LOCUS       NM_025144               5399 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens alpha kinase 1 (ALPK1), transcript variant 1, mRNA.
ACCESSION   NM_025144
VERSION     NM_025144.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5399)
  AUTHORS   Zhao,J., Feng,Y., Liu,X., Li,H., Guo,H., Ke,J. and Long,X.
  TITLE     The relationship of ALPK1, hyaluronic acid and M1 macrophage
            polarization in the temporomandibular joint synovitis
  JOURNAL   J Cell Mol Med 28 (7), e18172 (2024)
   PUBMED   38494837
  REMARK    GeneRIF: The relationship of ALPK1, hyaluronic acid and M1
            macrophage polarization in the temporomandibular joint synovitis.
REFERENCE   2  (bases 1 to 5399)
  AUTHORS   Lou,S., Wang,J., Chen,J., Xie,H., Chen,H., Zhou,B., Zhang,B.,
            Hou,J. and Jiang,D.K.
  TITLE     The Role of ALPK1 in Inhibiting Hepatitis B Virus Replication
            Facilitates the Identification of ALPK1 P660L Variant for
            Predicting Response to Pegylated Interferon alpha Therapy
  JOURNAL   J Infect Dis 228 (6), 694-703 (2023)
   PUBMED   36932045
  REMARK    GeneRIF: The Role of ALPK1 in Inhibiting Hepatitis B Virus
            Replication Facilitates the Identification of ALPK1 P660L Variant
            for Predicting Response to Pegylated Interferon alpha Therapy.
REFERENCE   3  (bases 1 to 5399)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 5399)
  AUTHORS   Bauer,M., Nascakova,Z., Mihai,A.I., Cheng,P.F., Levesque,M.P.,
            Lampart,S., Hurwitz,R., Pfannkuch,L., Dobrovolna,J., Jacobs,M.,
            Bartfeld,S., Dohlman,A., Shen,X., Gall,A.A., Salama,N.R.,
            Topfer,A., Weber,A., Meyer,T.F., Janscak,P. and Muller,A.
  TITLE     The ALPK1/TIFA/NF-kappaB axis links a bacterial carcinogen to
            R-loop-induced replication stress
  JOURNAL   Nat Commun 11 (1), 5117 (2020)
   PUBMED   33037203
  REMARK    GeneRIF: The ALPK1/TIFA/NF-kappaB axis links a bacterial carcinogen
            to R-loop-induced replication stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5399)
  AUTHORS   Zhong,L., Wang,J., Wang,W., Wang,L., Quan,M., Tang,X., Gou,L.,
            Wei,M., Xiao,J., Zhang,T., Sui,R., Zhou,Q. and Song,H.
  TITLE     Juvenile Onset Splenomegaly and Oculopathy Due to Germline Mutation
            in ALPK1
  JOURNAL   J Clin Immunol 40 (2), 350-358 (2020)
   PUBMED   31939038
  REMARK    GeneRIF: Juvenile Onset Splenomegaly and Oculopathy Due to Germline
            Mutation in ALPK1.
REFERENCE   6  (bases 1 to 5399)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
REFERENCE   7  (bases 1 to 5399)
  AUTHORS   Heine,M., Cramm-Behrens,C.I., Ansari,A., Chu,H.P., Ryazanov,A.G.,
            Naim,H.Y. and Jacob,R.
  TITLE     Alpha-kinase 1, a new component in apical protein transport
  JOURNAL   J Biol Chem 280 (27), 25637-25643 (2005)
   PUBMED   15883161
  REMARK    GeneRIF: the phosphorylation of myosin I by ALPK1 is an essential
            process in the apical trafficking of raft-associated
            sucrose-isomaltase
REFERENCE   8  (bases 1 to 5399)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
REFERENCE   9  (bases 1 to 5399)
  AUTHORS   Ryazanov,A.G., Pavur,K.S. and Dorovkov,M.V.
  TITLE     Alpha-kinases: a new class of protein kinases with a novel
            catalytic domain
  JOURNAL   Curr Biol 9 (2), R43-R45 (1999)
   PUBMED   10021370
REFERENCE   10 (bases 1 to 5399)
  AUTHORS   Kozycki,C., Kastner,D., Huryn,L., Kodati,S. and Warner,B.M.
  TITLE     ALPK1-Related Autoinflammatory Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   38935811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB250317.1, AY044164.1, BC060780.1, AK026715.1, BE155590.1 and
            AC004049.1.
