LOCUS       NM_001008218            1785 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens amylase alpha 1B (AMY1B), transcript variant 1, mRNA.
ACCESSION   NM_001008218
VERSION     NM_001008218.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1785)
  AUTHORS   Barber,T.M., Bhatti,A.A., Elder,P.J.D., Ball,S.P., Calvez,R.,
            Ramsden,D.B., Cuthbertson,D.J., Pfeiffer,A.F., Burnett,D. and
            Weickert,M.O.
  TITLE     AMY1 Gene Copy Number Correlates With Glucose Absorption and
            Visceral Fat Volume, but Not with Insulin Resistance
  JOURNAL   J Clin Endocrinol Metab 105 (10) (2020)
   PUBMED   32697825
  REMARK    GeneRIF: AMY1 Gene Copy Number Correlates With Glucose Absorption
            and Visceral Fat Volume, but Not with Insulin Resistance.
REFERENCE   3  (bases 1 to 1785)
  AUTHORS   Valsesia,A., Kulkarni,S.S., Marquis,J., Leone,P., Mironova,P.,
            Walter,O., Hjorth,M.F., Descombes,P., Hager,J., Saris,W.H.,
            Astrup,A., Darimont,C. and O'Callaghan,N.J.
  TITLE     Salivary alpha-amylase copy number is not associated with weight
            trajectories and glycemic improvements following clinical weight
            loss: results from a 2-phase dietary intervention study
  JOURNAL   Am J Clin Nutr 109 (4), 1029-1037 (2019)
   PUBMED   30982860
  REMARK    GeneRIF: At baseline, a modest association between AMY1 gene copy
            number and BMI (P = 0.04) was observed but AMY1 gene copy was not
            associated with baseline glycemic variables.
REFERENCE   4  (bases 1 to 1785)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1785)
  AUTHORS   Carpenter,D., Mitchell,L.M. and Armour,J.A.
  TITLE     Copy number variation of human AMY1 is a minor contributor to
            variation in salivary amylase expression and activity
  JOURNAL   Hum Genomics 11 (1), 2 (2017)
   PUBMED   28219410
  REMARK    GeneRIF: AMY1 copy number was significantly correlated with the
            variation observed in salivary amylase production and enzyme
            activity but did not explain the majority of observed variation
            between individuals. AMY1-odd and AMY1-even haplotypes showed a
            different relationship between copy number and expression levels,
            but the difference was not statistically significant.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1785)
  AUTHORS   Groot,P.C., Mager,W.H., Henriquez,N.V., Pronk,J.C., Arwert,F.,
            Planta,R.J., Eriksson,A.W. and Frants,R.R.
  TITLE     Evolution of the human alpha-amylase multigene family through
            unequal, homologous, and inter- and intrachromosomal crossovers
  JOURNAL   Genomics 8 (1), 97-105 (1990)
   PUBMED   2081604
REFERENCE   7  (bases 1 to 1785)
  AUTHORS   Groot,P.C., Bleeker,M.J., Pronk,J.C., Arwert,F., Mager,W.H.,
            Planta,R.J., Eriksson,A.W. and Frants,R.R.
  TITLE     The human alpha-amylase multigene family consists of haplotypes
            with variable numbers of genes
  JOURNAL   Genomics 5 (1), 29-42 (1989)
   PUBMED   2788608
REFERENCE   8  (bases 1 to 1785)
  AUTHORS   Gumucio,D.L., Wiebauer,K., Caldwell,R.M., Samuelson,L.C. and
            Meisler,M.H.
  TITLE     Concerted evolution of human amylase genes
  JOURNAL   Mol Cell Biol 8 (3), 1197-1205 (1988)
   PUBMED   2452973
REFERENCE   9  (bases 1 to 1785)
  AUTHORS   Nishide,T., Nakamura,Y., Emi,M., Yamamoto,T., Ogawa,M., Mori,T. and
            Matsubara,K.
  TITLE     Primary structure of human salivary alpha-amylase gene
  JOURNAL   Gene 41 (2-3), 299-304 (1986)
   PUBMED   2423416
REFERENCE   10 (bases 1 to 1785)
  AUTHORS   Pronk,J.C., Frants,R.R., Jansen,W., Eriksson,A.W. and Tonino,G.J.
  TITLE     Evidence of duplication of the human salivary amylase gene
  JOURNAL   Hum Genet 60 (1), 32-35 (1982)
   PUBMED   6176528
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513482.13.
            
            On Sep 16, 2020 this sequence version replaced NM_001008218.1.
