LOCUS       NM_001384743            8615 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens archaelysin family metallopeptidase 1 (AMZ1),
            transcript variant 8, mRNA.
ACCESSION   NM_001384743 XM_011515150
VERSION     NM_001384743.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8615)
  AUTHORS   Berndt,S.I., Gustafsson,S., Magi,R., Ganna,A., Wheeler,E.,
            Feitosa,M.F., Justice,A.E., Monda,K.L., Croteau-Chonka,D.C.,
            Day,F.R., Esko,T., Fall,T., Ferreira,T., Gentilini,D.,
            Jackson,A.U., Luan,J., Randall,J.C., Vedantam,S., Willer,C.J.,
            Winkler,T.W., Wood,A.R., Workalemahu,T., Hu,Y.J., Lee,S.H.,
            Liang,L., Lin,D.Y., Min,J.L., Neale,B.M., Thorleifsson,G., Yang,J.,
            Albrecht,E., Amin,N., Bragg-Gresham,J.L., Cadby,G., den Heijer,M.,
            Eklund,N., Fischer,K., Goel,A., Hottenga,J.J., Huffman,J.E.,
            Jarick,I., Johansson,A., Johnson,T., Kanoni,S., Kleber,M.E.,
            Konig,I.R., Kristiansson,K., Kutalik,Z., Lamina,C., Lecoeur,C.,
            Li,G., Mangino,M., McArdle,W.L., Medina-Gomez,C.,
            Muller-Nurasyid,M., Ngwa,J.S., Nolte,I.M., Paternoster,L.,
            Pechlivanis,S., Perola,M., Peters,M.J., Preuss,M., Rose,L.M.,
            Shi,J., Shungin,D., Smith,A.V., Strawbridge,R.J., Surakka,I.,
            Teumer,A., Trip,M.D., Tyrer,J., Van Vliet-Ostaptchouk,J.V.,
            Vandenput,L., Waite,L.L., Zhao,J.H., Absher,D., Asselbergs,F.W.,
            Atalay,M., Attwood,A.P., Balmforth,A.J., Basart,H., Beilby,J.,
            Bonnycastle,L.L., Brambilla,P., Bruinenberg,M., Campbell,H.,
            Chasman,D.I., Chines,P.S., Collins,F.S., Connell,J.M.,
            Cookson,W.O., de Faire,U., de Vegt,F., Dei,M., Dimitriou,M.,
            Edkins,S., Estrada,K., Evans,D.M., Farrall,M., Ferrario,M.M.,
            Ferrieres,J., Franke,L., Frau,F., Gejman,P.V., Grallert,H.,
            Gronberg,H., Gudnason,V., Hall,A.S., Hall,P., Hartikainen,A.L.,
            Hayward,C., Heard-Costa,N.L., Heath,A.C., Hebebrand,J., Homuth,G.,
            Hu,F.B., Hunt,S.E., Hypponen,E., Iribarren,C., Jacobs,K.B.,
            Jansson,J.O., Jula,A., Kahonen,M., Kathiresan,S., Kee,F.,
            Khaw,K.T., Kivimaki,M., Koenig,W., Kraja,A.T., Kumari,M.,
            Kuulasmaa,K., Kuusisto,J., Laitinen,J.H., Lakka,T.A.,
            Langenberg,C., Launer,L.J., Lind,L., Lindstrom,J., Liu,J.,
            Liuzzi,A., Lokki,M.L., Lorentzon,M., Madden,P.A., Magnusson,P.K.,
            Manunta,P., Marek,D., Marz,W., Mateo Leach,I., McKnight,B.,
            Medland,S.E., Mihailov,E., Milani,L., Montgomery,G.W., Mooser,V.,
            Muhleisen,T.W., Munroe,P.B., Musk,A.W., Narisu,N., Navis,G.,
            Nicholson,G., Nohr,E.A., Ong,K.K., Oostra,B.A., Palmer,C.N.,