            
            On Nov 23, 2018 this sequence version replaced NM_025144.3.
            
            Summary: This gene encodes an alpha kinase. Mice which were
            homozygous for disrupted copies of this gene exhibited coordination
            defects (PMID: 21208416). Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.21906.1,
                                           SRR1660809.114154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000650871.1/ ENSP00000498374.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               DB250317.1         27-197
            172-876             AY044164.1         1-705
            877-3381            BC060780.1         793-3297
            3382-3504           AY044164.1         3211-3333
            3505-4386           BC060780.1         3420-4301
            4387-4669           AK026715.1         1094-1376
            4670-4687           BE155590.1         63-80               c
            4688-5002           AK026715.1         1395-1709
            5003-5003           AC004049.1         154778-154778
            5004-5396           AK026715.1         1711-2103
            5397-5399           AC004049.1         155172-155174
FEATURES             Location/Qualifiers
     source          1..5399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..5399
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /note="alpha kinase 1"
                     /db_xref="GeneID:80216"
                     /db_xref="HGNC:HGNC:20917"
                     /db_xref="MIM:607347"
     exon            1..101
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            102..153
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            154..374
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..3988
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lymphocyte alpha-kinase; alpha-protein kinase 1;
                     chromosome 4 kinase; lymphocyte alpha-protein kinase"
                     /codon_start=1
                     /product="alpha-protein kinase 1 isoform 1"
                     /protein_id="NP_079420.3"
                     /db_xref="CCDS:CCDS3697.1"
                     /db_xref="GeneID:80216"
                     /db_xref="HGNC:HGNC:20917"
                     /db_xref="MIM:607347"
                     /translation="MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLP
                     SELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILAR
                     DCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGK
                     LLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIW
                     ASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLL
                     SAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEI
                     GLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNF
                     STSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQG
                     DFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQE
                     KPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGE
                     GAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTA
                     LSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGI
                     FLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQK
                     EEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDA
                     PLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQ
                     LLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQP
                     GNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEA
                     RTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQET
                     IVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTA
                     QHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTK
                     VVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKV
                     FTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT"
     exon            375..529
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            530..728
