LOCUS       NM_001631               3241 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens alkaline phosphatase, intestinal (ALPI), mRNA.
ACCESSION   NM_001631
VERSION     NM_001631.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3241)
  AUTHORS   Duan,R., von Ehrlich-Treuenstatt,V.H., Kakoschke,S.C., Schardey,J.,
            Wirth,U., Albertsmeier,M., Renz,B.W., Andrassy,J., Bazhin,A.V.,
            Hodin,R.A., Werner,J., Ilmer,M. and Kuhn,F.
  TITLE     Effect of Surgery on Postoperative Levels of the Gut
            Homeostasis-Regulating Enzyme Intestinal Alkaline Phosphatase
  JOURNAL   J Am Coll Surg 238 (1), 70-80 (2024)
   PUBMED   37870235
  REMARK    GeneRIF: Effect of Surgery on Postoperative Levels of the Gut
            Homeostasis-Regulating Enzyme Intestinal Alkaline Phosphatase.
REFERENCE   2  (bases 1 to 3241)
  AUTHORS   Martins,R.D.S., Kooi,E.M.W., Poelstra,K. and Hulscher,J.B.F.
  TITLE     The role of intestinal alkaline phosphatase in the development of
            necrotizing enterocolitis
  JOURNAL   Early Hum Dev 183, 105797 (2023)
   PUBMED   37300991
  REMARK    GeneRIF: The role of intestinal alkaline phosphatase in the
            development of necrotizing enterocolitis.
            Review article
REFERENCE   3  (bases 1 to 3241)
  AUTHORS   Singh,S.B., Coffman,C.N., Varga,M.G., Carroll-Portillo,A.,
            Braun,C.A. and Lin,H.C.
  TITLE     Intestinal Alkaline Phosphatase Prevents Sulfate Reducing
            Bacteria-Induced Increased Tight Junction Permeability by
            Inhibiting Snail Pathway
  JOURNAL   Front Cell Infect Microbiol 12, 882498 (2022)
   PUBMED   35694541
  REMARK    GeneRIF: Intestinal Alkaline Phosphatase Prevents Sulfate Reducing
            Bacteria-Induced Increased Tight Junction Permeability by
            Inhibiting Snail Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3241)
  AUTHORS   Noda,S., Yamada,A., Asawa,Y., Nakamura,H., Matsumura,T., Orimo,H.
            and Goseki-Sone,M.
  TITLE     Characterization and Structure of Alternatively Spliced Transcript
            Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 68 (4), 284-293 (2022)
   PUBMED   36047100
  REMARK    GeneRIF: Characterization and Structure of Alternatively Spliced
            Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI)
            Gene.
REFERENCE   5  (bases 1 to 3241)
  AUTHORS   Nishihara,Y., Hayashi,Y., Adachi,T., Koyama,I., Stigbrand,T. and
            Hirano,K.
  TITLE     Chemical nature of intestinal-type alkaline phosphatase in human
            kidney
  JOURNAL   Clin Chem 38 (12), 2539-2542 (1992)
   PUBMED   1458595
REFERENCE   6  (bases 1 to 3241)
  AUTHORS   Henthorn,P.S., Raducha,M., Kadesch,T., Weiss,M.J. and Harris,H.
  TITLE     Sequence and characterization of the human intestinal alkaline
            phosphatase gene
  JOURNAL   J Biol Chem 263 (24), 12011-12019 (1988)
   PUBMED   2841341
REFERENCE   7  (bases 1 to 3241)
  AUTHORS   Henthorn,P.S., Raducha,M., Edwards,Y.H., Weiss,M.J., Slaughter,C.,
            Lafferty,M.A. and Harris,H.
  TITLE     Nucleotide and amino acid sequences of human intestinal alkaline
            phosphatase: close homology to placental alkaline phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 84 (5), 1234-1238 (1987)
   PUBMED   3469665
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1987 Jun;84(12):4088]
REFERENCE   8  (bases 1 to 3241)
  AUTHORS   Berger,J., Garattini,E., Hua,J.C. and Udenfriend,S.
  TITLE     Cloning and sequencing of human intestinal alkaline phosphatase
            cDNA
  JOURNAL   Proc Natl Acad Sci U S A 84 (3), 695-698 (1987)
   PUBMED   3468508
REFERENCE   9  (bases 1 to 3241)
  AUTHORS   Knoll,B.J., Rothblum,K.N. and Longley,M.
  TITLE     Two gene duplication events in the evolution of the human
            heat-stable alkaline phosphatases
  JOURNAL   Gene 60 (2-3), 267-276 (1987)
   PUBMED   3443302
REFERENCE   10 (bases 1 to 3241)
  AUTHORS   Hua,J.C., Berger,J., Pan,Y.C., Hulmes,J.D. and Udenfriend,S.