            Palotie,A., Peden,J.F., Pedersen,N., Peters,A., Polasek,O.,
            Pouta,A., Pramstaller,P.P., Prokopenko,I., Putter,C.,
            Radhakrishnan,A., Raitakari,O., Rendon,A., Rivadeneira,F.,
            Rudan,I., Saaristo,T.E., Sambrook,J.G., Sanders,A.R., Sanna,S.,
            Saramies,J., Schipf,S., Schreiber,S., Schunkert,H., Shin,S.Y.,
            Signorini,S., Sinisalo,J., Skrobek,B., Soranzo,N., Stancakova,A.,
            Stark,K., Stephens,J.C., Stirrups,K., Stolk,R.P., Stumvoll,M.,
            Swift,A.J., Theodoraki,E.V., Thorand,B., Tregouet,D.A., Tremoli,E.,
            Van der Klauw,M.M., van Meurs,J.B., Vermeulen,S.H., Viikari,J.,
            Virtamo,J., Vitart,V., Waeber,G., Wang,Z., Widen,E., Wild,S.H.,
            Willemsen,G., Winkelmann,B.R., Witteman,J.C., Wolffenbuttel,B.H.,
            Wong,A., Wright,A.F., Zillikens,M.C., Amouyel,P., Boehm,B.O.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Cupples,L.A., Cusi,D., Dedoussis,G.V., Erdmann,J., Eriksson,J.G.,
            Franks,P.W., Froguel,P., Gieger,C., Gyllensten,U., Hamsten,A.,
            Harris,T.B., Hengstenberg,C., Hicks,A.A., Hingorani,A., Hinney,A.,
            Hofman,A., Hovingh,K.G., Hveem,K., Illig,T., Jarvelin,M.R.,
            Jockel,K.H., Keinanen-Kiukaanniemi,S.M., Kiemeney,L.A., Kuh,D.,
            Laakso,M., Lehtimaki,T., Levinson,D.F., Martin,N.G., Metspalu,A.,
            Morris,A.D., Nieminen,M.S., Njolstad,I., Ohlsson,C.,
            Oldehinkel,A.J., Ouwehand,W.H., Palmer,L.J., Penninx,B., Power,C.,
            Province,M.A., Psaty,B.M., Qi,L., Rauramaa,R., Ridker,P.M.,
            Ripatti,S., Salomaa,V., Samani,N.J., Snieder,H., Sorensen,T.I.,
            Spector,T.D., Stefansson,K., Tonjes,A., Tuomilehto,J.,
            Uitterlinden,A.G., Uusitupa,M., van der Harst,P., Vollenweider,P.,
            Wallaschofski,H., Wareham,N.J., Watkins,H., Wichmann,H.E.,
            Wilson,J.F., Abecasis,G.R., Assimes,T.L., Barroso,I., Boehnke,M.,
            Borecki,I.B., Deloukas,P., Fox,C.S., Frayling,T., Groop,L.C.,
            Haritunian,T., Heid,I.M., Hunter,D., Kaplan,R.C., Karpe,F.,
            Moffatt,M.F., Mohlke,K.L., O'Connell,J.R., Pawitan,Y., Schadt,E.E.,
            Schlessinger,D., Steinthorsdottir,V., Strachan,D.P.,
            Thorsteinsdottir,U., van Duijn,C.M., Visscher,P.M., Di Blasio,A.M.,
            Hirschhorn,J.N., Lindgren,C.M., Morris,A.P., Meyre,D., Scherag,A.,
            McCarthy,M.I., Speliotes,E.K., North,K.E., Loos,R.J. and
            Ingelsson,E.
  TITLE     Genome-wide meta-analysis identifies 11 new loci for anthropometric
            traits and provides insights into genetic architecture
  JOURNAL   Nat Genet 45 (5), 501-512 (2013)
   PUBMED   23563607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006028.3.
