LOCUS       NM_005782               1097 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens Aly/REF export factor (ALYREF), transcript variant 1,
            mRNA.
ACCESSION   NM_005782 XM_946253 XM_946254
VERSION     NM_005782.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1097)
  AUTHORS   Jin,Y., Yao,J., Fu,J., Huang,Q., Luo,Y., You,Y., Zhang,W.,
            Zhong,Q., Xia,T. and Xia,L.
  TITLE     ALYREF promotes the metastasis of nasopharyngeal carcinoma by
            increasing the stability of NOTCH1 mRNA
  JOURNAL   Cell Death Dis 15 (8), 578 (2024)
   PUBMED   39117671
  REMARK    GeneRIF: ALYREF promotes the metastasis of nasopharyngeal carcinoma
            by increasing the stability of NOTCH1 mRNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1097)
  AUTHORS   Jin,T., Yang,L., Chang,C., Luo,H., Wang,R., Gan,Y., Sun,Y., Guo,Y.,
            Tang,R., Chen,S., Meng,D., Dai,P. and Liu,M.
  TITLE     HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via
            ALYREF/NXF1 Complex to Foster Breast Cancer Development
  JOURNAL   Adv Sci (Weinh) 11 (24), e2307639 (2024)
   PUBMED   38626369
  REMARK    GeneRIF: HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective
            Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.
REFERENCE   3  (bases 1 to 1097)
  AUTHORS   Ye,X., Tuo,Z., Chen,K., Wu,R., Wang,J., Yu,Q., Ye,L., Miyamoto,A.,
            Yoo,K.H., Zhang,C., Wei,W., Li,D. and Feng,D.
  TITLE     Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)
  JOURNAL   Oncol Res 32 (3), 503-515 (2024)
   PUBMED   38361753
  REMARK    GeneRIF: Pan-cancer analysis of RNA 5-methylcytosine reader
            (ALYREF).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1097)
  AUTHORS   Zhao,Y., Xing,C. and Peng,H.
  TITLE     ALYREF (Aly/REF export factor): A potential biomarker for
            predicting cancer occurrence and therapeutic efficacy
  JOURNAL   Life Sci 338, 122372 (2024)
   PUBMED   38135116
  REMARK    GeneRIF: ALYREF (Aly/REF export factor): A potential biomarker for
            predicting cancer occurrence and therapeutic efficacy.
            Review article
REFERENCE   5  (bases 1 to 1097)
  AUTHORS   Wang,N., Chen,R.X., Deng,M.H., Wei,W.S., Zhou,Z.H., Ning,K.,
            Li,Y.H., Li,X.D., Ye,Y.L., Wen,J.H., Dong,B., Zhang,X.P., Liu,Z.W.
            and Zhou,F.J.
  TITLE     m5C-dependent cross-regulation between nuclear reader ALYREF and
            writer NSUN2 promotes urothelial bladder cancer malignancy through
            facilitating RABL6/TK1 mRNAs splicing and stabilization
  JOURNAL   Cell Death Dis 14 (2), 139 (2023)
   PUBMED   36806253
  REMARK    GeneRIF: m[5]C-dependent cross-regulation between nuclear reader
            ALYREF and writer NSUN2 promotes urothelial bladder cancer
            malignancy through facilitating RABL6/TK1 mRNAs splicing and
            stabilization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1097)
  AUTHORS   Muravenko,O.V., Gizatullin,R.Z., Al-Amin,A.N., Protopopov,A.I.,
            Kashuba,V.I., Zelenin,A.V. and Zabarovsky,E.R.
  TITLE     Human ALY/BEF gene Map position 17q25.3
  JOURNAL   Chromosome Res 8 (6), 562 (2000)
   PUBMED   11032328
REFERENCE   7  (bases 1 to 1097)
  AUTHORS   Virbasius,C.M., Wagner,S. and Green,M.R.
  TITLE     A human nuclear-localized chaperone that regulates dimerization,
            DNA binding, and transcriptional activity of bZIP proteins
  JOURNAL   Mol Cell 4 (2), 219-228 (1999)
   PUBMED   10488337
REFERENCE   8  (bases 1 to 1097)
  AUTHORS   Wichmann,I., Garcia-Lozano,J.R., Respaldiza,N.,
            Gonzalez-Escribano,M.F. and Nunez-Roldan,A.
  TITLE     Autoantibodies to transcriptional regulation proteins DEK and ALY
            in a patient with systemic lupus erythematosus
  JOURNAL   Hum Immunol 60 (1), 57-62 (1999)
   PUBMED   9952027
REFERENCE   9  (bases 1 to 1097)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   10 (bases 1 to 1097)
  AUTHORS   Bruhn,L., Munnerlyn,A. and Grosschedl,R.
