LOCUS       NM_001634               3423 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens adenosylmethionine decarboxylase 1 (AMD1), transcript
            variant 1, mRNA.
ACCESSION   NM_001634
VERSION     NM_001634.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3423)
  AUTHORS   Liao,R., Chen,X., Cao,Q., Bai,L., Ma,C., Dai,Z. and Dong,C.
  TITLE     AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A
            hypusination-TCF4 axis
  JOURNAL   Breast Cancer Res 26 (1), 70 (2024)
   PUBMED   38654332
  REMARK    GeneRIF: AMD1 promotes breast cancer aggressiveness via a
            spermidine-eIF5A hypusination-TCF4 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3423)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3423)
  AUTHORS   Sari,I.N., Yang,Y.G., Wijaya,Y.T., Jun,N., Lee,S., Kim,K.S.,
            Bajaj,J., Oehler,V.G., Kim,S.H., Choi,S.Y., Park,S.H., Kim,D.W.,
            Reya,T., Han,J. and Kwon,H.Y.
  TITLE     AMD1 is required for the maintenance of leukemic stem cells and
            promotes chronic myeloid leukemic growth
  JOURNAL   Oncogene 40 (3), 603-617 (2021)
   PUBMED   33203990
  REMARK    GeneRIF: AMD1 is required for the maintenance of leukemic stem
            cells and promotes chronic myeloid leukemic growth.
REFERENCE   4  (bases 1 to 3423)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3423)
  AUTHORS   Raney,A., Law,G.L., Mize,G.J. and Morris,D.R.
  TITLE     Regulated translation termination at the upstream open reading
            frame in s-adenosylmethionine decarboxylase mRNA
  JOURNAL   J Biol Chem 277 (8), 5988-5994 (2002)
   PUBMED   11741992
REFERENCE   6  (bases 1 to 3423)
  AUTHORS   Raney,A., Baron,A.C., Mize,G.J., Law,G.L. and Morris,D.R.
  TITLE     In vitro translation of the upstream open reading frame in the
            mammalian mRNA encoding S-adenosylmethionine decarboxylase
  JOURNAL   J Biol Chem 275 (32), 24444-24450 (2000)
   PUBMED   10829027
REFERENCE   7  (bases 1 to 3423)
  AUTHORS   Hill,J.R. and Morris,D.R.
  TITLE     Cell-specific translational regulation of S-adenosylmethionine
            decarboxylase mRNA. Dependence on translation and coding capacity
            of the cis-acting upstream open reading frame
  JOURNAL   J Biol Chem 268 (1), 726-731 (1993)
   PUBMED   8416975
REFERENCE   8  (bases 1 to 3423)
  AUTHORS   Hill,J.R. and Morris,D.R.
  TITLE     Cell-specific translation of S-adenosylmethionine decarboxylase
            mRNA. Regulation by the 5' transcript leader
  JOURNAL   J Biol Chem 267 (30), 21886-21893 (1992)
   PUBMED   1400498
REFERENCE   9  (bases 1 to 3423)
  AUTHORS   Maric,S.C., Crozat,A. and Janne,O.A.
  TITLE     Structure and organization of the human S-adenosylmethionine
            decarboxylase gene
  JOURNAL   J Biol Chem 267 (26), 18915-18923 (1992)
   PUBMED   1527020
REFERENCE   10 (bases 1 to 3423)
  AUTHORS   Stanley,B.A. and Pegg,A.E.
  TITLE     Amino acid residues necessary for putrescine stimulation of human
            S-adenosylmethionine decarboxylase proenzyme processing and
            catalytic activity
  JOURNAL   J Biol Chem 266 (28), 18502-18506 (1991)
   PUBMED   1917972
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365206.24 and AL357515.26.
            
            On Oct 23, 2020 this sequence version replaced NM_001634.5.
