LOCUS       NM_152698               6216 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens APC membrane recruitment protein 3 (AMER3), transcript
            variant 1, mRNA.
ACCESSION   NM_152698
VERSION     NM_152698.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6216)
  AUTHORS   Brauburger,K., Akyildiz,S., Ruppert,J.G., Graeb,M., Bernkopf,D.B.,
            Hadjihannas,M.V. and Behrens,J.
  TITLE     Adenomatous polyposis coli (APC) membrane recruitment 3, a member
            of the APC membrane recruitment family of APC-binding proteins, is
            a positive regulator of Wnt-beta-catenin signalling
  JOURNAL   FEBS J 281 (3), 787-801 (2014)
   PUBMED   24251807
  REMARK    GeneRIF: Data suggest Amer3 activates Wnt signaling, in contrast to
            Amer1/Amer2 which inhibit Wnt, suggesting non-redundant role of
            Amer proteins in regulation of Wnt pathway. Knockdown of Amer3
            reduces Wnt target gene expression in colorectal cancer cells.
REFERENCE   2  (bases 1 to 6216)
  AUTHORS   Boutet,A., Comai,G. and Schedl,A.
  TITLE     The WTX/AMER1 gene family: evolution, signature and function
  JOURNAL   BMC Evol Biol 10, 280 (2010)
   PUBMED   20843316
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA102742.1, BC113445.1, AC140481.3 and AK095696.1.
            
            On Jun 2, 2019 this sequence version replaced NM_152698.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095696.1, AK291424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321420.5/ ENSP00000314914.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                DA102742.1         106-192
            88-1171             BC113445.1         1-1084
            1172-1172           AC140481.3         27559-27559         c
            1173-2762           BC113445.1         1086-2675
            2763-3168           AK095696.1         2763-3168
            3169-6216           AC140481.3         22515-25562         c
FEATURES             Location/Qualifiers
     source          1..6216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..6216
                     /gene="AMER3"
                     /gene_synonym="FAM123C"
                     /note="APC membrane recruitment protein 3"
                     /db_xref="GeneID:205147"
                     /db_xref="HGNC:HGNC:26771"
     exon            1..135
                     /gene="AMER3"
                     /gene_synonym="FAM123C"
                     /inference="alignment:Splign:2.1.0"
     exon            136..6216
                     /gene="AMER3"
                     /gene_synonym="FAM123C"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2740
                     /gene="AMER3"
                     /gene_synonym="FAM123C"
                     /note="protein FAM123C; family with sequence similarity
                     123C"
                     /codon_start=1
                     /product="APC membrane recruitment protein 3"
                     /protein_id="NP_689911.2"
                     /db_xref="CCDS:CCDS2164.1"
                     /db_xref="GeneID:205147"
                     /db_xref="HGNC:HGNC:26771"
                     /translation="MELKRGKTFIKSSLQVSHEKPPDPAAVAAAREGTGPWSVLPGGQ