            
            On Jun 26, 2020 this sequence version replaced XM_011515150.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2986772.1,
                                           SRR14038192.1440197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156099 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683327.1/ ENSP00000506962.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC006028.3         173090-173184       c
            96-617              AC006028.3         160631-161152       c
            618-785             AC006028.3         158497-158664       c
            786-914             AC006028.3         152670-152798       c
            915-1084            AC006028.3         152142-152311       c
            1085-1261           AC006028.3         151570-151746       c
            1262-8615           AC006028.3         141703-149056       c
FEATURES             Location/Qualifiers
     source          1..8615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..8615
                     /gene="AMZ1"
                     /note="archaelysin family metallopeptidase 1"
                     /db_xref="GeneID:155185"
                     /db_xref="HGNC:HGNC:22231"
                     /db_xref="MIM:615168"
     exon            1..95
                     /gene="AMZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            96..617
                     /gene="AMZ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1810
                     /gene="AMZ1"
                     /note="isoform 1 is encoded by transcript variant 8;
                     archaemetzincin-1; metalloproteinase-like protein;
                     archeobacterial metalloproteinase-like protein 1"
                     /codon_start=1
                     /product="archaemetzincin-1 isoform 1"
                     /protein_id="NP_001371672.1"
                     /db_xref="CCDS:CCDS34589.1"
                     /db_xref="GeneID:155185"
                     /db_xref="HGNC:HGNC:22231"
                     /db_xref="MIM:615168"
                     /translation="MLQCRPAQEFSFGPRALKDALVSTDAALQQLYVSAFSPAERLFL
                     AEAYNPQRTLFCTLLIRTGFDWLLSRPEAPEDFQTFHASLQHRKPRLARKHIYLQPID
                     LSEEPVGSSLLHQLCSCTEAFFLGLRVKCLPSVAAASIRCSSRPSRDSDRLQLHTDGI
                     LSFLKNNKPGDALCVLGLTLSDLYPHEAWSFTFSKFLPGHEVGVCSFARFSGEFPKSG
                     PSAPDLALVEAAADGPEAPLQDRGWALCFSALGMVQCCKVTCHELCHLLGLGNCRWLR
                     CLMQGALSLDEALRRPLDLCPICLRKLQHVLGFRLIERYQRLYTWTQAVVGTWPSQEA
                     GEPSVWEDTPPASADSGMCCESDSEPGTSVSEPLTPDAGSHTFASGPEEGLSYLAASE
                     APLPPGGPAEAIKEHERWLAMCIQALQREVAEEDLVQVDRAVDALDRWEMFTGQLPAT
                     RQDPPSSRDSVGLRKVLGDKFSSLRRKLSARKLARAESAPRPWDGEES"
     exon            618..785
                     /gene="AMZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..914
                     /gene="AMZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1084