            
            Summary: This gene encodes an important intermediate enzyme in
            polyamine biosynthesis. The polyamines spermine, spermidine, and
            putrescine are low-molecular-weight aliphatic amines essential for
            cellular proliferation and tumor promotion. Multiple alternatively
            spliced transcript variants have been identified. Pseudogenes of
            this gene are found on chromosomes 5, 6, 10, X and Y. [provided by
            RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX640599.1, SRR3476690.763716.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368885.8/ ENSP00000357880.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            regulatory uORF        :: PMID: 8416975, 10829027, 11741992
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               AL365206.24        9217-9647
            432-518             AL365206.24        21937-22023
            519-645             AL365206.24        23289-23415
            646-748             AL365206.24        24686-24788
            749-791             AL365206.24        26593-26635
            792-936             AL365206.24        26731-26875
            937-1029            AL365206.24        27167-27259
            1030-1185           AL357515.26        169-324
            1186-3423           AL357515.26        735-2972
FEATURES             Location/Qualifiers
     source          1..3423
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..3423
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /note="adenosylmethionine decarboxylase 1"
                     /db_xref="GeneID:262"
                     /db_xref="HGNC:HGNC:457"
                     /db_xref="MIM:180980"
     exon            1..431
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12..32
                     /regulatory_class="uORF"
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:8416975]"
                     /note="this uORF encodes a 6 aa peptide (PMID:8416975,
                     10829027)"
     CDS             322..1326
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /EC_number="4.1.1.50"
                     /note="isoform 1 is encoded by transcript variant 1;
                     S-adenosylmethionine decarboxylase 1; S-adenosylmethionine
                     decarboxylase proenzyme"
                     /codon_start=1
                     /product="S-adenosylmethionine decarboxylase proenzyme
                     isoform 1"
                     /protein_id="NP_001625.2"
                     /db_xref="CCDS:CCDS5086.1"
                     /db_xref="GeneID:262"
                     /db_xref="HGNC:HGNC:457"
                     /db_xref="MIM:180980"
                     /translation="MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILL
                     KDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYS
                     GFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLY
                     TLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVI
                     DATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFK
                     PGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
                     "
     exon            432..518
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            519..645
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            646..748
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            749..791
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            792..936
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1029
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1185
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..3423
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3390..3395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /note="hexamer: AATAAA"
     polyA_site      3423
                     /gene="AMD1"
                     /gene_synonym="ADOMETDC; AMD; SAMDC"
                     /note="major polyA site"
ORIGIN      
        1 gcttacacag tatggccggc gacattagct agcgctcgct ctactctctc taacgggaaa
       61 gcagcggaat acaagagact gaactgtatc tgcctctatt tccaaaagac tcacgttcaa
