LOCUS       NM_001387011            5249 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens autophagy and beclin 1 regulator 1 (AMBRA1),
            transcript variant 10, mRNA.
ACCESSION   NM_001387011 XM_005253009
VERSION     NM_001387011.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5249)
  AUTHORS   Gottlieb,S., Shang,W., Ye,D., Kubo,S., Jiang,P.D., Shafer,S.,
            Xu,L., Zheng,L., Park,A.Y., Song,J., Chan,W., Zeng,Z., He,T.,
            Schwarz,B., Haupl,B., Oellerich,T., Lenardo,M.J. and Yao,Y.
  TITLE     AMBRA1 controls the translation of immune-specific genes in T
            lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 121 (44), e2416722121 (2024)
   PUBMED   39436665
  REMARK    GeneRIF: AMBRA1 controls the translation of immune-specific genes
            in T lymphocytes.
REFERENCE   2  (bases 1 to 5249)
  AUTHORS   Sankar,D.S., Kaeser-Pebernard,S., Vionnet,C., Favre,S., de Oliveira
            Marchioro,L., Pillet,B., Zhou,J., Stumpe,M., Kovacs,W.J.,
            Kressler,D., Antonioli,M., Fimia,G.M. and Dengjel,J.
  TITLE     The ULK1 effector BAG2 regulates autophagy initiation by modulating
            AMBRA1 localization
  JOURNAL   Cell Rep 43 (9), 114689 (2024)
   PUBMED   39207901
  REMARK    GeneRIF: The ULK1 effector BAG2 regulates autophagy initiation by
            modulating AMBRA1 localization.
REFERENCE   3  (bases 1 to 5249)
  AUTHORS   Di Leo,L., Pagliuca,C., Kishk,A., Rizza,S., Tsiavou,C.,
            Pecorari,C., Dahl,C., Pacheco,M.P., Tholstrup,R., Brewer,J.R.,
            Berico,P., Hernando,E., Cecconi,F., Ballotti,R., Bertolotto,C.,
            Filomeni,G., Gjerstorff,M.F., Sauter,T., Lovat,P., Guldberg,P. and
            De Zio,D.
  TITLE     AMBRA1 levels predict resistance to MAPK inhibitors in melanoma
  JOURNAL   Proc Natl Acad Sci U S A 121 (25), e2400566121 (2024)
   PUBMED   38870061
  REMARK    GeneRIF: AMBRA1 levels predict resistance to MAPK inhibitors in
            melanoma.
REFERENCE   4  (bases 1 to 5249)
  AUTHORS   Xu,W., Hua,Z., Wang,Y., Tang,W., Ou,W., Liu,F., Yang,Y., Ding,W.,
            Wang,Z., Cui,L., Ge,W., Gu,Y., Wang,X., Chen,Y., Liu,C.Y. and Du,P.
  TITLE     AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c
            mediated IKK dephosphorylation in an autophagy-independent manner
  JOURNAL   Cell Death Differ 31 (5), 618-634 (2024)
   PUBMED   38424148
  REMARK    GeneRIF: AMBRA1 promotes intestinal inflammation by antagonizing
            PP4R1/PP4c mediated IKK dephosphorylation in an
            autophagy-independent manner.
REFERENCE   5  (bases 1 to 5249)
  AUTHORS   Qu,X., Li,X.Y., Feng,Y., Wang,X., Li,L., Wang,Y.P. and Chu,Y.L.
  TITLE     sh- Ambra1 inhibits IRS-1/PI3K/Akt signalling pathway to reduce
            autophagy in gestational diabetes
  JOURNAL   Endokrynol Pol 75 (1), 61-70 (2024)
   PUBMED   38497391
  REMARK    GeneRIF: sh- Ambra1 inhibits IRS-1/PI3K/Akt signalling pathway to
            reduce autophagy in gestational diabetes.
REFERENCE   6  (bases 1 to 5249)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   7  (bases 1 to 5249)
  AUTHORS   Cecconi,F., Di Bartolomeo,S., Nardacci,R., Fuoco,C., Corazzari,M.,
            Giunta,L., Romagnoli,A., Stoykova,A., Chowdhury,K., Fimia,G.M. and
            Piacentini,M.