                     /gene="AMZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1261
                     /gene="AMZ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..8615
                     /gene="AMZ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4346..4351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMZ1"
                     /note="hexamer: ATTAAA"
     polyA_site      4368
                     /gene="AMZ1"
     regulatory      8535..8540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMZ1"
                     /note="hexamer: AATAAA"
     polyA_site      8562
                     /gene="AMZ1"
     regulatory      8595..8600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMZ1"
                     /note="hexamer: AATAAA"
     polyA_site      8615
                     /gene="AMZ1"
                     /note="major polyA site"
ORIGIN      
        1 gatcctcccg gcccaggccg agctgcccac gctgctgccc ggggctcggt gcccggcgcg
       61 gcctctgccg gctccggcgg gcgcgggact gcgagggtgc tgtgggccca gaagcgccca
      121 tgcctgagag cgtccaggac caggcagagc tgggccttaa gggcccttgg accagtgtct
      181 gtctgcaggg agcccccggt agccactcgg atcagcccga gggaagattc tggacgagac
      241 cgtggccgtc ccccgggtgg cccatggaca gcagcagggg ctcccaggag tggccaggcc
      301 ctgcccgccc accatgctgc agtgtagacc cgcacaggag ttcagcttcg ggccccgggc
      361 cttgaaggac gctctggtct ccactgacgc agccctgcag cagctgtatg tgtccgcctt
      421 ctcccctgcc gagcggctct tcctggccga ggcctacaac ccgcagagga cgctcttctg
      481 caccctgctc atccgcacgg gcttcgactg gctcctgagc cgacccgagg ctcccgagga
      541 cttccagacc ttccacgcct ccctgcagca ccggaagccc cgcctggctc ggaagcacat
      601 ctacctacag ccgatagacc tgagcgagga gccggtggga agctccctgc tgcaccagct
      661 gtgcagctgc acagaggcct tcttcctggg cctgcgcgtc aagtgcctgc cgtcggtggc
      721 agccgcgtcc atccgctgct cctcgcggcc cagccgggac tctgacaggc tccagctcca
      781 cacagacggc atcctgtcct tcttgaagaa caacaagcca ggggacgcgc tgtgtgtgct
      841 gggcctcaca ctgtctgacc tgtaccccca tgaggcctgg agcttcacct tcagcaagtt
      901 ccttccaggg cacgaagtgg gcgtctgcag cttcgcccgg ttctcagggg aattcccgaa
      961 gtcggggccc agcgcccctg atctggccct ggtagaggca gcagcagacg gccccgaggc
     1021 ccccctgcag gacaggggct gggccctgtg cttcagtgcc ctggggatgg ttcagtgctg
     1081 caaggtcacg tgccacgagc tctgccacct tctgggcctg gggaactgcc gctggctccg
     1141 ctgcctcatg cagggtgcgc tcagcctgga cgaggccctg cggcggcccc tggacctctg
     1201 tcccatctgc ctgaggaagc tgcagcatgt cctgggtttc aggctcatcg agaggtacca
     1261 gagactctac acctggactc aggcggtggt ggggacgtgg cccagccagg aggcggggga
     1321 gccgtcagtg tgggaggaca ccccgcctgc cagcgccgac tcgggcatgt gctgtgagag
     1381 tgactcggag cccggcacca gtgtgtcgga gcccctcacc cctgatgccg ggagtcacac
     1441 cttcgcctcg gggccagagg aagggctgag ctacctggca gcctcagagg ctccgctgcc
     1501 acctgggggc cctgcggagg ccatcaagga gcatgaacgg tggctggcca tgtgcatcca
     1561 ggccctgcag cgggaagtgg cagaggagga cctggtgcag gtggacagag ccgtggacgc
