LOCUS       NM_016201               4868 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens angiomotin like 2 (AMOTL2), transcript variant 2,
            mRNA.
ACCESSION   NM_016201
VERSION     NM_016201.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4868)
  AUTHORS   Wang,H., Li,J., Yu,K., Lu,Y., Ma,M. and Li,Y.
  TITLE     The cellular localization and oncogenic or tumor suppressive
            effects of angiomiotin-like protein 2 in tumor and normal cells
  JOURNAL   IUBMB Life 76 (10), 764-779 (2024)
   PUBMED   38717123
  REMARK    GeneRIF: The cellular localization and oncogenic or tumor
            suppressive effects of angiomiotin-like protein 2 in tumor and
            normal cells.
            Review article
REFERENCE   2  (bases 1 to 4868)
  AUTHORS   Zhang,Y., Zhang,Y., Hutterer,E., Hultin,S., Bergman,O.,
            Kolbeinsdottir,S., Jin,H., Forteza,M.J., Ketelhuth,D.F.J., Roy,J.,
            Hedin,U., Enge,M., Matic,L., Eriksson,P. and Holmgren,L.
  TITLE     The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic
            inflammation and the formation of abdominal aortic aneurysms
  JOURNAL   Nat Cardiovasc Res 2 (7), 629-644 (2023)
   PUBMED   39195920
  REMARK    GeneRIF: The VE-cadherin/AmotL2 mechanosensory pathway suppresses
            aortic inflammation and the formation of abdominal aortic
            aneurysms.
REFERENCE   3  (bases 1 to 4868)
  AUTHORS   Rotoli,D., Diaz-Flores,L., Gutierrez,R., Morales,M., Avila,J. and
            Martin-Vasallo,P.
  TITLE     AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem
            Cell Niches
  JOURNAL   J Histochem Cytochem 70 (1), 9-16 (2022)
   PUBMED   34165350
  REMARK    GeneRIF: AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in
            Glioblastoma Stem Cell Niches.
            Review article
REFERENCE   4  (bases 1 to 4868)
  AUTHORS   Hwang,D., Kim,M., Kim,S., Kwon,M.R., Kang,Y.S., Kim,D., Kang,H.C.
            and Lim,D.S.
  TITLE     AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by
            facilitating LATS activation
  JOURNAL   Life Sci Alliance 4 (10), e202000953 (2021)
   PUBMED   34404733
  REMARK    GeneRIF: AMOTL2 mono-ubiquitination by WWP1 promotes contact
            inhibition by facilitating LATS activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4868)
  AUTHORS   Chen,X., Lu,Y., Guo,G., Zhang,Y., Sun,Y., Guo,L., Li,R., Nan,Y.,
            Yang,X., Dong,J., Jin,X. and Huang,Q.
  TITLE     AMOTL2-knockdown promotes the proliferation, migration and invasion
            of glioma by regulating beta-catenin nuclear localization
  JOURNAL   Oncol Rep 46 (1) (2021)
   PUBMED   34036399
  REMARK    GeneRIF: AMOTL2knockdown promotes the proliferation, migration and
            invasion of glioma by regulating betacatenin nuclear localization.
REFERENCE   6  (bases 1 to 4868)
  AUTHORS   Paramasivam,M., Sarkeshik,A., Yates,J.R. 3rd, Fernandes,M.J. and
            McCollum,D.
  TITLE     Angiomotin family proteins are novel activators of the LATS2 kinase
            tumor suppressor
  JOURNAL   Mol Biol Cell 22 (19), 3725-3733 (2011)
   PUBMED   21832154
  REMARK    GeneRIF: AMOTL2 is as a novel activator of LATS2.
REFERENCE   7  (bases 1 to 4868)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 4868)
  AUTHORS   Wang,W., Huang,J. and Chen,J.
  TITLE     Angiomotin-like proteins associate with and negatively regulate
            YAP1
  JOURNAL   J Biol Chem 286 (6), 4364-4370 (2011)
   PUBMED   21187284
REFERENCE   9  (bases 1 to 4868)
  AUTHORS   Zhao,B., Li,L., Lu,Q., Wang,L.H., Liu,C.Y., Lei,Q. and Guan,K.L.
  TITLE     Angiomotin is a novel Hippo pathway component that inhibits YAP
            oncoprotein
  JOURNAL   Genes Dev 25 (1), 51-63 (2011)
   PUBMED   21205866
REFERENCE   10 (bases 1 to 4868)
  AUTHORS   Bratt,A., Wilson,W.J., Troyanovsky,B., Aase,K., Kessler,R., Van
            Meir,E.G. and Holmgren,L.
