LOCUS       NM_001113490            7613 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens angiomotin (AMOT), transcript variant 1, mRNA.
ACCESSION   NM_001113490 XM_005262087
VERSION     NM_001113490.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7613)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 7613)
  AUTHORS   Rheinemann,L., Thompson,T., Mercenne,G., Paine,E.L., Peterson,F.C.,
            Volkman,B.F., Alam,S.L., Alian,A. and Sundquist,W.I.
  TITLE     Interactions between AMOT PPxY motifs and NEDD4L WW domains
            function in HIV-1 release
  JOURNAL   J Biol Chem 297 (2), 100975 (2021)
   PUBMED   34284061
  REMARK    GeneRIF: Interactions between AMOT PPxY motifs and NEDD4L WW
            domains function in HIV-1 release.
REFERENCE   3  (bases 1 to 7613)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7613)
  AUTHORS   Qiu,Y., Mao,Y.T., Zhu,J.H., Zhao,K., Wang,J.F., Huang,J.M.,
            Chang,G.Q., Guan,Y.T., Huang,F.Y., Hu,Y.J., Chen,J.Q. and Liu,J.L.
  TITLE     CLIC1 knockout inhibits invasion and migration of gastric cancer by
            upregulating AMOT-p130 expression
  JOURNAL   Clin Transl Oncol 23 (3), 514-525 (2021)
   PUBMED   32656583
  REMARK    GeneRIF: CLIC1 knockout inhibits invasion and migration of gastric
            cancer by upregulating AMOT-p130 expression.
            Erratum:[Clin Transl Oncol. 2021 Mar;23(3):663-664. doi:
            10.1007/s12094-020-02495-4.. PMID: 32936439]
REFERENCE   5  (bases 1 to 7613)
  AUTHORS   Wigerius,M., Quinn,D. and Fawcett,J.P.
  TITLE     Emerging roles for angiomotin in the nervous system
  JOURNAL   Sci Signal 13 (655) (2020)
   PUBMED   33109746
  REMARK    GeneRIF: Emerging roles for angiomotin in the nervous system.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7613)
  AUTHORS   Bratt,A., Wilson,W.J., Troyanovsky,B., Aase,K., Kessler,R., Van
            Meir,E.G. and Holmgren,L.
  TITLE     Angiomotin belongs to a novel protein family with conserved
            coiled-coil and PDZ binding domains
  JOURNAL   Gene 298 (1), 69-77 (2002)
   PUBMED   12406577
  REMARK    Erratum:[Gene. 2003 May 22;310;231. Meir, EG [corrected to Van
            Meir, EG]]
REFERENCE   7  (bases 1 to 7613)
  AUTHORS   Zetter,B.R.
  TITLE     Hold that line. Angiomotin regulates endothelial cell motility
  JOURNAL   J Cell Biol 152 (6), F35-F36 (2001)
   PUBMED   11257132
REFERENCE   8  (bases 1 to 7613)
  AUTHORS   Troyanovsky,B., Levchenko,T., Mansson,G., Matvijenko,O. and
            Holmgren,L.
  TITLE     Angiomotin: an angiostatin binding protein that regulates
            endothelial cell migration and tube formation
  JOURNAL   J Cell Biol 152 (6), 1247-1254 (2001)
   PUBMED   11257124
REFERENCE   9  (bases 1 to 7613)
  AUTHORS   Rubinstein,M.H.
  TITLE     A new granulation method for compressed tablets [proceedings]
  JOURNAL   J Pharm Pharmacol 28 Suppl, 67P (1976)
   PUBMED   12345
REFERENCE   10 (bases 1 to 7613)
  AUTHORS   Aoyagi,F., Fujino,T. and Ohshiro,T.
  TITLE     Detection of small vessels for microsurgery by a Doppler flowmeter
  JOURNAL   Plast Reconstr Surg 55 (3), 372-373 (1975)
   PUBMED   123345
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004827.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Sep 18, 2020 this sequence version replaced
            XM_005262087.1, NM_001113490.1.