            
            Summary: Amylases are secreted proteins that hydrolyze
            1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides,
            and thus catalyze the first step in digestion of dietary starch and
            glycogen. The human genome has a cluster of several amylase genes
            that are expressed at high levels in either salivary gland or
            pancreas. This gene encodes an amylase isoenzyme produced by the
            salivary gland. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.600112.1,
                                           DRR138524.14726.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330330.10/ ENSP00000330484.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AL513482.13        29638-29806         c
            170-383             AL513482.13        29068-29281         c
            384-530             AL513482.13        28576-28722         c
            531-728             AL513482.13        27575-27772         c
            729-959             AL513482.13        26896-27126         c
            960-1093            AL513482.13        26023-26156         c
            1094-1216           AL513482.13        25084-25206         c
            1217-1316           AL513482.13        24890-24989         c
            1317-1435           AL513482.13        22790-22908         c
            1436-1561           AL513482.13        22554-22679         c
            1562-1785           AL513482.13        21011-21234         c
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.1"
     gene            1..1785
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /note="amylase alpha 1B"
                     /db_xref="GeneID:277"
                     /db_xref="HGNC:HGNC:475"
                     /db_xref="MIM:104701"
     exon            1..169
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..383
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1751
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /EC_number="3.2.1.1"
                     /note="glycogenase; amylase, salivary, alpha-1B; salivary
                     amylase alpha 1B; alpha-amylase 1; salivary alpha-amylase;
                     1,4-alpha-D-glucan glucanohydrolase 1; amylase alpha 1B
                     (salivary); alpha-amylase 1A; alpha-amylase 1B"
                     /codon_start=1
                     /product="alpha-amylase 1B precursor"
                     /protein_id="NP_001008219.1"
                     /db_xref="CCDS:CCDS30783.1"
                     /db_xref="GeneID:277"
                     /db_xref="HGNC:HGNC:475"
                     /db_xref="MIM:104701"
                     /translation="MKLFWLLFTIGFCWAQYSSNTQQGRTSIVHLFEWRWVDIALECE
                     RYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCN
                     NVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGS
                     GDIENYNDATQVRDCRLSGLLDLALGKDYVRSKIAEYMNHLIDIGVAGFRIDASKHMW
                     PGDIKAILDKLHNLNSNWFPEGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAK
                     LGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDAR
                     LYKMAVGFMLAHPYGFTRVMSSYRWPRYFENGKDVNDWVGPPNDNGVTKEVTINPDTT
                     CGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWT
                     FSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAE
                     SKL"
     exon            384..530
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..728
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..959
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1093
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1216
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1316
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1435
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1561
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1785
                     /gene="AMY1B"
                     /gene_synonym="AMY1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctagaggc tgggaagggc tcctgaacca gttgtttccg tcttgtcggt ctgtcagggt
       61 tggaaagtcc aagccatagg acccagtttc ctttcttagc ttacgttatc taccagagca
      121 ccgtgggctg ttacttgcct tgagttggaa gcggttcgca tttataccgg aatataaata
      181 gtttctggaa aggacactga caacttcaaa gcaaaatgaa gctcttttgg ttgcttttca
      241 ccattgggtt ctgctgggct cagtattcct caaatacaca acaaggacga acatctattg
      301 ttcatctgtt tgaatggcga tgggttgata ttgctcttga atgtgagcga tatttagctc
      361 ccaagggatt tggaggggtt caggtctctc caccaaatga aaatgttgcc attcacaacc
      421 ctttcagacc ttggtgggaa agataccaac cagttagcta taaattatgc acaagatctg
      481 gaaatgaaga tgaatttaga aacatggtga ctagatgcaa caatgttggg gttcgtattt
      541 atgtggatgc tgtaattaat catatgtgtg gtaatgctgt gagtgcagga acaagcagta
      601 cctgtggaag ttacttcaac cctggaagta gggactttcc agcagtccca tattctggat
      661 gggattttaa tgatggtaaa tgtaaaactg gaagtggaga tatcgagaac tataatgatg
      721 ctactcaggt cagagattgt cgtctgtctg gtcttctcga tcttgcactg gggaaggatt
      781 atgtgcgttc taagattgcc gaatatatga accatctcat tgacattggt gttgcagggt
      841 tcagaattga tgcttccaag cacatgtggc ctggagacat aaaggcaatt ttggacaaac
      901 tgcataatct aaacagtaac tggttcccgg aaggtagtaa acctttcatt taccaggagg
      961 taattgatct gggtggtgag ccaattaaaa gcagtgacta ctttggtaat ggccgggtga
     1021 cagaattcaa gtatggtgca aaactcggca cagttattcg caagtggaat ggagagaaga
     1081 tgtcttactt aaagaactgg ggagaaggtt ggggtttcat gccttctgac agagcgcttg
     1141 tctttgtgga taaccatgac aatcaacgag gacatggcgc tggaggagcc tctatactta
     1201 ccttctggga tgctaggctg tacaaaatgg cagttggatt tatgcttgct catccttatg
     1261 gatttacacg agtaatgtca agctaccgtt ggccaagata ttttgaaaat ggaaaagatg
     1321 ttaatgattg ggttgggcca ccaaatgata atggagtaac taaagaagtt actattaatc
     1381 cagacactac ttgtggcaat gactgggtct gtgaacatcg atggcgccaa ataaggaaca
     1441 tggttaattt ccgcaatgta gtggatggcc agccttttac aaactggtat gataatggga
     1501 gcaaccaagt ggcttttggg agaggaaaca gaggattcat tgttttcaac aatgatgact
     1561 ggacattttc tttaactttg caaactggtc ttcctgctgg cacatactgt gatgtcattt
     1621 ctggagataa aattaatggc aactgcacag gcattaaaat ctacgtttct gatgatggca
     1681 aagctcattt ttctattagt aactctgctg aagatccatt tattgcaatt catgctgaat
     1741 ctaaattgta aaatttaaaa ttaaatgcaa atccgcaaag caata
//
