LOCUS       NM_152704              10610 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens APC membrane recruitment protein 2 (AMER2), transcript
            variant 1, mRNA.
ACCESSION   NM_152704
VERSION     NM_152704.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10610)
  AUTHORS   Pfister,A.S., Hadjihannas,M.V., Rohrig,W., Schambony,A. and
            Behrens,J.
  TITLE     Amer2 protein interacts with EB1 protein and adenomatous polyposis
            coli (APC) and controls microtubule stability and cell migration
  JOURNAL   J Biol Chem 287 (42), 35333-35340 (2012)
   PUBMED   22898821
  REMARK    GeneRIF: the Amer2-EB1-APC complex regulates cell migration by
            altering microtubule stability.
REFERENCE   2  (bases 1 to 10610)
  AUTHORS   Siesser,P.F., Motolese,M., Walker,M.P., Goldfarb,D., Gewain,K.,
            Yan,F., Kulikauskas,R.M., Chien,A.J., Wordeman,L. and Major,M.B.
  TITLE     FAM123A binds to microtubules and inhibits the guanine nucleotide
            exchange factor ARHGEF2 to decrease actomyosin contractility
  JOURNAL   Sci Signal 5 (240), ra64 (2012)
   PUBMED   22949735
  REMARK    GeneRIF: FAM123A binds to microtubules and inhibits the guanine
            nucleotide exchange factor ARHGEF2 to decrease actomyosin
            contractility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10610)
  AUTHORS   Pfister,A.S., Tanneberger,K., Schambony,A. and Behrens,J.
  TITLE     Amer2 protein is a novel negative regulator of Wnt/beta-catenin
            signaling involved in neuroectodermal patterning
  JOURNAL   J Biol Chem 287 (3), 1734-1741 (2012)
   PUBMED   22128170
  REMARK    GeneRIF: data characterize Amer2 for the first time as a negative
            regulator of Wnt signaling both in cell lines and in vivo and
            define Amer proteins as a novel family of Wnt pathway regulators.
REFERENCE   4  (bases 1 to 10610)
  AUTHORS   Boutet,A., Comai,G. and Schedl,A.
  TITLE     The WTX/AMER1 gene family: evolution, signature and function
  JOURNAL   BMC Evol Biol 10, 280 (2010)
   PUBMED   20843316
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10610)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   6  (bases 1 to 10610)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359757.21.
            
            On Jul 31, 2020 this sequence version replaced NM_152704.3.
            
            Transcript Variant: This variant (1) represents an unspliced
            transcript that encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC041392.1, AK098343.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000515384.2/ ENSP00000426528.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10610             AL359757.21        132020-142629       c
FEATURES             Location/Qualifiers
     source          1..10610
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.13"
     gene            1..10610
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /note="APC membrane recruitment protein 2"
                     /db_xref="GeneID:219287"
                     /db_xref="HGNC:HGNC:26360"
                     /db_xref="MIM:614659"
