LOCUS       NM_015391               1170 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens anaphase promoting complex subunit 13 (ANAPC13),
            transcript variant 1, mRNA.
ACCESSION   NM_015391
VERSION     NM_015391.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1170)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1170)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1170)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1170)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1170)
  AUTHORS   Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
            Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
            and Rape,M.
  TITLE     Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
            and Protein Quality Control
  JOURNAL   Cell 171 (4), 918-933 (2017)
   PUBMED   29033132
REFERENCE   6  (bases 1 to 1170)
  AUTHORS   Jin,L., Williamson,A., Banerjee,S., Philipp,I. and Rape,M.
  TITLE     Mechanism of ubiquitin-chain formation by the human
            anaphase-promoting complex
  JOURNAL   Cell 133 (4), 653-665 (2008)
   PUBMED   18485873
REFERENCE   7  (bases 1 to 1170)
  AUTHORS   Weedon,M.N., Lango,H., Lindgren,C.M., Wallace,C., Evans,D.M.,
            Mangino,M., Freathy,R.M., Perry,J.R., Stevens,S., Hall,A.S.,
            Samani,N.J., Shields,B., Prokopenko,I., Farrall,M., Dominiczak,A.,
            Johnson,T., Bergmann,S., Beckmann,J.S., Vollenweider,P.,
            Waterworth,D.M., Mooser,V., Palmer,C.N., Morris,A.D.,
            Ouwehand,W.H., Zhao,J.H., Li,S., Loos,R.J., Barroso,I.,
            Deloukas,P., Sandhu,M.S., Wheeler,E., Soranzo,N., Inouye,M.,
            Wareham,N.J., Caulfield,M., Munroe,P.B., Hattersley,A.T.,
            McCarthy,M.I. and Frayling,T.M.
  CONSRTM   Diabetes Genetics Initiative; Wellcome Trust Case Control
            Consortium; Cambridge GEM Consortium
  TITLE     Genome-wide association analysis identifies 20 loci that influence
            adult height
  JOURNAL   Nat Genet 40 (5), 575-583 (2008)
   PUBMED   18391952
REFERENCE   8  (bases 1 to 1170)
  AUTHORS   Dube,P., Herzog,F., Gieffers,C., Sander,B., Riedel,D., Muller,S.A.,
            Engel,A., Peters,J.M. and Stark,H.
  TITLE     Localization of the coactivator Cdh1 and the cullin subunit Apc2 in
            a cryo-electron microscopy model of vertebrate APC/C
  JOURNAL   Mol Cell 20 (6), 867-879 (2005)
   PUBMED   16364912
REFERENCE   9  (bases 1 to 1170)
  AUTHORS   Castro,A., Bernis,C., Vigneron,S., Labbe,J.C. and Lorca,T.
  TITLE     The anaphase-promoting complex: a key factor in the regulation of
            cell cycle
  JOURNAL   Oncogene 24 (3), 314-325 (2005)
   PUBMED   15678131
  REMARK    Review article
REFERENCE   10 (bases 1 to 1170)
  AUTHORS   Schwickart,M., Havlis,J., Habermann,B., Bogdanova,A., Camasses,A.,
            Oelschlaegel,T., Shevchenko,A. and Zachariae,W.
  TITLE     Swm1/Apc13 is an evolutionarily conserved subunit of the
            anaphase-promoting complex stabilizing the association of Cdc16 and
            Cdc27
  JOURNAL   Mol Cell Biol 24 (8), 3562-3576 (2004)
   PUBMED   15060174
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005398.1 and AK026550.1.
            
            On Jun 2, 2019 this sequence version replaced NM_015391.3.
            
            Summary: This gene encodes a component of the anaphase promoting
            complex, a large ubiquitin-protein ligase that controls cell cycle
            progression by regulating the degradation of cell cycle regulators
            such as B-type cyclins. The encoded protein is evolutionarily
            conserved and is required for the integrity and ubiquitin ligase
            activity of the anaphase promoting complex. Pseudogenes and splice
            variants have been found for this gene; however, the biological
            validity of some of the splice variants has not been determined.
