LOCUS       NM_001633               1262 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens alpha-1-microglobulin/bikunin precursor (AMBP), mRNA.
ACCESSION   NM_001633
VERSION     NM_001633.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1262)
  AUTHORS   Jin,L., Niu,C. and Ni,Y.
  TITLE     Correlation between peripheral blood alpha1-MG, DNMT1 expression,
            and the severity of diabetic nephropathy renal pathological damage
  JOURNAL   Medicine (Baltimore) 102 (42), e35409 (2023)
   PUBMED   37861555
  REMARK    GeneRIF: Correlation between peripheral blood alpha1-MG, DNMT1
            expression, and the severity of diabetic nephropathy renal
            pathological damage.
REFERENCE   2  (bases 1 to 1262)
  AUTHORS   Xu,Y., Carr,P.D., Guss,J.M. and Ollis,D.L.
  TITLE     The crystal structure of bikunin from the inter-alpha-inhibitor
            complex: a serine protease inhibitor with two Kunitz domains
  JOURNAL   J Mol Biol 276 (5), 955-966 (1998)
   PUBMED   9566199
REFERENCE   3  (bases 1 to 1262)
  AUTHORS   Vetr,H. and Gebhard,W.
  TITLE     Structure of the human alpha 1-microglobulin-bikunin gene
  JOURNAL   Biol Chem Hoppe Seyler 371 (12), 1185-1196 (1990)
   PUBMED   1708673
REFERENCE   4  (bases 1 to 1262)
  AUTHORS   Diarra-Mehrpour,M., Bourguignon,J., Sesboue,R., Salier,J.P.,
            Leveillard,T. and Martin,J.P.
  TITLE     Structural analysis of the human inter-alpha-trypsin inhibitor
            light-chain gene
  JOURNAL   Eur J Biochem 191 (1), 131-139 (1990)
   PUBMED   1696200
REFERENCE   5  (bases 1 to 1262)
  AUTHORS   Schreitmuller,T., Hochstrasser,K., Reisinger,P.W., Wachter,E. and
            Gebhard,W.
  TITLE     cDNA cloning of human inter-alpha-trypsin inhibitor discloses three
            different proteins
  JOURNAL   Biol Chem Hoppe Seyler 368 (8), 963-970 (1987)
   PUBMED   3663330
REFERENCE   6  (bases 1 to 1262)
  AUTHORS   Kaumeyer,J.F., Polazzi,J.O. and Kotick,M.P.
  TITLE     The mRNA for a proteinase inhibitor related to the HI-30 domain of
            inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin
            (protein HC)
  JOURNAL   Nucleic Acids Res 14 (20), 7839-7850 (1986)
   PUBMED   2430261
REFERENCE   7  (bases 1 to 1262)
  AUTHORS   Traboni,C. and Cortese,R.
  TITLE     Sequence of a full length cDNA coding for human protein HC (alpha 1
            microglobulin)
  JOURNAL   Nucleic Acids Res 14 (15), 6340 (1986)
   PUBMED   2428011
REFERENCE   8  (bases 1 to 1262)
  AUTHORS   Lopez Otin,C., Grubb,A.O. and Mendez,E.
  TITLE     The complete amino acid sequence of human complex-forming
            glycoprotein heterogeneous in charge (protein HC) from one
            individual
  JOURNAL   Arch Biochem Biophys 228 (2), 544-554 (1984)
   PUBMED   6198962
REFERENCE   9  (bases 1 to 1262)
  AUTHORS   Takagi,T., Takagi,K. and Kawai,T.
  TITLE     Complete amino acid sequence of human alpha 1-microglobulin
  JOURNAL   Biochem Biophys Res Commun 98 (4), 997-1001 (1981)
   PUBMED   6164372
REFERENCE   10 (bases 1 to 1262)
  AUTHORS   Ekstrom,B. and Berggard,I.
  TITLE     Human alpha1-microglobulin. Purification procedure, chemical and
            physiochemical properties
  JOURNAL   J Biol Chem 252 (22), 8048-8057 (1977)
   PUBMED   72071
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC041593.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001633.3.
