LOCUS       NM_001113402            1952 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens antagonist of mitotic exit network 1 homolog (AMN1),
            transcript variant 1, mRNA.
ACCESSION   NM_001113402
VERSION     NM_001113402.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Fang,O., Hu,X., Wang,L., Jiang,N., Yang,J., Li,B. and Luo,Z.
  TITLE     Amn1 governs post-mitotic cell separation in Saccharomyces
            cerevisiae
  JOURNAL   PLoS Genet 14 (10), e1007691 (2018)
   PUBMED   30273335
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Yazar,S., Mishra,A., Ang,W., Kearns,L.S., Mountain,J.A.,
            Pennell,C., Montgomery,G.W., Young,T.L., Hammond,C.J.,
            Macgregor,S., Mackey,D.A. and Hewitt,A.W.
  TITLE     Interrogation of the platelet-derived growth factor receptor alpha
            locus and corneal astigmatism in Australians of Northern European
            ancestry: results of a genome-wide association study
  JOURNAL   Mol Vis 19, 1238-1246 (2013)
   PUBMED   23761726
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC045831.1 and BC067906.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001113402.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037897.2, SRR1660803.78179.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281471.11/ ENSP00000281471.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1056              BC045831.1         98-1153
            1057-1381           BC067906.1         1065-1389
            1382-1576           BC045831.1         1479-1673
            1577-1952           BC067906.1         1585-1960
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.21"
     gene            1..1952
                     /gene="AMN1"
                     /note="antagonist of mitotic exit network 1 homolog"
                     /db_xref="GeneID:196394"
                     /db_xref="HGNC:HGNC:27281"
                     /db_xref="MIM:620564"
     exon            1..51
                     /gene="AMN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..790
                     /gene="AMN1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein AMN1 homolog"
                     /codon_start=1
                     /product="protein AMN1 homolog isoform 1"
                     /protein_id="NP_001106873.1"
                     /db_xref="CCDS:CCDS44858.1"
                     /db_xref="GeneID:196394"
                     /db_xref="HGNC:HGNC:27281"
                     /db_xref="MIM:620564"
                     /translation="MPRPRRVSQLLDLCLWCFMKNISRYLTDIKPLPPNIKDRLIKIM
                     SMQGQITDSNISEILHPEVQTLDLRSCDISDAALLHLSNCRKLKKLNLNASKGNRVSV
                     TSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLH
                     ALGKNCPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTY
                     CPQIRILLFHGCPLITDHSREVLEQLVGPNKLKQVTWTVY"
     exon            52..184
                     /gene="AMN1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..329
                     /gene="AMN1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..547
                     /gene="AMN1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..604
                     /gene="AMN1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..716
                     /gene="AMN1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..1952
                     /gene="AMN1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      999
                     /gene="AMN1"
                     /note="major polyA site"
     regulatory      1186..1191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMN1"
                     /note="hexamer: AGTAAA"
     polyA_site      1207
                     /gene="AMN1"
                     /note="major polyA site"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMN1"
                     /note="hexamer: AATAAA"
     polyA_site      1952
                     /gene="AMN1"
                     /note="major polyA site"
ORIGIN      
        1 agacgctgca gcgatgcctc gcccacggcg ggtcagtcag ctcctggatc tatgcctttg
       61 gtgcttcatg aagaatattt ccagatatct cacagacatt aagcctttgc ctcccaacat
      121 aaaagacaga ctgattaaaa taatgagtat gcagggacag ataacagatt caaatataag
      181 tgagatttta catcctgaag tccaaactct agatctacgg agctgcgata tatcagatgc
      241 tgctctcctg cacctgtcta actgtagaaa actgaagaaa ttaaatttaa atgcttcaaa
      301 agggaaccga gtttctgtaa cttcagaagg aataaaagct gtggcttcat cttgttcata
      361 cctacacgaa gcttctttga aaagatgctg caatctcact gacgaaggag tcgttgctct
      421 tgcactcaat tgccagctgc taaagatcat cgatttaggt ggctgcttaa gtattactga
      481 tgtgtcctta catgcattag gaaaaaactg cccatttttg cagtgtgtcg acttttcagc
      541 tactcaggta tctgacagtg gtgtgattgc acttgttagt ggaccttgtg cgaagaaatt
      601 agaggagatt catatgggac attgtgtaaa tctgactgat ggggctgtcg aagctgtcct
      661 tacttactgt cctcaaatac gtatattact cttccatgga tgccccttga taacagatca
      721 ttcccgagaa gtgttggagc aattagtagg cccaaacaaa ctaaagcaag tgacatggac
      781 tgtttattga tgcttttttg aagatgatca atgctaggaa agcttatcaa aactactttc
      841 ccaggaaacc atctatagag atttgcattc tacttaatgt taacactatt tttaattatt
      901 ttattgtctt aagttataac tctcagagaa ttagctaagt cttggtatat acatggtttg
      961 tgctttactc ttaaacatct ttaaagtgct attattctat atctgttgga tgagtcatta
     1021 tttttgaaat gataatccta gcatgaactc tgatctatgg tgttggattc tgtttcttaa
     1081 ataactttaa aattaactgt tttcccttga gatttccttc tcctatgtag gtatttgagc
     1141 tattgttcta agtttacctg taagtataaa ccttgggaga atctaagtaa acatatttct
     1201 aaaagcatag ttaccttcct attttctggc tcttaccttc ttggagtatt taaatgccca
     1261 tttgccaaaa gcagacctga acatcaagcc tgttaattct tcaaagaatt taggtatttg
     1321 tttcaccgaa atgaagtgac ttattagcca ttcagcgtat tagtattaca gaggctcttg
     1381 cccagccaca tccattcatt gatttttatg gctactcttc ccagttacat tttatgcatc
     1441 tgtaagcttt ccttccttag caaaattgca ttcaaaaatg tgtaaaaatg agtaaataca
     1501 gaatatcact acagagactt gtatcctcag gtttattgat ttcacattgt gaaataaaca
     1561 gcaaaggtct tagttttcaa gtgaaaactt tttggtaatc acaaaattac ctgacacata
     1621 ccacgcttaa accaaccccc aaatttagca tattcatttt gccatgagcc agtcttgaga
     1681 ttttcttaaa agatttctta ttttgcctct gatgtagtga aaaacggggt aagtatgcta
     1741 actttcttgt atatgttggg gggtacttat tcaactccat ttcttgtcct tacaagattt
     1801 ataaatgtgg tatgtttata gtgtggatat atatgttgcc actgcaaagg tggtgcatat
     1861 gtatatatgt gcaaaatggg taaggcctgt tctaactatg aaatttttct aaagacaaat
     1921 tcaataaaat ttaatactga atatttaacc aa
//