     exon            1..10610
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /inference="alignment:Splign:2.1.0"
     CDS             670..2685
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM123A; family with sequence similarity 123A"
                     /codon_start=1
                     /product="APC membrane recruitment protein 2 isoform 1"
                     /protein_id="NP_689917.2"
                     /db_xref="CCDS:CCDS53859.1"
                     /db_xref="GeneID:219287"
                     /db_xref="HGNC:HGNC:26360"
                     /db_xref="MIM:614659"
                     /translation="METSRSRGGGGAVSERGGAGASVGVCRRKAEAGAGTGTLAADMD
                     LHCDCAAETPAAEPPSGKINKAAFKLFKKRKSGGTMPSIFGVKNKGDGKSSGPTGLVR
                     SRTHDGLAEVLVLESGRKEEPRGGGDSGGGGGGRPNPGPPRAAGPGGGSLASSSVAKS
                     HSFFSLLKKNGRSENGKGEPVDASKAGGKQKRGLRGLFSGMRWHRKDKRAKAEAAEGR
                     APGGGLILPGSLTASLECVKEETPRAAREPEEPSQDAPRDPAGEPAGGEEVPAPADRA
                     PARSCREAEGLAHPGDTGARGEDAAGHRRAEPGPGEVRTAEDASRTGAVPVKTVPLVD
                     SEGGSGRAPAAPDPASVDPPSDPSADRICLMFSDVTSLKSFDSLTGCGDIIADQEEEA
                     GPSCDKHVPGPGKPALSKKNPGVVAYQGGGEEMASPDEVDDTYLQEFWDMLSQTEEQG
                     PEPQEGAAKVAAALETKVVPETPKDTRCVEAAKDASSVKRRRLNRIPIEPHPKEEPKH
                     PEKEQQEGVPNSDEGYWDSTTPGPEEDSSSSGKKAGIPRDSYSGDALYDLYADPDGSP
                     ATLPGGKDNEETSSLSRLKPVSPGTITCPLRTPGSLLKDSKIPISIKHLTNLPSSHPV
                     VHQQPSRSEMPRTKIPVSKVLVRRVSNRGLAGTTIRATACHDSAKKL"
     regulatory      3348..3353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /note="hexamer: AATAAA"
     polyA_site      3369
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /note="major polyA site"
     regulatory      5358..5363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /note="hexamer: AATAAA"
     polyA_site      5379
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
     regulatory      10576..10581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /note="hexamer: AATAAA"
     polyA_site      10610
                     /gene="AMER2"
                     /gene_synonym="FAM123A"
                     /note="major polyA site"
ORIGIN      
        1 aggcaaactc caccccgggg agctgttgtg cttgcattgc tgggctgctg atagactgat
       61 tgagtggtgg cgtgtacttt tgtcacaaga accataacca caatgacagc cacacagcat
      121 ggacctagcg tgtgctcagc tctggacaag acatggatgt aggcagacat gcttcctgcc
      181 tgctgggctt agtgcaccaa tgctaaggac agacatgaag ggcttgggaa aggcatgaag
      241 atgcagggag tctaggagag aggataagaa aaacaagcat tttgtggtgg gttgaattgc
      301 gttgtcgttt ttagaggcat ttcgtgatcc atggttgcgc tcccgtgaag agcgagtcta
      361 gagaaggaat ccgaaggtgg gtgagagttg agggaatttg aattccataa ttacgactcg
      421 aatttctgca atcagctcgc ggctgtgttg cctgctcctg ccacaaaaac gccatgcagc
      481 gccgagccaa gtcggatgga agtgggttag ggtattatat aagcccttgc gggagggaag
      541 atggtctttt atgtgtgttt cttttgcagc ggcggcggcg agcgcggctc aggttgattt
      601 agaatacggg tgacagtggc ctggcgcgag cccactgctg acgaaagcgg cttatcccgc
      661 gcggtttcca tggagacgag ccggagccgc ggcggcggcg gggctgtcag cgagcgcggc
