LOCUS       NM_001370299            3224 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens adhesion molecule with Ig like domain 2 (AMIGO2),
            transcript variant 3, mRNA.
ACCESSION   NM_001370299 XM_005268837
VERSION     NM_001370299.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3224)
  AUTHORS   Iida,Y., Osaki,M., Sato,S., Izutsu,R., Seong,H., Komatsu,H.,
            Taniguchi,F. and Okada,F.
  TITLE     AMIGO2 is involved in the spread of peritoneal metastasis in serous
            ovarian cancer via promoting adhesion to the peritoneal mesothelial
            cells
  JOURNAL   Int J Clin Oncol 29 (9), 1354-1363 (2024)
   PUBMED   38811439
  REMARK    GeneRIF: AMIGO2 is involved in the spread of peritoneal metastasis
            in serous ovarian cancer via promoting adhesion to the peritoneal
            mesothelial cells.
REFERENCE   2  (bases 1 to 3224)
  AUTHORS   Chen,S., Du,W., Feng,K., Liu,K., Li,C., Li,S. and Yin,H.
  TITLE     AMIGO2 is a pivotal therapeutic target related to M2 polarization
            of macrophages in pancreatic ductal adenocarcinoma
  JOURNAL   Aging (Albany NY) 16 (2), 1111-1127 (2024)
   PUBMED   38189855
  REMARK    GeneRIF: AMIGO2 is a pivotal therapeutic target related to M2
            polarization of macrophages in pancreatic ductal adenocarcinoma.
REFERENCE   3  (bases 1 to 3224)
  AUTHORS   Chen,L.K., Lin,S.P., Xie,Y.H., Tan,X.P., Xiong,B.H., Zeng,X.F.,
            Zhu,C.R., Cao,S.Y., Ye,X.Y., Liu,H.J. and Wu,X.P.
  TITLE     AMIGO2 attenuates innate cisplatin sensitivity by suppression of
            GSDME-conferred pyroptosis in non-small cell lung cancer
  JOURNAL   J Cell Mol Med 27 (16), 2412-2423 (2023)
   PUBMED   37438979
  REMARK    GeneRIF: AMIGO2 attenuates innate cisplatin sensitivity by
            suppression of GSDME-conferred pyroptosis in non-small cell lung
            cancer.
REFERENCE   4  (bases 1 to 3224)
  AUTHORS   Izutsu,R., Osaki,M., Jehung,J.P., Seong,H.K. and Okada,F.
  TITLE     Liver Metastasis Formation Is Defined by AMIGO2 Expression via
            Adhesion to Hepatic Endothelial Cells in Human Gastric and
            Colorectal Cancer Cells
  JOURNAL   Pathol Res Pract 237, 154015 (2022)
   PUBMED   35843033
  REMARK    GeneRIF: Liver Metastasis Formation Is Defined by AMIGO2 Expression
            via Adhesion to Hepatic Endothelial Cells in Human Gastric and
            Colorectal Cancer Cells.
REFERENCE   5  (bases 1 to 3224)
  AUTHORS   Goto,K., Morimoto,M., Osaki,M., Tanio,A., Izutsu,R., Fujiwara,Y.
            and Okada,F.
  TITLE     The impact of AMIGO2 on prognosis and hepatic metastasis in gastric
            cancer patients
  JOURNAL   BMC Cancer 22 (1), 280 (2022)
   PUBMED   35296279
  REMARK    GeneRIF: The impact of AMIGO2 on prognosis and hepatic metastasis
            in gastric cancer patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3224)
  AUTHORS   Tao,S., Wang,Z., Feng,J., Hsu,F.C., Jin,G., Kim,S.T., Zhang,Z.,
            Gronberg,H., Zheng,L.S., Isaacs,W.B., Xu,J. and Sun,J.
  TITLE     A genome-wide search for loci interacting with known prostate
            cancer risk-associated genetic variants
  JOURNAL   Carcinogenesis 33 (3), 598-603 (2012)
   PUBMED   22219177
REFERENCE   7  (bases 1 to 3224)
  AUTHORS   Kahle,J.J., Gulbahce,N., Shaw,C.A., Lim,J., Hill,D.E.,
            Barabasi,A.L. and Zoghbi,H.Y.
  TITLE     Comparison of an expanded ataxia interactome with patient medical
            records reveals a relationship between macular degeneration and
            ataxia
  JOURNAL   Hum Mol Genet 20 (3), 510-527 (2011)
   PUBMED   21078624
REFERENCE   8  (bases 1 to 3224)
  AUTHORS   Rabenau,K.E., O'Toole,J.M., Bassi,R., Kotanides,H., Witte,L.,
            Ludwig,D.L. and Pereira,D.S.