                     QRPHSEKGPQASPSAQEYDRCPNKGAQLDPKGGPAALCGATFKPVRKCKTHDSMSGAG
                     RATAATGQLVGSASFPGSPGSRRMIDYRHFVPQMPFVPAVAKSIPRKRISLKRPKKCF
                     RNLFHIRRNKTEDLASLAAEGKSLPSPGDPSDPGGRRSKAFLPPGEGPGLDGLCQDLL
                     DSELLADASFGLCRALCEDVASLQSFDSLTGCGEVFADESSVPSLELNEGPESPTQAA
                     QGLESKVPRGPLQGSVEQLASPAQNEASDFTRFWDSVNRSVRQQQRALLGPWLSGPQG
                     TDRDQSRLDTAGLAELPLCPCRDPRSGSKASSIDTGTPKSEQPESVSTSDEGYYDSFS
                     PGLEEDKKEAESPGTPAATFPRDSYSGDALYELFHDPSEGPLGPSPDDDLCVSESLSG
                     PALGTPLSICSFRVGAEENLAPAPGPDLLSQGFLQSSWKGKECLLKLCDTELAITMGI
                     VSWLRRGPTPRAPPTPGQPAAPPGSQGAPRAPTEKLGGREGLASDAGGATVCSAPSRQ
                     ELWAHPGTTGLLAGESKALGGATQGTGTLSRDASREEETRGHSEGLFSSMESAATSTT
                     DTSGKNKAPVPSTWPCSQKEPGPPGVLGCFRGPWRPGHGGDTLDAEPMLAGCVARVAA
                     LKISSNEQPPAAWPPRQDMGSGLFGQRWARGPDMLEQKQSSSSPSMTTIHGLPYSAST
                     QDQRCRDRVQDLSWLRVEPTGLGVQAWASVEDQPLQLSTEAVEQVAHGSQLDSEPRSA
                     PAARWSSQGHHPESLGLTLNSQQEGGVSASAPECRCSLLAREGLLCGQPEVGASGPAM
                     AEPHL"
     regulatory      4466..4471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMER3"
                     /gene_synonym="FAM123C"
                     /note="hexamer: TATAAA"
     polyA_site      4488
                     /gene="AMER3"
                     /gene_synonym="FAM123C"
                     /note="major polyA site"
     regulatory      6199..6204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMER3"
                     /gene_synonym="FAM123C"
                     /note="hexamer: AATGAA"
     polyA_site      6216
                     /gene="AMER3"
                     /gene_synonym="FAM123C"
                     /note="major polyA site"
ORIGIN      
        1 aatccacccc agccccaggc actgaaccac gcgtgcagac ccctcgtcct cagttctgcg
       61 gagacagagt ccccacagca tttctgctcc tccctcaaga ctgcggcaga gcacagcacc
      121 agtagacccc acacacagct ggggcactgg cagcatggag ctgaagagag gaaagacctt
      181 catcaagtcc agcctgcagg tttcccacga gaaaccccca gacccagcag ccgtggctgc
      241 agccagggag gggacaggcc cctggtcagt ccttccagga gggcaacaga ggccccacag
      301 tgagaagggc ccccaagcca gccccagtgc ccaagaatac gacagatgcc ccaacaaagg
      361 ggcgcagctg gaccccaaag ggggacccgc agccctctgt ggagccacct tcaaaccggt
      421 gcgaaagtgc aagactcacg acagcatgtc tggggcaggc agggccacgg ctgccacagg
      481 gcagctggtg ggcagtgcaa gcttcccggg ctccccgggc agccggcgca tgatcgacta
      541 ccgccacttt gtgccccaga tgccctttgt gccagctgtg gccaagagca tcccgaggaa
      601 gaggatttcc ctgaagaggc ccaagaagtg ctttcggaac ctattccaca ttcggagaaa
      661 caagactgag gacttggcct cgctggcggc cgaggggaaa agcctgccct ccccagggga
      721 cccgtcagac cctggggggc ggcgaagcaa agccttcctc cccccgggtg aggggccggg
      781 gctggacggc ctgtgccagg acctgttgga cagcgagctc ctggccgatg catcctttgg
      841 tctctgcagg gccctgtgtg aggacgtggc ctcactccag agcttcgact cgctcacggg
      901 ttgtggggag gtgttcgcag atgagagctc ggtgccatct ctggagctga acgagggccc
      961 ggagagccca acccaggctg ctcagggcct ggagagcaag gttcccaggg gccctctcca
     1021 gggcagtgtg gagcagctgg cctcgcccgc ccagaatgaa gcctctgact tcaccaggtt
     1081 ctgggacagt gtgaatcgct cagtgcgtca gcagcagcgt gccctcctag gcccgtggct
