LOCUS       NM_198722               2856 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens adhesion molecule with Ig like domain 3 (AMIGO3),
            mRNA.
ACCESSION   NM_198722
VERSION     NM_198722.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Anderson,C.A., Boucher,G., Lees,C.W., Franke,A., D'Amato,M.,
            Taylor,K.D., Lee,J.C., Goyette,P., Imielinski,M., Latiano,A.,
            Lagace,C., Scott,R., Amininejad,L., Bumpstead,S., Baidoo,L.,
            Baldassano,R.N., Barclay,M., Bayless,T.M., Brand,S., Buning,C.,
            Colombel,J.F., Denson,L.A., De Vos,M., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Fehrmann,R.S., Floyd,J.A., Florin,T.,
            Franchimont,D., Franke,L., Georges,M., Glas,J., Glazer,N.L.,
            Guthery,S.L., Haritunians,T., Hayward,N.K., Hugot,J.P., Jobin,G.,
            Laukens,D., Lawrance,I., Lemann,M., Levine,A., Libioulle,C.,
            Louis,E., McGovern,D.P., Milla,M., Montgomery,G.W., Morley,K.I.,
            Mowat,C., Ng,A., Newman,W., Ophoff,R.A., Papi,L., Palmieri,O.,
            Peyrin-Biroulet,L., Panes,J., Phillips,A., Prescott,N.J.,
            Proctor,D.D., Roberts,R., Russell,R., Rutgeerts,P., Sanderson,J.,
            Sans,M., Schumm,P., Seibold,F., Sharma,Y., Simms,L.A.,
            Seielstad,M., Steinhart,A.H., Targan,S.R., van den Berg,L.H.,
            Vatn,M., Verspaget,H., Walters,T., Wijmenga,C., Wilson,D.C.,
            Westra,H.J., Xavier,R.J., Zhao,Z.Z., Ponsioen,C.Y., Andersen,V.,
            Torkvist,L., Gazouli,M., Anagnou,N.P., Karlsen,T.H., Kupcinskas,L.,
            Sventoraityte,J., Mansfield,J.C., Kugathasan,S., Silverberg,M.S.,
            Halfvarson,J., Rotter,J.I., Mathew,C.G., Griffiths,A.M., Gearry,R.,
            Ahmad,T., Brant,S.R., Chamaillard,M., Satsangi,J., Cho,J.H.,
            Schreiber,S., Daly,M.J., Barrett,J.C., Parkes,M., Annese,V.,
            Hakonarson,H., Radford-Smith,G., Duerr,R.H., Vermeire,S.,
            Weersma,R.K. and Rioux,J.D.
  TITLE     Meta-analysis identifies 29 additional ulcerative colitis risk
            loci, increasing the number of confirmed associations to 47
  JOURNAL   Nat Genet 43 (3), 246-252 (2011)
   PUBMED   21297633
  REMARK    Erratum:[Nat Genet. 2011 Sep;43(9):919]
REFERENCE   2  (bases 1 to 2856)
  AUTHORS   Morgan,A.R., Han,D.Y., Lam,W.J., Fraser,A.G. and Ferguson,L.R.
  TITLE     Association analysis of 3p21 with Crohn's disease in a New Zealand
            population
  JOURNAL   Hum Immunol 71 (6), 602-609 (2010)
   PUBMED   20307617
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2856)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   4  (bases 1 to 2856)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC110418.1 and AC099668.2.
            
            On May 17, 2019 this sequence version replaced NM_198722.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC110418.1, SRR1660805.57005.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320431.8/ ENSP00000323096.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2147              BC110418.1         12-2158
            2148-2148           AC099668.2         18736-18736
            2149-2851           BC110418.1         2160-2862
            2852-2856           AC099668.2         19440-19444
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2856
                     /gene="AMIGO3"
                     /gene_synonym="ALI3; AMIGO-3"
                     /note="adhesion molecule with Ig like domain 3"
                     /db_xref="GeneID:386724"
                     /db_xref="HGNC:HGNC:24075"
                     /db_xref="MIM:615691"
     exon            1..2856
                     /gene="AMIGO3"
                     /gene_synonym="ALI3; AMIGO-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1734
                     /gene="AMIGO3"
                     /gene_synonym="ALI3; AMIGO-3"
                     /EC_number="2.7.7.13"
                     /note="amphoterin-induced gene and ORF 3;
                     amphoterin-induced protein 3; alivin-3"
                     /codon_start=1
                     /product="amphoterin-induced protein 3 precursor"
                     /protein_id="NP_942015.1"
                     /db_xref="CCDS:CCDS33759.1"
                     /db_xref="GeneID:386724"
                     /db_xref="HGNC:HGNC:24075"
                     /db_xref="MIM:615691"
                     /translation="MTWLVLLGTLLCMLRVGLGTPDSEGFPPRALHNCPYKCICAADL
                     LSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRALHLDHNELDALGR
                     GVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHLDEHAFHGLRALS
                     HLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGHISVPELAALPAFLKNGLYLHN
                     NPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCLAFKVPASRVRFFQHSRVFENCSSA
                     PALGLERPEEHLYALVGRSLRLYCNTSVPAMRIAWVSPQQELLRAPGSRDGSIAVLAD
                     GSLAIGNVQEQHAGLFVCLATGPRLHHNQTHEYNVSVHFPRPEPEAFNTGFTTLLGCA
                     VGLVLVLLYLFAPPCRCCRRACRCRRWPQTPSPLQELSAQSSVLSTTPPDAPSRKASV
                     HKHVVFLEPGRRGLNGRVQLAVAEEFDLYNPGGLQLKAGSESASSIGSEGPMTT"
     regulatory      2814..2819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMIGO3"
                     /gene_synonym="ALI3; AMIGO-3"
                     /note="hexamer: AATAAA"
     polyA_site      2856
                     /gene="AMIGO3"
                     /gene_synonym="ALI3; AMIGO-3"
                     /note="major polyA site"
ORIGIN      
        1 gagagggcta gcgaagccga agggagcgcg gctaagagtg ccgcaccgcc tcacaacctg
       61 ggaaccggag agtaggggcc gtcggctggc aagaacccgc cgtgcctcct cggcaagggc
      121 catccggtgc cacccatgtc gcactagagc agaagagggt gagtcctgga actgcaacct
      181 gcacagagct gctctgtact gtccctggtg gtcgccgcca tgacctggtt ggtgctgctg
      241 gggacactgc tctgcatgct gcgcgttggg ttaggcaccc cggactccga gggtttcccg
      301 ccccgtgcgc tccacaactg cccctacaaa tgtatctgcg ctgccgacct gctaagctgc
      361 actggcctag ggctgcagga cgtgccagcc gagttacctg ccgctactgc ggacctcgac
      421 ctgagccaca acgcgctcca gcgcctgcgc cccggctggt tggcgcccct cttccagctg
      481 cgcgccctgc acctagacca caacgaacta gatgcgctgg gtcgcggcgt cttcgtcaac
      541 gccagcggcc tgaggctgct cgatctatca tctaacacgt tgcgggcgct tggccgccac
      601 gacctcgacg ggctgggggc gctggagaag ctgcttctgt tcaataaccg cttggtgcac
      661 ttggacgagc atgccttcca cggcctgcgc gcgctcagcc atctctacct gggctgcaac
      721 gaactcgcct cgttctcctt cgaccacctg cacggtctga gcgccaccca cctgcttact
      781 ctggacctct cctccaaccg gctgggacac atctccgtac ctgagctggc cgcgctgccg
      841 gccttcctca agaacggcct ctacttgcac aacaaccctt tgccttgcga ctgccgcctc
      901 taccacctgc tacagcgctg gcaccagcgg ggcctgagcg ccgtgcgcga ctttgcgcgc
      961 gagtacgtat gcttggcctt caaggtaccc gcgtcccgcg tgcgcttctt ccagcacagc
     1021 cgcgtctttg agaactgctc gtcggcccca gctcttggcc tagagcggcc ggaagagcac
     1081 ctgtacgcgc tggtgggtcg gtccctgagg ctttactgca acaccagcgt cccggccatg
     1141 cgcattgcct gggtttcgcc gcagcaggag cttctcaggg cgccaggatc ccgcgatggc
     1201 agcatcgcgg tgctggccga cggcagcttg gccataggca acgtacagga gcagcatgcg
     1261 ggactcttcg tgtgcctggc cactgggccc cgcctgcacc acaaccagac gcacgagtac
     1321 aacgtgagcg tgcactttcc gcgcccagag cccgaggctt tcaacacagg cttcaccaca
     1381 ctgctgggct gtgccgtggg ccttgtgctc gtgctgctct acctgttcgc cccaccctgc
     1441 cgctgctgcc gccgtgcctg ccgctgccgc cgctggcccc aaacacccag cccgctccaa
     1501 gagctgagcg cacagtcctc agtactcagc accacaccgc cagacgcacc cagccgcaag
     1561 gccagcgtcc acaagcacgt agtctttctg gagccaggcc ggaggggcct caatggccgc
     1621 gtgcagctgg cagtagctga ggaattcgat ctctacaacc ctggaggcct gcagctgaag
     1681 gctggctctg agtccgccag ctccataggc tccgagggtc ccatgacaac ctagactgcc
     1741 cagggctccc ccacccaggc ccccaccctc ttgctgctcg ccctgctccc tgcttcggtc
     1801 cagagaactg gcagatactg gtgggaagca ctgtgcctgg ccccccagct tcctgtatgg
     1861 gcctcgaaac acaatgggcc ttctcgctca ctggtagaga caggggttgt ggtccccaac
     1921 ctgccttctg ctctgcccct gcacaggacc caaaggcccc aggccctgca aggtgtgcta
     1981 gttcctgctt tcccgcggac ttcctagtgc ccaaatgccc tgtgaggctg agagacccag
     2041 gcccctgtgg ctttcaacac agcacagctg tggaagtggc tgtgttcttc tacagcctgt
     2101 ggaagaaccc ctgtagcaga gcctcccgtc caccctcagg ggctgagaca gctctcgagg
     2161 agtggtgctc aagagctgac gcagggccac ctccccttcc caagggggtg ggagggagtg
     2221 ggcccacagg gaaaagaagg cggctctgaa ggaagatctc gcccacaccc caggacagaa
     2281 agaggaaaca agcccgccct ctggtgaaat gggactccct ccatccacca acacccaacc
     2341 tcctgaaagc ttcacaactt cacgcagagt ccggtgggca ggcaccaggc aggaaaggct
     2401 cctcaagagg ttcctggtgg tctggcctaa gccccagcca gaggccctgc tctctctggc
     2461 ctggggcatc cacccgttgt tctgaaggca gagcccattc tgtgggctca caagacacag
     2521 tgaaggggat catggcctgc acccctgctt ttcagcagta aaaagcccga aaagcctggc
     2581 gagcatggcc gagctgggag ggccgagccg gaactccacg tccctcgaga gcaggagcct
     2641 cttaagggct ggcactggtc tcagcctaat ggctgaggcg gtaccctggc ttcatatgca
     2701 tctcactgct cccactgcag gggggcaggg aaggggggtc tgggagccct tcatgtgtgg
     2761 gggccgagct gggggccccc atggccatcc tggacctcgc tgctccagag tttaataaag
     2821 gtagcacatg cttattgcta gagcctttgc agacaa
//