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            729..788
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            789..875
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            876..952
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1048
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1153
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..3287
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3441
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3604
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3791
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..3980
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..5399
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4356..4361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /note="hexamer: ATTAAA"
     polyA_site      4386
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /note="major polyA site"
     regulatory      4424..4429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /note="hexamer: CATAAA"
     polyA_site      4451
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
     regulatory      4573..4578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /note="hexamer: ATTAAA"
     polyA_site      4592
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
     regulatory      5382..5387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
                     /note="hexamer: AGTAAA"
     polyA_site      5399
                     /gene="ALPK1"
                     /gene_synonym="8430410J10Rik; LAK; ROSAH"
ORIGIN      
        1 gtttatgaga aacagtgtgt ttcagagagg ctgtaccaga attaactctg ctcagagtta
       61 gatttgctgg tcttaaagta cttttcctct ttaagataaa agaagttctt ctaaatcagg
      121 aatggattga aatctaatga accgaaactt tgggtacttc ggccttcaag gggctccttt
      181 attgagaatc aatgtcttct cctaggtaat tgatcaccct agacccaggg acacccaatt
      241 catcgtaatc atcatgaata atcaaaaagt ggtagctgtg ctactgcaag agtgcaagca
      301 agtgctggat cagctcttgt tggaagcgcc agatgtgtcg gaagaggaca agagcgagga
      361 ccagcgctgc agagctttac tccccagcga gttaaggacc ctgatccagg aggcaaagga
      421 aatgaagtgg cccttcgtgc ctgaaaagtg gcagtacaaa caagccgtgg gcccagagga
      481 caaaacaaac ctgaaggatg tgattggcgc cgggttgcag cagttactgg cgtccctgag
      541 ggcctccatc ctcgctcggg actgtgcggc tgcggcggct attgtgttct tggtggaccg
      601 gttcctgtat gggctcgacg tctctggaaa acttctgcag gtcgccaaag gtctccacaa
      661 gttgcagcca gccacgccaa ttgccccgca ggtggttatt cgccaagccc gaatctccgt
      721 gaactcagga aaacttttaa aagcagagta tattctgagc agtctaataa gcaacaatgg
      781 agcaacgggt acctggctgt acagaaatga aagtgacaag gtcctggtgc agtcggtctg
      841 tatacagatc agagggcaga ttctgcaaaa gctggggatg tggtacgaag cagcagagtt
      901 aatatgggcc tccattgtag gatatttggc acttcctcag ccggataaaa agggcctctc
      961 cacgtcgcta ggtatactgg cagacatctt tgtttccatg agcaagaacg attatgaaaa
     1021 gtttaaaaac aatccacaaa ttaatttgag cctgctgaag gagtttgacc accatttgct
     1081 gtccgctgca gaagcctgca agctggcagc tgccttcagt gcctatacgc cgctcttcgt
     1141 gctcacagct gtgaatatcc gtggcacgtg tttattgtcc tacagtagtt caaatgactg
     1201 tcctccagaa ttgaaaaact tacatctgtg tgaagccaaa gaggcctttg agattggcct
     1261 cctcaccaag agagatgatg agcctgttac tggaaaacag gagcttcaca gctttgtcaa
     1321 agctgctttc ggtctcacca cagtgcacag aaggctccat ggggagacag ggacggtcca
     1381 tgcagcaagt cagctctgta aggaagcaat ggggaagctg tacaatttca gcacttcctc
     1441 cagaagtcag gacagagaag ctctgtctca agaagttatg tctgtgattg cccaggtgaa
     1501 ggaacattta caagttcaaa gcttctcaaa tgtagatgac agatcttatg ttcccgagag
     1561 tttcgagtgc aggttggata aacttatctt gcatgggcaa ggggatttcc aaaaaatcct
     1621 tgacacctat tcacagcacc atacttcggt gtgtgaagta tttgaaagtg attgtggaaa
     1681 caacaaaaat gaacagaaag atgcaaaaac aggagtctgc atcactgctc taaaaacaga
     1741 aataaaaaac atagatactg tgagtactac tcaagaaaag ccacattgtc aaagagacac
     1801 aggaatatct tcctccctaa tgggtaagaa tgttcagagg gaactcagaa ggggaggaag
     1861 gagaaactgg acccattctg atgcatttcg agtctccttg gatcaagatg tggagactga
     1921 gactgagcca tcggactaca gcaatggtga gggagctgtt ttcaacaagt ctctgagtgg
     1981 cagccagact tccagtgctt ggagcaactt atcagggttt agttcctctg caagctggga
     2041 ggaagtgaat tatcacgttg acgacaggtc agccagaaaa gagcctggca aagaacatct
