LOCUS       NM_130847               8980 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens angiomotin like 1 (AMOTL1), transcript variant 1,
            mRNA.
ACCESSION   NM_130847
VERSION     NM_130847.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8980)
  AUTHORS   Xu,X.C., Jiang,J.X., Zhou,Y.Q., He,S., Liu,Y., Li,Y.Q., Wei,P.P.,
            Bei,J.X., Sun,J. and Luo,C.L.
  TITLE     SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of
            nasopharyngeal carcinoma through regulating the nucleus
            translocation of YAP1
  JOURNAL   Cell Death Dis 14 (8), 511 (2023)
   PUBMED   37558679
  REMARK    GeneRIF: SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of
            nasopharyngeal carcinoma through regulating the nucleus
            translocation of YAP1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8980)
  AUTHORS   Strong,A., Rao,S., von Hardenberg,S., Li,D., Cox,L.L., Lee,P.C.,
            Zhang,L.Q., Awotoye,W., Diamond,T., Gold,J., Gooch,C.,
            Gowans,L.J.J., Hakonarson,H., Hing,A., Loomes,K., Martin,N.,
            Marazita,M.L., Mononen,T., Piccoli,D., Pfundt,R., Raskin,S.,
            Scherer,S.W., Sobriera,N., Vaccaro,C., Wang,X., Watson,D.,
            Weksberg,R., Bhoj,E., Murray,J.C., Lidral,A.C., Butali,A.,
            Buckley,M.F., Roscioli,T., Koolen,D.A., Seaver,L.H., Prows,C.A.,
            Stottmann,R.W. and Cox,T.C.
  TITLE     A mutational hotspot in AMOTL1 defines a new syndrome of orofacial
            clefting, cardiac anomalies, and tall stature
  JOURNAL   Am J Med Genet A 191 (5), 1227-1239 (2023)
   PUBMED   36751037
  REMARK    GeneRIF: A mutational hotspot in AMOTL1 defines a new syndrome of
            orofacial clefting, cardiac anomalies, and tall stature.
            Erratum:[Am J Med Genet A. 2023 Sep;191(9):2454-2455. doi:
            10.1002/ajmg.a.63352.. PMID: 37428002]
REFERENCE   3  (bases 1 to 8980)
  AUTHORS   Vogel,A., Crawford,A. and Nyarko,A.
  TITLE     Multivalent Angiomotin-like 1 and Yes-associated protein form a
            dynamic complex
  JOURNAL   Protein Sci 31 (5), e4295 (2022)
   PUBMED   35481651
REFERENCE   4  (bases 1 to 8980)
  AUTHORS   Xu,G., Seng,Z., Zhang,M. and Qu,J.
  TITLE     Angiomotin-like 1 plays a tumor-promoting role in glioma by
            enhancing the activation of YAP1 signaling
  JOURNAL   Environ Toxicol 36 (12), 2500-2511 (2021)
   PUBMED   34480788
  REMARK    GeneRIF: Angiomotin-like 1 plays a tumor-promoting role in glioma
            by enhancing the activation of YAP1 signaling.
REFERENCE   5  (bases 1 to 8980)
  AUTHORS   Rips,J., Mor-Shaked,H., Erdin,S., Yanovsky-Dagan,S.,
            Eventov-Friedman,S. and Harel,T.
  TITLE     De novo variant in AMOTL1 in infant with cleft lip and palate,
            imperforate anus and dysmorphic features
  JOURNAL   Am J Med Genet A 185 (1), 190-195 (2021)
   PUBMED   33026150
  REMARK    GeneRIF: De novo variant in AMOTL1 in infant with cleft lip and
            palate, imperforate anus and dysmorphic features.
REFERENCE   6  (bases 1 to 8980)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
REFERENCE   7  (bases 1 to 8980)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   8  (bases 1 to 8980)
  AUTHORS   Patrie,K.M.
  TITLE     Identification and characterization of a novel tight
            junction-associated family of proteins that interacts with a WW
            domain of MAGI-1
  JOURNAL   Biochim Biophys Acta 1745 (1), 131-144 (2005)
   PUBMED   16019084
REFERENCE   9  (bases 1 to 8980)
  AUTHORS   Bratt,A., Wilson,W.J., Troyanovsky,B., Aase,K., Kessler,R., Van
            Meir,E.G. and Holmgren,L.