      721 ggagctggcg cgtccgtggg ggtctgcagg aggaaggcgg aggccggggc cgggaccggg
      781 accctcgcgg cagacatgga cttgcattgt gactgtgccg ccgaaacgcc ggccgccgag
      841 ccgccgtcgg ggaagattaa taaagctgcc ttcaaattat tcaagaagag gaaatcgggt
      901 ggcaccatgc ccagcatttt tggggtcaaa aacaaagggg acgggaaaag ctcgggtccg
      961 acggggctgg tgaggagcag gacccacgac ggacttgccg aggtgctggt gctggagagc
     1021 ggcaggaagg aggagccgcg cggcgggggc gacagcggcg ggggcggcgg ggggcggccg
     1081 aacccggggc cccccagagc cgcagggccc ggcgggggct ccctcgccag cagctcggtg
     1141 gccaagtcgc acagcttctt ctcgctgctg aagaagaacg ggcgctcgga aaacggcaag
     1201 ggagagcctg tggacgcgag caaggccggc ggcaaacaaa agcgggggct gcgggggctg
     1261 ttcagcggca tgcgctggca caggaaagac aagcgggcca aggcggaggc cgcggagggg
     1321 cgcgcgcccg ggggcggctt gatcctaccc ggctcgctca ccgccagcct ggagtgcgtc
     1381 aaggaggaga cgcccagagc cgcgcgcgag ccggaggagc ccagccagga cgccccgcga
     1441 gacccagcag gtgagcccgc agggggagag gaggtgcccg cccccgccga ccgcgcccca
     1501 gcgcggagct gccgagaggc agagggcctc gcgcaccccg gcgacaccgg cgcccgggga
     1561 gaggacgccg cggggcatcg gcgcgccgag ccggggcccg gggaggtccg cacggcagag
     1621 gacgcttcca ggacgggggc cgttcccgta aagacggtcc cccttgtcga ctccgaaggc
     1681 ggcagcggcc gggcgcccgc cgccccagac cctgcctctg tcgatccacc ctcagacccg
     1741 tcggcagatc gtatttgttt gatgttttct gacgtgactt cactgaaaag ctttgactct
     1801 cttacaggct gtggagatat tattgcagac caagaggaag aggcaggtcc cagctgtgac
     1861 aagcatgtcc ccgggccagg caagccggct ctgtctaaaa agaaccccgg cgtggtggcc
     1921 taccaaggag gcggggaaga gatggccagc ccggacgagg tggacgacac ctatctacag
     1981 gagttctggg acatgctctc ccagaccgag gagcagggac ccgagcccca ggagggcgcg
     2041 gctaaggtgg cagctgcgct ggaaaccaag gtggtgcccg agacccccaa agacaccagg
     2101 tgtgtggaag cggccaagga cgcgtcctcg gtcaagcgca ggaggctcaa ccggattccc
     2161 atcgagcccc atcctaagga ggagcccaag cacccggaga aggagcagca ggaaggcgtc
     2221 cccaacagcg acgagggcta ctgggactcc accacgccag gcccagagga agacagctcg
     2281 agcagcggga agaaggcggg catcccccgg gatagctaca gcggggacgc gctctatgat
     2341 ctctatgctg acccggacgg aagtccagca acccttcctg gagggaagga caacgaggag
     2401 acgtcctccc tgtcccggtt aaagcccgta tctccaggca ccatcacctg tccactgcga
     2461 acaccaggca gcttgctgaa ggactctaag atccctatta gcatcaagca cctgaccaac
     2521 cttccatcta gccatcccgt ggtgcaccag caaccctcca ggagtgagat gcccagaaca
     2581 aaaatcccgg tttccaaagt gctggtccgc agagtcagca accggggctt ggctgggacc
     2641 accatcagag caacggcctg ccacgacagt gccaaaaagt tgtgaggtct tccaggccaa
     2701 ggtggatggg ccccatgcca aggaatacaa cttttccctg gaaaccacta aagtaagttt
     2761 tgcttttcct aaagaaagtc ttttaggaca ccacccgtcc cccgccctgc tccagagcgt
     2821 ggaccgagga ggtctttgtg ccctgagcag ggaccggata acaccagaaa gagggatgct
     2881 acacgggggt ttctcctctc aagataagtc cctgagaatt attttcaagc acttttttct
     2941 tttttacctt taagtttttc ttccttttgc tttaatatac tgaacacttg gaagtcacct
     3001 ttacttgcct ttgcagaaaa cagaacttag ccaaacctaa gtaagagtca tgcctggata
     3061 ttgggataag ccagtgtcta gaggcctgaa ggaaccgctg aagaaccaga ggagatctcc
     3121 tcttccaaga cacgtttcct tccttccctt ctttcctctt tcctttccag ttaaaaaaaa