  TITLE     A novel role for autophagy in neurodevelopment
  JOURNAL   Autophagy 3 (5), 506-508 (2007)
   PUBMED   17622796
REFERENCE   8  (bases 1 to 5249)
  AUTHORS   Le Bot,N.
  TITLE     Autophagy: a new regulator of development
  JOURNAL   Nat Cell Biol 9 (7), 741 (2007)
   PUBMED   17603510
REFERENCE   9  (bases 1 to 5249)
  AUTHORS   Fimia,G.M., Stoykova,A., Romagnoli,A., Giunta,L., Di Bartolomeo,S.,
            Nardacci,R., Corazzari,M., Fuoco,C., Ucar,A., Schwartz,P.,
            Gruss,P., Piacentini,M., Chowdhury,K. and Cecconi,F.
  TITLE     Ambra1 regulates autophagy and development of the nervous system
  JOURNAL   Nature 447 (7148), 1121-1125 (2007)
   PUBMED   17589504
REFERENCE   10 (bases 1 to 5249)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127035.6, AC115097.6, AC024293.18 and AC116021.5.
            
            On Sep 18, 2020 this sequence version replaced XM_005253009.4.
            
            Transcript Variant: This variant (10), as well as variant 5,
            encodes isoform 5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.5294.1,
                                           SRR11853559.5750.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683756.1/ ENSP00000508322.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC127035.6         74078-74273         c
            197-451             AC127035.6         28496-28750         c
            452-510             AC127035.6         28067-28125         c
            511-694             AC127035.6         27363-27546         c
            695-867             AC127035.6         25854-26026         c
            868-934             AC127035.6         24225-24291         c
            935-2388            AC127035.6         22195-23648         c
            2389-2475           AC115097.6         82909-82995         c
            2476-2655           AC115097.6         78373-78552         c
            2656-2736           AC115097.6         64306-64386         c
            2737-2837           AC115097.6         63790-63890         c
            2838-2948           AC115097.6         13670-13780         c
            2949-3137           AC115097.6         5031-5219           c
            3138-3292           AC115097.6         3656-3810           c
            3293-3432           AC024293.18        36247-36386         c
            3433-3525           AC024293.18        28610-28702         c
            3526-3719           AC024293.18        26847-27040         c
            3720-5249           AC116021.5         162925-164454       c
FEATURES             Location/Qualifiers
     source          1..5249
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..5249
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /note="autophagy and beclin 1 regulator 1"
                     /db_xref="GeneID:55626"
                     /db_xref="HGNC:HGNC:25990"
                     /db_xref="MIM:611359"
     exon            1..196
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            197..451
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..4213
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /note="isoform 5 is encoded by transcript variant 10; WD
                     repeat domain 94; DDB1 and CUL4 associated factor 3;
                     activating molecule in BECN1-regulated autophagy protein
                     1; activating molecule in beclin-1-regulated autophagy;