  TITLE     Angiomotin belongs to a novel protein family with conserved
            coiled-coil and PDZ binding domains
  JOURNAL   Gene 298 (1), 69-77 (2002)
   PUBMED   12406577
  REMARK    Erratum:[Gene. 2003 May 22;310;231. Meir, EG [corrected to Van
            Meir, EG]]
REFERENCE   10 (bases 1 to 8980)
  AUTHORS   Nishimura,M., Kakizaki,M., Ono,Y., Morimoto,K., Takeuchi,M.,
            Inoue,Y., Imai,T. and Takai,Y.
  TITLE     JEAP, a novel component of tight junctions in exocrine cells
  JOURNAL   J Biol Chem 277 (7), 5583-5587 (2002)
   PUBMED   11733531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX648729.1, BC037539.1 and
            AP001152.4.
            
            On Nov 23, 2018 this sequence version replaced NM_130847.2.
            
            Summary: The protein encoded by this gene is a peripheral membrane
            protein that is a component of tight junctions or TJs. TJs form an
            apical junctional structure and act to control paracellular
            permeability and maintain cell polarity. This protein is related to
            angiomotin, an angiostatin binding protein that regulates
            endothelial cell migration and capillary formation. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.149517.1, BC037539.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433060.3/ ENSP00000387739.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BX648729.1         15-29
            16-3376             BC037539.1         1-3361
            3377-8980           AP001152.4         83665-89268
FEATURES             Location/Qualifiers
     source          1..8980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..8980
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /note="angiomotin like 1"
                     /db_xref="GeneID:154810"
                     /db_xref="HGNC:HGNC:17811"
                     /db_xref="MIM:614657"
     exon            1..205
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..3027
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     angiomotin-like protein 1; junction-enriched and
                     associated protein"
                     /codon_start=1
                     /product="angiomotin-like protein 1 isoform 1"
                     /protein_id="NP_570899.1"
                     /db_xref="CCDS:CCDS44712.1"
                     /db_xref="GeneID:154810"
                     /db_xref="HGNC:HGNC:17811"
                     /db_xref="MIM:614657"
                     /translation="MWRAKLRRGTCEPAVKGSPSACYSPSSPVQVLEDSTYFSPDFQL
                     YSGRHETSALTVEATSSIREKVVEDPLCNFHSPNFLRISEVEMRGSEDAAAGTVLQRL
                     IQEQLRYGTPTENMNLLAIQHQATGSAGPAHPTNNFSSTENLTQEDPQMVYQSARQEP
                     QGQEHQVDNTVMEKQVRSTQPQQNNEELPTYEEAKAQSQFFRGQQQQQQQQGAVGHGY
                     YMAGGTSQKSRTEGRPTVNRANSGQAHKDEALKELKQGHVRSLSERIMQLSLERNGAK
                     QHLPGSGNGKGFKVGGGPSPAQPAGKVLDPRGPPPEYPFKTKQMMSPVSKTQEHGLFY
                     GDQHPGMLHEMVKPYPAPQPVRTDVAVLRYQPPPEYGVTSRPCQLPFPSTMQQHSPMS
                     SQTSSASGPLHSVSLPLPLPMALGAPQPPPAASPSQQLGPDAFAIVERAQQMVEILTE
                     ENRVLHQELQGYYDNADKLHKFEKELQRISEAYESLVKSTTKRESLDKAMRNKLEGEI
                     RRLHDFNRDLRDRLETANRQLSSREYEGHEDKAAEGHYASQNKEFLKEKEKLEMELAA
                     VRTASEDHRRHIEILDQALSNAQARVIKLEEELREKQAYVEKVEKLQQALTQLQSACE