            
            Summary: This gene belongs to the motin family of angiostatin
            binding proteins characterized by conserved coiled-coil domains and
            C-terminal PDZ binding motifs. The encoded protein is expressed
            predominantly in endothelial cells of capillaries as well as larger
            vessels of the placenta where it may mediate the inhibitory effect
            of angiostatin on tube formation and the migration of endothelial
            cells toward growth factors during the formation of new blood
            vessels. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2791571.1,
                                           SRR14038195.2281437.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371959.9/ ENSP00000361027.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               AC004827.1         10560-10939
            381-457             AC004827.1         19021-19097
            458-606             AC004827.1         26171-26319
            607-1540            AC004827.1         28203-29136
            1541-2060           AC004827.1         35514-36033
            2061-2205           AC004827.1         39998-40142
            2206-2298           AC004827.1         41405-41497
            2299-2444           AC004827.1         46299-46444
            2445-2594           AC004827.1         59410-59559
            2595-2785           AC004827.1         60609-60799
            2786-2908           AC004827.1         68729-68851
            2909-3141           AC004827.1         70273-70505
            3142-3825           AC004827.1         71711-72394
            3826-7613           AC004827.1         72727-76514
FEATURES             Location/Qualifiers
     source          1..7613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..7613
                     /gene="AMOT"
                     /note="angiomotin"
                     /db_xref="GeneID:154796"
                     /db_xref="HGNC:HGNC:17810"
                     /db_xref="MIM:300410"
     exon            1..380
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            381..457
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            458..606
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            607..1540
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     CDS             669..3923
                     /gene="AMOT"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="angiomotin isoform 1"
                     /protein_id="NP_001106962.1"
                     /db_xref="CCDS:CCDS48154.1"
                     /db_xref="GeneID:154796"
                     /db_xref="HGNC:HGNC:17810"
                     /db_xref="MIM:300410"
                     /translation="MRNSEEQPSGGTTVLQRLLQEQLRYGNPSENRSLLAIHQQATGN
                     GPPFPSGSGNPGPQSDVLSPQDHHQQLVAHAARQEPQGQEIQSENLIMEKQLSPRMQN
                     NEELPTYEEAKVQSQYFRGQQHASVGAAFYVTGVTNQKMRTEGRPSVQRLNPGKMHQD
                     EGLRDLKQGHVRSLSERLMQMSLATSGVKAHPPVTSAPLSPPQPNDLYKNPTSSSEFY
                     KAQGPLPNQHSLKGMEHRGPPPEYPFKGMPPQSVVCKPQEPGHFYSEHRLNQPGRTEG
                     QLMRYQHPPEYGAARPAQDISLPLSARNSQPHSPTSSLTSGGSLPLLQSPPSTRLSPA
                     RHPLVPNQGDHSAHLPRPQQHFLPNQAHQGDHYRLSQPGLSQQQQQQQQQHHHHHHHQ
                     QQQQQQPQQQPGEAYSAMPRAQPSSASYQPVPADPFAIVSRAQQMVEILSDENRNLRQ
                     ELEGCYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGEIRRMHDFN
                     RDLRERLETANKQLAEKEYEGSEDTRKTISQLFAKNKESQREKEKLEAELATARSTNE
                     DQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLE
                     HRLRTRLERELESLRIQQRQGNCQPTNVSEYNAAALMELLREKEERILALEADMTKWE
                     QKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKR
                     CLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSCMRPAKSLMSISNAGSGL
                     LSHSSTLTGSPIMEEKRDDKSWKGSLGILLGGDYRAEYVPSTPSPVPPSTPLLSAHSK
                     TGSRDCSTQTERGTESNKTAAVAPISVPAPVAAAATAAAITATAATITTTMVAAAPVA
                     VAAAAAPAAAAAPSPATAAATAAAVSPAAAGQIPAAASVASAAAVAPSAAAAAAVQVA
                     PAAPAPVPAPALVPVPAPAAAQASAPAQTQAPTSAPAVAPTPAPTPTPAVAQAEVPAS
                     PATGPGPHRLSIPSLTCNPDKTDGPVFHSNTLERKTPIQILGQEPDAEMVEYLI"
     exon            1541..2060
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2205
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2298
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2444
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2594
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2785
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2908
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3141
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3825
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..7613
                     /gene="AMOT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7538..7543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMOT"
                     /note="hexamer: AATAAA"
     polyA_site      7563
                     /gene="AMOT"
                     /note="major polyA site"
     regulatory      7588..7593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMOT"
                     /note="hexamer: AATAAA"
     polyA_site      7613
                     /gene="AMOT"
                     /note="major polyA site"
ORIGIN      
        1 acctcccatc ctttgcccag gagctgcctt ggcagtcacg ccccttcctt ccgaggagct
       61 ttctggctgc ctaaactggt agaccccctg aattactcct ccatctccgc tctctttcgc
      121 ctcctcttct cttagttctc tccgcctccc cctcaactac caccacctcc agtcagtctc
      181 gcctccggct atccgctgct ccaccctctg gcccggtatc ctgcctgtcc gctgccacca
      241 aggagagccc ggacggagca gcgaggaggg gagcagccgg gagttggggc ttcccccctg
      301 cccatccctg gccgctggcc cgggaccgaa gccacttgag cgagcagaga gtcgtcacct
      361 tgtcttcttt gccttcaggg agctgctaag aaggacaaat aagatagcag agtgaaagag
      421 cttttgtctc cttagaagga aggctgagaa actaaagagt gaccagtggt tggactcttg
      481 gcggcgctta ccctgaacct gagtgttagg ggagagggaa tctgccgttg cggtttctgg
      541 agctgctcat aagcaagaat tccctatcct gatcaaggct ttaagcctaa aagaaagcag
      601 aaataggtca agggcagccc aggtgcccaa tttctctctc tcttcacaag gcaccaccag
      661 caatagagat gagaaattct gaagaacagc caagtggagg gaccacggta ttgcagcgtt
      721 tgctacaaga gcagcttcgc tatggcaatc ctagtgagaa tcgcagcctg cttgccatac
      781 accagcaagc cacagggaat ggccctcctt tccccagtgg cagtgggaac ccgggccctc
      841 agagtgatgt gttgagtccc caagaccacc accaacagct tgtggctcat gctgctcgac
      901 aagaacccca ggggcaggaa atccagtcag aaaacctcat catggagaag cagctgtctc
      961 ctcgaatgca aaataatgaa gaactcccga cctatgaaga agccaaggtc cagtcccagt
     1021 actttcgggg ccaacagcat gccagtgttg gagctgcctt ctatgtcact ggagtcacca
     1081 accagaagat gaggactgag ggacgcccat cagttcagcg gctcaatcct ggaaagatgc
     1141 accaagatga gggactcaga gaccttaagc aagggcatgt ccgttccttg agtgaacgac
     1201 taatgcagat gtcactggcc accagtggag ttaaggccca tccacctgtt accagtgctc
     1261 ccctctcccc accacaaccc aatgacctct acaagaatcc cacaagttcc agtgaattct
     1321 acaaggccca agggccactt cctaaccagc atagcctgaa gggcatggaa caccgaggcc
     1381 ccccaccaga atatcccttc aagggcatgc caccccaatc tgtagtgtgc aagccccaag
     1441 agccagggca cttctatagt gagcatcgcc tgaaccagcc agggagaaca gaggggcaac
     1501 tgatgaggta tcagcatccc cctgagtatg gagcagccag gccagcgcag gacatctcat
     1561 tgccattgtc agccaggaac tcgcagcctc acagccctac ttcttctctg acctctgggg
     1621 ggtccttgcc cttgctacaa tctccaccat ccactagatt gtctcctgcc cgacacccct