                     autophagy/beclin-1 regulator 1"
                     /codon_start=1
                     /product="activating molecule in BECN1-regulated autophagy
                     protein 1 isoform 5"
                     /protein_id="NP_001373940.1"
                     /db_xref="CCDS:CCDS91466.1"
                     /db_xref="GeneID:55626"
                     /db_xref="HGNC:HGNC:25990"
                     /db_xref="MIM:611359"
                     /translation="MKVVPEKNAVRILWGRERGARAMGAQRLLQELVEDKTRWMKWEG
                     KRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKTGKCVHSLIGHRRTPWCVT
                     FHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQLLLIATANEI
                     HFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSNQQGDDEPEIPIDGT
                     ELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQVGEQSTVQDSATPSPPPPPPQ
                     PSTERPRTSAYIRLRQRVSYPTAECCQHLGILCLCSRCSGTRVPSLLPHQDSVPPASA
                     RATTPSFSFVQTEPFHPPEQASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTR
                     RSLGGPLSSHPSRYHREIAPGLTGSEWTRTVLSLNSRSEAESMPPPRTSASSVSLLSV
                     LRQQEGGSQASVYTSATEGRGFPASGLATESDGGNGSSQNNSGSIRHELQCDLRRFFL
                     EYDRLQELDQSLSGEAPQTQQAQEMLNNNIESERPGPSHQPTPHSSENNSNLSRGHLN
                     RCRACHNLLTFNNDTLRWERTTPNYSSGEASSSWQVPSSFESVPSSGSQLPPLERTEG
                     QTPSSSRLELSSSASPQEERTVGVAFNQETGHWERIYTQSSRSGTVSQEALHQDMPEE
                     SSEEDSLRRRLLESSLISLSRYDGAGSREHPIYPDPARLSPAAYYAQRMIQYLSRRDS
                     IRQRSMRYQQNRLRSSTSSSSSDNQGPSVEGTDLEFEDFEDNGDRSRHRAPRNARMSA
                     PSLGRFVPRRFLLPEYLPYAGIFHERGQPGLATHSSVNRVLAGAVIGDGQSAVASNIA
                     NTTYRLQWWDFTKFDLPEISNASVNVLVQNCKIYNDASCDISADGQLLAAFIPSSQRG
                     FPDEGILAVYSLAPHNLGEMLYTKRFGPNAISVSLSPMGRYVMVGLASRRILLHPSTE
                     HMVAQVFRLQQAHGGETSMRRVFNVLYPMPADQRRHVSINSARWLPEPGLGLAYGTNK
                     GDLVICRPEALNSGVEYYWDQLNETVFTVHSNSRSSERPGTSRATWRTDRDMGLMNAI
                     GLQPRNPATSVTSQGTQTLALQLQNAETQTEREVPEPGTAASGPGEGEGSEYGASGED
                     ALSRIQRLMAEGGMTAVVQREQSTTMASMGGFGNNIIVSHRIHRSSQTGTEPGAAHTS
                     SPQPSTSRGLLPEAGQLAERGLSPRTASWDQPGTPGREPTQPTLPSSSPVPIPVSLPS
                     AEGPTLHCELTNNNHLLDGGSSRGDAAGPRGEPRNR"
     exon            452..510
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            511..694
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            695..867
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            868..934
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            935..2388
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2475
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2655
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2736
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2837
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2948
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3137
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3292
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3432
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3525
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3719
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     exon            3720..5249
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5227..5232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /note="hexamer: ATTAAA"
