LOCUS       NM_001002248             638 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens anaphase promoting complex subunit 11 (ANAPC11),
            transcript variant 6, mRNA.
ACCESSION   NM_001002248
VERSION     NM_001002248.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 638)
  AUTHORS   Yan,D., He,Q., Pei,L., Yang,M., Huang,L., Kong,J., He,W., Liu,H.,
            Xu,S., Qin,H., Lin,T. and Huang,J.
  TITLE     The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein
            degradation to promote cell proliferation and lymph node metastasis
            in urothelial bladder cancer
  JOURNAL   Cell Death Dis 14 (8), 516 (2023)
   PUBMED   37573356
  REMARK    GeneRIF: The APC/C E3 ligase subunit ANAPC11 mediates FOXO3 protein
            degradation to promote cell proliferation and lymph node metastasis
            in urothelial bladder cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 638)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 638)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 638)
  AUTHORS   Drouet,Y., Treilleux,I., Viari,A., Leon,S.,
            Devouassoux-Shisheboran,M., Voirin,N., de la Fouchardiere,C.,
            Manship,B., Puisieux,A., Lasset,C. and Moyret-Lalle,C.
  TITLE     Integrated analysis highlights APC11 protein expression as a likely
            new independent predictive marker for colorectal cancer
  JOURNAL   Sci Rep 8 (1), 7386 (2018)
   PUBMED   29743633
  REMARK    GeneRIF: Overexpression of APC11 is correlated with chromosomal
            instability in colorectal cancer. An association is observed
            between APC11 expression and lymphovascular invasion and residual
            tumor. High levels of APC11 protein in primary colorectal tumors is
            specifically correlated with metastasis at diagnosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 638)
  AUTHORS   Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
            Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
            and Rape,M.
  TITLE     Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
            and Protein Quality Control
  JOURNAL   Cell 171 (4), 918-933 (2017)
   PUBMED   29033132
REFERENCE   6  (bases 1 to 638)
  AUTHORS   Gmachl,M., Gieffers,C., Podtelejnikov,A.V., Mann,M. and Peters,J.M.
  TITLE     The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are
            sufficient to ubiquitinate substrates of the anaphase-promoting
            complex
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8973-8978 (2000)
   PUBMED   10922056
REFERENCE   7  (bases 1 to 638)
  AUTHORS   Kramer,E.R., Scheuringer,N., Podtelejnikov,A.V., Mann,M. and
            Peters,J.M.
  TITLE     Mitotic regulation of the APC activator proteins CDC20 and CDH1
  JOURNAL   Mol Biol Cell 11 (5), 1555-1569 (2000)
   PUBMED   10793135
REFERENCE   8  (bases 1 to 638)
  AUTHORS   Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
            Peters,J.M., Bartek,J. and Lukas,J.
  TITLE     Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
            rearrangement of the anaphase-promoting complex
  JOURNAL   Nature 401 (6755), 815-818 (1999)
   PUBMED   10548110
REFERENCE   9  (bases 1 to 638)
  AUTHORS   Ohta,T., Michel,J.J., Schottelius,A.J. and Xiong,Y.
  TITLE     ROC1, a homolog of APC11, represents a family of cullin partners
            with an associated ubiquitin ligase activity
  JOURNAL   Mol Cell 3 (4), 535-541 (1999)
   PUBMED   10230407
REFERENCE   10 (bases 1 to 638)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY067392.1, BC000607.1, AF151048.1 and AK308091.1.
            
            On May 21, 2020 this sequence version replaced NM_001002248.2.
            
            Transcript Variant: This variant (6) uses an alternate splice site
            and contains an alternate exon in the 5' UTR and lacks an exon in
            the 3' coding region, which results in a frameshift, compared to
            variant 1. The encoded isoform (2) has a distinct C-terminus and is
            shorter than isoform 1. Variants 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11
            encode the isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM549143.1, BC095454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344877.10/ ENSP00000339695.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                HY067392.1         12-74
            64-119              BC000607.1         50-105
            120-392             AF151048.1         97-369
            393-638             AK308091.1         246-491
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..638
                     /gene="ANAPC11"
                     /gene_synonym="APC11; Apc11p; HSPC214"
                     /note="anaphase promoting complex subunit 11"
                     /db_xref="GeneID:51529"
                     /db_xref="HGNC:HGNC:14452"
                     /db_xref="MIM:614534"
     exon            1..119
                     /gene="ANAPC11"
                     /gene_synonym="APC11; Apc11p; HSPC214"
                     /inference="alignment:Splign:2.1.0"
     exon            120..182
                     /gene="ANAPC11"
                     /gene_synonym="APC11; Apc11p; HSPC214"
                     /inference="alignment:Splign:2.1.0"
     exon            183..302
                     /gene="ANAPC11"
                     /gene_synonym="APC11; Apc11p; HSPC214"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..448
                     /gene="ANAPC11"
                     /gene_synonym="APC11; Apc11p; HSPC214"
                     /note="isoform 2 is encoded by transcript variant 6;
                     anaphase promoting complex subunit 11 (yeast APC11
                     homolog); cyclosome subunit 11; hepatocellular
                     carcinoma-associated RING finger protein; APC11 anaphase
                     promoting complex subunit 11 homolog"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 11 isoform 2"
                     /protein_id="NP_001002248.1"
                     /db_xref="CCDS:CCDS11789.1"
                     /db_xref="GeneID:51529"
                     /db_xref="HGNC:HGNC:14452"
                     /db_xref="MIM:614534"
                     /translation="MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDC
                     PLVWGQCSHCFHMHCILKWLHAQQVQQHCPMCRQEWKFKE"
     exon            303..638
                     /gene="ANAPC11"
                     /gene_synonym="APC11; Apc11p; HSPC214"
                     /inference="alignment:Splign:2.1.0"
     regulatory      619..624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC11"
                     /gene_synonym="APC11; Apc11p; HSPC214"
                     /note="hexamer: ATTAAA"
     polyA_site      638
                     /gene="ANAPC11"
                     /gene_synonym="APC11; Apc11p; HSPC214"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcactg gcgtgcgaga ctcggcgggc gctgttgagg gagtcgggcc gcgactgtgg
       61 tcgtttttat accttcccgc gcggacgccg gcgctgccaa cggaagggcg ggtagggcga
      121 gacggagttt cgtcatgttg gccaggccca tttgagatct ttgaagatat cctcaacgtg
      181 aggctctgct gccatgaagg tgaagattaa gtgctggaac ggcgtggcca cttggctctg
      241 ggtggccaac gatgagaact gtggcatctg caggatggca tttaacggat gctgccctga
      301 ctgcaaggtg cccggcgacg actgcccgct ggtgtggggc cagtgctccc actgcttcca
      361 catgcattgc atcctcaagt ggctgcacgc acagcaggtg cagcagcact gccccatgtg
      421 ccgccaggaa tggaagttca aggagtgagg cccgacctgg ctctcgctgg aggggcatcc
      481 tgagactcct tcctcatgct ggcgccgatg gctgctgggg acagcgcccc tgagctgcaa
      541 caaggtggaa acaagggctg gagctgcgtt tgttttgcca tcactatgtt gacactttta
      601 tccaataagt gaaaactcat taaactactc aaatcttg
//
