LOCUS       NM_016627               1932 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens archaelysin family metallopeptidase 2 (AMZ2),
            transcript variant 1, mRNA.
ACCESSION   NM_016627
VERSION     NM_016627.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Huang,W., Wang,Y., Chu,W. and Tseng,R.
  TITLE     Refined-mapping of the novel TSG within the 17q24.3 chromosomal
            region in non-small cell lung cancer samples
  JOURNAL   Oncol Lett 12 (3), 1975-1980 (2016)
   PUBMED   27602123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK126146.1 and BQ432895.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016627.4.
            
            Summary: The protein encoded by this gene is a zinc metalloprotease
            that displays some activity against angiotensin-3. The encoded
            protein is inhibited by the aminopeptidase inhibitor amastatin, as
            well as by the general inhibitors o-phenanthroline and batimastat.
            Defects in this gene may be associated with lung tumorigenesis.
            [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1-5 and 7-17 all encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.627744.1, AK126146.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359904.8/ ENSP00000352976.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-750               AK126146.1         470-1219
            751-1431            BQ432895.1         77-757
            1432-1932           AK126146.1         1901-2401
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..1932
                     /gene="AMZ2"
                     /note="archaelysin family metallopeptidase 2"
                     /db_xref="GeneID:51321"
                     /db_xref="HGNC:HGNC:28041"
                     /db_xref="MIM:615169"
     exon            1..663
                     /gene="AMZ2"
                     /inference="alignment:Splign:2.1.0"
     CDS             664..1746
                     /gene="AMZ2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     archaemetzincins-2; archeobacterial metalloproteinase-like
                     protein 2"
                     /codon_start=1
                     /product="archaemetzincin-2 isoform 1"
                     /protein_id="NP_057711.3"
                     /db_xref="CCDS:CCDS11674.1"
                     /db_xref="GeneID:51321"
                     /db_xref="HGNC:HGNC:28041"
                     /db_xref="MIM:615169"
                     /translation="MQIIRHSEQTLKTALISKNPVLVSQYEKLNAGEQRLMNEAFQPA
                     SDLFGPITLHSPSDWITSHPEAPQDFEQFFSDPYRKTPSPNKRSIYIQSIGSLGNTRI
                     ISEEYIKWLTGYCKAYFYGLRVKLLEPVPVSVTRCSFRVNENTHNLQIHAGDILKFLK
                     KKKPEDAFCVVGITMIDLYPRDSWNFVFGQASLTDGVGIFSFARYGSDFYSMHYKGKV
                     KKLKKTSSSDYSIFDNYYIPEITSVLLLRSCKTLTHEIGHIFGLRHCQWLACLMQGSN
                     HLEEADRRPLNLCPICLHKLQCAVGFSIVERYKALVRWIDDESSDTPGATPEHSHEDN
                     GNLPKPVEAFKEWKEWIIKCLAVLQK"
     exon            664..946
                     /gene="AMZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1120
                     /gene="AMZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1249
                     /gene="AMZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1413
                     /gene="AMZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1590
                     /gene="AMZ2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1932
                     /gene="AMZ2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1824..1829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMZ2"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="AMZ2"
                     /note="major polyA site"
     regulatory      1911..1916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMZ2"
                     /note="hexamer: AATAAA"
     polyA_site      1932
                     /gene="AMZ2"
ORIGIN      
        1 agtgcgaagg gacgcggtgc gcatgcgcgt gagggctgcc gcgggtgggt ggtatcgagg
       61 cctgtcgggt cagggcggtt cgcgggtgct gtcagagctg ggccggggcc cctaggcagg
      121 gtagccgggt cgtagaggcg ggggccggtc gcggtcggtg gagcgggatg aggatgtagg
      181 aggggcggac gtggcggaag ccgcggggtc cgcggggtcg gtgcctctag ggagccaggg
      241 aggcctttcc cgaggctcct ggggaagaag aggcgaagcg agagtccctg gggaaccccc
      301 actccactcc cagctggaga ctgggttgtg tctgcatgga ccagagccca cagtgcgagt
      361 tgctataggc aaccagccag ggtggccagc tccttcccgt ttgcccgtga tgttctggtt
      421 ttgggaccaa agcatcctag gcctccagcc cactgcagtg accgaattct gcgccccctg
      481 cccatcttct cccgcagctt ccctagatta ggcttgggag gcaagaggag gcctcctgac
      541 ctttcacact gcctttttaa tattaagatg aagtcacact ccacaacttt cttccagcca
      601 ggcccagaca tgtccgtcct tgtaagttaa aagcttccat gggagccttc cttcctaatc
      661 aagatgcaaa taatacggca ctccgaacag acactaaaaa cagctctcat ctcaaagaac
      721 ccagtgcttg tatcacagta tgagaaatta aatgctgggg aacaacgttt aatgaatgaa
      781 gccttccagc cagccagtga tctctttgga cccattacct tgcattctcc atcagattgg
      841 atcacctccc accctgaggc tccccaagac tttgaacagt tcttcagtga tccttacaga
      901 aagacaccct ctccaaacaa acgcagcatt tatatacagt ccattggctc tctaggaaac
      961 accagaatta tcagtgaaga atatattaaa tggctcacgg gctactgtaa agcatatttc
     1021 tatggcttga gagtaaaact cctagaacca gttcctgttt ctgtaacaag atgttccttt
     1081 agagtcaatg agaacacaca caacctacaa attcatgcag gggacatcct gaagttcttg
     1141 aaaaagaaga aacctgaaga tgccttctgt gttgtgggaa taacaatgat tgatctttac
     1201 ccaagagact cgtggaattt tgtctttgga caggcctctt tgacagatgg tgtggggata
     1261 ttcagctttg ccaggtatgg cagtgatttt tatagcatgc actataaagg caaagtgaag
     1321 aagctcaaga aaacatcttc aagtgactat tcaattttcg acaactatta tattccagaa
     1381 ataactagtg ttttactact tcgatcctgt aagactttaa cccatgagat cggacacata
     1441 tttggactgc gacactgcca gtggcttgca tgcctcatgc aaggctccaa ccacttggaa
     1501 gaagctgacc ggcgccctct aaacctttgc cctatctgtt tgcacaagtt gcagtgtgct
     1561 gttggcttca gcattgtaga aagatacaaa gcactggtga ggtggattga tgatgaatct
     1621 tctgacacac ctggagcaac tccagaacac agtcacgagg ataatgggaa tttaccgaaa
     1681 cccgtggaag cctttaagga atggaaagag tggataataa aatgcctggc tgttctccaa
     1741 aaatgaggac cttcaaatag gagtgattga aataaataac tacttgcatg ttatgctttc
     1801 atttgggtgg aatacttcat tggaataaac tactgatctt gtgctgtgtc aaagtaacag
     1861 actagaacct tctttcaagt acctgaattg aaatgaaact cattttgaat aataaaaact
     1921 ctagaaactc tt
//