     polyA_site      5249
                     /gene="AMBRA1"
                     /gene_synonym="DCAF3; WDR94"
                     /note="major polyA site"
ORIGIN      
        1 cttcttgctt gatgtctcct gagcggcggc ggcgccgggt cgagggctga gttgtccgcg
       61 aggccccgcg ctcaagccgc cttctcctgc cggtcggtag aacggacccc ttcctttatt
      121 cctgtctcct ctttcttttt ccctgtggct cagcccgttc gctggactgc aaaccgagct
      181 cccgtctgcc ttgcagattt ccatgaggac aacttacaag gacctgtatg gcctcatttt
      241 agctgcttca gtgtgttgga gctgttactt gctccttcat ttcctgggcc tggtgtgaca
      301 gtggctactg agcgccatga aggttgtccc agaaaagaat gctgtccgga tactctgggg
      361 gcgagaacgg ggtgctcggg ccatgggagc tcagcggctt ctgcaggagc tggtagaaga
      421 taaaacccgg tggatgaaat gggagggcaa gagagtagaa ctgccggata gtccacgctc
      481 taccttctta ttggccttca gcccagacag gactctctta gcctccaccc atgtgaacca
      541 taatatctat attacggagg tgaagactgg caagtgtgtt cattccctga ttggacaccg
      601 ccgtactcca tggtgtgtca cttttcatcc caccatctca ggccttattg cttctggctg
      661 cctagatggg gaggttagga tttgggattt acacggtggc agtgaaagct ggttcacaga
      721 tagcaacaat gccattgcct ccctggcttt ccaccctacg gctcagctcc tgctgattgc
      781 cactgccaat gagatccact tctgggactg gagtcgacgg gaaccctttg ctgtggtgaa
      841 gacagctagt gagatggaac gggtccgtct ggtgagattt gatccacttg gacactactt
      901 actcacagca attgttaacc cctctaatca acagggtgat gacgaaccag agatccccat
      961 agatggaaca gaattatccc actaccgtca gcgtgccctc ctgcaatcac agccagttcg
     1021 ccggacgcct ctcctccaca atttcctgca catgctgtcc tcccgctctt ctggcatcca
     1081 ggtgggagag caaagcacag tgcaagattc tgctaccccc tcacccccac cgcctccccc
     1141 tcagccctcc acggagcgcc ccaggacttc cgcttacatc aggctccgac agcgggtcag
     1201 ttaccccaca gctgagtgct gccagcacct tgggatcctg tgcctttgca gccgctgctc
     1261 tggcactcga gttccttccc tcttgccaca ccaggacagt gtcccccctg cttctgccag
     1321 agctactacc ccttcctttt cttttgtaca gaccgagccc ttccatcccc cggagcaggc
     1381 ctcgtcaacg cagcaggacc agggcctcct gaaccggccg tctgccttca gtacagtcca
     1441 gagcagcact gccggcaaca cgctccgcaa cctcagtctg ggtcctaccc gccgctcttt
     1501 gggagggcct ctgtctagcc acccttctag gtatcaccga gaaatagctc ctgggttgac
     1561 aggatctgag tggacccgga cagtactcag tctgaactcc cgctctgagg cggaatccat
     1621 gcccccgccc agaaccagtg cctcttcggt gagtttgctg tctgtgctga gacagcagga
     1681 aggtggctct caggcatctg tgtacacttc agccacagaa gggaggggtt ttccggcatc
     1741 agggttggca actgagtcag atggagggaa tggctccagc caaaacaact cgggcagcat
     1801 tcgccatgag cttcagtgtg acctgagacg cttctttctg gagtatgacc ggcttcagga
     1861 gctggatcag agcctgagtg gggaagctcc ccagacccaa caggcccagg aaatgctcaa
     1921 caataacatt gaatctgaga ggccaggccc ttcccaccag cccaccccac acagcagtga
     1981 gaacaactcc aacctgtccc gtggccacct gaatcgctgt cgtgcttgcc acaatctcct
     2041 gaccttcaac aacgataccc tgcgctggga aagaaccaca cctaactact cctctggcga
     2101 ggctagttcc tcttggcagg tccccagctc ctttgagagt gtgccatcaa gtggcagcca
     2161 gttgccacct ctcgagcgga ctgagggcca aacgcccagc tccagcaggc tggagttgag
     2221 cagctctgct agtccgcagg aggagaggac tgtgggggtg gcctttaacc aggagacagg
     2281 ccactgggaa agaatttaca cccagtccag cagatctgga actgtgtcac aggaggcctt
     2341 acatcaggat atgcctgagg agagctctga ggaggattca ctcaggagga ggctgctgga
     2401 atcttccctc atttcattat cccgttatga tggagcagga tccagagagc acccaattta
     2461 cccagaccca gcgagattat ctcctgctgc atactacgcc cagaggatga tccagtatct