     1681 tggtcccaaa ccagggagac cattcagctc acctgcctag gccgcagcag catttccttc
     1741 ctaatcaggc tcaccagggg gatcattacc gtctctccca acctggcctg agtcagcagc
     1801 agcagcaaca gcagcagcag caccatcatc accatcacca ccaacaacag cagcagcagc
     1861 agccacagca gcagccagga gaagcctatt cagctatgcc tcgggctcag ccatcctctg
     1921 cttcttatca gccagtgcca gcagaccctt ttgccattgt ttccagagcc cagcagatgg
     1981 ttgagatcct ctcagacgag aaccggaact tgaggcaaga gttggaagga tgctatgaga
     2041 aggtggcaag actgcagaag gtggagacag aaatccagcg cgtctcggag gcatatgaga
     2101 acctcgtgaa gtcatcctcc aaaagagagg ccctagagaa agccatgaga aacaagctag
     2161 agggcgagat tcggaggatg catgatttca acagggatct gagagagcgt ctagagactg
     2221 ccaacaagca gcttgcagag aaggaatatg aggggtcaga ggacaccaga aaaaccatct
     2281 cgcagctctt tgcaaaaaat aaagaaagcc agcgtgagaa ggagaagctg gaagcggagc
     2341 tggccactgc ccgttctacc aatgaggacc aaagacgaca catcgaaatc cgagatcagg
     2401 ccctgagtaa tgcccaggcc aaggtggtaa agctggaaga agagctgaaa aagaagcaag
     2461 tgtacgttga caaggtggag aagatgcagc aggcccttgt acagctccag gcagcatgtg
     2521 aaaaacgtga gcagctagag caccgtctcc ggacacgact ggagagggaa ctggaatccc
     2581 tgagaatcca gcagcgtcag ggcaactgtc agcccaccaa cgtttcagaa tacaatgctg
     2641 ctgcactgat ggagctcctt cgggagaaag aggagaggat tctggctctg gaagctgata
     2701 tgacaaagtg ggagcagaaa tatttggagg agaatgtgat gagacatttt gctctggatg
     2761 ctgctgcaac tgtggctgct cagagggaca caacagtcat cagtcactct cctaacacca
     2821 gctatgacac agctctagaa gctcgcatcc agaaagagga ggaagaaatc ttgatggcca
     2881 ataagcgttg ccttgacatg gagggcagga ttaagaccct ccatgcccag attattgaga
     2941 aggatgccat gatcaaagta ctccagcagc gttcccggaa ggagccgagc aagacagagc
     3001 agctgtcgtg catgcggcca gcgaagtctc tgatgtccat ttccaatgct ggatcaggct
     3061 tgctctccca ctcatccacc ctgactggct cccccatcat ggaagaaaag cgagacgaca
     3121 agagctggaa ggggagccta ggcattctcc tgggtggaga ctaccgtgct gaatatgtcc
     3181 cttccacacc ctcgcctgtg ccaccctcga ctcccctgct ctcggctcac tccaagacag
     3241 gcagccgaga ctgcagtacc caaactgaac gtgggacgga atcgaacaaa actgcagctg
     3301 ttgctcccat ctctgttcct gctccagttg ctgctgccgc cactgctgcc gccatcactg
     3361 ccactgctgc caccatcacc accaccatgg tagctgctgc tccagttgct gttgctgctg
     3421 ctgctgctcc agctgctgct gctgccccgt ctccagccac tgccgctgct actgctgctg
     3481 ctgtttctcc agctgctgct ggtcagattc cagctgctgc ctctgttgcc tcagctgctg
     3541 ccgttgctcc ttctgctgct gctgctgctg ctgttcaggt tgctccagct gctccggctc
     3601 cagttccagc tccggctctg gttccggttc cagctccagc agcggctcag gcttctgctc
     3661 ctgctcagac tcaggcacca acttcagctc cggctgtggc tccaactcca gctccaactc
     3721 caactccagc tgtggctcag gctgaggttc ctgcaagtcc agctaccggt cctggaccac
     3781 atcgtttgtc tataccaagt ttgacctgca atccagacaa aacagatggg cctgtgttcc
     3841 actccaatac tctggaaaga aaaactccca ttcagatcct gggacaagag cctgatgcag
     3901 agatggtgga atatctcatc taaacggcca aatcaagagc tgcagattat cagcaaaaat
     3961 gcttttaatc attttccccc ttttattggt tcttgttttg agggtgagga caagggttgt
     4021 ggggagggga tgttttttaa caggactttt tattggaaca atgtactact tgagtaatac
     4081 catgtgaaca ccagtctatt ttggtatgct tagggagtac ctctaaagac agattaatca
     4141 gaatgtgctc taaagcttat tgtttgaatt tatacgaata ctgggactgt taacaggtgg
     4201 ctatacatcg acgttttcaa tgtgcttaaa tttgtttaaa ttttccatat tctagatcat
     4261 tttttattga agagcacagt atgtgtggaa gacagtgtat aacacgtagt ttggaagtgg
     4321 gaagctagag agaattgagt gtgtgctgtt ttgtatagtt actatcctgt gcagcagctg
     4381 gagaaagcac tcacctcagg cttacaaaag ggaatagttt caggagctat gtaagctgga
     4441 aaaaaggtag ggagttttgg ggtgcagaag ggtactggag ctaatttttt cttccagttt
     4501 cccagctacc ctgccccagg gaattgtgtt tgtcttcatt tcagtggtgc tttggaaatg
     4561 gattcttttg gttccctcct ggaggttcat acattcatat atatgctctg gagtaattta
     4621 tgcatttgga taattaatat attgctttca gatgctggga gagtacatta actgagtgat