                     KREQMERRLRTWLERELDALRTQQKHGNGQPANMPEYNAPALLELVREKEERILALEA
                     DMTKWEQKYLEESTIRHFAMNAAATAAAERDTTIINHSRNGSYGESSLEAHIWQEEEE
                     VVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAGKTDSSSLRPARSVPSIA
                     AATGTHSRQTSLTSSQLAEEKKEEKTWKGSIGLLLGKEHHEHASAPLLPPPPTSALSS
                     IASTTAASSAHAKTGSKDSSTQTDKSAELFWPSMASLPSRGRLSTTPAHSPVLKHPAA
                     KGTAEKLENSPGHGKSPDHRGRVSSLLHKPEFPDGEMMEVLI"
     exon            206..355
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            356..1277
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1569
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1714
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1804
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1950
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2100
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2291
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2417
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2644
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2920
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..8980
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /note="hexamer: TATAAA"
     polyA_site      3376
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /note="major polyA site"
     regulatory      8418..8423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /note="hexamer: AATATA"
     polyA_site      8444
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
     regulatory      8878..8883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /note="hexamer: AATAAA"
     polyA_site      8903
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /note="major polyA site"
     regulatory      8958..8963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
                     /note="hexamer: AATAAA"
     polyA_site      8980
                     /gene="AMOTL1"
                     /gene_synonym="JEAP"
ORIGIN      
        1 agcgcgcgag aagctctagg acccagcagc ggttgtcggg tttggggctg gaggtgaagc
       61 cctgtgtgaa tggggttgat tgtccggcgc cacttccccg cgctgcccgg cagccgtctt
      121 ccccagccga gggactgaac tagccatgat cgcctcatgt ggagggcaaa gttgcgccgg
      181 ggaacttgtg agcctgcggt gaaagggtcc ccttctgctt gttatagccc cagtagtcct
      241 gtccaggttc tagaagactc cacctacttt tccccagact ttcagctcta ttctgggagg
      301 catgaaacat ctgctttgac ggtggaggca accagtagca tcagggaaaa agttgttgaa
      361 gatcctcttt gtaacttcca ctccccaaac ttcctgagga tctcagaggt ggaaatgaga
      421 ggttccgagg atgcggcagc tggaacagta ttgcagcggc tgatccagga acaactgcgg
      481 tatggcaccc caaccgagaa catgaacttg ctggccattc agcaccaggc cacagggagt
      541 gcaggaccag cccatcctac aaacaacttt tcttccacgg aaaacctcac tcaagaagac
      601 ccacaaatgg tctaccagtc agcacgccaa gaaccgcagg gtcaagaaca ccaggtggac
      661 aatacggtga tggagaaaca ggtccggtcc acgcagcctc agcagaacaa cgaggaactg
      721 cccacttacg aggaggccaa agcacagtcg cagttcttca gggggcagca gcagcagcaa
      781 cagcagcagg gggcggtggg ccatggttac tacatggcag ggggcaccag tcagaagtcc
      841 cgaactgagg ggaggcccac tgtgaaccgt gccaacagtg gacaggcgca taaggacgag
      901 gcgctgaagg aactgaagca gggccacgtc cgctcgctca gcgagagaat catgcagctg
      961 tccctggaga ggaatggggc caagcaacac cttcccggct cggggaatgg aaagggcttc
     1021 aaagtaggag gggggccctc ccctgcccag cctgcaggta aagtgctgga ccctcggggt
