LOCUS       NM_001256706            1444 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens anaphase promoting complex subunit 10 (ANAPC10),
            transcript variant 1, mRNA.
ACCESSION   NM_001256706
VERSION     NM_001256706.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1444)
  AUTHORS   Wu,H., Zhang,X., Shen,Q., Liu,Y., Gao,Y., Wang,G., Lv,M., Hua,R.,
            Xu,Y., Zhou,P., Wei,Z., Tao,F., He,X., Cao,Y. and Liu,M.
  TITLE     A homozygous loss-of-function mutation in FBXO43 causes human
            non-obstructive azoospermia
  JOURNAL   Clin Genet 101 (1), 55-64 (2022)
   PUBMED   34595750
REFERENCE   2  (bases 1 to 1444)
  AUTHORS   Wang,Y., Han,T., Gan,M., Guo,M., Xie,C., Jin,J., Zhang,S., Wang,P.,
            Cao,J. and Wang,J.B.
  TITLE     A novel function of anaphase promoting complex subunit 10 in tumor
            progression in non-small cell lung cancer
  JOURNAL   Cell Cycle 18 (9), 1019-1032 (2019)
   PUBMED   31023143
  REMARK    GeneRIF: APC10 was overexpressed in non-small cell lung cancer cell
            lines compared to human bronchial epithelial cell lines. APC10 was
            shown to interact with GAC; knocking down APC10 downregulated
            glutamine metabolism to induce autophagy, resulting in effective
            inhibition of the proliferation and migration of non-small cell
            lung cancer cells.
REFERENCE   3  (bases 1 to 1444)
  AUTHORS   Yau,R.G., Doerner,K., Castellanos,E.R., Haakonsen,D.L., Werner,A.,
            Wang,N., Yang,X.W., Martinez-Martin,N., Matsumoto,M.L., Dixit,V.M.
            and Rape,M.
  TITLE     Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle
            and Protein Quality Control
  JOURNAL   Cell 171 (4), 918-933 (2017)
   PUBMED   29033132
REFERENCE   4  (bases 1 to 1444)
  AUTHORS   Zhang,S., Chang,L., Alfieri,C., Zhang,Z., Yang,J., Maslen,S.,
            Skehel,M. and Barford,D.
  TITLE     Molecular mechanism of APC/C activation by mitotic phosphorylation
  JOURNAL   Nature 533 (7602), 260-264 (2016)
   PUBMED   27120157
REFERENCE   5  (bases 1 to 1444)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   6  (bases 1 to 1444)
  AUTHORS   Gotthardt,M., Trommsdorff,M., Nevitt,M.F., Shelton,J.,
            Richardson,J.A., Stockinger,W., Nimpf,J. and Herz,J.
  TITLE     Interactions of the low density lipoprotein receptor gene family
            with cytosolic adaptor and scaffold proteins suggest diverse
            biological functions in cellular communication and signal
            transduction
  JOURNAL   J Biol Chem 275 (33), 25616-25624 (2000)
   PUBMED   10827173
REFERENCE   7  (bases 1 to 1444)
  AUTHORS   Kramer,E.R., Scheuringer,N., Podtelejnikov,A.V., Mann,M. and
            Peters,J.M.
  TITLE     Mitotic regulation of the APC activator proteins CDC20 and CDH1
  JOURNAL   Mol Biol Cell 11 (5), 1555-1569 (2000)
   PUBMED   10793135
REFERENCE   8  (bases 1 to 1444)
  AUTHORS   Lukas,C., Sorensen,C.S., Kramer,E., Santoni-Rugiu,E., Lindeneg,C.,
            Peters,J.M., Bartek,J. and Lukas,J.
  TITLE     Accumulation of cyclin B1 requires E2F and cyclin-A-dependent
            rearrangement of the anaphase-promoting complex
  JOURNAL   Nature 401 (6755), 815-818 (1999)
   PUBMED   10548110
REFERENCE   9  (bases 1 to 1444)
  AUTHORS   Kurasawa,Y. and Todokoro,K.
  TITLE     Identification of human APC10/Doc1 as a subunit of anaphase
            promoting complex
  JOURNAL   Oncogene 18 (37), 5131-5137 (1999)
   PUBMED   10498862
REFERENCE   10 (bases 1 to 1444)
  AUTHORS   Grossberger,R., Gieffers,C., Zachariae,W., Podtelejnikov,A.V.,
            Schleiffer,A., Nasmyth,K., Mann,M. and Peters,J.M.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J Biol Chem 274 (20), 14500-14507 (1999)
   PUBMED   10318877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF693880.1, AL080090.1, AF132794.1, BU175327.1 and AC097649.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001256706.1.