     4681 gcgcaacttc ctctctctta gggaattaga ccatcagagg ccttgatgga gagttgcatg
     4741 gggtgctata tgcagacttc catggtttgt gtgtagccat gaacacagct tgcttgcatt
     4801 tagtaagacc aatcagctta gtgtttattt cttctacagc acagattcac tggctgggtc
     4861 tccagtctca aattgccaat catttgcaaa gtgaggaagg atctttgttg acaggttgaa
     4921 tgctttgaat ttctggtgac tactttgaaa taacttgttt tgtttgtcaa attctaagca
     4981 tatgtcttaa aaggcatttt tgactatcac ctccaaggga atagcttgag aaacccaaag
     5041 tactatgctg cagtcggggg agaggtggat tgcagcagta tcctcaacta cctcttctca
     5101 ctgtcagtga caccatcttg gaataccttt gggaagcagc aggaaatgtg catgtgggta
     5161 gagatcaaag gaggcaatgg ctccaagcct tgccataggg ctgcctccaa ggacacagaa
     5221 ggatgccagt tgccacaggt ccctgccctg tgtcacctgt ctgcccttca ttaaggtgag
     5281 aaatctgcag atagcatcat taagatcagt tttaaggggt atagggaggg tgagggaagt
     5341 ggggggtgtt aggtaagggt tgggggtaga ggttttggga tgtcttagtt agaaaccaga
     5401 ttaatagaag agtaggcctg atatattaca tcatgagcca tagtggtggg aaagaacttt
     5461 agcaatatag ccctacctcc tcattttagt gatgaggaat ctgagaactg gagaggttca
     5521 gtgacttttt gaaagtcata caacacagct aaccattatg ccaatcacca tgcttatttt
     5581 gggaaactct ttatcttttt taaattccat tttatgaaaa ggcatcttca tggtccaggg
     5641 aatatgtatc ttgtaaaatg tacctggttg gagtagcttg tccagtcttg acaaactact
     5701 gaatttctgt cttgcctctc cttcagtgcc ttttaaaagg ttttcccttt tctgatctgc
     5761 atttcaacat agagtcacat aaatgtcccc ctgagaaacc aatcccactt ctttctagga
     5821 gattgggtat cttagataat cttttggggt tcctctgtga gtataggaat ggtatccttc
     5881 ctaattatct tccaaaggaa ttattttgtg tgtgtgcctg tgtgtgtgta gagacataaa
     5941 ggagggtgat gtgattttca gctagtcctt tcacattttc aataatgagg taatcatgtt
     6001 acatacacat tagtcctcag ttataaagtg aatctcagat agaaattaaa agtgcagttg
     6061 tgttaagact ctttcatact accctttagt cataaggaga aaaaaacact caaatagtag
     6121 aagcagcaag tagcaaactt caggagagct actttctatc caaataattt aaaaaacact
     6181 tttcacctac tcctttcatg gttataacac attggcagac tttttgctgg ctctgggagc
     6241 catgatttta atcacattct gcaaggtgac aaatgtcata cattccacat tgtgtggtag
     6301 ccatctcttt agactcatgt gttttgggga aaggaagaag ttcttggctg agtactattt
     6361 tgaactttcc agaaccctct cacaccagag acagttcttc tctgttcagt ttccaatccc
     6421 cgataatttg ctaaaataac attgtacatc caagagaggg aagaagagta tgtcagtata
     6481 ttatgcagaa gatagataca gccttttcag aagatctcca ctagtttttg ttccaaaaat
     6541 tcaagtttat gggagaaatc tcaattagcc accttttcac agttgtgtgg atataacatt
     6601 tgggggatct ttctggactc ctacctatct gtgcatttta ccggcacctc aggaaaggag
     6661 ggtgaccagg ttgtcttagc ttgtactgct tggtgatctc tgaggacctt ctaattcagt
     6721 tgtaccccag tgttccatgt atagaaaaac ttcattagaa caaactttac ttgatatgaa
     6781 actcctatta acagtctttt tttgaaataa aaagtagctt gagctttctt ttaaaatcat
     6841 gtatcttgat tgttgattta atgaaggatt tccttttaat gctgcttttg agcttcaagg
     6901 taataggaca gcaggaacct aaaatatctg ccatcatctg ccataggaaa gatacccaga
     6961 gacccatcat gttctctttt tgttgttaca ctgttgggtg ggtataacaa ttggaaaatg
     7021 aacaaactga ttgattgtgc aaactacttt ttatgacaag cctaaaccct cataatgcgg
     7081 cagcttaaag tgtatacata tgcactaact ttgatcaatt atattctcat atctgttagc
     7141 tacacagtct cctattatct caattgctta tgtgcatatg gaatatgtta cttaaaacgt
     7201 gtgcattctt actgaaaatg ttttcaaagg aaggtatcag ctgtgggcta attgccacca
     7261 atttcagcct gccacgattc ttggaaatat gtcttccaag tgccatccat catcagtagg
     7321 acaagtgtcg ggagtttgtt tatttttttc cagtagcaac gatgggttac atggagccat
     7381 gaaacctcct tctggcctcc cttgtgatta atggcatgtg tttgtaaaat ggatagctgg
     7441 ggttggcaga tggctagaga agaatcgcct ttggtttaaa atgtatgtgg tcccctaatg
     7501 attgtgaccc cattctgtaa tcaactgagc tagttccaat aaagttaagc aggtttaaat
     7561 ccactttgtg cctatctttt cactgacaat aaagttagct attttaaaat gca
//