  TITLE     DEGA/AMIGO-2, a leucine-rich repeat family member, differentially
            expressed in human gastric adenocarcinoma: effects on ploidy,
            chromosomal stability, cell adhesion/migration and tumorigenicity
  JOURNAL   Oncogene 23 (29), 5056-5067 (2004)
   PUBMED   15107827
  REMARK    GeneRIF: Stable expression of a DEGA/AMIGO-2 antisense construct
            led to altered morphology, increased ploidy, chromosomal
            instability, decreased cell adhesion/migration, and a nearly
            complete abrogation of tumorigenicity in nude mice.
REFERENCE   9  (bases 1 to 3224)
  AUTHORS   Ono,T., Sekino-Suzuki,N., Kikkawa,Y., Yonekawa,H. and Kawashima,S.
  TITLE     Alivin 1, a novel neuronal activity-dependent gene, inhibits
            apoptosis and promotes survival of cerebellar granule neurons
  JOURNAL   J Neurosci 23 (13), 5887-5896 (2003)
   PUBMED   12843293
  REMARK    GeneRIF: Expression of ali1 promotes depolarization-dependent
            survival of cerebellar granule neurons. Mouse ali1 mapped to a
            chromosome 15 locus syntenic to candidate loci for familial
            Alzheimer's disease type 5 and Parkinson's disease 8 on human
            chromosome 12.
REFERENCE   10 (bases 1 to 3224)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004010.1.
            
            On May 4, 2019 this sequence version replaced XM_005268837.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138514.18657.1, AL833007.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000550413.2/ ENSP00000449034.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               AC004010.1         113643-114140       c
            499-605             AC004010.1         113323-113429       c
            606-3224            AC004010.1         110628-113246       c
FEATURES             Location/Qualifiers
     source          1..3224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..3224
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /note="adhesion molecule with Ig like domain 2"
                     /db_xref="GeneID:347902"
                     /db_xref="HGNC:HGNC:24073"
                     /db_xref="MIM:615690"
     exon            1..498
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /inference="alignment:Splign:2.1.0"
     exon            499..605
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /inference="alignment:Splign:2.1.0"
     exon            606..3224
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             669..2237
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /note="amphoterin induced gene 2; amphoterin-induced
                     protein 2; transmembrane protein AMIGO2; differentially
                     expressed in gastric adenocarcinoma; alivin 1;
                     differentially expressed in gastric adenocarcinomas"
                     /codon_start=1
                     /product="amphoterin-induced protein 2 precursor"
                     /protein_id="NP_001357228.1"
                     /db_xref="CCDS:CCDS8751.1"
                     /db_xref="GeneID:347902"
                     /db_xref="HGNC:HGNC:24073"
                     /db_xref="MIM:615690"
                     /translation="MSLRVHTLPTLLGAVVRPGCRELLCLLMITVTVGPGASGVCPTA
                     CICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLILRH
                     NNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVLEVLLLYNNHISYLDPSA
                     FGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNRIPSMPMHHINLVPGK
                     QLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLWSDSRHSRQVLLLQ
                     DSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIWVGPDNRLLEPD
                     KEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVSNFTVSRSHA
                     HEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKTKRQKNMLHQSNAHSSILSPGPA
                     SDASADERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSEAVIAEGILKSTRGKSDSDS
                     VNSVFSDTPFVAST"
     regulatory      3095..3100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /note="hexamer: AATATA"
     polyA_site      3117
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /note="major polyA site"
     regulatory      3146..3151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /note="hexamer: CATAAA"
     polyA_site      3170