            
            Summary: ANAPC10 is a core subunit of the anaphase-promoting
            complex (APC), or cyclosome, a ubiquitin protein ligase that is
            essential for progression through the cell cycle. APC initiates
            sister chromatid separation by ubiquitinating the anaphase
            inhibitor securin (PTTG1; MIM 604147) and triggers exit from
            mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the
            activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940)
            (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by
            OMIM, Feb 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1, 2, 3 and 4 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.3904241.1, BI668952.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000507656.6/ ENSP00000423995.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BF693880.1         24-30
            8-37                AL080090.1         5-34
            38-105              AF132794.1         5-72
            106-699             BU175327.1         99-692
            700-1444            AC097649.3         62794-63538         c
FEATURES             Location/Qualifiers
     source          1..1444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..1444
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /note="anaphase promoting complex subunit 10"
                     /db_xref="GeneID:10393"
                     /db_xref="HGNC:HGNC:24077"
                     /db_xref="MIM:613745"
     exon            1..77
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            78..204
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..647
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclosome subunit 10"
                     /codon_start=1
                     /product="anaphase-promoting complex subunit 10 isoform 1"
                     /protein_id="NP_001243635.1"
                     /db_xref="CCDS:CCDS43273.1"
                     /db_xref="GeneID:10393"
                     /db_xref="HGNC:HGNC:24077"
                     /db_xref="MIM:613745"
                     /translation="MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQ
                     LRDDNLETYWQSDGSQPHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNF
                     HNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYT
                     PVEESSIGKFPRCTTIDFMMYRSIR"
     exon            205..295
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..416
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..1444
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      831..836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /note="hexamer: AATAAA"
     polyA_site      862
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /note="major polyA site"
     regulatory      1425..1430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
                     /note="hexamer: ATTAAA"
     polyA_site      1444
                     /gene="ANAPC10"
                     /gene_synonym="APC10; DOC1"
ORIGIN      
        1 gttcaacgcc gttggcgaag ccagctgctg gaggtgccga gaatctgagt ttcggcaagc
       61 agccaggtct ggaaactaat attttaaaaa tgactacacc aaacaagaca cctcctggtg
      121 ctgaccccaa gcagttggaa aggactggaa cagtacggga aattgggtca caagctgttt
      181 ggtcactctc atcttgcaaa ccaggatttg gagtggatca gttacgagat gacaatctag
      241 aaacttattg gcaatcagat ggttcccagc ctcatttagt gaacatccaa ttcagaagaa
      301 aaacaacagt gaagacatta tgtatttatg cagactacaa atctgatgaa agctatactc
      361 caagcaagat ctcagtcaga gtaggaaata attttcacaa ccttcaagaa attcggcaac
      421 ttgagttggt ggaaccaagt ggctggattc atgttccctt aactgacaat cataagaagc
      481 caactcgtac attcatgata cagattgctg ttctagccaa tcaccagaat ggaagagaca
      541 cccatatgag acaaattaaa atatacacac cagtagaaga gagctccatt ggtaaatttc
      601 ctagatgtac aactatagat ttcatgatgt atcgttcaat aaggtgactt taaaatgaga
      661 cgaaaatcat taaacgtatc tttgttttat cctgtattta aataatatat catgtacctt
      721 tattgaacaa ggcatccgtt atatctaatt ttgtatatgt ttaaaaatat tttattgtaa
      781 ctttgacaaa taaatttggg gtcatattat ctttattttc tttaacatgt aataaagctc
      841 acatatttta cattactaaa aatggatttg aagccaatca ttttattttc ccttgtatca
      901 aaagaaaaga gttccttgta tcaaaagaaa agagttgaac tgaaaatttc agtatataca
      961 caattataat agctaggtga ttatttcatt agtgttcata cattagagta atggtttatt
     1021 gcatatttga gaacaagact gtgttttatc aatatatatc atctttaata ggtcaaaatt
     1081 actatttttt ctacccagag gaaggttatt cttttaatac tggatctttt aaaaaacagt
     1141 gtcaaataag cttagtgtta ggttgtctga tgagaaccaa tctaatatgg ggagtataat
     1201 taattgtctc atattcacct tcacggaata cttacagccc tagggttgtc tgtatcctaa
     1261 tgatattatg taaagattgc ctgtataatc tagcagtact tatggaagag ttctagcagt
     1321 acttatggaa gagttatttt caaatttgtg tctgacattg tagcattccc tgggcagtca
     1381 tatatcccat aaaatcgtaa aagtatgtga aattttttat atatattaaa agattttaaa
     1441 gaaa
//