     1141 ttcaggcccc caggggacag acagggacca atcccggctg gacacagctg ggctcgctga
     1201 gctgcccctc tgcccctgca gggaccctcg cagcggctcc aaagccagct ccatcgacac
     1261 aggcaccccc aagagcgagc agcccgaatc cgtgtccaca agtgacgagg gctactatga
     1321 ttccttctcg ccaggacttg aggaggacaa gaaggaagct gagagcccag gcactcctgc
     1381 cgccaccttc ccacgggaca gctacagtgg ggacgccctc tacgagctct tccacgaccc
     1441 cagcgagggt cctcttggcc ccagcccaga tgatgacctg tgcgtgtctg agagtctgtc
     1501 agggccggcc ctggggacgc cactgtccat atgcagcttc cgagtggggg ccgaggagaa
     1561 cttggcccca gcaccaggcc ctgacctgct cagccagggc ttcctacaga gctcctggaa
     1621 gggcaaggag tgcctgctga agctgtgtga cactgagctc gccatcacca tgggcatcgt
     1681 cagctggctg cgccgaggcc ccacgccccg tgccccaccc acccctgggc agcctgcagc
     1741 tccacctggt tcccagggag cccctagggc acccacagag aagctggggg gcagggaggg
     1801 cctggcctca gatgcagggg gggcgacagt ttgctcagca cccagcaggc aggagctgtg
     1861 ggcacacccg ggcaccacag gcctgctcgc cggagagagc aaggccctcg gaggggccac
     1921 acaagggact ggcacactgt ccagggatgc ctctcgagag gaagagacac gaggtcactc
     1981 tgaaggcttg ttctcctcta tggagtctgc agccacttcg acaacagata cttccggtaa
     2041 aaataaggcc ccagttcctt ctacctggcc ctgctcccag aaggagcctg ggccaccagg
     2101 ggtcctgggg tgtttccgag gcccctggag gccaggtcac ggaggtgaca ctctggatgc
     2161 agagcccatg ctggcaggct gtgtggcccg tgtggcagcc ctgaagatca gctcaaacga
     2221 acagcccccg gccgcatggc ctccaaggca agacatgggc agtgggctct ttgggcagcg
     2281 ctgggccagg ggccctgaca tgctggagca gaaacagtcc agcagctccc ccagcatgac
     2341 caccatccat ggcctaccct actcagccag cacacaggac cagaggtgtc gagatcgtgt
     2401 ccaggacctg agctggctca gggtggagcc caccgggcta ggtgtccagg cctgggcctc
     2461 tgtggaggac cagcccttgc agctcagcac agaggctgtg gagcaggtgg cacacggcag
     2521 ccagctggac tctgagcccc gctcagcccc tgctgcccgg tggagttccc agggccacca
     2581 tccagaaagc ctgggcctca ctttgaacag ccagcaggaa gggggggtct ctgcaagtgc
     2641 cccagaatgc cgctgcagcc tcctggcccg tgagggcctc ctctgtggcc agccagaagt
     2701 gggggcctct gggccagcca tggctgagcc ccatctgtag gacaggctca catgcaccag
     2761 gaactgcatg tgtcttcatg accactttca ggagagccta ggactcaaat ctctatcttt
     2821 tgtccctgat gtggggactg tgttgggggt ggggggtggc aggactcagg catgcagagg
     2881 gtagcatgtt catgtggagg catccttgcc tgaacccacc agctcaggca gcccaccgcc
     2941 aaagacagcg cgaagctgca accacctagc tgctcctcat gcaggggctg gagagagggg
     3001 ctagggcttg aaactgaggg ggagaaagag ctgcacattg taaatgggaa gcagagagcc
     3061 aatgagtctg cctgggatgt gtgtgaatcc caaaagacgc aatcccaaat gccatagtcc
     3121 caagtgttga gaatccaaaa tattaaaatt actatactct aaaatccgaa aatcacaatc
     3181 ccaaaagatc taaatcctgg aaatataatt ctgggaaaat ttttttttaa ttttttaaaa
     3241 gatacttaca ttttaaaagg atttatttga gaaacataaa aacacaacag aacacatcag
     3301 ccacttcaca caataaaata ggcaataata catatttttg gaagcataaa caggtataca
     3361 gacagttaca ccggtgtgag ttattagcag acaaactata ttcatgaaga aataggtcaa
     3421 aatgggaaat gtatacatgc atgtcactat gcttggtaat tgtgtgcacc tcgctttata
     3481 cttgcagtca tatcatgacc aacaacctaa gtcttttgac gaagtcaatc tatgatgcgt
     3541 caccaccaca cacacagttg cccaaagagc ggagatggca agaactttca tctctcacaa
     3601 ttgcagatgt acaaaaatta catctcttca tttattgagg aagttttgac gtttttatac