     2521 ctcacggaga gacagtattc gccagcgctc catgcgctac caacagaacc gtctccgttc
     2581 ttccacctcc tcctcttcct cagacaacca gggtccatca gtagagggaa ccgacttgga
     2641 atttgaggac tttgaggaca atggtgacag atccaggcac cgagctccac gcaatgcccg
     2701 gatgtctgca ccttcgcttg gacgctttgt cccaaggcgt ttcttgctgc ctgagtactt
     2761 gccttatgct gggatttttc atgaacgtgg acagcctggc ttggctactc actcttctgt
     2821 taacagggtc ctggcagggg cagtgatcgg tgatggacag tctgctgtgg ccagtaacat
     2881 tgccaatact acctaccggc tccagtggtg ggacttcact aagtttgacc tccctgaaat
     2941 cagtaatgct tccgtgaatg tgctggtgca gaactgcaag atctacaatg atgccagctg
     3001 tgacatttct gcagatggcc agctcctggc agctttcatc cccagcagcc agaggggctt
     3061 tcctgatgaa ggcatcctgg cagtgtactc cctggccccc cataacctgg gcgaaatgct
     3121 ctacaccaag cgatttggtc ccaatgccat ttcggtgagc ctgtccccaa tgggcagata
     3181 tgtaatggtg ggcttggcct cacgaaggat cctgctgcac ccctccacag agcacatggt
     3241 ggcccaggtc ttcaggctgc aacaggccca tggtggagag acctccatga ggagagtttt
     3301 caacgtcctt tatcccatgc ctgccgacca gcggagacat gtcagtatca actctgcccg
     3361 ttggctgcct gagccagggc ttggcttggc ctatggtact aacaaaggag acctggtgat
     3421 ctgccgacca gaggccttaa actctggtgt tgagtactac tgggaccagc tgaacgagac
     3481 ggtcttcact gtccattcca acagcaggag cagcgagcgg cctggaacca gcagagccac
     3541 atggaggaca gacagagaca tggggctgat gaatgccatt gggcttcagc cccggaaccc
     3601 tgccacctca gtgacatctc agggcaccca gactctggcc cttcagctgc agaatgccga
     3661 aacacagact gagagggagg tgccggagcc agggacagcc gcctcaggtc ctggtgaagg
     3721 tgagggttca gagtatggtg ccagtggaga agatgcgctc agcaggatcc agaggctgat
     3781 ggcggagggc ggcatgacag ccgtggtgca gcgggagcag agcaccacca tggcctccat
     3841 gggcggcttc ggcaacaaca tcatcgtcag ccaccgcatt caccgcagct ctcagacggg
     3901 cactgaacct ggtgccgccc acacctcctc accccagccc tccacctctc ggggactgct
     3961 cccagaggcc gggcaactgg cagagcgagg cctaagcccc cggacagctt cctgggacca
     4021 gcctggtacc cctgggcggg agccaaccca gccaaccctg ccctcttcct cccctgtccc
     4081 cattcctgtt tcccttccca gcgctgaggg accaaccctc cactgcgagt tgaccaataa
     4141 caaccacctt ctggatggtg gcagcagcag gggggacgct gcaggcccta ggggagaacc
     4201 acggaacagg tagagacaaa cgttgcactg gtgcctcccc tcgaaccgcc aagcagaaac
     4261 cggacctcac agctgactgg gaactggaca tgtggaagag ctgctggctg catcagggaa
     4321 caggaggagg aagagggtca gggtggagag gaagatcagt cagtgggcac aagacagtca
     4381 aatgggcaag gcctgcctcg gggaactaga accttccagg atctggagcc cgggagagcc
     4441 acactgtggg cttaatgtga atagaggaac aagtgggtat ctctgccagg caccccactt
     4501 tctcctagta acatgggctc aggggactca gccctggaca gagagcctcc agagagtgaa
     4561 cagtcttcca gatctgggcc aatcatcctg gacagaggcc cgcgaggcag ctttgccctg
     4621 tccacctgtt gggtgggcag agccaccagg aacccagaca ccacctccaa ctctgagcct
     4681 tccagagctt cagcctctct tcgtcgtctt accccactga aaccaacagg gatcgggcca
     4741 ggctcccaga ttcttgagga cagggacttc ggcatttact aatgggggac tactgtgggg
     4801 taagggggcg cctgcttgcc tgatacagga tggggtcaag ggacagtggg caggtcctca
     4861 ctcaggagtg gggggtgtag gctggccagc ccccagggct tgtccaccag tcttctcccc
     4921 gcaaggccct cagagcagcg cctgtgggtg tcagtattac ctgagcctag gccaaagcta
     4981 gcccaaggct ggggaagggg aggagactcc aggtcagaat gtgaggtctc agtctgtgat
     5041 ttaaggtgtt gcatgtggac tcttaactgt acgtgtagtt tctagtggag aaatcaaggc
     5101 tctgatcatt ttgtttttag tatgaaaatg tgatttcctt tctgtttgta actcatcata
     5161 gaaacattgt ggtgggagga gaggggatag tctacagcta atgagggaaa caccaaagat
     5221 cacatcatta aaatgatgac atgcccctc
//