     1081 cctccacctg agtacccctt caagaccaag caaatgatgt ccccagtcag caagacccag
     1141 gagcacggac ttttttatgg tgaccagcac cccgggatgc tccacgagat ggtcaagccc
     1201 taccctgctc ctcagcctgt gagaacagat gtggccgtcc tgcggtacca gccaccccct
     1261 gagtatgggg taacgagccg cccatgccaa cttccgttcc catcaaccat gcagcagcac
     1321 agccccatgt cctcccagac ctcttccgcc agcgggccac tgcactctgt ctccctgccg
     1381 cttccactcc cgatggccct gggtgctcca cagcccccgc ctgccgcctc ccccagccag
     1441 cagcttggtc cagatgcctt tgcgattgtg gagcgagccc agcaaatggt ggagatatta
     1501 acagaggaga accgggtgct tcaccaggaa cttcagggtt actacgacaa tgccgacaag
     1561 ctccacaagt ttgaaaaaga acttcagaga atttcggaag cctatgaaag tctggtcaag
     1621 tctaccacca agcgagaatc gctggacaag gccatgagaa acaaattgga aggcgagatt
     1681 agaagacttc atgatttcaa cagagacctc cgagatcgac tagagactgc taacaggcaa
     1741 ctatccagca gggaatacga agggcatgaa gacaaagctg cagaggggca ttatgcttcc
     1801 cagaacaaag aattcttgaa ggaaaaggag aaattagaaa tggagttagc agcagtgcgg
     1861 actgcaagtg aggaccatcg gagacacatc gagatcctgg accaggcttt gagcaacgcc
     1921 caggccaggg tcatcaagct ggaagaggag ttacgagaga agcaagcata tgttgagaaa
     1981 gttgagaagc tgcagcaggc cctgacccag ctgcagtctg catgtgagaa gcgagaacag
     2041 atggagcgga gactgcggac ttggctggag agagagctgg atgcactgag aacccagcag
     2101 aaacatggaa atggccagcc agccaacatg ccggaataca atgccccagc cctcctggaa
     2161 cttgtgcggg agaaggagga gcggatcctg gccctggagg ccgacatgac aaagtgggag
     2221 cagaagtacc tggaggagag caccatccga cactttgcca tgaatgccgc agccactgca
     2281 gcagctgaga gggacaccac gatcatcaac cactcacgga atggcagcta cggagagagc
     2341 tcgctggagg cccacatctg gcaagaggag gaggaggtgg tgcaggccaa cagaaggtgt
     2401 caggacatgg aatacactat taaaaatctc catgccaaaa tcatagagaa agatgctatg
     2461 attaaggtcc tgcagcagcg atctcgtaaa gatgccggga agacagactc ctccagccta
     2521 cgtcctgccc gctccgttcc atccatagca gcagctactg ggacacactc tcgccagacc
     2581 tctcttacca gcagccagct ggctgaggaa aagaaggaag agaagacctg gaaggggagc
     2641 ataggattgc tgctggggaa ggagcaccat gagcatgcct ctgccccact gctgccaccc
     2701 ccacccacct cagcactgtc ctccatagcc tccactacgg cagccagcag tgcccacgcc
     2761 aagacaggca gcaaggacag cagcacacag actgacaaga gtgccgagct cttctggccc
     2821 agcatggcct cccttcccag ccgcggccgg ctgagcacga cccctgctca cagccccgtc
     2881 ctgaaacacc cagcggccaa agggaccgca gagaaactgg agaactctcc tggccatggg
     2941 aagtcgcctg accacagagg ccgggtcagc agcttgctgc acaagcccga gttccctgat
     3001 ggagagatga tggaagtcct catctaactg ccatccctgt ggaatttcag tacagaacac
     3061 tgacaaacaa ggaaagcggc agagaaagaa gaaagaccta gaaggttgta gatgggaaat
     3121 caggaatgat ttgaactgat aaagatttca gactcataag aacacatttt ataaatgtta
     3181 aacacaaaaa ctacatgact gaagatagaa gagaatgcga tggattttat tacacatggt
     3241 ggaagagaga agaggcgtgt aggtttgcaa acaaagttaa gaaataggaa actgaatttt
     3301 tcattgtaca gaaaatgtat ctcttgggga gggcctgtgt acccccattc tctgattata
     3361 aacagataaa cccaaatgtg gatcatcctt ggaatacccc cattctcctt gcctcttagc
     3421 atgtttgatt taagaaaagc ctccaggaaa tcttgagagc ctgtcttggc ataatgcagt
     3481 gtcacctgtg ccaaccatgg ggtgtcccgt gagtgtgagt gtggcagtga gaagaagcat
     3541 cgagggcgag gggaatatga aagttggtct tcacctaatt acctgtttgg tttggatttt
     3601 caagagatga ttgggcttct tagcttttct gaattctgca gtattttcta aacaggatag
     3661 attatgatct cggtccccat ccatcctaac ttctgagttc atctctgtct ctgctttaca
