LOCUS       NM_020703               5130 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens adhesion molecule with Ig like domain 1 (AMIGO1),
            mRNA.
ACCESSION   NM_020703 XM_371279
VERSION     NM_020703.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5130)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5130)
  AUTHORS   Peltola,M.A., Kuja-Panula,J., Liuhanen,J., Voikar,V., Piepponen,P.,
            Hiekkalinna,T., Taira,T., Lauri,S.E., Suvisaari,J., Kulesskaya,N.,
            Paunio,T. and Rauvala,H.
  TITLE     AMIGO-Kv2.1 Potassium Channel Complex Is Associated With
            Schizophrenia-Related Phenotypes
  JOURNAL   Schizophr Bull 42 (1), 191-201 (2016)
   PUBMED   26240432
  REMARK    GeneRIF: AMIGO1 is identified as a candidate gene for human
            schizophrenia and related psychiatric disorders.
REFERENCE   3  (bases 1 to 5130)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   4  (bases 1 to 5130)
  AUTHORS   Kuja-Panula,J., Kiiltomaki,M., Yamashiro,T., Rouhiainen,A. and
            Rauvala,H.
  TITLE     AMIGO, a transmembrane protein implicated in axon tract
            development, defines a novel protein family with leucine-rich
            repeats
  JOURNAL   J Cell Biol 160 (6), 963-973 (2003)
   PUBMED   12629050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY122839.1, AK295678.1 and AL355145.31.
            
            On Nov 22, 2018 this sequence version replaced NM_020703.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.144517.1,
                                           SRR1660807.150197.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369864.5/ ENSP00000358880.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                HY122839.1         26-60
            36-210              AK295678.1         2-176
            211-211             AL355145.31        37574-37574         c
            212-2225            AK295678.1         178-2191
            2226-5130           AL355145.31        32235-35139         c
FEATURES             Location/Qualifiers
     source          1..5130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..5130
                     /gene="AMIGO1"
                     /gene_synonym="ALI2; AMIGO; AMIGO-1"
                     /note="adhesion molecule with Ig like domain 1"
                     /db_xref="GeneID:57463"
                     /db_xref="HGNC:HGNC:20824"
                     /db_xref="MIM:615689"
     exon            1..308
                     /gene="AMIGO1"
                     /gene_synonym="ALI2; AMIGO; AMIGO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..5130
                     /gene="AMIGO1"
                     /gene_synonym="ALI2; AMIGO; AMIGO-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..1877
                     /gene="AMIGO1"
                     /gene_synonym="ALI2; AMIGO; AMIGO-1"
                     /note="amphoterin-induced protein 1; amphoterin-induced
                     gene and ORF; alivin-2"
                     /codon_start=1
                     /product="amphoterin-induced protein 1 precursor"
                     /protein_id="NP_065754.2"
                     /db_xref="CCDS:CCDS30795.1"
                     /db_xref="GeneID:57463"
                     /db_xref="HGNC:HGNC:20824"
                     /db_xref="MIM:615689"
                     /translation="MHPHRDPRGLWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNI
                     LSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFIS
                     SEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQL
                     QKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYL
                     HNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEYKER
                     AWEAHLGDTLIIKCDTKQQGMTKVWVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVE
                     DGGVYTCYAMGETFNETLSVELKVHNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLY
                     LTPCRCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAGGDKDDGFDRRVAFLEPAGPG
                     QGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSDTPIVV"
     regulatory      5100..5105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMIGO1"
                     /gene_synonym="ALI2; AMIGO; AMIGO-1"
                     /note="hexamer: ATTAAA"
     polyA_site      5130
                     /gene="AMIGO1"
                     /gene_synonym="ALI2; AMIGO; AMIGO-1"
                     /note="major polyA site"
ORIGIN      
        1 gctcgctgcc cccacgccgc tccctccgct gggatcgctg cgcctccggc tccccgcacc
       61 gatccgcgcc aggcctgcgg acctggaggc agcgaccgcg gtcggtgggc tccggcgggc
      121 tcagcggtcg aggcggtggc agggtgagcg gagcggggcc ccgcaagtcc ccgggaggcg
      181 acggtgccgg gcgcgggccc ctgcgtaagg tgggcgcagt gacaggccgg ccggtgaggc
      241 gccgccggga gaggccgcga cggagctccc agaccggcca tgggctgaga cacgtcctcg
      301 ccgagcagtg acccttccgt accccaccag aacatgcccg ggtgacctcc tcccagatct
      361 tccttgtggc cttcctcgcc cactccagtg acactatgca cccccaccgt gacccgagag
      421 gcctctggct cctgctgccg tccttgtccc tgctgctttt tgaggtggcc agagctggcc
      481 gagccgtggt tagctgtcct gccgcctgct tgtgcgccag caacatcctc agctgctcca
      541 agcagcagct gcccaatgtg ccccattcct tgcccagtta cacagcacta ctggacctca
      601 gtcacaacaa cctgagccgc ctgcgggccg agtggacccc cacgcgcctg acccaactgc
      661 actccctgct gctgagccac aaccacctga acttcatctc ctctgaggcc ttttccccgg
      721 tacccaacct gcgctacctg gacctctcct ccaaccagct gcgtacactg gatgagttcc
      781 tgttcagtga cctgcaagta ctggaggtgc tgctgctcta caataaccac atcatggcgg
      841 tggaccggtg cgccttcgat gacatggccc agctgcagaa actctacttg agccagaacc
      901 agatctctcg cttccctctg gaactggtca aggaaggagc caagctaccc aaactaacgc
      961 tcctggatct ctcttctaac aagctgaaga acttgccatt gcctgacctg cagaagctgc
     1021 cggcctggat caagaatggg ctgtacctac ataacaaccc cctgaactgc gactgtgagc
     1081 tctaccagct gttttcacac tggcagtatc ggcagctgag ctccgtgatg gactttcaag
     1141 aggatctgta ctgcatgaac tccaagaagc tgcacaatgt cttcaacctg agtttcctca
     1201 actgtggcga gtacaaggag cgtgcctggg aggcccacct gggtgacacc ttgatcatca
     1261 agtgtgacac caagcagcaa gggatgacca aggtgtgggt gacaccaagt aatgaacggg
     1321 tgctagatga ggtgaccaat ggcacagtga gtgtgtctaa ggatggcagt cttcttttcc
     1381 agcaggtgca ggtcgaggac ggtggtgtgt atacctgcta tgccatggga gagactttca
     1441 atgagacact gtctgtggaa ttgaaagtgc acaatttcac cttgcacgga caccatgaca
     1501 ccctcaacac agcctatacc accctagtgg gctgtatcct tagtgtggtc ctggtcctca
     1561 tatacctata cctcacccct tgccgctgct ggtgccgggg tgtagagaag ccttccagcc
     1621 atcaaggaga cagcctcagc tcttccatgc ttagtaccac acccaaccat gatcctatgg
     1681 ctggtgggga caaagatgat ggttttgacc ggcgggtggc tttcctggaa cctgctggac
     1741 ctgggcaggg tcaaaacggc aagctcaagc caggcaacac cctgccagtg cctgaggcca
     1801 caggcaaggg ccaacggagg atgtcggatc cagaatcagt cagctcggtc ttctctgata
     1861 cgcccattgt ggtgtgagca ggatgggttg gtggggagat tctgccccag gagaggtaat
     1921 gcacccctga aggatatgag gggatggaag agagggctgg ctgcccaagg gaatggattc
     1981 ctcctgacct caagggaatt ggtcccaggt acaacagaga gcaagacccc aaacagggcg
     2041 tggctgccac gattttcaaa tgggggtata ttaatcctca ggcaaatgct acacccgtac
     2101 ccaaagccct gccaattctc agtgtggtag aggaagagaa gcatgtctga gttggatggg
     2161 aatgaggaag gagtgagggg aagaacagat tccctaaact ttcatgaggt catccctagc
