LOCUS       XM_006712655            4649 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens alsin Rho guanine nucleotide exchange
            factor ALS2 (ALS2), transcript variant X6, mRNA.
ACCESSION   XM_006712655
VERSION     XM_006712655.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_006712655.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..4649
                     /gene="ALS2"
                     /gene_synonym="ALS2CR6; ALSJ; IAHSP; PLSJ"
                     /note="alsin Rho guanine nucleotide exchange factor ALS2;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 34 ESTs, 618 long SRA reads, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 80 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:57679"
                     /db_xref="HGNC:HGNC:443"
                     /db_xref="MIM:606352"
     CDS             156..3065
                     /gene="ALS2"
                     /gene_synonym="ALS2CR6; ALSJ; IAHSP; PLSJ"
                     /codon_start=1
                     /product="alsin isoform X6"
                     /protein_id="XP_006712718.1"
                     /db_xref="GeneID:57679"
                     /db_xref="HGNC:HGNC:443"
                     /db_xref="MIM:606352"
                     /translation="MGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTV
                     QLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSIT
                     NFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLPIRRLHNYA
                     KVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMTDS
                     LRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLWAEPL
                     SEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSS
                     VQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL
                     EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLL
                     RSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGL
                     YYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWG
                     SGIKITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQG
                     EVWKAWDNIAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRK
                     YLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRF
                     LFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLY
                     PPLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVL
                     PTTKDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLF
                     PVFLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN"
ORIGIN      
        1 tgcaggcagg gattattccc tgtttttagt ggatacagaa gacttccagc ctgggttata
       61 ttacagtggc cgacaggacc ctacagaagc ttggatatat aagcagagtg acagcaggaa
      121 aagatagcta tttagccttg gtggataaaa acattatggg gtatattgcc agtctccacg
      181 agttagctac tacagaaaga cgattctatt caaaactaag tgatatcaaa tctcagattc
      241 tcaggcctct tctcagttta gaaaatttgg gcactacaac tacagtccag ctgttgcagg
      301 aggtggctag ccgattcagc aagctgtgtt acctcattgg tcagcatgga gcctcattga
      361 gcagcttcct tcatggggta aaggaagcca ggagtttggt catcctgaag cattcaagtc
      421 tcttcttgga tagttataca gagtattgca catctattac aaatttcctg gttatgggag
      481 gattccagct tcttgctaag cctgccattg atttcctaaa taaaaaccaa gagctgttgc
      541 aagatttgtc agaagtgaat gacgaaaaca ctcagttgat ggaaatactg aatactttgt
      601 ttttcttgcc aatcagacga cttcataatt acgcaaaagt tttgctaaag cttgctactt
      661 gttttgaagt ggcatctcca gaatatcaga aactgcagga ttccagttct tgttatgagt
      721 gtcttgctct ccatctcggc aggaaaagga aggaagcaga atacacactg ggcttctgga
      781 agaccttccc cggaaaaatg acggattcct tgaggaagcc agagcgtcga ctgctgtgtg
      841 agagtagtaa ccgagccctg tctctgcagc atgctgggag gttttccgtg aattggttca
      901 ttctctttaa tgatgccctg gtccatgccc agttctccac gcaccatgtt ttccctctgg
      961 ccacgctgtg ggcagagcca ctgtctgaag aagctggtgg tgtgaatggc ttaaagataa
     1021 ctacacctga ggagcagttc actctcattt catctacacc ccaggaaaag acaaagtggc
     1081 tacgagctat aagccaagcc gtagatcagg ctttgagagg gatgtctgat ctcccccctt
     1141 atggaagtgg tagcagtgtt cagagacagg aaccacccat ttcacgcagt gccaaatata
     1201 ctttctacaa ggatcctcgc ctaaaggatg ccacctatga tggacgctgg ctttcaggga
