rape,M.
  TITLE     Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
            and Protein Quality Control
  JOURNAL   Cell 171 (4), 918-933 (2017)
   PUBMED   29033132
REFERENCE   4  (bases 1 to 2798)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2798)
  AUTHORS   Zhang,S., Chang,L., Alfieri,C., Zhang,Z., Yang,J., Maslen,S.,
            Skehel,M. and Barford,D.
  TITLE     Molecular mechanism of APC/C activation by mitotic phosphorylation
  JOURNAL   Nature 533 (7602), 260-264 (2016)
   PUBMED   27120157
REFERENCE   6  (bases 1 to 2798)
  AUTHORS   Sudakin,V., Chan,G.K. and Yen,T.J.
  TITLE     Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
            complex of BUBR1, BUB3, CDC20, and MAD2
  JOURNAL   J Cell Biol 154 (5), 925-936 (2001)
   PUBMED   11535616
REFERENCE   7  (bases 1 to 2798)
  AUTHORS   Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
   PUBMED   10500174
REFERENCE   8  (bases 1 to 2798)
  AUTHORS   Chan,G.K., Jablonski,S.A., Sudakin,V., Hittle,J.C. and Yen,T.J.
  TITLE     Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E
            functions at kinetochores and binds the cyclosome/APC
  JOURNAL   J Cell Biol 146 (5), 941-954 (1999)
   PUBMED   10477750
REFERENCE   9  (bases 1 to 2798)
  AUTHORS   Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
            Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J Biol Chem 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   10 (bases 1 to 2798)
  AUTHORS   Yu,H., Peters,J.M., King,R.W., Page,A.M., Hieter,P. and
            Kirschner,M.W.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC144548.8.
            
            On Jul 10, 2020 this sequence version replaced XM_017019425.1.
            
            Summary: This gene encodes a tetratricopeptide repeat containing
            component of the anaphase promoting complex/cyclosome (APC/C), a
            large E3 ubiquitin ligase that controls cell cycle progression by
            targeting a number of cell cycle regulators such as B-type cyclins
            for 26S proteasome-mediated degradation through ubiquitination. The
            encoded protein is required for proper protein ubiquitination
            function of APC/C and for the interaction of APC/C with certain
            transcription coactivators. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.940761.1,
                                           SRR1660809.151542.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC144548.8         52003-52184
            183-369             AC144548.8         59259-59445
            370-489             AC144548.8         60491-60610
            490-601             AC144548.8         67088-67199
            602-755             AC144548.8         67819-67972
            756-898             AC144548.8         69242-69384
            899-1016            AC144548.8         72751-72868
            1017-1213           AC144548.8         73763-73959
            1214-1364           AC144548.8         79495-79645
            1365-2798           AC144548.8         81378-82811
FEATURES             Location/Qualifiers
     source          1..2798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..2798
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="anaphase promoting complex subunit 7"
                     /db_xref="GeneID:51434"
                     /db_xref="HGNC:HGNC:17380"
                     /db_xref="MIM:606949"
     exon            1..182
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1554
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="isoform e is encoded by transcript variant 6;
                     cyclosome subunit 7"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 7 isoform e"
                     /protein_id="NP_001372140.1"
                     /db_xref="GeneID:51434"
                     /db_xref="HGNC:HGNC:17380"
                     /db_xref="MIM:606949"
                     /translation="MNVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPPQKYQ
                     LLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEI
                     EVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKE
                     VLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNS
                     RAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDV
                     YGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQL
                     NSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGREQKYEDGIALLRN
                     ALANQSDCVLHRILGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPT
                     DATQEEDVDDMEGSGEEGDLEGSDSEAAQWADQEQWFGMQ"
     exon            183..369