     1621 cctcgaccgc tgggagatgt tcacgggcca gctcccggcc accaggcagg acccacccag
     1681 cagcagggac agcgtggggc tgcgcaaggt gctgggggac aagttctcct ccctgaggag
     1741 gaagctgagt gcccgaaaac tcgccagagc agagtcggcc ccccgtccct gggatgggga
     1801 agagagttag tacagcaggg gctgccctac gtctccttcc ctaaggatgc tggccagcac
     1861 tgtccagtag ctgaggccac tactgacctg ccagggataa agaggaaggg tctgcctggg
     1921 tggtggctca ggcctgtcat cccatcactt tgagaggcca ggagtttgag accagactgg
     1981 gcaacatggt gagactctgc ctctacaaaa gaaaaattaa aaaattagct ggatgaagtg
     2041 gttcatgcct gtgttcccag ctattcagga ggctgaggtg ggaggattgc ttgagcctag
     2101 gaggtcgagg ctgcagtggg atgtgatcat accactgtac tgcagtctgg gccacacaga
     2161 aagactgtct ccagaaaaaa aaaagttctt tggagaagcc acagaccacc tgtcttcagg
     2221 cgcctccttc aactcctgag tcccagccag ccgctcccag gggcctgcac acatggagag
     2281 gcctccctga tcctgggtgc ttctcgtgga gtacaagccg gactgtgctg aggttgggac
     2341 agagccccct cccctgcaga ggcagaagga agcagcgtgc gtcctgtctc cttccaggct
     2401 gtgggcctgc ccttcagtta tttatagctg gagctggaga ggctggctca gatgaggagt
     2461 gaccccgggg gcacacaggc tccacactgc cacccagctt ccaaggctga gtctcctccc
     2521 taacggggaa gtgacggggt tttgtctcta tcatctcagg cgtcaaccac atgcacacac
     2581 acactgtcac gttctgtggc gctaacagca tcctgatcct gacggacttc accggggctc
     2641 tccaggcatc tcttctgaca aacactgcag gaggtgaggg tgtctgacgt gcactgaggg
     2701 cagaggcccc cttattcctg aggcggctac agctcaccgt ggggaagatc aactgtggtg
     2761 atgtttttgg gacagtttct tggcaaaggt ggccgcgctg tcagtaccaa gtagctggag
     2821 gtggtgatca gatgatctgt ctttcctttt tttttcggtc tagttctgtc agttgctgag
     2881 agaggggtat tattgccatg gctgggcgtt tgatctgtct ccctttagtt ttgccggatt
     2941 ttgcttcctg cactttgaag ctcctttacg tccctgcaca tttgattgtt gtgtcttcct
     3001 gaggaattga cccttttatt gtcacacgta ccccctcagc ctgtggtgga gggtctctgg
     3061 gagagagact tccggttctg acagcggaat cccttcggag tgacgagggc ggggtcacag
     3121 ctcgcgcacc ctcatctgga gagaggcaag aacagggcag cttggacctt ttgtgggtgg
     3181 gtggctcaca cggttatgga gggcttctaa gaaaaacaaa atacaaaact aaaactagaa
     3241 gggctatgca ggtgaggtgg gctgaggctt ccttgtgaat ctgacattgg tggaggccga
     3301 ctgaaggctc ccggtcctgg tcccactccg tgttgacttc agagaagcaa agatgcagct
     3361 cagaagtagc attaggatct tcgtcccgtt ctcttttgcg tagcttcaaa aaggcgtaac
     3421 agtgacctgg gaggggagat gaagagctag gcctttcaga aagtgaccaa tggaaggtgc
     3481 cggcagagca ccctgcagta acagaaggtg aaagccggag cctggtggct gttgctgcaa
     3541 acaaccaccc aaaacttagt ggcttaaaat caccacagtc tagctcatga atctgtaact
     3601 tgggcagagc tcggtggaga cggtttgccc ctgtggctcg actggagtgt tcgttcacac
     3661 ggctgccaag tggaatttgg ctgggaatct caggccttgg ttcctgccca cgtgagactc
     3721 tccatggagg aggggcatct tcttaggaag gcagctgcca taccgtgagg aaacccgaca
     3781 aacagggcag ccagagccag acagcaggct cctggtccca gtcccggaaa atgcaaaggg
     3841 acaagtatgt gttgatttca gagaagctca gatgtagcat taggaccttc atccataccc
     3901 ttctcttttg catggcttct aaagggcatg acagtgacct gggaggtaac tgtgccagaa