  TITLE     Angiomotin belongs to a novel protein family with conserved
            coiled-coil and PDZ binding domains
  JOURNAL   Gene 298 (1), 69-77 (2002)
   PUBMED   12406577
  REMARK    Erratum:[Gene. 2003 May 22;310;231. Meir, EG [corrected to Van
            Meir, EG]]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA330301.1, AK291616.1,
            BC011454.1, AF175966.1, AW294642.1 and AI214560.1.
            
            On Jun 2, 2019 this sequence version replaced NM_016201.3.
            
            Summary: Angiomotin is a protein that binds angiostatin, a
            circulating inhibitor of the formation of new blood vessels
            (angiogenesis). Angiomotin mediates angiostatin inhibition of
            endothelial cell migration and tube formation in vitro. The protein
            encoded by this gene is related to angiomotin and is a member of
            the motin protein family. Alternative splicing results in multiple
            transcript variants of this gene. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, uses an
            alternate in-frame splice site in the 3' coding region and
            initiates translation at a downstream start site, compared to
            variant 1. It encodes isoform 2, which is shorter at the N-terminus
            and contains an additional internal amino acid compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.108581.1,
                                           SRR1803614.100505.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249883.10/ ENSP00000249883.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                DA330301.1         125-198
            75-2362             AK291616.1         157-2444
            2363-4079           BC011454.1         1464-3180
            4080-4338           AF175966.1         3284-3542
            4339-4529           AW294642.1         184-374
            4530-4868           AI214560.1         3-341               c
FEATURES             Location/Qualifiers
     source          1..4868
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.2"
     gene            1..4868
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /note="angiomotin like 2"
                     /db_xref="GeneID:51421"
                     /db_xref="HGNC:HGNC:17812"
                     /db_xref="MIM:614658"
     exon            1..106
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     exon            107..901
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2510
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /note="isoform 2 is encoded by transcript variant 2; Leman
                     coiled-coil protein; angiomotin-like protein 2"
                     /codon_start=1
                     /product="angiomotin-like protein 2 isoform 2"
                     /protein_id="NP_057285.3"
                     /db_xref="CCDS:CCDS33860.1"
                     /db_xref="GeneID:51421"
                     /db_xref="HGNC:HGNC:17812"
                     /db_xref="MIM:614658"
                     /translation="MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAG
                     TGGTGSPQASLEILAPEDSQVLQQATRQEPQGQEHQGGENHLAENTLYRLCPQPSKGE
                     ELPTYEEAKAHSQYYAAQQAGTRPHAGDRDPRGAPGGSRRQDEALRELRHGHVRSLSE
                     RLLQLSLERNGARAPSHMSSSHSFPQLARNQQGPPLRGPPAEGPESRGPPPQYPHVVL
                     AHETTTAVTDPRYRARGSPHFQHAEVRILQAQVPPVFLQQQQQYQYLQQSQEHPPPPH
                     PAALGHGPLSSLSPPAVEGPVSAQASSATSGSAHLAQMEAVLRENARLQRDNERLQRE
                     LESSAEKAGRIEKLESEIQRLSEAHESLTRASSKREALEKTMRNKMDSEMRRLQDFNR
                     DLRERLESANRRLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIED
                     QRRRAELLEQALGNAQGRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLEL
                     RLRTRLEQELKALRAQQRQAGAPGGSSGSGGSPELSALRLSEQLREKEEQILALEADM