     3721 gtctttaatt ttttgttgtt ccttcatttt tttcttttta ataagacata gcagaattcc
     3781 ttaggtatgg gatttatgag accagtacct gaactgtcat cattcctact gtgtttgata
     3841 gtgaccagta ggacaaagcc acgtgccgac ttcctggctg cttcaccttt gcatagctgg
     3901 gttgcagctg cgaacctcat tctgactgtg aactaagcaa gctttgagga ggcaggagat
     3961 tccgtgggtc cctgtgacat attgcattaa gatcgtggca cttgcttttt tgtctttcac
     4021 atcggctgtc ttgcaaggag cttgacattt ccaaattcca ttgctctgtt tggggaagac
     4081 ttaggacagc actccaggaa acagatgaca atttacagac agttgtctca gtggtttcca
     4141 gaatctcacc agcctcccgt atagcttctt gtattgaggc tcatgagcgt attcacactc
     4201 tttcctcccc cgcgcacgcc tctgcttgct ctcgatcagc atccagacct ccgtggcacc
     4261 aggttgcctc tgttgtgaac ttcttttgta acctaccagg ccagttgtat atacagtgtt
     4321 gtcaggtttt tccgggtttc agttttgagg cagtttattc aaagtgagac agaagtgcca
     4381 cggaaaagag gcaggagtgt gttaggtggt gggtccatta gacctctgct gtgacattgc
     4441 atattcagct ctgcagacac tggcttcctt tacaaatcta agagatgctg gattagaaaa
     4501 gaggagaagc tcatcgggcc atcagagaga tgctcctaca gggtcctgat gtttttgtac
     4561 ctccaggtca gctggatcgc tgttttccca gttccctttg ctcatgctta cttagaggaa
     4621 gaaagaaagg ggggtacctc ttccaagtac cttctaaatg aaacactcaa gagagtgcta
     4681 ctcaggaaac tttgcttgga tcctaaaatg gactggtctt gggtgtgtaa ccccggtgaa
     4741 gttatagcct ccccaaattg aggtgacaga aggaagacaa gaggtgtaag ctggagaggg
     4801 aagggaagaa atcagtggct ttggccagcc tctgtgccac ccagtacgac agaggagtgg
     4861 gaactggccc tctggggctc tgcttggcca taggcactgc acattgtgcc acctgctcat
     4921 cacctcctct agtctcacac tgagcatcgg agtacctgtt gtgcagacag gaaaactgag
     4981 gagctctgag aggctgagca tggagctcac cccatgccat agggtgtggg aagagggcac
     5041 aggaggcctc atccatgggg gaaagggttg aggatggaca tgggtgggga gagggcatag
     5101 acatcccttc ctaatctctg ttcccaccac atttcatagg agatgagtta ggagatgaca
     5161 gctaactctc ttaaggacat tttgacccca gtttatgttg gggatggacc agaaaggaaa
     5221 atgtctagag ataggaaggt aaatcaactc tgccagcccc taccatcagg tctgggccac
     5281 cccaaacttg ggctgcctcc cttagacata ggttagagtg agagacccag ctgtttctcc
     5341 cgaagcctcg tcttcatgcc ccagacacct gattgcccca atcaggtgtc agacttgctt
     5401 gctcttcgag gtccccctga gctgccaagt gttttcattg taaacagaca catcgccatg
     5461 tttcagggct tcaacggcat tgtattttgg actttgaccg tatttttttt ctcttaacct
     5521 actgagactc ttccttaaga acaggatcta tagctttaaa atgtcttctt ctatgggaaa
     5581 tttcctgcca agccagggca ctaaattctt tcatcattag agctttcctg aagtccggcc
     5641 atatactgag tacctgctct gagttctggg cagcttacaa tatcttaaac agattttcag
     5701 aaaaataatg caactatatt ttctagtgtc aactgtatgc aaacagtgtg gtaaatacct
     5761 tttaattagt cctccaccca cctggagtac agggggtgcg tttattattc tgatttcact
     5821 gatgaggaaa tgggctcaga aaggttaagt cccttcctga aatctcacag ccaggagaag
     5881 ctaggatgat ttaaaacaaa gtttggagag gcactgggca tagaccctgg ctgtacagcc
     5941 tctaacatgc ggcactgcat cttggcagtc tctatgcctg tctgtgatgt gtgtgtgcac
     6001 gtgtaactac acacacacac acacacacac acacacacac acacagctat cacacatctc
     6061 agagcctaag aaataggact aagcccagaa ctcctagaat cacctataaa tgctaggcat
     6121 agatggaaat tattgtgttc caccagaagc acagctccaa actataccta aaaaatattt
     6181 ctgcacttcc cagagacctg gacttcaaac tttcccagtg gagcctgatt atagaacttg
     6241 agggtcctat ctcaggatga aggggagagg ccctggcttc acgggaaggt attccagcat
     6301 tgttctgctt cacccttgac tgcgttgtct ggcagtttct gtgtgctgcc aggatattat