     3961 taaagagggg agacgaaaaa aagagggtca ctttcagaaa gggacctggg cttcctcaca
     4021 atatggcggt tgccctccta aggtggacat cgggagggtc agatggaagc tctgtggcct
     4081 ttcctaactc ggcctcacgt cacagagcgt cacctttcct gcactccacg gcggcagtga
     4141 caaggacccc accccaggtt cacggggagg ggacgtggca gggaatgtga gacaacacaa
     4201 tattgctgtg gccattcatg aacagtcagt cagccccact cggcgttcac tgtggggatt
     4261 tggctggtgc acctgcgagg tggcctgacc tgttttccga tttccttcat cttctgcaaa
     4321 aggttaaccg ctggagtgat gcgagattaa acagaggtga taaaaataga atgcctggct
     4381 catgctgagg gtgggagccc actggggtta tgaccaaagc ctcggcgctc tctgtacccg
     4441 tgtcctttga ccctcagctg tgatgtgtgt cccaaaaaag cgttttgaag tgggaaggag
     4501 caaaccacta aaaaaaactc cttttatccg cagcgtttac caacttgcag atgtcagtga
     4561 aattttttaa gacagctgtt agaaggactg ttttgaaatg caactttgag gaagagaaat
     4621 tggtttccct cctctccccc gtgttagccc caggttctgt ctgtgctgtg gtgaagagtg
     4681 acttgggaca gtcaccagga aagacgcaag gcagaggaga gagaatgagg gctgccttct
     4741 cgaggaaggt cacagctcac gaatctttct aaacttaagt gctgcagaag ttgaactgag
     4801 attaaattta gagatgatgg tttccaagac acacagggcc acggttcttt cagtttttaa
     4861 acacgtgcaa agtccactga attgctttct cgtctcatct gtcagaagcc cctgcattca
     4921 caaggatggg tcttccagct tgacgatgac ctctcttcgg agagcctcac ccatcttggt
     4981 aagccaagtc agcggggcct catggagcta aaaatagttt caggtcatga cagatgttat
     5041 ctgtattgct gtgtgtgcga tgagtctggg gaagctaaca catgccttct gaagtggcta
     5101 gaatacacac tcccacgtca cagccatgct atgatgaagg ggtgagaagc agtgtcccct
     5161 ctgaggcaaa tctctcttca ggcagccccg cagtcctctt ccgaaatctc attcttttcc
     5221 ctctcttcct ccccaaaaag cccaaactca ttgtcagagt ggggagaggg gagaagcagc
     5281 atcctgactc ctgtccatgg tgtgaaccct gagggcacgg gacagtgagt ggagctctgc
     5341 caccacccgt ttccagagca tgggtgagga gggagggatg ccgacctgtt aatatttgct
     5401 tcagaccttt ccccgatgaa cgaaatctcc aaaagcctta aacataaaat ggcttagtca
     5461 agcacgagtg ataaagctgg gagtccaaat ttagatccca ccaagttcaa agggggaggc
     5521 tagaacattc cagggacaca cctacacgca gagggtctcc atacagtgcc aagggagctg
     5581 ctctgcagac ccaccaggca gggacggcca ggcctcggag agagggaccg gctgccctgc
     5641 ccaaggccca cctggacagg caagtcttcc ctagtgggtc agtcaactcc accgcttaag
     5701 gggtccttcc tatgtaacgg aattttttta catcatcatc gagtctcgaa atgacctgta
     5761 aggcagatgg ctgcatcccc accatatggc tgtggctgtc gagatgggac tgggaagggc
     5821 tggagcctca gaaacggcag agcggaagtt gaggcgcagt ctgttcttgc ttgaaccccg
     5881 agttctcccg ctgttgtgca gctttctaaa agcaagctgg agcggtctga gcaggaagag
     5941 agtaagaagg cgcacggacg cgggaggcct gcaccctgat ccctgagcag cccccacaca
     6001 ccggcaccca cgcccctcgg ttctgataac caggaggctt tctggcccgt gcagctcctt
     6061 cggactctga ggagaggcct gggtgggtgg ccggcactct taggtgaggt gccaacgaaa
     6121 acacccccgt gattgctggg gcttcactga tttgttttgt ttataaaagg agggcgaggc
     6181 ctgcacagga atatttttat ccccgtgaag acggagagaa tcagggcttc gcgacggggc
     6241 tcatagacct gaactgggtc tgcctgcctg tgtgctggaa gcaaacgacg gcccgtcctc