     1261 agcctcatgg cagaggggtt ttgaagtggc ctgatggaaa gatgtattct ggcatgttca
     1321 ggaatggctt ggaagatggg tatggagaat acagaatccc aaacaaggca atgaacaaag
     1381 aagaccatta tgtgggccat tggaaagaag gaaaaatgtg cggtcaagga gtctacagct
     1441 atgcttctgg tgaagtattt gagggctgtt ttcaagataa tatgcgtcat ggtcatggtc
     1501 ttctacgaag tgggaaattg acgtcctctt ctcctagtat gttcattggc cagtgggtaa
     1561 tggataagaa agcaggatat ggtgtctttg atgatatcac taggggggaa aagtatatgg
     1621 gaatgtggca agatgatgtg tgtcaaggga atggtgtggt ggttacccag tttggattat
     1681 actacgaggg caactttcac cttaataaaa tgatgggaaa tggggttttg ctttccgaag
     1741 atgatactat ctatgaagga gaattttcag atgactggac tcttagtgga aagggaacac
     1801 tgactatgcc aaatggagac tacattgaag gttattttag tggagaatgg ggatctggga
     1861 taaaaatcac tggaacctac ttcaaaccta gtctatatga gagtgataaa gacagaccta
     1921 aagttttcag gaagctagga aacctggcag tgccagctga tgagaagtgg aaagcggtgt
     1981 ttgacgaatg ttggcgccaa ctgggctgtg agggcccagg ccaaggggaa gtttggaaag
     2041 catgggacaa tattgctgtg gccttgacca ccagtcggcg ccagcacaga gacagtccag
     2101 aaatactgag tcgttcacag actcagacac tagagagttt ggaattcatt ccacagcatg
     2161 ttggtgcctt ctctgtggag aaatatgatg acatcaggaa atatttaata aaggcctgtg
     2221 acactcctct gcaccccctg ggcaggcttg tggagacact ggttgcagtg tatagaatga
     2281 catacgtggg cgtaggagcc aaccgcaggt tattgcagga ggctgtaaag gagattaagt
     2341 cctatcttaa gcgaattttc cagctggtga ggttcttatt tcctgagctg cctgaagaag
     2401 gcagcacaat tcctctctct gctcctctgc caaccgaaag gaagtctttt tgcactggga
     2461 agtcagattc ccgatctgaa tcaccagagc caggttatgt agtaacgagt tctggattat
     2521 tgcttcctgt gctgctacct cggctctacc caccgctgtt tatgctttat gctttggata
     2581 atgatcgcga ggaagacatt tactgggaat gtgtccttcg actaaataag cagccagata
     2641 ttgctctcct gggctttctt ggggtgcaga ggaaattttg gccagcaacc ttgtcaatcc
     2701 ttggagagag taaaaaggtt ttgccaacca cgaaagatgc ttgttttgcc tcagcagtag
     2761 aatgtctgca gcagatcagc acaacattta ccccatcaga caaacttaag gtcatccagc
     2821 agacttttga ggagatctct cagagtgtcc tggcgtcact ccacgaagac ttcttgtggt
     2881 ccatggatga cttgtttcct gttttcttat atgtggtgct acgggccagg attaggaatt
     2941 taggctctga ggtacacctc attgaggatc taatggaccc ctatcttcag catggggaac
     3001 agggtataat gttcaccacc ttgaaggcat gttactacca gattcagcgt gagaagctta
     3061 actaggctgc ataacagctt gaaaactgga ttatctacta cagagtgtta taacaccatc
     3121 tggagtcttc ctgtagtggc aaaaaagaac agtgttgaaa ttggaaagga ctttgtgtta
     3181 tttaggttgt tagaatgagc cttaccaata ataagagccc tgagcccaga aaaaaggact
     3241 gtatagttta aagggaggat tgaaagggag gtaaaaaatc agattagacc agttcttggc
     3301 ctatgataag ttccaaaaat accatttatc tactatttga aaaaagaaga ggatatccct
     3361 tcctacagta aagggtatgt cagctacatg aagttgtaag aaaagcttcc agtagagctt
     3421 cttatattaa agaagttgat ggatattttt gaatttctgg tttgcctgaa tccacctgca
     3481 gttaccccga tccgtttgca agaaccagat cgtacttgaa actatagtgg ccacactctg
     3541 ccttcctgag tcccttccag tcatgtgtgc atcatgtctc tttgccaagg gaggggagaa
     3601 aggaactttt aaactgcagt tttaactttt tctaagctgt ttcttgatgg gagaggttct
     3661 gtgcaaaact accacattct gtccccaaaa tgtggaatgc atccaaatag gagtcttctg
     3721 cctcttaact taaaagaaca taggaatttt gtttttggtt tctttatcat gctacagaga
     3781 gtgaatacac tggaattcag acaccgactc tgagctgcta ggaacctcat ttgtccatgt
     3841 gcaaacgctg tattccaagg cctgtgaatg gcagcctgag gaagttttgc atgcaggctg
     3901 tgttttcgag caggactaac aactgggaaa taagcaaaaa actgcatcga tccccagcct
     3961 ggtgttgttc ttccctatac ttcacactga actcaggatg ggaagaaaaa ggaaacaagc
     4021 tttggctttt tccatctcaa aagtattgtg gcacctcaac atttcagtgt tttgcttttt
     4081 aaaaaatgcc ctattgtaag ttgttggttt atactgtata agtaacacta gtagctgttt
     4141 tgaataacat aggtgctctt cctcatctca tctcctacac cgtggtgagc atacagagtg
     4201 tcctgatttg tgttaagtga ctgagaagat gttaattact tttgaaaaag gatcatggtt
     4261 tttgctctac tttataatca agacaagtgt ttattaaaat actgttttgg aatgttggct
     4321 gtaatgtaac agcaattttc ataataaaag gcattcatct ttatgtggtt gttttatgat
     4381 tgtagaagaa atgaacaggg cagcctaaaa gatgaaagga aacccagact tagtatttct
     4441 ttagcccaca ttgtaatcca tgcctctaag tattggcctc aaaagtccct ctggggtttt
     4501 agaaatctct gtctttaaaa taaacgtaaa ccaatagtta tagcaccctt tctagcaaag
     4561 agcaaattaa ctttctgacc ccaataaccc aaggacacgg gtctccaaag aaatctatta
     4621 tttctttgaa taaaaagcat attttgata
//