  TITLE     Partial sequencing of human adult, human fetal, and bovine
            intestinal alkaline phosphatases: comparison with the human
            placental and liver isozymes
  JOURNAL   Proc Natl Acad Sci U S A 83 (8), 2368-2372 (1986)
   PUBMED   3458202
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA376676.1, BC132678.1 and
            AC068134.5.
            
            On Nov 29, 2018 this sequence version replaced NM_001631.4.
            
            Summary: There are at least four distinct but related alkaline
            phosphatases: intestinal, placental, placental-like, and
            liver/bone/kidney (tissue non-specific). The intestinal alkaline
            phosphatase gene encodes a digestive brush-border enzyme. This
            enzyme is a component of the gut mucosal defense system and is
            thought to function in the detoxification of lipopolysaccharide,
            and in the prevention of bacterial translocation in the gut.
            [provided by RefSeq, Dec 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132678.1, AH002601.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295463.4/ ENSP00000295463.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA376676.1         42-58
            18-2276             BC132678.1         1-2259
            2277-3241           AC068134.5         167926-168890
FEATURES             Location/Qualifiers
     source          1..3241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..3241
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /note="alkaline phosphatase, intestinal"
                     /db_xref="GeneID:248"
                     /db_xref="HGNC:HGNC:437"
                     /db_xref="MIM:171740"
     exon            1..114
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1634
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /EC_number="3.1.3.1"
                     /note="alkaline phosphomonoesterase; Kasahara isozyme;
                     glycerophosphatase; intestinal-type alkaline phosphatase;
                     intestinal alkaline phosphatase"
                     /codon_start=1
                     /product="intestinal-type alkaline phosphatase precursor"
                     /protein_id="NP_001622.2"
                     /db_xref="CCDS:CCDS2492.1"
                     /db_xref="GeneID:248"
                     /db_xref="HGNC:HGNC:437"
                     /db_xref="MIM:171740"
                     /translation="MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKK
                     LQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTY
                     NVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGK
                     SVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVI
                     LGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQAS
                     LDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRI
                     DHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSS
                     IFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSET
                     HGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPV
                     AASLPLLAGTLLLLGASAAP"
     exon            115..231
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            232..347
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            348..522
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            523..695
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            696..830
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            831..903
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1038
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1230
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1347
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..3241
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /note="hexamer: AATAAA"
     polyA_site      2520
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /note="major polyA site"
     regulatory      3068..3073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /note="hexamer: AATAAA"
     polyA_site      3101
                     /gene="ALPI"
                     /gene_synonym="IAP"
     regulatory      3215..3220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALPI"