     6301 taagctggct ttgcagctcc agtaagagtg agagactcac gggggcctgg ctgccgtcct
     6361 gggagaggcc ccgggaaccg gctcgccctg tacccaaggg ctctctggag ctcaccccgc
     6421 acgcaggctg ctccagagct gaaatctagc tgtgatccct gtggggcaac tgcacacaga
     6481 ggtgcccagt ttcaaggaaa cctaaagcag cagcaaattt atggctcttg gaacacgagg
     6541 ctgtcaaaga taaacaccgc agggtaatct aggaaacact tccggcttga ctgtaaagag
     6601 ccctggcctg cgaacgctgt taaaaacaga tgcagatcgc gggtggagac ggccggccga
     6661 gccttccctt ttctgacatc ctacagcagc accttgatga atgagaaccc ggaagaatgg
     6721 aggtttattt ttgaactcag cttcttgggt agggaggcaa atgaaaacag gctgatgtca
     6781 ggggtttatt ttaaaaagca atttccaaga agcgtcctgg ggtcaccacg cgttcagtcc
     6841 aactcttccc cgctgcagtg ttcccgtgac gatgaggcaa atccaaatag tcaccggagt
     6901 cgagcaaaca cggcggcccc tgcctccccc ggcggctcca caatggccct cagagggtcc
     6961 gcggcagcca ggcccgtcca acctcctgcc ctctctgaga ggggcccgag ctctcgcaag
     7021 attaaccaga gacgacacct accagattcc accactgagg cctccctcga tgcctgctcc
     7081 ctgggctttt taatgaacgc acttctgtca catggaaact gagcccggca tggagtcacg
     7141 tggctccacc ctggggctcc tctgatgccg agagctctgg ctctcctgac tgtgggccca
     7201 gtgtccattt tctctctcag gcagggtgct ctgcccgcca cagtgtgcct ggttttctgg
     7261 atacagcatg actgaaccgc cccttctcag caaaggccaa cacgtctttc tcgagtccaa
     7321 gaccatctcc cgttcaaggg ccctcaccgc gctttgtgag tctgtctcgt gggcctcctt
     7381 cagtggtctg tgaccagcgg gaatgaatgg ggacgtgttt tgttcagccc tgactcttgg
     7441 acgctggtgg cagccgcggg cgcccactca cctggcacgt ggacgaaggt gatgagcgcg
     7501 gctgacggct cccgggggca gtgtggggtc cagtctgaag ccgacgcccc tctcggtcag
     7561 gctttcagca gcagaaggca gtggactctt caccatttct tccaacactt tctcacgtag
     7621 gagctccact gtcccttcta acaggacagg gcttgtgcag ccgggcttgg tcttgtggtc
     7681 agggagaagc gggcaggcca gggccgagct gcgtccggct ctcagggact tcctctccct
     7741 gtgctctgcc cacctggggt aggcctctgg gaacagggga gtcacagaaa ccacgggaaa
     7801 cggagtgggt tggaagaggc agagaacacg cttttctcag ggtcgcttaa cacaggcagg
     7861 ggtacaggag agctccggcc atttattcca aatgtatgag caggaaggaa agagggaggg
     7921 aagctgcaag aacaggcgac tttttttttt ttttttcccc cccatctgaa gtgagatcaa
     7981 acttctacca cattctacct gtgcccttct gggtgggtgg tggccgtcct cttgggcgcc
     8041 cccttgtgag ggctcgaggc ctttactgga tgggcaggat gcgggcagca gctttgtcgg
     8101 ctgccaaccc aactcctccg acagaacggc aggtggcccc tgtcggaagg ggggtgtctc
     8161 tttattcctg ccatcctccg gccgcctctc ccgcctgcac cacttggagg cagttgtttc
     8221 acgtggggct cttgatggca taacctgatg tctgtcacgg acccccaagc aggagcaatg
     8281 cctaaagagg gcaaaggccc gcgcgcctgg cagagctccc tcctctgctc caacagcaga
     8341 gcccagagca tcccttggcc cgacgcacaa gtcccacaat agcctctccc aacgggaacg
     8401 acttagccct aattacatga gctttgatca ccgctcgatt gtatggcaca gttattttta
     8461 aaaatccagt ccaagtggaa atacacctgg aacattttat actgcaatga ctgatggacg
     8521 actttgatat acaaaataaa ttgttactca gcttttctat aatgcttaca tcttacattt
     8581 tcattctcaa aattaataaa tgctatcaac cccaa
//
