LOCUS       NM_001386925            1786 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens amylase alpha 1B (AMY1B), transcript variant 2, mRNA.
ACCESSION   NM_001386925 XM_011541262
VERSION     NM_001386925.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Barber,T.M., Bhatti,A.A., Elder,P.J.D., Ball,S.P., Calvez,R.,
            Ramsden,D.B., Cuthbertson,D.J., Pfeiffer,A.F., Burnett,D. and
            Weickert,M.O.
  TITLE     AMY1 Gene Copy Number Correlates With Glucose Absorption and
            Visceral Fat Volume, but Not with Insulin Resistance
  JOURNAL   J Clin Endocrinol Metab 105 (10) (2020)
   PUBMED   32697825
  REMARK    GeneRIF: AMY1 Gene Copy Number Correlates With Glucose Absorption
            and Visceral Fat Volume, but Not with Insulin Resistance.
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Valsesia,A., Kulkarni,S.S., Marquis,J., Leone,P., Mironova,P.,
            Walter,O., Hjorth,M.F., Descombes,P., Hager,J., Saris,W.H.,
            Astrup,A., Darimont,C. and O'Callaghan,N.J.
  TITLE     Salivary alpha-amylase copy number is not associated with weight
            trajectories and glycemic improvements following clinical weight
            loss: results from a 2-phase dietary intervention study
  JOURNAL   Am J Clin Nutr 109 (4), 1029-1037 (2019)
   PUBMED   30982860
  REMARK    GeneRIF: At baseline, a modest association between AMY1 gene copy
            number and BMI (P = 0.04) was observed but AMY1 gene copy was not
            associated with baseline glycemic variables.
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Carpenter,D., Mitchell,L.M. and Armour,J.A.
  TITLE     Copy number variation of human AMY1 is a minor contributor to
            variation in salivary amylase expression and activity
  JOURNAL   Hum Genomics 11 (1), 2 (2017)
   PUBMED   28219410
  REMARK    GeneRIF: AMY1 copy number was significantly correlated with the
            variation observed in salivary amylase production and enzyme
            activity but did not explain the majority of observed variation
            between individuals. AMY1-odd and AMY1-even haplotypes showed a
            different relationship between copy number and expression levels,
            but the difference was not statistically significant.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Groot,P.C., Mager,W.H., Henriquez,N.V., Pronk,J.C., Arwert,F.,
            Planta,R.J., Eriksson,A.W. and Frants,R.R.
  TITLE     Evolution of the human alpha-amylase multigene family through
            unequal, homologous, and inter- and intrachromosomal crossovers
  JOURNAL   Genomics 8 (1), 97-105 (1990)
   PUBMED   2081604
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Groot,P.C., Bleeker,M.J., Pronk,J.C., Arwert,F., Mager,W.H.,
            Planta,R.J., Eriksson,A.W. and Frants,R.R.
  TITLE     The human alpha-amylase multigene family consists of haplotypes
            with variable numbers of genes
  JOURNAL   Genomics 5 (1), 29-42 (1989)
   PUBMED   2788608
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   Gumucio,D.L., Wiebauer,K., Caldwell,R.M., Samuelson,L.C. and
            Meisler,M.H.
  TITLE     Concerted evolution of human amylase genes
  JOURNAL   Mol Cell Biol 8 (3), 1197-1205 (1988)
   PUBMED   2452973
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   Nishide,T., Nakamura,Y., Emi,M., Yamamoto,T., Ogawa,M., Mori,T. and
            Matsubara,K.
  TITLE     Primary structure of human salivary alpha-amylase gene
  JOURNAL   Gene 41 (2-3), 299-304 (1986)
   PUBMED   2423416
REFERENCE   10 (bases 1 to 1786)
  AUTHORS   Pronk,J.C., Frants,R.R., Jansen,W., Eriksson,A.W. and Tonino,G.J.
  TITLE     Evidence of duplication of the human salivary amylase gene
  JOURNAL   Hum Genet 60 (1), 32-35 (1982)
   PUBMED   6176528
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513482.13.
            
            On Sep 18, 2020 this sequence version replaced XM_011541262.1.
