LOCUS       NM_001385208            3341 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens anaphase promoting complex subunit 7 (ANAPC7),
            transcript variant 3, mRNA.
ACCESSION   NM_001385208 XM_011538454
VERSION     NM_001385208.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3341)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
  REMARK    GeneRIF: APC7 mediates ubiquitin signaling in constitutive
            heterochromatin in the developing mammalian brain.
REFERENCE   2  (bases 1 to 3341)
  AUTHORS   Wild,T., Budzowska,M., Hellmuth,S., Eibes,S., Karemore,G.,
            Barisic,M., Stemmann,O. and Choudhary,C.
  TITLE     Deletion of APC7 or APC16 Allows Proliferation of Human Cells
            without the Spindle Assembly Checkpoint
  JOURNAL   Cell Rep 25 (9), 2317-2328 (2018)
   PUBMED   30485802
  REMARK    GeneRIF: the contribution of the anaphase-promoting
            complex/cyclosome subunits APC7 and APC16 to APC/C composition and
            function in human cells.
REFERENCE   3  (bases 1 to 3341)
  AUTHORS   Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
            Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
            and Rape,M.
  TITLE     Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
            and Protein Quality Control
  JOURNAL   Cell 171 (4), 918-933 (2017)
   PUBMED   29033132
REFERENCE   4  (bases 1 to 3341)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3341)
  AUTHORS   Zhang,S., Chang,L., Alfieri,C., Zhang,Z., Yang,J., Maslen,S.,
            Skehel,M. and Barford,D.
  TITLE     Molecular mechanism of APC/C activation by mitotic phosphorylation
  JOURNAL   Nature 533 (7602), 260-264 (2016)
   PUBMED   27120157
REFERENCE   6  (bases 1 to 3341)
  AUTHORS   Sudakin,V., Chan,G.K. and Yen,T.J.
  TITLE     Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
            complex of BUBR1, BUB3, CDC20, and MAD2
  JOURNAL   J Cell Biol 154 (5), 925-936 (2001)
   PUBMED   11535616
REFERENCE   7  (bases 1 to 3341)
  AUTHORS   Gieffers,C., Peters,B.H., Kramer,E.R., Dotti,C.G. and Peters,J.M.
  TITLE     Expression of the CDH1-associated form of the anaphase-promoting
            complex in postmitotic neurons
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11317-11322 (1999)
   PUBMED   10500174
REFERENCE   8  (bases 1 to 3341)
  AUTHORS   Chan,G.K., Jablonski,S.A., Sudakin,V., Hittle,J.C. and Yen,T.J.
  TITLE     Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E
            functions at kinetochores and binds the cyclosome/APC
  JOURNAL   J Cell Biol 146 (5), 941-954 (1999)
   PUBMED   10477750
REFERENCE   9  (bases 1 to 3341)
  AUTHORS   Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
            Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J Biol Chem 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   10 (bases 1 to 3341)
  AUTHORS   Yu,H., Peters,J.M., King,R.W., Page,A.M., Hieter,P. and
            Kirschner,M.W.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC144548.8.
            
            On Jul 10, 2020 this sequence version replaced XM_011538454.2.