            
            Summary: This gene encodes a complex glycoprotein secreted in
            plasma. The precursor is proteolytically processed into distinct
            functioning proteins: alpha-1-microglobulin, which belongs to the
            superfamily of lipocalin transport proteins and may play a role in
            the regulation of inflammatory processes, and bikunin, which is a
            urinary trypsin inhibitor belonging to the superfamily of
            Kunitz-type protease inhibitors and plays an important role in many
            physiological and pathological processes. This gene is located on
            chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041593.1, SRR5189652.12257.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265132.8/ ENSP00000265132.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1262              BC041593.1         136-1397
FEATURES             Location/Qualifiers
     source          1..1262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1262
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /note="alpha-1-microglobulin/bikunin precursor"
                     /db_xref="GeneID:259"
                     /db_xref="HGNC:HGNC:453"
                     /db_xref="MIM:176870"
     exon            1..208
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1150
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /note="protein HC; complex-forming glycoprotein
                     heterogeneous in charge; uronic-acid-rich protein;
                     trypstatin; bikunin; inter-alpha-trypsin inhibitor light
                     chain; protein AMBP; uristatin; growth-inhibiting protein
                     19"
                     /codon_start=1
                     /product="protein AMBP preproprotein"
                     /protein_id="NP_001624.1"
                     /db_xref="CCDS:CCDS6800.1"
                     /db_xref="GeneID:259"
                     /db_xref="HGNC:HGNC:453"
                     /db_xref="MIM:176870"
                     /translation="MRSLGALLLLLSACLAVSAGPVPTPPDNIQVQENFNISRIYGKW
                     YNLAIGSTCPWLKKIMDRMTVSTLVLGEGATEAEISMTSTRWRKGVCEETSGAYEKTD
                     TDGKFLYHKSKWNITMESYVVHTNYDEYAIFLTKKFSRHHGPTITAKLYGRAPQLRET
                     LLQDFRVVAQGVGIPEDSIFTMADRGECVPGEQEPEPILIPRVRRAVLPQEEEGSGGG
                     QLVTEVTKKEDSCQLGYSAGPCMGMTSRYFYNGTSMACETFQYGGCMGNGNNFVTEKE
                     CLQTCRTVAACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECR
                     EYCGVPGDGDEELLRFSN"
     exon            209..351
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            352..428
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            429..545
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            546..647
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            648..694
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            695..776
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            777..944
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1118
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1262
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1241..1246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /note="hexamer: ACTAAA"
     polyA_site      1262
                     /gene="AMBP"
                     /gene_synonym="A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL;
                     ITILC; UTI"
                     /note="major polyA site"
ORIGIN      
        1 agttcacagc tgccctgttg cagggaggcg gtggcccttc tgttgctaga ccgagcctgt
       61 gggatatacc aaggcagagg agcccatagc catgaggagc ctcggggccc tgctcttgct
      121 gctgagcgcc tgcctggcgg tgagcgctgg ccctgtgcca acgccgcccg acaacatcca
      181 agtgcaggaa aacttcaata tctctcggat ctatgggaag tggtacaacc tggccatcgg
      241 ttccacctgc ccctggctga agaagatcat ggacaggatg acagtgagca cgctggtgct
      301 gggagagggc gctacagagg cggagatcag catgaccagc actcgttggc ggaaaggtgt
      361 ctgtgaggag acgtctggag cttatgagaa aacagatact gatgggaagt ttctctatca
      421 caaatccaaa tggaacataa ccatggagtc ctatgtggtc cacaccaact atgatgagta
      481 tgccattttc ctgaccaaga aattcagccg ccatcatgga cccaccatta ctgccaagct
      541 ctacgggcgg gcgccgcagc tgagggaaac tctcctgcag gacttcagag tggttgccca
      601 gggtgtgggc atccctgagg actccatctt caccatggct gaccgaggtg aatgtgtccc
      661 tggggagcag gaaccagagc ccatcttaat cccgagagtc cggagggctg tgctacccca
      721 agaagaggaa ggatcagggg gtgggcaact ggtaactgaa gtcaccaaga aagaagattc
      781 ctgccagctg ggctactcgg ccggtccctg catgggaatg accagcaggt atttctataa
      841 tggtacatcc atggcctgtg agactttcca gtacggcggc tgcatgggca acggtaacaa
      901 cttcgtcaca gaaaaggagt gtctgcagac ctgccgaact gtggcggcct gcaatctccc
      961 catagtccgg ggcccctgcc gagccttcat ccagctctgg gcatttgatg ctgtcaaggg
     1021 gaagtgcgtc ctcttcccct acgggggctg ccagggcaac gggaacaagt tctactcaga
     1081 gaaggagtgc agagagtact gcggtgtccc tggtgatggt gatgaggagc tgctgcgctt
     1141 ctccaactga caactggccg gtctgcaagt cagaggatgg ccagtgtctg tcccggggtc
     1201 ctgtggcagg cagcgccaag caacctgggt ccaaataaaa actaaattgt aaactcctga
     1261 aa
//