     3181 acaaaaacaa aaacaaaacc ctttgctgta tcactgtgtg gaaaatacct ccaaagctga
     3241 aagagccagg tatttacctg atgagcagag gggaccactg attggcagaa aacttcccta
     3301 cgttcagttg ttagatatgc aaattgataa ggatctaaca ctaggaaaat aaaggcgagt
     3361 tttggtttgg ttggtttcag tcatttgttt ggggagatat aaaaggctca ggagagcagg
     3421 cttttgcttt tgcttttgtt tgtttcttcc cccacccagt gcagaaatca ggatcaggga
     3481 aagattttat taaatgccaa tagatacagt atttaagcat ttataaactg aaaccttttc
     3541 atgtgaagat aatgcatatt ttaccgttta tccagctgtt aacattttgt aatcagtcaa
     3601 ttcaatagaa ttattctgga taattctata tctagaatat aaaatctggt cttatagcta
     3661 gacatgatga tggtccccaa accattgatg ttctgttatg tactgtaatg ggaagcgatt
     3721 ctgattttgt tttatatggg ttctctggtt ctcaaaaaaa aaaaaaatct attgtgctgg
     3781 tgtcccagag gaatggctct gccttgtttt gggtaagagt ctgtttctca ccccaaaccc
     3841 tgttttcaga ttttttttta ccttgattgt aaaatttcag atccaaccat tcctcaatat
     3901 aatgagtgca aaatgaggaa cacataaaga aaaacaatag aaagatacag tttttcacat
     3961 catttgcctt ttgctttata gacttatgac aaagacaagt gtgttcagaa tatgacactg
     4021 gcaagcttat gtattgtaaa cactttatgc caagtttttt ttgaaaagtg gtttgcttct
     4081 atgtatgttt tctaatattt cagatgaaac atttatttca gaaagggtta ttatatgcct
     4141 agtttgaatg ataaactgaa gcagttccta gaatgctatt agtgtctaat gatgaaatta
     4201 atatcctttt tgaaatacac ttcagtgtat ttaatcaaaa gaccagagct tctactagga
     4261 ggtgattcat cataccagga agattatgca tattcacgtg aaactgcaca tatgtaaatg
     4321 acatgaacac ttctgtataa gtctcatttc cagagagatt gcattagtaa tgaactgtta
     4381 ttacatgctt tttaagtttg ttttctgttt cataaatgaa agaacaaggc aagttaaata
     4441 tatgaaaacc tattttaata atatgaagaa agtaacaaaa taaatggaca tcaaaggaaa
     4501 gcaaattgag ccagtagcag aaagtaggcc attccccatt ttaaatttgc agtgattcaa
     4561 ttaggagagg tttgctgaat ttcttcatta gtcatatgac tggcttttat tgcattgtct
     4621 cagatccata atgttatttc aaagtaatct tttaatattt aatttcttta tgtgtgtaaa
     4681 tgaggcccta tatgcagtca tagccttaag cattctgaac acactaccaa gaattcatat
     4741 aagcatctca cactcacgtg ctcatgcact caactgtgta cagactaaca gacaaaagac
     4801 atctactcta gatctggaaa ttatttttga aattatttct gtattaaaca agggatttac
     4861 atttgatttc atgccgctgg tactatttag gctcaaaata cattcatctt cccctagtga
     4921 atggagaaaa tataaatttt attcctagct gtaaaacaaa ggatcttgat ttccttgttg
     4981 tacattttcc tgcaagggtt atattctcct ttgcatgaat ccatggcaaa gttatgttgg
     5041 ttcatttgtt caattgtaca ggaaagttaa gaatacctga aaaacttatg agaatattgt
     5101 aatagtaaag gcaatctatt tcttaagcag tagaagaaaa gtttttgctt tcataatttt
     5161 aggacttaat cctccattta caccattatg ctgtgtctcc tctttataag aaaaggaaca
     5221 cgtgagcaaa gtttatctta atttccactg acctgtcaat taaccagtta taaaagatat
     5281 aaaatatttt cttttaaaat ttatattttc cacttttttt ttaccttatt ttttaagaat
     5341 tgcacccaca ccaatcaaat aaaggatttg ggcaatgaat taaacagcct caatcacttg
     5401 atgggaaatc cctggagtgg caggaagagt agattctcaa ctttttccaa ccatagaaaa
     5461 gggatcatag ttgctttctt gtgccaaggg ctactttctc tcatttgtgt tcatggagat
     5521 tgttttttca agaattttcc tagatttaca ttccaatttt tattaataca ttatatctaa
     5581 tgaccttgtg aagattattc aggcccatat ttgctgactt tttaagggaa ggattggata