            
            Summary: This gene encodes a tetratricopeptide repeat containing
            component of the anaphase promoting complex/cyclosome (APC/C), a
            large E3 ubiquitin ligase that controls cell cycle progression by
            targeting a number of cell cycle regulators such as B-type cyclins
            for 26S proteasome-mediated degradation through ubiquitination. The
            encoded protein is required for proper protein ubiquitination
            function of APC/C and for the interaction of APC/C with certain
            transcription coactivators. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.114256.1,
                                           SRR1803616.271693.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               AC144548.8         53762-54261
            501-687             AC144548.8         59259-59445
            688-807             AC144548.8         60491-60610
            808-919             AC144548.8         67088-67199
            920-1073            AC144548.8         67819-67972
            1074-1216           AC144548.8         69242-69384
            1217-1334           AC144548.8         72751-72868
            1335-1531           AC144548.8         73763-73959
            1532-1756           AC144548.8         78094-78318
            1757-1907           AC144548.8         79495-79645
            1908-3341           AC144548.8         81378-82811
FEATURES             Location/Qualifiers
     source          1..3341
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..3341
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="anaphase promoting complex subunit 7"
                     /db_xref="GeneID:51434"
                     /db_xref="HGNC:HGNC:17380"
                     /db_xref="MIM:606949"
     exon            1..500
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..2097
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; cyclosome subunit 7"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 7 isoform c
                     precursor"
                     /protein_id="NP_001372137.1"
                     /db_xref="GeneID:51434"
                     /db_xref="HGNC:HGNC:17380"
                     /db_xref="MIM:606949"
                     /translation="MHQACSLLWALVLAVPPATVLISALPPPSGFSLDISPKEPSLTP
                     RTLGELFSPPQKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGN
                     SASTPQSQCLPSEIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINMMLANLYK
                     KAGQERPSVTSYKEVLRQCPLALDAILGLLSLSVKGAEVASMTMNVIQTVPNLDWLSV
                     WIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLLGSLADLYFRAGDNKNSVLKFEQ
                     AQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNISDQHAEPWVVSGCHSFYSKR
                     YSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEG
                     LIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALT
                     QRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDFLVAVNEYQEA
                     MDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSGEEGDLEGSDSEA
                     AQWADQEQWFGMQ"
     exon            501..687
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            688..807
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            808..919
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1073
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1216
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1334
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1531
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1756
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1907
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..3341
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="hexamer: AATAAA"
     polyA_site      2763
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="major polyA site"
     regulatory      2800..2805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
                     /note="hexamer: AATAGA"
     polyA_site      2832
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
     polyA_site      3332
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
     polyA_site      3341
                     /gene="ANAPC7"