     3661 acacgcacaa tgcttacaca cacagtcaac ctgggatgcc ggcagggtgg ctcaggacga
     3721 aagcctcagg acccaggagg gccatgggtg taagttccag agtccaaagg ccagcgagcc
     3781 tgaagctctg atgtcaaggc agtggaagaa aagcctgtcc cagctctgag agagagacca
     3841 gtttgccttc tttatttgtt ctccctgggc ctcagcagat tgaatgctgc ccaccaacat
     3901 tgagggtgga tcttccacac ctaggcccct cagattcaca cactaatctc tggaaacacc
     3961 tcacagacat gcccagaata atgatctccc aggtctctag gtatccctta acccagtcga
     4021 gttcacaccc aaaatgaagt ccacaggtcc accccttgtc aacttggcat ccatccgcat
     4081 ccccttaaac cattttcagt ctccaaataa agccccaagc aaggcagtag ctccacctaa
     4141 catgatgcaa ctatcccggg attgtgattt ttaagacttt agatgttagg gatttgaaac
     4201 tttagagatt tgcgtctttc agtatttcaa tgttggggac cagtgtttgg gattatgtct
     4261 tttagaataa tgatccaaac ttgtgtgagg actgtgaggc tcagggtggg agacgggtgg
     4321 gggagccgac cttaggaggg cccactgaac cggcctcaat ctggccccag tctggcctac
     4381 tcgctgcccc aggacaggtg gctacaacat gctgagggcc tgaagggcgt cccctcagga
     4441 acattgtatt actgttttgt gttgctataa aggataactg tgaccagatc atttataaag
     4501 taaagaagtt tatttggctt gtaattctgc aggtgtagag gcatggcacc agcatctgct
     4561 gctgcttttt tttttttttt tttttttttt gagacagggt ctcactttgt tgcccaggtg
     4621 ggaatgggag tgcagtggca cagtcttggc tcactgcagc ctctacctcc tgggctcaag
     4681 cagtcctccc acctcagcct cccaagtagc tgggactaca ggcgtgcgcc accttgcctg
     4741 gctaattttt ctattttttt gtagagacgg gttttcgcca tgttgcctca gctaaaatgt
     4801 ctcaaaatct cctcaactaa aatgtctcaa aatctcagcc tcccacagtg ctggatgaca
     4861 ggagtgagcc agccagcatc atgcatccct gtgcgccctg ccagggctgg cgggaccctc
     4921 ccacccttgt tgatgggcag tgctagatta tttgtcacga atcatcccct acaaacaatg
     4981 atttccctcc gcttgcactc tctaactaga gccatggatg gccaaatgct ttttgggaag
     5041 aagccaatgg attctcctcg gctctgcctg caagtaacaa aggcttttga ctccactccc
     5101 tccacgctgt cagatcgcca ttccccttca ggaaaacttc gaatggggct gtggacctca
     5161 ctccccaaaa tgtcacaaca catgtgcagc accccgacat tcagaaccat gaagggagaa
     5221 ggtggctggt gtctgtagga gggacaggtg tccgtcctgg gccagtgtca ggccagcagg
     5281 tgcagggaca gatgggccat ccacattctc caagattagc ttctacctca accagcacac
     5341 ctcagcaaga tgccaggatt gggctccaca ggcagccatg aaatgggttt ctggaggaaa
     5401 gatcagcaca ggaaaagggg tcagtcaggt cgcaggcaaa gtgctaggga aatcccatct
     5461 catgcagagc tcccaccaag aggagcgtga gttgtgctgt cctggctcga gaagaaggca
     5521 gcacaggatc tgtagctgag ggtggccctc ccaccagggg acgctggtca gtgcctctcc
     5581 tgactgcctg acgcttggtc tccggtggcc ctctctcacc agggctccct gaggcctgct
     5641 gcaagcagga cacaggctgc acatcacagg ttccaaagtg tgcagcaagg cttctgacca
     5701 ggcccgtcca gatctggagc ccctgtggag ccacatctga gccctcctcc caagactcac
     5761 acacaggacc acagcagcat cactgagccg agctgggggc aagtttcacc agattcgctt
     5821 acctgatcct tgcatcaacc tcaatgcagt tgtcagcccc atttttcaga cctggacacg
     5881 gaggcacagg gtgctggtgt gacttgccca cagttattag tgtgtgaggt gatgggtttt
     5941 gtcccgtccc agctccaaag gccctgctct tcctcaagct ccagaacctc tcactgagct
     6001 cctgcagtga agtcccccct cagagccctc agcccttcct gctttcaggc tccagatgtc
     6061 agagcaccct tgggtgccag ccacaagtgg ccctccagca ggctgagcac ccagggggag
     6121 gctgccctga ctcaacccca gcctggggct ttgtgctgca cctgagggag tagccgctct
     6181 gtaaatcctt gttgaaagaa tgaagtgtca aaaggt
//