  TITLE     ALY, a context-dependent coactivator of LEF-1 and AML-1, is
            required for TCRalpha enhancer function
  JOURNAL   Genes Dev 11 (5), 640-653 (1997)
   PUBMED   9119228
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC052302.1 and BU624466.1.
            
            On May 17, 2019 this sequence version replaced NM_005782.3.
            
            Summary: The protein encoded by this gene is a heat stable, nuclear
            protein and functions as a molecular chaperone. It is thought to
            regulate dimerization, DNA binding, and transcriptional activity of
            basic region-leucine zipper (bZIP) proteins. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.79565.1,
                                           SRR1163657.63300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000505490.3/ ENSP00000421592.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-956               BC052302.1         1-956
            957-1097            BU624466.1         17-157              c
FEATURES             Location/Qualifiers
     source          1..1097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1097
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /note="Aly/REF export factor"
                     /db_xref="GeneID:10189"
                     /db_xref="HGNC:HGNC:19071"
                     /db_xref="MIM:604171"
     exon            1..264
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..801
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /note="bZIP enhancing factor; tho4; ally of AML-1 and
                     LEF-1; bZIP-enhancing factor BEF; transcriptional
                     coactivator Aly/REF; THO complex 4"
                     /codon_start=1
                     /product="THO complex subunit 4"
                     /protein_id="NP_005773.3"
                     /db_xref="CCDS:CCDS32768.2"
                     /db_xref="GeneID:10189"
                     /db_xref="HGNC:HGNC:19071"
                     /db_xref="MIM:604171"
                     /translation="MPDSAPAMADKMDMSLDDIIKLNRSQRGGRGGGRGRGRAGSQGG
                     RGGGAQAAARVNRGGGPIRNRPAIARGAAGGGGRNRPAPYSRPKQLPDKWQHDLFDSG
                     FGGGAGVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTADVHF
                     ERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDAQRRPAQSVNRGGMTRNRGAGGFGG
                     GGGTRRGTRGGARGRGRGAGRNSKQQLSAEELDAQLDAYNARMDTS"
     exon            265..396
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /inference="alignment:Splign:2.1.0"
     exon            397..544
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /inference="alignment:Splign:2.1.0"
     exon            545..608
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /inference="alignment:Splign:2.1.0"
     exon            609..786
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1097
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1068..1073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /note="hexamer: AATAAA"
     regulatory      1073..1078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /note="hexamer: AATAGA"
     polyA_site      1088
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /note="major polyA site"
     polyA_site      1097
                     /gene="ALYREF"
                     /gene_synonym="ALY; ALY/REF; BEF; REF; THOC4"
                     /note="major polyA site"
ORIGIN      
        1 gagccgatgc ccgattccgc gcccgccatg gccgacaaaa tggacatgtc tctggacgac
       61 atcattaaac tgaaccggag ccagcgaggc ggccggggcg ggggccgggg ccgcggccgg
      121 gccggctccc agggcggccg cggcggtggg gcgcaggccg ccgcgcgagt gaatcgaggc
      181 ggcgggccca tccggaaccg gccggccatc gcccgcggcg cggccggcgg aggcggcagg
      241 aaccgaccgg cgccctacag caggccaaaa caacttcccg acaagtggca gcacgatctt
      301 ttcgacagtg gcttcggcgg tggtgccggc gtggagacag gtgggaaact gctggtgtcc
      361 aatctggatt ttggagtctc agacgccgat attcaggaac tctttgctga atttggaacg
      421 ctgaagaagg cggctgtgca ctatgatcgc tctggtcgca gcttaggaac agcagacgtg
      481 cactttgagc ggaaggcaga tgccctgaag gccatgaagc agtacaacgg cgtccctctg
      541 gatggccgcc ccatgaacat tcagcttgtc acgtcacaga ttgacgcaca gcggaggcct
      601 gcacagagcg taaacagagg tggcatgact agaaaccgtg gcgctggagg ttttggtggt
      661 ggtggaggca cccggagagg cacccgcgga ggcgcccgtg gaagaggcag aggtgccggc
      721 aggaattcaa agcagcagct ttcggcagag gagctggatg cccagctgga cgcctataat
      781 gcgagaatgg acaccagtta aacagaccag caaatccgcg tgcggaacag gacccaggcg
      841 tctcctcttg ctccctggtt ggggggcggt ggctggggct gtgcggccaa tgatggattt
      901 gtttctttta tgttttaaaa taggatttaa aaactcatgt aaaggttttt tttttttctt
      961 tttttttttt tttaattctg aaacagacct gttttgtacc gagttatttt tgggataaat
     1021 tttactggtt gctgttgtgg agaaggtggc gtttccacct tttccataat aaaatagaaa
     1081 tgtgtgtaga actggaa
//