     2101 ggtggacact cagtgttcca ctgccttgtc tgaggagcta gagaatgaca gggaaggcag
     2161 agctatgcat tcattgcatt cacagcttca tgatctctct cttcaggaac ccaacaatga
     2221 caatttggag ccttctcaaa atcagccaca gcaacagatg cccttgacac ccttctcgcc
     2281 tcataatacc ccaggcattt tcttggcccc tggtgcaggg cttctagaag gagctccaga
     2341 aggtatccag gaagtcagaa atatgggacc cagaaatact tctgctcact ccagaccctc
     2401 atatcgttct gcttcttggt cttctgattc tggtaggccc aagaatatgg gcacacatcc
     2461 ttcagtccaa aaagaagaag cctttgaaat aattgttgag tttccagaaa ccaactgcga
     2521 tgtcaaagac aggcagggga aagagcaggg agaagaaatt agtgaaagag gcgcaggccc
     2581 tacatttaaa gctagtccct cctgggttga cccagaagga gaaacagcag aaagcactga
     2641 agatgcaccc ttagactttc acagggtcct gcacaattct ctgggaaaca tttccatgct
     2701 gccatgtagc tccttcaccc ctaattggcc tgttcaaaat cctgactcca gaaaaagtgg
     2761 tggcccagtc gcagagcagg gcatcgaccc tgatgcctcc acagtggatg aggaggggca
     2821 actgctcgac agcatggatg ttccctgcac aaatgggcac ggctctcata gactgtgcat
     2881 tctgagacag ccgcctggtc agagggcgga gacccccaat tcctctgtaa gcggtaacat
     2941 cctcttccct gtcctcagcg aggactgcac taccacagag gaaggaaatc agcctggaaa
     3001 catgctaaac tgcagccaga actccagctc atcctcagtg tggtggctga aatcacctgc
     3061 attttccagt ggttcttctg agggggacag cccttggtcc tatctgaatt ccagtgggag
     3121 ttcttgggtt tcattgccgg gaaagatgag gaaagagatc cttgaggctc gcaccttgca
     3181 acctgatgac tttgaaaagc tgttggcagg agtgaggcat gattggctgt ttcagagact
     3241 agagaatacg ggggttttta agcccagtca actccaccga gcacatagtg ctcttttgtt
     3301 aaaatattca aaaaaatctg aactgtggac ggcccaggaa actattgtct atttggggga
     3361 ctacttgact gtgaagaaaa aaggcagaca aagaaatgct ttttgggttc atcatcttca
     3421 tcaagaagaa attctgggga ggtatgttgg gaaagactat aaggagcaga aggggctctg
     3481 gcaccacttc actgatgtgg agcgacagat gaccgcacag cactatgtga cagaatttaa
     3541 caagagactc tatgaacaaa acattcccac ccagatattc tacatcccat ccacaatact
     3601 actgatttta gaggacaaga caataaaggg atgtatcagt gtggagcctt acatactggg
     3661 agaatttgta aaattgtcaa ataacacgaa agtggtgaaa acagaataca aagccacaga
     3721 atatggcttg gcctatggcc atttttctta tgagttttct aatcatagag atgttgtggt
     3781 cgatttacaa ggttgggtaa ccggtaatgg aaaaggactc atctacctca cagatcccca
     3841 gattcactcc gttgatcaga aagttttcac taccaatttt ggaaagagag gaatttttta
     3901 cttctttaat aaccagcatg tggaatgtaa tgaaatctgc catcgtcttt ctttgactag
     3961 accttcaatg gagaaaccat gcacatagaa tacggcacag tctggtcctt tggggcttgg
     4021 gcagggccgt gacacaggtt ctggccaatg atttgcaaga ggaattgatc agtatcactt
     4081 taagtcctgc atttaattgg cagcacaaga tcctgcagag cctctttccc tctgccacag
     4141 ttatcaagaa tgggtcagga gaccgctgct tctgggcata agtcctgcaa ggaaagcaac
     4201 atggaaaaca gccccaactc acccatgagg gatgaaaagc actcttgaga aaggcatgtg
     4261 ttgtttaagc cattgagatt ttagagcttt ttgtcactat ctgtcaagac tgatactact
     4321 ggggcttttc ctattgattt gggagttctt tacatattaa aaaaatgtga gcctttgtga
     4381 tacgaattca atttgttttc ctgtcttttg acatttgact ttgcataaaa gtttatctgt
     4441 gcataatttt atatgtagtt gaattcatca atcttttatt ttgtatggct ttttggttat
     4501 gtataatact tagatcctcc ttatactctg agtttctttc tttttaattc tcctgtattt
     4561 ccttctagta taattaaatc tgtaaaaagt aagatggaag agtggtacag ttttctttat
     4621 ccagtctgtc cttgatgggc atttaggtag actggataaa gaaaatgtgg tacatataca
     4681 ccatggaaca ctatgtgtat taatccactc tcacactgct atgaagagat acctgagact
     4741 gggtaattta gaaagaaaag aggtttaatt aactcacagt tccacatggc tggggagacc
     4801 tcaggaaact tacaatcatg gcagaaggca cctcttcata gggtagcagg agagagaatg
     4861 agtgccagca ggggaaatgc cagatgctta taaagccatc agatcttgtg agaattcatt
     4921 cactctcacg agaacagcat gggaaaaact gcctcaatta cctcctacca ggtccttccc
     4981 atgacacatg ggaattatgg gactacaatt cgagatgaga tttgggtggg gacacaaagc
     5041 caaaccatat cacaatgtaa ccataaaaaa gaatgagatc atgtcctttg cagggacatg
     5101 gatagagctg gaggccatta tttttagcaa actaatgcaa gaacagaaaa ctaaatacca
     5161 cttgttctca cttataggtg agagctaagt gatgagagta ggtggacaca tagagggaac
     5221 aacacacacc agggcttatc agagggtgga cagtgggagg agggagagga tcaggaaaaa
     5281 taactaatgg gtactaggct gaatacctgg gtgatgaagt aattcgcaca acaaaccccc
     5341 atgacacaaa cctgcacatg tacccctgaa cttaaaataa aagtaaaaaa aaaaaatca
//