                     TKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLTGGHRHQE
                     MESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQGSLRPAKSVPSVFAAAAAGTQGW
                     QGLSSSERQTADAPARLTTADRAPTEEPVVTAPPAAHAKHGSRDGSTQTEGPPDSTST
                     CLPPEPDSLLGCSSSQRAASLDSVATSRVQDLSDMVEILI"
     exon            902..1208
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1353
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1446
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1742
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..2050
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2271
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2451
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..4868
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4318..4323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /note="hexamer: ATTAAA"
     regulatory      4332..4337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /note="hexamer: ATTAAA"
     polyA_site      4342
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /note="major polyA site"
     polyA_site      4352
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
     regulatory      4849..4854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
                     /note="hexamer: ATTAAA"
     polyA_site      4868
                     /gene="AMOTL2"
                     /gene_synonym="LCCP"
ORIGIN      
        1 agagcgtcgg cgccacggcc gagaacacat cttcgccgcc gagctgagct gggccgagcc
       61 ggaggttgtg gtgtctgact gcgctgggca ccctcgggcc gcagcggtgc tctggggcca
      121 ggtgccaccg gccattgtcc aggcagctgt gtgcaagcca aagaagcatg aggacactgg
      181 aagactcctc ggggacagtc ctgcaccgcc tcatccagga gcagctgcgc tacggcaacc
      241 tgactgagac gcgcacgctg ctagccatcc agcagcaggc cctgaggggt ggggctggaa
      301 ctgggggtac agggagcccc caggcctccc tggagatcct ggccccagag gacagtcagg
      361 tgctgcagca ggccaccagg caggagcccc agggccagga gcaccagggc ggtgagaacc
      421 acctggcaga gaacaccctc taccggctat gcccacagcc cagcaaggga gaggagctgc
      481 ccacctatga ggaggccaaa gcccactcgc agtactatgc ggcccagcag gcagggaccc
      541 ggccacatgc gggggaccga gatccccgtg gggccccggg aggcagtcgg aggcaggacg
      601 aggccctgcg ggagctgagg catgggcacg tgcgctcgtt gagtgaacgg ctccttcagt
      661 tgtccctgga gaggaacggc gcccgggccc ccagccacat gagctcctcc cacagcttcc
      721 cacagctggc ccgcaaccag cagggccccc cactgagggg cccccctgct gagggcccag
      781 agtcccgagg acccccacct cagtaccctc atgttgtact agctcatgag accaccactg
      841 ctgtcactga cccacggtac cgtgcccgcg gcagcccgca cttccagcat gctgaagtca
      901 ggatcctgca ggcccaggtg cctcctgtgt tcctccaaca gcagcagcag taccagtacc
      961 tgcagcaatc tcaggagcac ccccctcccc cacatccagc tgctctcggc catggccccc
     1021 tgagctccct cagtccacct gctgtggagg ggccagtgag tgcccaggcc tcctcagcca
     1081 cctcgggcag tgcccacctg gcccagatgg aggccgtgct gagggagaat gccaggctgc
     1141 agagagacaa tgagcggctg cagagggagc tggagagctc tgcggagaag gctggccgca
     1201 ttgagaagct ggaaagcgaa atccagcggc tctctgaggc ccatgagagc ctgaccagag
     1261 cctcctccaa gcgtgaggcc ctggagaaga ccatgcggaa caagatggac agtgaaatga
     1321 ggaggctgca agacttcaac cgggatctta gagagagatt ggaatctgca aatcgccgcc
     1381 tggcaagcaa gacacaggag gcccaggccg gcagtcagga catggtggcc aagctgcttg
     1441 ctcagagcta cgaacagcag caggagcaag agaagctgga gcgagagatg gcactgctgc
     1501 gcggcgccat cgaggaccag cggcggcgtg ccgagctgct ggagcaggct ctgggcaatg
     1561 cgcagggccg ggcagctcga gccgaagagg agctgcgcaa gaagcaggcc tatgtggaga
     1621 aagtggagcg gctgcagcag gcgctcgggc agctgcaggc agcctgtgag aagcgggagc
     1681 agctggagct gcgtctgcgg actcgcctgg agcaggaact caaggccctg cgtgcacagc
     1741 agagacaggc aggtgcccca ggtggtagca gtggcagtgg tgggtctcca gagctcagcg
     1801 ccctgcgact gtcagaacaa ctgcgagaga aggaggagca gatcctggcg ctggaggccg