            [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG568379.1, AK026550.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1970526,
                                           SAMEA2142670 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354910.10/ ENSP00000346987.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               BC005398.1         3-340
            339-1170            AK026550.1         329-1160
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.2"
     gene            1..1170
                     /gene="ANAPC13"
                     /gene_synonym="APC13; SWM1"
                     /note="anaphase promoting complex subunit 13"
                     /db_xref="GeneID:25847"
                     /db_xref="HGNC:HGNC:24540"
                     /db_xref="MIM:614484"
     exon            1..34
                     /gene="ANAPC13"
                     /gene_synonym="APC13; SWM1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..160
                     /gene="ANAPC13"
                     /gene_synonym="APC13; SWM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..286
                     /gene="ANAPC13"
                     /gene_synonym="APC13; SWM1"
                     /note="cyclosome subunit 13"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 13"
                     /protein_id="NP_056206.1"
                     /db_xref="CCDS:CCDS3085.1"
                     /db_xref="GeneID:25847"
                     /db_xref="HGNC:HGNC:24540"
                     /db_xref="MIM:614484"
                     /translation="MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNG
                     GTTESVKEQEMKWTDLALQYLHENVPPIGN"
     exon            161..1170
                     /gene="ANAPC13"
                     /gene_synonym="APC13; SWM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1147..1152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC13"
                     /gene_synonym="APC13; SWM1"
                     /note="hexamer: ACTAAA"
     polyA_site      1170
                     /gene="ANAPC13"
                     /gene_synonym="APC13; SWM1"
                     /note="major polyA site"
ORIGIN      
        1 aggagcaagc gtctgccgcg gtggccgggt gccgatttga caagatcaaa gctgcaggaa
       61 aatggacagt gaggttcaga gagatggaag gatcttggat ttgattgatg atgcttggcg
      121 agaagacaag ctgccttatg aggatgtcgc aataccactg aatgagcttc ctgaacctga
      181 acaagacaat ggtggcacca cagaatctgt caaagaacaa gaaatgaagt ggacagactt
      241 agccttacag tacctccatg agaatgttcc ccccattgga aactgacgct tggctccttt
      301 cttgtggatg gattttctca aagtacacag ataaagcatg gtttgtttca gtctccaaat
      361 tcaaaccttt gagtaataaa tcagcactca aaaatgtaca cccatttagt ttgtggtagc
      421 aaagtgcaat gcgaaattga atgagaaact gagatttctc agtaatggtg aatatttcgc
      481 tctttaaacc taaaactctt cattgagtag cttatatttg aacatgattg gttaaacatt
      541 tgcctctacc tctgattttg ctttgctgtc aaagtttaac accttccaac tacttatgtg
      601 tgtcctgtaa cacaggtgat tgaacgtatg agagggaaag gcaaagaaaa aggaagccag
      661 acactaggag aattattaac ttctcatact tccccacatt gagaagcatt cggagtgtat
      721 ttagcctgta gatgttgtga tatgcaaata tcccattccc tggttactgg cattcctaag
      781 attcttcatg gtattttcaa actttggata aatttacaga ttagaaagat atctgacagt
      841 taatctctgt tctccttaca aattcctttt gtgctgctgg aaaggatctt tggctaggtg
      901 gatgactagt tttattcaaa gccttttctc aaagcccttt cagttacaac caccccacta
      961 tggaatcagt atttagttat acatttgtat aagaacctgt attttgaaaa acacattcat
     1021 gtatatttat tcctggaatt atttgcctgt taaacagtgt ctttcatgtt ctctccccag
     1081 attgtaaact ctgtaagaag ctgcttgtat ctgtatccct tgttgaaact ctgaaaacac
     1141 tgaataacta aaatctcttc tcatcctttt
//