            
            Summary: Amylases are secreted proteins that hydrolyze
            1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides,
            and thus catalyze the first step in digestion of dietary starch and
            glycogen. The human genome has a cluster of several amylase genes
            that are expressed at high levels in either salivary gland or
            pancreas. This gene encodes an amylase isoenzyme produced by the
            salivary gland. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL513482.13        29880-30049         c
            171-384             AL513482.13        29068-29281         c
            385-531             AL513482.13        28576-28722         c
            532-729             AL513482.13        27575-27772         c
            730-960             AL513482.13        26896-27126         c
            961-1094            AL513482.13        26023-26156         c
            1095-1217           AL513482.13        25084-25206         c
            1218-1317           AL513482.13        24890-24989         c
            1318-1436           AL513482.13        22790-22908         c
            1437-1562           AL513482.13        22554-22679         c
            1563-1786           AL513482.13        21011-21234         c
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.1"
     gene            1..1786
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /note="amylase alpha 1B"
                     /db_xref="GeneID:277"
                     /db_xref="HGNC:HGNC:475"
                     /db_xref="MIM:104701"
     exon            1..170
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..384
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1752
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /EC_number="3.2.1.1"
                     /note="glycogenase; amylase, salivary, alpha-1B; salivary
                     amylase alpha 1B; alpha-amylase 1; salivary alpha-amylase;
                     1,4-alpha-D-glucan glucanohydrolase 1; amylase alpha 1B
                     (salivary); alpha-amylase 1A; alpha-amylase 1B"
                     /codon_start=1
                     /product="alpha-amylase 1B precursor"
                     /protein_id="NP_001373854.1"
                     /db_xref="CCDS:CCDS30783.1"
                     /db_xref="GeneID:277"
                     /db_xref="HGNC:HGNC:475"
                     /db_xref="MIM:104701"
                     /translation="MKLFWLLFTIGFCWAQYSSNTQQGRTSIVHLFEWRWVDIALECE
                     RYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCN
                     NVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGS
                     GDIENYNDATQVRDCRLSGLLDLALGKDYVRSKIAEYMNHLIDIGVAGFRIDASKHMW
                     PGDIKAILDKLHNLNSNWFPEGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAK
                     LGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDAR
                     LYKMAVGFMLAHPYGFTRVMSSYRWPRYFENGKDVNDWVGPPNDNGVTKEVTINPDTT
                     CGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWT
                     FSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAE
                     SKL"
     exon            385..531
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..729
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..960
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1094
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1217
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1317
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1436
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1562
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1786
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttctcaa tatcagcact ggattgtaga acttgttgct gattttggcc tggcattcaa
       61 gttaactctt ccccttggta tctgtacata cctttgatgt cagtgtttag tacacgtggc
      121 ttggtcactt catggctaaa aacgtgcttg tggaagacaa gtctggcttg gaatataaat
      181 agtttctgga aaggacactg acaacttcaa agcaaaatga agctcttttg gttgcttttc
      241 accattgggt tctgctgggc tcagtattcc tcaaatacac aacaaggacg aacatctatt
      301 gttcatctgt ttgaatggcg atgggttgat attgctcttg aatgtgagcg atatttagct
      361 cccaagggat ttggaggggt tcaggtctct ccaccaaatg aaaatgttgc cattcacaac
      421 cctttcagac cttggtggga aagataccaa ccagttagct ataaattatg cacaagatct
      481 ggaaatgaag atgaatttag aaacatggtg actagatgca acaatgttgg ggttcgtatt
      541 tatgtggatg ctgtaattaa tcatatgtgt ggtaatgctg tgagtgcagg aacaagcagt
      601 acctgtggaa gttacttcaa ccctggaagt agggactttc cagcagtccc atattctgga
      661 tgggatttta atgatggtaa atgtaaaact ggaagtggag atatcgagaa ctataatgat
      721 gctactcagg tcagagattg tcgtctgtct ggtcttctcg atcttgcact ggggaaggat
      781 tatgtgcgtt ctaagattgc cgaatatatg aaccatctca ttgacattgg tgttgcaggg
      841 ttcagaattg atgcttccaa gcacatgtgg cctggagaca taaaggcaat tttggacaaa
      901 ctgcataatc taaacagtaa ctggttcccg gaaggtagta aacctttcat ttaccaggag
      961 gtaattgatc tgggtggtga gccaattaaa agcagtgact actttggtaa tggccgggtg
     1021 acagaattca agtatggtgc aaaactcggc acagttattc gcaagtggaa tggagagaag
     1081 atgtcttact taaagaactg gggagaaggt tggggtttca tgccttctga cagagcgctt
     1141 gtctttgtgg ataaccatga caatcaacga ggacatggcg ctggaggagc ctctatactt
     1201 accttctggg atgctaggct gtacaaaatg gcagttggat ttatgcttgc tcatccttat
     1261 ggatttacac gagtaatgtc aagctaccgt tggccaagat attttgaaaa tggaaaagat
     1321 gttaatgatt gggttgggcc accaaatgat aatggagtaa ctaaagaagt tactattaat
     1381 ccagacacta cttgtggcaa tgactgggtc tgtgaacatc gatggcgcca aataaggaac
     1441 atggttaatt tccgcaatgt agtggatggc cagcctttta caaactggta tgataatggg
     1501 agcaaccaag tggcttttgg gagaggaaac agaggattca ttgttttcaa caatgatgac
     1561 tggacatttt ctttaacttt gcaaactggt cttcctgctg gcacatactg tgatgtcatt
     1621 tctggagata aaattaatgg caactgcaca ggcattaaaa tctacgtttc tgatgatggc
     1681 aaagctcatt tttctattag taactctgct gaagatccat ttattgcaat tcatgctgaa
     1741 tctaaattgt aaaatttaaa attaaatgca aatccgcaaa gcaata
//