      121 ctttcgctca cacaaagccg ggaaaatttt attagtcctt tttttaaaaa aagttaatat
      181 aaaattatag caaaaaaaaa aaggaacctg aactttagta acacagctgg aacaatccgc
      241 agcggcggcg gcagcggcgg gagaagaggt ttaatttagt tgattttctg tggttgttgg
      301 ttgttcgcta gtctcacggt gatggaagct gcacattttt tcgaagggac cgagaagctg
      361 ctggaggttt ggttctcccg gcagcagccc gacgcaaacc aaggatctgg ggatcttcgc
      421 actatcccaa gatctgagtg ggacatactt ttgaaggatg tgcaatgttc aatcataagt
      481 gtgacaaaaa ctgacaagca ggaagcttat gtactcagtg agagtagcat gtttgtctcc
      541 aagagacgtt tcattttgaa gacatgtggt accaccctct tgctgaaagc actggttccc
      601 ctgttgaagc ttgctaggga ttacagtggg tttgactcaa ttcaaagctt cttttattct
      661 cgtaagaatt tcatgaagcc ttctcaccaa gggtacccac accggaattt ccaggaagaa
      721 atagagtttc ttaatgcaat tttcccaaat ggagcagcat attgtatggg acgtatgaat
      781 tctgactgtt ggtacttata tactctggat ttcccagaga gtcgggtaat cagtcagcca
      841 gatcaaacct tggaaattct gatgagtgag cttgacccag cagttatgga ccagttctac
      901 atgaaagatg gtgttactgc aaaggatgtc actcgtgaga gtggaattcg tgacctgata
      961 ccaggttctg tcattgatgc cacaatgttc aatccttgtg ggtattcgat gaatggaatg
     1021 aaatcggatg gaacttattg gactattcac atcactccag aaccagaatt ttcttatgtt
     1081 agctttgaaa caaacttaag tcagacctcc tatgatgacc tgatcaggaa agttgtagaa
     1141 gtcttcaagc caggaaaatt tgtgaccacc ttgtttgtta atcagagttc taaatgtcgc
     1201 acagtgcttg cttcgcccca gaagattgaa ggttttaagc gtcttgattg ccagagtgct
     1261 atgttcaatg attacaattt tgtttttacc agttttgcta agaagcagca acaacagcag
     1321 agttgattaa gaaaaatgaa gaaaaaacgc aaaaagagaa cacatgtaga aggtggtgga
     1381 tgctttctag atgtcgatgc tgggggcagt gctttccata accaccactg tgtagttgca
     1441 gaaagcccta gatgtaatga tagtgtaatc attttgaatt gtatgcatta ttatatcaag
     1501 gagttagata tcttgcatga atgctctctt ctgtgtttag gtattctctg ccactcttgc
     1561 tgtgaaattg aagtgcatgt agaaaaaacc ttttactata tgaaacttta caacacttgt
     1621 gaaagcaact caatttggtt tatgcacagt gtaatatttc tccaagtatc atccaaaatt
     1681 ccccacagac aaggctttcg tcctcattag gtgttggcct cagcctaacc ctctaggact
     1741 gttctattaa attgctgcca gaattttaca tccagttacc tccactttct agaacatatt
     1801 ctttactaat gttattgaaa ccaatttcta cttcatactg atgtttttgg aaacagcaat
     1861 taaagttttt cttccatgag ttgagtcctt aagaaaatga ttccagttac tcattttgca
     1921 tatttgctat tttaacatta ttggaccctg catttatagt cctttgattt cttccctctc
     1981 cctggtgtct cccccaagac cccaaataaa gcaatacact gttaacactg tgggtttata
     2041 tactaattct ataccccaga tggggaatgg gggagatggt ccctgggctt aatattcttt
     2101 aaagggcatg ggaatttagc ctctctttta ttgtaatgtg ctcttttgga aaatagttgg
     2161 ttagcaggga agacccagag ttgtagattg agattagggt gtactggctg aactgtggaa
     2221 aacatacaat tctgtgttcc tcagtaaatg agattagcgt ctaatgagta gcaccccttt
     2281 actaacttag tagtagtata aaatcatttt tatttagtta attaccagag agatttagca
     2341 taattttgtt ctggattcag taaatcaagt cagcttggat cattcacctt aacttttcct
     2401 ttagcagcca tttccactag tttccattaa gtagtgttct ataaactttg atccaaagca
     2461 gaatcaatgt cttttccatc tcgtgactta aagttctgtg actgtgatgc atgtgagtgt
     2521 tccgacttca tctgttcctc ttaactacgg tgtttccctt accatggcat tcataggatg
     2581 aaatgaatga ctgcccagaa tgagaatttg tccagattat tcagataaac atcataaagc
     2641 agaatacatt ataaataagt agaatatgaa taaatagaat aataaaattc caaaatactc
     2701 aatgggaaat gactagtaat ataggctttc aagagttggt accttttagc tatatttgca
     2761 gattctctgg gattttaagg aactgagaaa acagcaaagt tgactaaatt ttatatttct
     2821 tgtcctctaa atattttgat aatttctgga ttgatgcagt gatgtttttg ttccttccgt
     2881 atttataaat gaaacacctt tttttagtgt ttctaaacct aaaatctact tggtttgaaa
     2941 tcaagtggtt ggaacactgt ttgactttta tttgaagcat gttgttgatt gaaaatttca
     3001 ttgaggaagt tttcaatcag tgtgatcagt ttgattctgt aatgagcaca gcacctaata
     3061 ttttgaggag ctctgttttg aggaccaatg cttaaggtgg actttgttcg taaacaatat
     3121 cccaatagat ttgttgactt gaggtctggt ttggttttgt ttttgttttg ttttgttttg
     3181 ttttgtttcc aatagaatta agaattctaa tgttgaaaaa ctgcacaaat ttttatggga
     3241 caaagcctag aaaagagaaa tgtagtttga atcataatct aaatcatcgt atgatagaag
     3301 agggaaagtt ttggtgccat aatttctcct ttcactggtg ttggacttaa atcagttgaa
     3361 atgtatttct gtaccacaat ttacgcttca ataaaagttt aattgtctag tgacattcag
     3421 aaa
//