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            370..489
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            490..601
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            602..755
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            756..898
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1016
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1213
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1364
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..2798
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2198..2203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="hexamer: AATAAA"
     polyA_site      2220
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="major polyA site"
     regulatory      2257..2262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="hexamer: AATAGA"
     polyA_site      2289
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
     polyA_site      2789
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
     polyA_site      2798
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
ORIGIN      
        1 attttggagt cttccctaag gatcctctac cggcttttcg agtcagtgct gccgccgctg
       61 cccgcggctt tgcagagcag gatgaatgtg atagaccacg tgcgggacat ggcggccgcg
      121 gggctgcact ccaacgtgcg gctcctcagc agcttgttac ttacaatgag taataacaac
      181 cctgagttat tctccccacc tcagaagtac cagcttttgg tgtatcatgc agattctctc
      241 tttcatgata aggaatatcg gaatgctgtg agtaagtata ccatggcttt acagcagaag
      301 aaagcgctaa gtaaaacttc aaaagtgaga ccttcaactg gaaattctgc atctactcca
      361 caaagtcagt gtcttccatc tgaaattgaa gtgaaataca aaatggctga atgttataca
      421 atgctaaaac aagataaaga tgccattgct atacttgatg ggatcccttc aagacaaaga
      481 actcccaaaa taaacatgat gctggcaaac ctgtacaaga aggctggtca ggagcgccct
      541 tcagtcacca gctataagga ggtgctgagg cagtgcccat tagcccttga tgccattcta
      601 ggcttgttgt ccctttctgt aaaaggggca gaggtggcat ccatgacaat gaatgtgatc
      661 caaaccgtgc ctaacttgga ctggctctct gtgtggatca aagcgtatgc ttttgtgcac
      721 actggtgaca actcaagagc aatcagtacc atctgttcac tagagaaaaa atccttattg
      781 cgagataacg tggacctatt gggaagcttg gcagatctgt acttcagagc tggagacaat
      841 aaaaactctg tcctcaagtt tgaacaggca cagatgttgg atccttatct gataaaagga
      901 atggatgtat atggctacct actggcacga gaagggcggc tagaggatgt tgagaacctt
      961 ggatgccgcc ttttcaatat ctctgatcag catgcagaac cgtgggtggt ttctggctgt
     1021 cacagcttct atagcaaacg ctactcccgg gccctctatt taggagccaa ggccattcag
     1081 ctgaacagta atagtgttca agctctgcta cttaagggag cagcacttag gaacatgggc
     1141 agagtccaag aagcaataat ccactttcgg gaggccatac ggctcgcacc ttgtcgctta
     1201 gattgttatg aaggcagaga acagaaatat gaagatggaa ttgctttgct gaggaacgca
     1261 ctggctaatc agagtgactg tgtcctgcat cggatcctag gagatttcct tgtagctgtc
     1321 aatgagtatc aggaggcaat ggaccagtat agtatagcac taagtttgga ccccaatgac
     1381 cagaagtctc tagaggggat gcagaagatg gagaaggagg agagtcccac ggatgccact
     1441 caggaggagg atgtggacga catggaaggg agtggggaag aaggggacct ggagggcagc
     1501 gacagtgagg cggcccagtg ggctgaccag gagcagtggt tcggcatgca gtgagggggc
     1561 ggcagctcca tggccgcagt ggcctgccct gctctgagca cttccgtgga ctgaaggaac
     1621 cgtaggagcc tgctctcaga aggacaatga ttcagcatgt gattgcagca ggggtctctg
     1681 ccccctcgct cccaattcct agtcgtgact tcatttctaa aacagagcct gaccaacctt
     1741 ccatgtatct ccatcctccc ctgctccagc cagggaggac tgagggagtg ccccgagacc
     1801 cacgcacatg ttggggcttc tgggccaaga gtacttttta tataactaat ttctaaatcc
     1861 aaaagctcaa ggaatagaca gtgttctgtg acatggattg gtttgaagga gttacccacc
     1921 atcccagcac gataatgtca tctcccaagt tggatggcag cacgatctgg ccctagggag
     1981 cttcctgttc ccagaagtca ttgtcctggg ctatccagat gtccctagta aatcttgctt
     2041 ccttctgcaa tgttagtaat gccttaagct gacagttgct attttgcaga acagttttcc
     2101 tctttgctta gctagtaact tgcctctgag cctgggctga tctgagaaac aggtgtgaca
     2161 agagcatgaa ccagaggtgc acctggggca gttccctaat aaaactggtt tgtacagtca
     2221 tggtgttggg gtgatcagaa tggaagccct tttcaaaata gactcttagt atttttgtct
     2281 tattcgcaat gcattgattc agccccagaa ttatttgcca gaaatagact ttcttcccct
     2341 ggtgttggga gccaggaggg ttggaaagct caggaaccct gagctggttc atctgtttgc
     2401 atattgggta ggttaatttc cctggagcct gagagtcttt ggccagattt cagctgcgtc
     2461 tgcctggctc ttttgctgca gctgtgagat tggggtctgg ttccagcagt ctgtcactgg
     2521 tcagcctgag tatcacaccc tgagctctgg ggctgggagt ttcttcccac accctctccc
     2581 ttgtgcctta agttgcgatg gctctgagta tacaattaat cggaggtgag gggtgggtgt
     2641 cacagctaat cccaaattca aaaattagtc caaggtgctg caaaatataa atttgatgtc
     2701 agtagaaagt cgtatcctaa aatgtaaaaa ctgtaagtgt acagtagtta atgagctcag
     2761 aacatctgat aactgcaatt taaaatgggc aaaaagtt
//