     2221 tccttaagag aaaaacattt agaaaaaaaa attttttcta tctctgccca cccacacctg
     2281 tgatgttgtg tgtgttgggg gagcttccac aggagccaca ctggggaaaa gctgtagtat
     2341 cttctttgtt tagcaagtca aacttcacag ctggggaagt tgaaaacctt tggaaaatga
     2401 gtcaggaaaa ggctgagacc tcaatcggta acaattcccc aaagctgttg taagactttg
     2461 cattaaagcc ttcctttttc ctgatgtgcc ctgggtggat ggatctttgc aggagcctgg
     2521 cctgctgcct tttagttaca acagcaatgt gggatgtggt atctgtgcct tgtcctggga
     2581 ccaatggcac agagggttat agcatgaact gaagggtcca tgtcacagca taggtgccag
     2641 cacgaaactt gtagatgggg ggtgaattcc agataggcta attccctggt tggtgaaacc
     2701 cttggttagt atttgattcc cagcatctgt gtgtcaggcc agagtggggg ctgctgaagg
     2761 cagagctttt atggatgcct gccacagacg tggtacatgg gcccacttca cgatagaagg
     2821 atgaaggtaa atcagcctct attatgtagc atccagctgg acctagctga ttctcaatgt
     2881 atgccatctc ttcatccagt ctccttatca agctcaggtg ggattctgaa ttttccctaa
     2941 tatgctgctc tgtaaaggga ggagtccaag aaagcctggc cccagctggc ttagagtagg
     3001 cttggcgata gtgaaaatcc agtatatatc tcctctgtgt ggacaaggtt gccttgctcc
     3061 tctcagagat accacctctg ctgcaaagtc aaagcatggg gttttgacat cagaagggtt
     3121 ggaattgggt ggtctctacc ccagaatggc aatttggagt gcagcttcaa gttctgccct
     3181 ctccacagat tccaggcaat cctgaagcag agataatcag tagtactaaa ctttcagaag
     3241 gggagttctg ccaccccatt cctccatcga gaggtctttg cagttgtggt tgtgaggcca
     3301 gaggaactta agaagaatga gctcaacatt ccattccatc caaggttgca gaatactttg
     3361 agtatggaga tgaccgatcc ctttaacctt tccctttgac tacactgcat gccctgtgag
     3421 tggctgctct gagctttggc gggggatgag cagggtgaag gtgaaaatgt tctctgatgt
     3481 tggtttttct tagggtctct tctctcccac gtttctagtc cattggaagt tctccagatc
     3541 ctctagattt ctgacctctt tttacattct aagaggtgtc atttacctgt gggtgagggg
     3601 cttggagggc ctgactatta agcttcctat tatgattggg gaaggggact caacatcttc
     3661 cccttgtctg gtcctgggaa ctcaagactg ctgtccatcc tttattagta acctagtttt
     3721 gttgagagag aggtgcagca tttccctcaa gtacctgcat gctcataggt atgcatgctt
     3781 ataggtatgc atgcacacca gcaccttgac ttccaccagg acagtgaatc tgtagtcccc
     3841 attaatgata ctctcagaat ggtctccacc aatgtgcaca acttcatgca cacaattgta
     3901 ttcctcttta ggagagacag tgaccatgcc aggctcttca aatacacact cctgtatttt
     3961 catttctgaa ctccctgaag cttcacccac atctccatgg cactgaatca cttttctgcc
     4021 caggctggag ttagaagaac catgggttga aggccttggg agaagaggtg gtaaggagct
     4081 acctggttct ttggactcct cagaaacctc ccgtgaagac tatatatatg agcaatatat
     4141 gagcaattaa gatagaacta ggtcattgaa ggactcagaa ggaaactggc aaggggctaa
     4201 gtagctgtga gctgctcttc ctgttaactg tcctcaggag agaaaagttg tcttgattta
     4261 ttccagagac tcctgagaat tttgttactg gagctatagg aactaggact ccctcctcag
     4321 actcatcagg aaatctggga aaatctcatc tccatgctgc agtctccccg cttggcacca
     4381 tctagggctc tgaagatctt taaagtgagc gttaaatgaa gcaggccttc tggggcatcg
     4441 tgatggagct cctgaggact gggagggccg ttttcttcat aattcctacc cagtttaggg
     4501 aatgagaaaa ggccctgtgg ctcttaagtc tcctgactat atccactagt ttggccttga
     4561 gtttgagaca cctggtagat gtacctggct gccctaccaa gagatttgat ttgtttcttc
     4621 ccgtggtttc aggtgataga acccaaaggt agctttttaa ttggagaatt gaataatcag
     4681 catatgtaag cgcactagaa ccctgtgttg aaaactgcca ggtgtgggta taagaaaagg
     4741 ccgagagatc accacctcct cttaccctac cccacaccca taaaccagac atgtctccca
     4801 ggaagcaggt gtccctggag acagaggatg acagggctct acaatctgtg taattattat
     4861 tattattatt attttgtatt tatggggccc aagaaagggg ccaggagagg gtacacccca
     4921 gctggggaga gcaaagcaga tggatccagt tttctgtgtg ttcttacctc tgtacttcct
     4981 cgtagctctg ctgacaaagc aagcaggcct cccgtgtcca agaccccatt cctcccactt
     5041 gtgtacacct aggctggcaa atcttggagc ctctgggctc tgaaaactag acaatgatca
     5101 ttaaacctgg cttgagtctc tgttctggca
//