                     /gene_synonym="IAP"
                     /note="hexamer: AATAAA"
     polyA_site      3241
                     /gene="ALPI"
                     /gene_synonym="IAP"
ORIGIN      
        1 cggttcctgg tgtccccact tcgcctccct cctgctgccc ccaagacatg caggggccct
       61 gggtgctgct gctgctgggc ctgaggctac agctctccct gggcgtcatc ccagctgagg
      121 aggagaaccc ggccttctgg aaccgccagg cagctgaggc cctggatgct gccaagaagc
      181 tgcagcccat ccagaaggtc gccaagaacc tcatcctctt cctgggcgat gggttggggg
      241 tgcccacggt gacagccacc aggatcctaa aggggcagaa gaatggcaaa ctggggcctg
      301 agacgcccct ggccatggac cgcttcccat acctggctct gtccaagaca tacaatgtgg
      361 acagacaggt gccagacagc gcagccacag ccacggccta cctgtgcggg gtcaaggcca
      421 acttccagac catcggcttg agtgcagccg cccgctttaa ccagtgcaac acgacacgcg
      481 gcaatgaggt catctccgtg atgaaccggg ccaagcaagc aggaaagtca gtaggagtgg
      541 tgaccaccac acgggtgcag cacgcctcgc cagccggcac ctacgcacac acagtgaacc
      601 gcaactggta ctcagatgct gacatgcctg cctcagcccg ccaggagggg tgccaggaca
      661 tcgccactca gctcatctcc aacatggaca ttgacgtgat ccttggcgga ggccgcaagt
      721 acatgtttcc catggggacc ccagaccctg agtacccagc tgatgccagc cagaatggaa
      781 tcaggctgga cgggaagaac ctggtgcagg aatggctggc aaagcaccag ggtgcctggt
      841 atgtgtggaa ccgcactgag ctcatgcagg cgtccctgga ccagtctgtg acccatctca
      901 tgggcctctt tgagcccgga gacacgaaat atgagatcca ccgagacccc acactggacc
      961 cctccctgat ggagatgaca gaggctgccc tgcgcctgct gagcaggaac ccccgcggct
     1021 tctacctctt tgtggagggc ggccgcatcg accatggtca tcatgagggt gtggcttacc
     1081 aggcactcac tgaggcggtc atgttcgacg acgccattga gagggcgggc cagctcacca
     1141 gcgaggagga cacgctgacc ctcgtcaccg ctgaccactc ccatgtcttc tcctttggtg
     1201 gctacacctt gcgagggagc tccatcttcg ggttggcccc cagcaaggct caggacagca
     1261 aagcctacac gtccatcctg tacggcaatg gcccgggcta cgtgttcaac tcaggcgtgc
     1321 gaccagacgt gaatgagagc gagagcggga gccccgatta ccagcagcag gcggcggtgc
     1381 ccctgtcgtc cgagacccac ggaggcgaag acgtggcggt gtttgcgcgc ggcccgcagg
     1441 cgcacctggt gcatggtgtg caggagcaga gcttcgtagc gcatgtcatg gccttcgctg
     1501 cctgtctgga gccctacacg gcctgcgacc tggcgcctcc cgcctgcacc accgacgccg
     1561 cgcacccagt tgccgcgtcg ctgccactgc tggccgggac cctgctgctg ctgggggcgt
     1621 ccgctgctcc ctgagtgccc cactccggag ttatcctgct ccccacctcc gggcgtcctg
     1681 ccctgttccc cgtcctgagc cgccacttcc agcgaacaca cacaggtgtc ctgccgttgg
     1741 accttcacct cctagagata aaccagcctc agctggcgca gcggggccct tcttccctcc
     1801 gcatcccctt cagggagcag gagcccaggg cgccctggga gctgagcctg ggacttccag
     1861 gacctcccct caggttgttc tctgattctt cctcccaacc ccagagactg cagatttgtg
     1921 ccatgcggct gcctgcaccc cagacaataa agggaccaaa accacccaac ccccaccctg
     1981 cctctatcct aaggaagacc aagcaggcct ggacccagag acgtccccca tcgtgggaca
     2041 cgacacaccc agaccgcgtg ccccaccgtc ttagcttcaa tcctggcagc acctggtaga
     2101 cccaaggact tgggtggatc aggacacctg aagaagagaa gcttccggca accctgcaac
     2161 ccacccaagg aggctactgg atcggggatt cccagggggg ctttgacaca gtcctctgct
     2221 gtctccccac taggatcatt ccacacccct gcacctgacc aagggaccaa tgaggcagag
     2281 gcttgcccca agtcacagcc actcagatgc ttcctgcccc ccagtgccca ttccaggtca
     2341 ccagatccaa ggagcgcttg aggagctctg ggtacagggc agcaacccag agcccatggg
     2401 ccctcccggg acatctggat gctgggcata gatttctcaa caaggaagac tcccctgcct
     2461 cctcaaggtc tccattctcc taggagacaa agcaataata aaaggtgtta gacaatgtaa
     2521 tgccagtact acttcctagg agaaaaatca tgagtgagtg tgggcacagt atctggagag
     2581 gtggataacg caggccagga ggtactgctg aggggcagat gattgagcaa gagacttgaa
     2641 cagagtgggg gcttgagcaa ggcagcacag cagtgcaaac gccctggggc agtgtcagca
     2701 ggtgctctgg gaggccaagg gctggatcag aggggtgggg gtgggtgggc agagtgggga
     2761 aagcctgagg ggtcaggaga gtggggtgtg catgggggac tgtgaagtct ggttagaggg
     2821 gtgtggttgg aggtctttga ggagggctgt gacctgccct ggttgggaaa taagcactct
     2881 ggctgctgcc aggagaaggg tctggtcttt tgggcagagg gtgggggtgg tggcaggctc
     2941 aggtgaaagc tggggaagga gctgactcca ggtgtttctg acctccctct gaaagtattc
     3001 tggagcgccc atcccaatac agccatactt agtgagtaca cacctgctcc aagagaacat
     3061 tgaaaagaat aaaggtgaaa tcaaccacat tttccagcaa attttgcagt attacaaatt
     3121 tatttgtaca tttacaaagg tgcaaaaaag catcttgctt ttgcaagaaa tagtaacatc
     3181 attcaatatg ctttcttatt tactaaaacc ttgaaataaa attgtaaaac atcagtttga
     3241 a
//