     5641 gaggctaatt atatctttcc cacatgtatg tatattctaa gatacttggt tgattgactt
     5701 cctttagttg aaaggctgcc caaattagac aggaaaaagt caaatcaatt gttgggcgaa
     5761 aatttatcgg ttggtttaat agctctgcac aaagacagcc tgacttgaat gtctatatta
     5821 cacatacact gttatttgaa acactctgct ttagtacaga tggtggttga tgcgtttatc
     5881 ctgccattag caccaattgg gagaaatttt actacagcat tttaaataat cacaagagta
     5941 aatagatttc tattatttta tctaataaca acaatagaat atagaataca aaggacttcc
     6001 tctagataca ttttatttta tctaataaca acaatggaat atagaataca aaggacttcc
     6061 tttagataca ttttccacaa attatctgct tatttaaata caaagggttt aatatctatg
     6121 aaggtaataa ctcaccgtgt ttaaaggatt tatttcttca tctcagaggt agtcttcaag
     6181 tatttgcagt taaacagtat gcaaatagcc ctttgcttac acaattatcc aggtaaaaag
     6241 actatgtcag gtgttgagat ttctttgaat tttctaagag ttttcattat ttacgccttt
     6301 gtcagattaa ttttaaaggc aactcttgac tgttagcttg gtgtgaagag atccactcag
     6361 gcagctcatg tctcctaagt gccctcagac agcagtgacg ggacacttca catgacgcta
     6421 gcatgttggc tctgtccgca tggcggaatg cattccctgc tgttagttat ctgaattttt
     6481 ctcctgaatt acaaatatat ggatttggct cccctgatgc tgggcttctg ctgagacctg
     6541 ttccagtaca ttcacgtatg ctttgctccc cttcattgtt aagaaattaa ttcaagaagt
     6601 tttttgctgt taaacataag gaataagcat cacaattgcc tcatctcatc actgaggaaa
     6661 gctggtttaa agtatctgag tgaaataaga ggaaaacccc aaatacttca cctaacccag
     6721 tttccctttc ccctcctcca ggcagagcaa ggaaaagaac agttgtaatt tgtgtaaact
     6781 cagccttaga aaatttcaat tcattacaca caaaaatatt tatgaagcag tttggaacca
     6841 aaggggtagt atggtagacg agtgtcttac agagcctgtg tggggaagca aaaggcaagg
     6901 gtgtagttca caggcagaag cgagctgtga cattgtcagt gcagcgtgta agtgtggctc
     6961 ctcacaggcg gccattgatt gtgagacctc atcttgctct gaagatttcc cggtggctgt
     7021 catgcattgc ttctcaaaag ccttgcactg tgataaggtt taaggagaca gattgttgca
     7081 acaatagcca cttctaagga atgttattat gtcactgcag atgatgtttt taagaggtga
     7141 ttcagaatga tagtttcgtg attacggaaa ggagttcctt ctcaaactgc aaaaggaaag
     7201 atgaaaatag tcatgaagcc tccagaactg aaattgggca ccttttatga tggatattta
     7261 ctttaattca atgcaacaca tatttatggg gcatagactg tatcaaatac ttaataaaac
     7321 ccattcagtt tggagctcac acctaagctg cgctgtaatt ggattttctt aatattcatt
     7381 aaaaacacaa aacaatatta ttttactttt ttttggtatt tgcatttgtt gcttatagtt
     7441 tgtggggtga agcaaagtgg tgtgaagttg aagaagggca ctatgaatta agccacacaa
     7501 atgcctctaa aaaatagtaa atgtaacaat ggttaacatt cattgaatac ttactatgtg
     7561 tcaggcactg ctaggagatt tagaaataat tacttagtcc tcttaacagc catgtggggt
     7621 aggtaatatt atctccccag taagacagct ttaattcatc ctttttgttt ctatcccttt
     7681 ccatctctgt ctgtctgtct ctctctctct tttcccctag tctctaggac agggatataa
     7741 actctttagt gattttcagt aatagagagc taagcactgc ttagtgtcat tgtcagctca
     7801 cttctaatag aaagagctaa cccatgtcca cgcagctgaa aattagtttt gtgtctgaga
     7861 tgatggtgct cacaatcata tacagggaac cctgccactg tgctatgctg agtaggcaaa
     7921 cattggcctt cccttggagg gatcctcttc tcttaggatt aatgtgggaa gtacagacag
     7981 aaatctcttc tgttgtcatg gcgatacttc ttccctgaca gggtatcatt cattcaaagc
     8041 atatttgttt catttgtttt tattcctacc ttaagccatc ttggtgggtt ctgggtggtc
     8101 tatgcatatg tgtgtgtgtt ttaattgcag taagaatatt gaatatgaga tctaccctct