                     /gene_synonym="APC7; FERBON"
ORIGIN      
        1 agacggagtc tcgctctgca cgatcttggc tcactgcaag cttcgccttc tgggttcacg
       61 ccattatcct gcctcagcct cccgagtagc tgggactaca ggcgcccgcc accgcaccca
      121 gctaattttt ttgtattttt agtagagaca gggtttcacg atggtctcga tctcctgacc
      181 tcgtgatccg cccgcctcgg cctcccaaag tgctgggatt acaggtgtga gccaccgcgc
      241 ccagccgacc agtctggtct tcaactcctg acctctggtg atcccgccgc ctcggcctcc
      301 caaagtttaa ggattacagg cgtgaaccat cgcttctggc ctctttgtgt tatttgaatg
      361 caccaagcgt gttctctact ctgggccctt gtacttgctg ttcctcctgc gacggtcctc
      421 atctcagcgt tgcctcctcc ttcaggtttt agcctggata tctctcctaa agagccttct
      481 ctgactccca ggactctcgg tgagttattc tccccacctc agaagtacca gcttttggtg
      541 tatcatgcag attctctctt tcatgataag gaatatcgga atgctgtgag taagtatacc
      601 atggctttac agcagaagaa agcgctaagt aaaacttcaa aagtgagacc ttcaactgga
      661 aattctgcat ctactccaca aagtcagtgt cttccatctg aaattgaagt gaaatacaaa
      721 atggctgaat gttatacaat gctaaaacaa gataaagatg ccattgctat acttgatggg
      781 atcccttcaa gacaaagaac tcccaaaata aacatgatgc tggcaaacct gtacaagaag
      841 gctggtcagg agcgcccttc agtcaccagc tataaggagg tgctgaggca gtgcccatta
      901 gcccttgatg ccattctagg cttgttgtcc ctttctgtaa aaggggcaga ggtggcatcc
      961 atgacaatga atgtgatcca aaccgtgcct aacttggact ggctctctgt gtggatcaaa
     1021 gcgtatgctt ttgtgcacac tggtgacaac tcaagagcaa tcagtaccat ctgttcacta
     1081 gagaaaaaat ccttattgcg agataacgtg gacctattgg gaagcttggc agatctgtac
     1141 ttcagagctg gagacaataa aaactctgtc ctcaagtttg aacaggcaca gatgttggat
     1201 ccttatctga taaaaggaat ggatgtatat ggctacctac tggcacgaga agggcggcta
     1261 gaggatgttg agaaccttgg atgccgcctt ttcaatatct ctgatcagca tgcagaaccg
     1321 tgggtggttt ctggctgtca cagcttctat agcaaacgct actcccgggc cctctattta
     1381 ggagccaagg ccattcagct gaacagtaat agtgttcaag ctctgctact taagggagca
     1441 gcacttagga acatgggcag agtccaagaa gcaataatcc actttcggga ggccatacgg
     1501 ctcgcacctt gtcgcttaga ttgttatgaa ggtcttatcg aatgttactt agcctccaac
     1561 agtattcgag aagcaatggt aatggctaac aacgtttaca aaactctggg agcaaatgca
     1621 cagaccctta cccttttagc caccgtttgt cttgaagacc cagtgacaca ggagaaagcc
     1681 aaaacattat tagataaagc cctgacccaa aggccagatt acattaaggc tgtggtgaaa
     1741 aaagcagaac tacttagcag agaacagaaa tatgaagatg gaattgcttt gctgaggaac
     1801 gcactggcta atcagagtga ctgtgtcctg catcggatcc taggagattt ccttgtagct
     1861 gtcaatgagt atcaggaggc aatggaccag tatagtatag cactaagttt ggaccccaat
     1921 gaccagaagt ctctagaggg gatgcagaag atggagaagg aggagagtcc cacggatgcc
     1981 actcaggagg aggatgtgga cgacatggaa gggagtgggg aagaagggga cctggagggc
     2041 agcgacagtg aggcggccca gtgggctgac caggagcagt ggttcggcat gcagtgaggg
     2101 ggcggcagct ccatggccgc agtggcctgc cctgctctga gcacttccgt ggactgaagg
     2161 aaccgtagga gcctgctctc agaaggacaa tgattcagca tgtgattgca gcaggggtct
     2221 ctgccccctc gctcccaatt cctagtcgtg acttcatttc taaaacagag cctgaccaac
     2281 cttccatgta tctccatcct cccctgctcc agccagggag gactgaggga gtgccccgag
     2341 acccacgcac atgttggggc ttctgggcca agagtacttt ttatataact aatttctaaa
     2401 tccaaaagct caaggaatag acagtgttct gtgacatgga ttggtttgaa ggagttaccc
     2461 accatcccag cacgataatg tcatctccca agttggatgg cagcacgatc tggccctagg
     2521 gagcttcctg ttcccagaag tcattgtcct gggctatcca gatgtcccta gtaaatcttg
     2581 cttccttctg caatgttagt aatgccttaa gctgacagtt gctattttgc agaacagttt
     2641 tcctctttgc ttagctagta acttgcctct gagcctgggc tgatctgaga aacaggtgtg
     2701 acaagagcat gaaccagagg tgcacctggg gcagttccct aataaaactg gtttgtacag
     2761 tcatggtgtt ggggtgatca gaatggaagc ccttttcaaa atagactctt agtatttttg
     2821 tcttattcgc aatgcattga ttcagcccca gaattatttg ccagaaatag actttcttcc
     2881 cctggtgttg ggagccagga gggttggaaa gctcaggaac cctgagctgg ttcatctgtt
     2941 tgcatattgg gtaggttaat ttccctggag cctgagagtc tttggccaga tttcagctgc
     3001 gtctgcctgg ctcttttgct gcagctgtga gattggggtc tggttccagc agtctgtcac
     3061 tggtcagcct gagtatcaca ccctgagctc tggggctggg agtttcttcc cacaccctct
     3121 cccttgtgcc ttaagttgcg atggctctga gtatacaatt aatcggaggt gaggggtggg
     3181 tgtcacagct aatcccaaat tcaaaaatta gtccaaggtg ctgcaaaata taaatttgat
     3241 gtcagtagaa agtcgtatcc taaaatgtaa aaactgtaag tgtacagtag ttaatgagct
     3301 cagaacatct gataactgca atttaaaatg ggcaaaaagt t
//