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
     regulatory      3189..3194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /note="hexamer: TATAAA"
     polyA_site      3224
                     /gene="AMIGO2"
                     /gene_synonym="ALI1; AMIGO-2; DEGA"
                     /note="major polyA site"
ORIGIN      
        1 gcaggctccg agctgctgcc cgcaggaggc aggacgcgca ggggtgggac cggcgcccca
       61 gcccgtctcc cggccccggg cgcgcgggaa ccccgggtcc tgcagcctcc cgagtgcgga
      121 gaggcggggc cgcccgctgc cgcccggctg cctgcgcccc ctcccgcggc cccggctctg
      181 ggagcggggc gccccgcgcg cgggcacacg gcggccagag cgccgaggcg gtaccttcag
      241 cctgcaatga gaggaacccg ggagagcccc cgggagccag cgaagagctt ggctgctgcg
      301 tccagggctg ctgctgccgc cgcggctgct tgaaactcct caaagttgag agccggctag
      361 agggtgccgc ccgccgggag ccggagggaa aggaagtcgg aaggtgcaag agtgacagac
      421 acggacagac ggacgcgcag accttcggaa ggcactgcgt aggcagcctc cccggagccc
      481 acgaggctcc ccagcaccga ctaacccagg aaagaggaaa aaatacattt aacagtgaag
      541 aggcaacaca gagctcccta ttgtgaaata aaacccattt caaaagttat tggaaagaaa
      601 gtaaggttca ctggtgggag gctgagccgg tggaaaagac accgggaaga gactcagagg
      661 cgaccataat gtcgttacgt gtacacactc tgcccaccct gcttggagcc gtcgtcagac
      721 cgggctgcag ggagctgctg tgtttgctga tgatcacagt gactgtgggc cctggtgcct
      781 ctggggtgtg ccccaccgct tgcatctgtg ccactgacat cgtcagctgc accaacaaaa
      841 acctgtccaa ggtgcctggg aaccttttca gactgattaa gagactggac ctgagttata
      901 acagaattgg gcttctggat tctgagtgga ttccagtatc gtttgcaaag ctgaacaccc
      961 taattcttcg tcataacaac atcaccagca tttccacggg cagtttttcc acaactccaa
     1021 atttgaagtg tcttgactta tcgtccaata agctgaagac ggtgaaaaat gctgtattcc
     1081 aagagttgaa ggttctggaa gtgcttctgc tttacaacaa tcacatatcc tatctcgatc
     1141 cttcagcgtt tggagggctc tcccagttgc agaaactcta cttaagtgga aattttctca
     1201 cacagtttcc gatggatttg tatgttggaa ggttcaagct ggcagaactg atgtttttag
     1261 atgtttctta taaccgaatt ccttccatgc caatgcacca cataaattta gtgccaggaa
     1321 aacagctgag aggcatctac cttcatggaa acccatttgt ctgtgactgt tccctgtact
     1381 ccttgctggt cttttggtat cgtaggcact ttagctcagt gatggatttt aagaacgatt
     1441 acacctgtcg cctgtggtct gactccaggc actcgcgtca ggtacttctg ctccaggata
     1501 gctttatgaa ttgctctgac agcatcatca atggttcctt tcgtgcgctt ggctttattc
     1561 atgaggctca ggtcggggaa agactgatgg tccactgtga cagcaagaca ggtaatgcaa
     1621 atacggattt catctgggtg ggtccagata acagactgct agagccggat aaagagatgg
     1681 aaaactttta cgtgtttcac aatggaagtc tggttataga aagccctcgt tttgaggatg
     1741 ctggagtgta ttcttgtatc gcaatgaata agcaacgcct gttaaatgaa actgtggacg
     1801 tcacaataaa tgtgagcaat ttcactgtaa gcagatccca tgctcatgag gcatttaaca
     1861 cagcttttac cactcttgct gcttgcgtgg ccagtatcgt tttggtactt ttgtacctct
     1921 atctgactcc atgcccctgc aagtgtaaaa ccaagagaca gaaaaatatg ctacaccaaa
     1981 gcaatgccca ttcatcgatt ctcagtcctg gccccgctag tgatgcctcc gctgatgaac
     2041 ggaaggcagg tgcaggtaaa agagtggtgt ttttggaacc cctgaaggat actgcagcag
     2101 ggcagaacgg gaaagtcagg ctctttccca gcgaggcagt gatagctgag ggcatcctaa
     2161 agtccacgag ggggaaatct gactcagatt cagtcaattc agtgttttct gacacacctt
     2221 ttgtggcgtc cacttaattt gtgcctatat ttgtatgatg tcataattta atctgttcat
     2281 atttaacttt gtgtgtggtc tgcaaaataa acagcaggac agaaattgtg ttgttttgtt
     2341 ctttgaaata caaccaaatt ctcttaaaat gattggtagg aaatgaggta aagtacttca
     2401 gttcctcaat gtgccataga aagatggggt tgttttccaa agtttaagtt ctagatcaca
     2461 atatcttagc ttttagcact attggtaatt tcagagtagg cccaaaggtg atatgactcc
     2521 cattgtccct ttatttagga tattgaaaga aaaaataaac tttatgtatt agtgtccttt
     2581 aaaaatagac tttgctaact tactagtacc agagttattt taaagaaaaa cactagtgtc
     2641 caatttcatt tttaaaagat gtagaaagaa gaatcaagca tcaattaatt ataaagccta
     2701 aagcaaagtt agatttgggg gttattcagc caaaattacc gttttagacc agaatgaata
     2761 gactacactg ataaaatgta ctggataatg ccacatccta tatggtgtta tagaaatagt
     2821 gcaaggaaag tacatttgtt tgcctgtctt ttcattttgt acattcttcc cattctgtat
     2881 tcttgtacaa aagatctcat tgaaaattta aagtcatcat aatttgttgc cataaatatg
     2941 taagtgtcaa taccaaaatg tctgagtaac ttcttaaatc cctgttctag caaactaata
     3001 ttggttcatg tgcttgtgta tatgtaaatc ttaaattatg tgaactatta aatagaccct
     3061 actgtactgt gctttggaca tttgaattaa tgtaaatata tgtaatctgt gacttgatat
     3121 tttgttttat ttggctattt aaaaacataa atctaaaatg tcttatgtta tcagattatg
     3181 ctattttgta taaagcacca ctgatagcaa atctctctcc aaaa
//