     1861 acatgaccaa gtgggagcag aagtatttgg aggaacgtgc catgaggcag tttgccatgg
     1921 atgcggctgc cacggctgct gctcagcgtg acaccactct catccgacat tccccccagc
     1981 cctcacccag cagcagcttc aatgagggtc tgctcactgg tggccacagg catcaggaga
     2041 tggaaagcag gttaaaggtg ctccatgccc agatcctgga gaaggatgca gtgatcaagg
     2101 tccttcagca gcgctccagg agagaccctg gcaaggccat ccagggctcc ctgcggcctg
     2161 ccaagtcggt gccatctgtt ttcgcggctg cggcagcagg aacccagggc tggcaagggc
     2221 tctcttctag tgagcgacaa acagcagacg cccctgctcg gctgactaca gcagacagag
     2281 cacccacaga ggagccagtg gtcacagctc cccctgctgc ccatgccaaa cacgggagca
     2341 gagatgggag cacccagact gagggccccc cagacagcac ctccacctgc ctgccaccgg
     2401 agcctgacag ccttctgggg tgcagcagta gccagagagc agcctctctg gactctgtag
     2461 ctacatccag agtccaggac ttgtcagaca tggtggagat actgatctga aggaggtggt
     2521 gcttcaggac tctgagccat tctctcccct cctctgccct gtgccactct cagccatttc
     2581 agcagccccg tcaaccgctg ctccgtccct ttccccagcc agacactcat tcccattgac
     2641 catctggtcc caggagctca ggaggaggac cccaggggag aggagagctg tgagagcacc
     2701 ggcaccccca gaagactctg cttcttagcc cacattcctc cgggccttat ggagaatgag
     2761 gattcagcct tgacttcttg cccaaggcct gctactgggg tagcaactga cagctcagaa
     2821 aggagctgag ctccctctgc cctgccagtt gtcagtcagg cagggaggga gtggctgtgt
     2881 tggtttgggg aactaatttc cacggacggc tgcccgtgga caccaggtgg actggttcac
     2941 taatcaagtc agccatattg ttctctggct aagtttggtt ccagccaacg tcatctgctc
     3001 ttcagttcct cactgccttc ttgggatact aagacttgaa ttttttgggg actattaagg
     3061 gtgttagtct tggagaagac acagcctcac cttctcactt gctgtgggtg aggggccatt
     3121 taagtggact gggagacagt gcgcagtttg tatataattc cctttcttgt ggaacagaag
     3181 actgaggcct gcaggttccg atgtgtctcc atgggctgtg ctcccctctt cctactgtca
     3241 gtttctgaaa cttctgactg gcctcccagt tatgcctcct cctcaagttc ctggcccgtg
     3301 gatgttaaag ctgctcgatt cccaggatct cggctgcctt ttcctctatc ttgagcccta
     3361 taaatgccca cgggaccccc accaccagcc tcttgaagtg gctccacagc tcctgtccct
     3421 ggaacatcct gtcagtttgg tcataaaccc tgagccagat gaaatgagcc accgtgaaca
     3481 gacatctgcc atgcccccag gtgggcttcg gtggccctac ccggtaccag ttctttctga
     3541 gaaactggag atgtcttgtt agcataagtg tcttcattcc cacctggagg gtttgggaga
     3601 ggagcaaagc agttgaaaac tagttaatga gctacaagag tcaaatagtc ctctgaatgg
     3661 agcccccatc acaaaacagt gcccaggagg ctggctcctc aagctaccca tgcccagcgc
     3721 cctaaagcag caccagatgc tttggaattg gggtgaaaca cccacatggc agcctgctag
     3781 cagcagtgac tttgacttct ggtcttaaag agtccctcac ttcagcccca ggagctattg
     3841 gtgggtttta gcagttttgt ctttaccgtt tttagttctc cttgattctt tgttttcttc
     3901 ctttatcgtt tttaggtttg gtatgtgttg ttttatttcc atggttcctc aagtttcctt
     3961 tttaaacatt tgcatttgct ggacaattgc aatttttttt aaaaaattcc cctacccctg
     4021 tttaaagctg aaaaatacat ttggttcatg tgcattgttt acaaagcaaa aagaaaaaag
     4081 aggaaaaaaa ggcaaaaaat attgtgaaag aaaaaaaaca acttaatata ttttggatta
     4141 atatttggta tttcttttaa agtatttttt gtgctgtgaa cattttctgc caaagaccat
     4201 gatgtgtgtc tgtatgttta agttatcgta aatatttaaa atgtaaacat ggctgttttg
     4261 ttatgccacc ctgtaccagg attgctgccg cattccactg ggtataacag tattttaatt
     4321 aaaaaaaaat aattaaaagt gatgtctttg cacaggtgag actttgcact gagggaaggg
     4381 aaagggtgag gattttgggg ggccacccaa gtcatagtcc aatctcttca aggacccaag
     4441 atagaattta ggaattttgt gaagctgcat taaggataga gttggaatga ggatgtggct
     4501 ggcatttttc ccctttcata gataacattt cttgaaggct gggaggggaa ggagggcctg
     4561 gcagatggca gcctcccgag gtagggctgt gttctaatca gctttgttcg gccacacgct
     4621 gtggttatcc acagtgggag tgggtgtcca aagatggctt tatccttccc ccactccttt
     4681 tcccactccc acctagcaca taaagttttg tccgaaacca tccagaaggc caggcaccat
     4741 gcagaggaca ttcaagaatg tgcatgttct tagccaccgc ctccctcctt tgctgtgaca
     4801 tcaccactct ttcctgatgc tcaggaaagc atattgctcc aattcaaaat taaagaaagc
     4861 cattctca
//