     6361 atggaactgg agaagttgga gtcaggtctc tgaagctaga gtttcactaa ttagatgcct
     6421 ctgtacatga gaactattac tgtctgcagg tccatatagc taagctgcca ggaaaaacac
     6481 attatcttcc aaaactttca gagcatgtgc agaacccttt cttagcgttt tcttctcagc
     6541 attttctctg cctcccagag gctggcagcc agtgacactg cagagttcag catgttctaa
     6601 ccatgcacgc agggcagggg ctgccttggc cctcctcagg ctttcgttgg gagagcaggc
     6661 agtggtggag cccttctggg tgcagtcctc tggggttgct ctttggaact catgtatgag
     6721 tttgactcca caaggcttgg catggatacc aaaacagttg caacaaatta gttctgaacc
     6781 tggaacagag aattcagtgc ttctgttact caggaaggag gtgttcagaa tgccccgtgc
     6841 agagcagcca gtcattactc ttgtttgttc tcacctgggt gcgcaccctc atgatgcagt
     6901 ggctgtagca ccttcatgcc aggtgctgag agaatgggaa attcttcctc cccattgacc
     6961 tgagtcccag agacttaggg acacagactt caggtgaggc tgcggacctc agaagcagtg
     7021 gataatagat tggggcatta aaagcttttg aggcaggggg ctcatgtttt gactgcaggg
     7081 agttatgctg agcaaagaga tgtgtttttc aaaaccaggg ttcaaaacca gtgtccacgc
     7141 tggagtaagt ggagcatgct tctctgtgtt ctctgaatga tcttgcactc ctcttaagca
     7201 aaggagtacc atgaccatag tcagtgggat cccacaaatg ttcttaaatg ggtaaggctt
     7261 taagtagcca gagagtatcc agcctaccat tggcttctcc acatcctaaa acctgagaca
     7321 gccttggtat atgctttata aatgtttctt ttcttgttgt ttaagtaatt aaagtgttta
     7381 aaatgtcttc attagatgtg acgattgttt aatgagtttg cctctgacgt gtggctccat
     7441 gggagatagg caaagtaatt aagaagttac cagaaattgg tcggctgggg aaatgcaaaa
     7501 gttagcattt cagtagtgaa tttctcctgg aacaaatgag caatttttcc tctttctctt
     7561 aagtagtata cccttttctc acttagtaat ttaatggtat ataaagacat gtgtataagt
     7621 gagtgcatac atatgaggta tgactatagg gttgtttgtg ggaatttctt ttcctaacat
     7681 acagaagatc aaagtgttca tctcaccccg ccctccttaa aaggtgtctt ttgggagact
     7741 atgtgctcat tgactatagt gctgccaagt aaaaatatct tgggaactct tctactagaa
     7801 tggccttcag ggcttggcat gttcctttgg tttaccctta gagatgagaa atcctcctcc
     7861 tttgaggatg gatttaagtt ctggaaataa tctcaagtgc ttgatagcac agttggatga
     7921 aaaaagatgg caattaaggt aagttacacc atttttgttt ctaaaaaaat ccctaagaaa
     7981 tttcttggaa tgagtctttg gcctcagagc ctctcaaagt gtccacttca aggggggatc
     8041 atcctcatta gcacacagat ttttaaaaat caattctctt gccatgcctc ctatgtgttc
     8101 acatctctgc atacactaca gatataagtg cataatcatt catataaaca tctggtaggt
     8161 attctgtaaa actgtgttta ctttagtgca tgttattgtc atgttatgat gtgactgggg
     8221 tgtttctttg tcatgaaact ttgcttcttc acagaattag aatactgctc tctctatatt
     8281 gaactacata tacagcgttt tcttgtatca gcccccaaag tctggatgcc cggtgttgtg
     8341 tttacatgtg attgtgccta ggagtctgtt cacatagaga cacctgtaag tatttattac
     8401 aaaacggaat gtaagcaaat atatccacat tggttttatt tgaatcaagg tgtttttttg
     8461 ttttttgttt tttttccttt tgaggaggaa cagggagcct cctcctccat gagcacttac
     8521 agaattgtgt aaaattctgt gaaacagtgg taagcatggg cacccgattt cagctgtcct
     8581 gctgccgctg ccctccaacc tgctctgtgt gtgtgtgtcg ctgtgcttgg tggcagtgtg
     8641 ccgtgctcgt gccggctctt cccagcagac tggtatctgg ctgtaacgtt tgacgtcttc
     8701 atattgccag tctgtattga ggggtgatgt acatggccat acagccaaat gggtctgtgt
     8761 accagtgtgg ggattccaag aacactgcct gtcccccaca gcaaatattg atgctgttgg
     8821 tcagccaaag attttcctct cctttgctgc ttaaacttgt gccttaatat tgtacataat
     8881 aaatggataa aatggcaaaa tgactctttt ctctcgcttg ctcctttctt ccttaaagaa
     8941 cttataaact gatgctcaat aaatgtttca tttcattgta
//