     8161 ttaatttttt tttttttttt ttttgagatg gagtcttact ctgtcaccca ggctggagtg
     8221 cagtggcttg atctcggctc actataacct ccacctccca ggttcaagtg attctcctgc
     8281 ctcagcctcc caagtagctg agactacagg cgtgcaccac catgcccgtt agtttttgta
     8341 tttttagtag agacagggtt tcaccatgtt ggccaggctg gtctcaaact cctgacctca
     8401 aatgatctgc ccacctctac ctccaaagtg ttgggattac aggcaatgag ccaccacgcc
     8461 cgggttacct tctttaattt ttaagtacac aatacagtat tgttaactat agccacagtg
     8521 ttgtacagca aatctctctc acctatgcat cctgcgtaac tgaaactctg tgcccattga
     8581 acagcagctc ctcatttcct cccccatcag cccctggcag ccatcattct actctctgct
     8641 tctgtgagtc tggctatttt agatccctta tagaagtgga aacgcgcagt atttgtcctt
     8701 ctgtgactgg cttatttcat tgagcataac gacccccaag tttagccatg ttgttgctta
     8761 tggcaggatt tccttctttt ttcaggctga ataatatttc cttatatgta tatgctgcat
     8821 ttttaaaaac cctttcatct actgacagac gtttagatta tttccacatc ttggctatta
     8881 tgagtaatgc tacaacgaac gagggagtga aaatatctct ttaagatcct gatttcagtt
     8941 tttttgaata aatacccaga agtggaatga ctgggtcatt catatggtaa ttctaattaa
     9001 acatagaatt atttttaatt ttttgagaaa cttctgtgct gctttccaca gtggttgcat
     9061 ctgtttacat acttaccaat ggtgcacaag ggttccaatt tctccacatc tttgccaact
     9121 tgttatctgt gtttgtttaa atgacagctg tatgagttgt cccttgcctc catgcaattc
     9181 tgaacttcag aaataagcac ttggctcctt taatagctgt ccgtcctatg ttgtgtctac
     9241 agccactgaa tcctgtccta cattttctga ttcattaact cattcaacta atagctattg
     9301 aacaccatca ataagtcagc caccatgaag atgagtattt tatattgaat tctactaaca
     9361 tatcctgtat gtttactatg ttgccagaga ggatgctgtg tgcttttttt acattgttat
     9421 ctttactctt cacaagaacc atgtaaggta ggtattggta aaatgggtaa ttttggaaat
     9481 gcttcaataa tcgagtagaa taacttttgc tctatgtgag aagatacgtt ttaaataaga
     9541 tatggcttag gtttctggtt acctgagaca tactatacct tctcagatac tctcagacct
     9601 gaatcattta acaaactaag gcagaaatac taaaaatatc tggttcaata acataggggc
     9661 atggagtaga catgcagaaa atgcttgttc acttgccttg aaatggctcc aggtggcctg
     9721 aaggaatcaa tgaaacttct caagtatcta cattacaacc actggtcccc actacacatt
     9781 tatttctaaa taaaggagga gaaactctag caaagtaata tttaacattt tcattgcttc
     9841 caggataaat cttattgaat atggaggatc tgatagtggt aggtctatca ggaatatcag
     9901 ggaaaatgct tttgatgttg ttggcaaagt caattcctat catttgtact tgacaccagc
     9961 tacctagcag gctcattgtg aacttcaggt ttcgcccacg ttatttatat aaagtatctc
    10021 agtgtaatat agggagttgc tggttatttg aaaatagtaa caaaaataac ccaaacgaga
    10081 aactccattt ccataattag ctttcctgaa agtcaggcat gtctttgagg acaggttttg
    10141 gcagtattat ttttgtgcac aggaggaaaa ttgttagtag gtttatagat gttattttta
    10201 taatagaatg ttaaacccct gaaaaacatc aaaaattgtc tcctagaact aattctatgt
    10261 tttaaaaact tgttttaaaa aggattctaa atagcaatag ggtctttcct cctttctcca
    10321 ctccaatggt ttaatgggat agaggaatca atgtttatat ttttaaacct gtaaatattt
    10381 tattttgggt attttgtata tttgttgata taattccatt ttgtgcatat gtaccattgt
    10441 gcatgttgct gtttttgata gtcactcttt taatgaatgt aagaagcttg ggctaatagc
    10501 acttttcttg ttccattcaa acatctgaaa atgaaattac aacactgcca ttttactgtt
    10561 gtgtttaatt cagtcaataa attttgttgc tcctttgcat ttaaagtgaa
//
