LOCUS       NM_001629                869 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens arachidonate 5-lipoxygenase activating protein
            (ALOX5AP), transcript variant 1, mRNA.
ACCESSION   NM_001629
VERSION     NM_001629.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   Song,P., Deng,H., Liu,Y. and Zhang,M.
  TITLE     Integrated bioinformatics analysis and experimental validation
            reveal the relationship between ALOX5AP and the prognosis and
            immune microenvironment in glioma
  JOURNAL   BMC Med Genomics 17 (1), 218 (2024)
   PUBMED   39169376
  REMARK    GeneRIF: Integrated bioinformatics analysis and experimental
            validation reveal the relationship between ALOX5AP and the
            prognosis and immune microenvironment in glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 869)
  AUTHORS   Han,G.D., Dai,J., Hui,H.X. and Zhu,J.
  TITLE     ALOX5AP suppresses osteosarcoma progression via
            Wnt/beta-catenin/EMT pathway and associates with clinical prognosis
            and immune infiltration
  JOURNAL   J Orthop Surg Res 18 (1), 446 (2023)
   PUBMED   37344882
  REMARK    GeneRIF: ALOX5AP suppresses osteosarcoma progression via
            Wnt/beta-catenin/EMT pathway and associates with clinical prognosis
            and immune infiltration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 869)
  AUTHORS   Cilensek,I., Seruga,M., Makuc,J., Zavrsnik,M. and Petrovic,D.
  TITLE     The ALOXA5AP gene (rs38022789) is associated with diabetic
            nephropathy in Slovenian patients with type 2 diabetes mellitus
  JOURNAL   Gene 741, 144551 (2020)
   PUBMED   32165305
  REMARK    GeneRIF: the study was designed to investigate the association
            between the polymorphism of the ALOX5 gene (rs12762303) and the
            ALOX5AP gene (rs3802278), and diabetic nephropathy (DN) in patients
            with type 2 diabetes mellitus.
REFERENCE   4  (bases 1 to 869)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 869)
  AUTHORS   Pavlenko,O.U., Strokina,I.G., Drevytska,T.I., Sokurenko,L.M. and
            Dosenko,V.E.
  TITLE     ASSOCIATION BETWEEN SINGLE POLYMORPHISM IN THE LOCUS RS17216473 OF
            THE GENE THAT ENCODES 5-LIPOXYGENASE-ACTIVATING PROTEIN AND RISK OF
            MYOCARDIAL INFARCTION
  JOURNAL   Wiad Lek 73 (11), 2431-2437 (2020)
   PUBMED   33454679
  REMARK    GeneRIF: ASSOCIATION BETWEEN SINGLE POLYMORPHISM IN THE LOCUS
            RS17216473 OF THE GENE THAT ENCODES 5-LIPOXYGENASE-ACTIVATING
            PROTEIN AND RISK OF MYOCARDIAL INFARCTION.
REFERENCE   6  (bases 1 to 869)
  AUTHORS   Steinhilber,D.
  TITLE     5-Lipoxygenase: enzyme expression and regulation of activity
  JOURNAL   Pharm Acta Helv 69 (1), 3-14 (1994)
   PUBMED   7938075
  REMARK    Review article
REFERENCE   7  (bases 1 to 869)
  AUTHORS   Charleson,S., Prasit,P., Leger,S., Gillard,J.W., Vickers,P.J.,
            Mancini,J.A., Charleson,P., Guay,J., Ford-Hutchinson,A.W. and
            Evans,J.F.
  TITLE     Characterization of a 5-lipoxygenase-activating protein binding
            assay: correlation of affinity for 5-lipoxygenase-activating
            protein with leukotriene synthesis inhibition
  JOURNAL   Mol Pharmacol 41 (5), 873-879 (1992)
   PUBMED   1588922
REFERENCE   8  (bases 1 to 869)
  AUTHORS   Evans,J.F., Leville,C., Mancini,J.A., Prasit,P., Therien,M.,
            Zamboni,R., Gauthier,J.Y., Fortin,R., Charleson,P., MacIntyre,D.E.
            et al.
  TITLE     5-Lipoxygenase-activating protein is the target of a quinoline
            class of leukotriene synthesis inhibitors
  JOURNAL   Mol Pharmacol 40 (1), 22-27 (1991)
   PUBMED   1857337
REFERENCE   9  (bases 1 to 869)
  AUTHORS   Kennedy,B.P., Diehl,R.E., Boie,Y., Adam,M. and Dixon,R.A.
  TITLE     Gene characterization and promoter analysis of the human
            5-lipoxygenase-activating protein (FLAP)
  JOURNAL   J Biol Chem 266 (13), 8511-8516 (1991)
   PUBMED   1673682
REFERENCE   10 (bases 1 to 869)
  AUTHORS   Dixon,R.A., Diehl,R.E., Opas,E., Rands,E., Vickers,P.J.,
            Evans,J.F., Gillard,J.W. and Miller,D.K.
  TITLE     Requirement of a 5-lipoxygenase-activating protein for leukotriene
            synthesis
  JOURNAL   Nature 343 (6255), 282-284 (1990)
   PUBMED   2300173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG569867.1 and BC018538.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001629.3.
            
            Summary: This gene encodes a protein which, with 5-lipoxygenase, is
            required for leukotriene synthesis. Leukotrienes are arachidonic
            acid metabolites which have been implicated in various types of
            inflammatory responses, including asthma, arthritis and psoriasis.
            This protein localizes to the plasma membrane. Inhibitors of its
            function impede translocation of 5-lipoxygenase from the cytoplasm
            to the cell membrane and inhibit 5-lipoxygenase activation.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified for this gene. [provided by RefSeq,
            Feb 2011].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018538.1, CA306377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380490.5/ ENSP00000369858.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-506               BG569867.1         38-543
            507-869             BC018538.1         495-857
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..869
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /note="arachidonate 5-lipoxygenase activating protein"
                     /db_xref="GeneID:241"
                     /db_xref="HGNC:HGNC:436"
                     /db_xref="MIM:603700"
     exon            1..133
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..549
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MK-886-binding protein"
                     /codon_start=1
                     /product="arachidonate 5-lipoxygenase-activating protein
                     isoform 1"
                     /protein_id="NP_001620.2"
                     /db_xref="CCDS:CCDS9337.1"
                     /db_xref="GeneID:241"
                     /db_xref="HGNC:HGNC:436"
                     /db_xref="MIM:603700"
                     /translation="MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQR
                     TGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYL
                     GERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLI
                     P"
     exon            134..233
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            234..304
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            305..386
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            387..869
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      840..845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /note="hexamer: AATAAA"
     polyA_site      869
                     /gene="ALOX5AP"
                     /gene_synonym="FLAP"
                     /note="major polyA site"
ORIGIN      
        1 ctgtacaggg caggttgtgc agctggaggc agagcagtcc tctctgggga gcctgaagca
       61 aacatggatc aagaaactgt aggcaatgtt gtcctgttgg ccatcgtcac cctcatcagc
      121 gtggtccaga atggattctt tgcccataaa gtggagcacg aaagcaggac ccagaatggg
      181 aggagcttcc agaggaccgg aacacttgcc tttgagcggg tctacactgc caaccagaac
      241 tgtgtagatg cgtaccccac tttcctcgct gtgctctggt ctgcggggct actttgcagc
      301 caagttcctg ctgcgtttgc tggactgatg tacttgtttg tgaggcaaaa gtactttgtc
      361 ggttacctag gagagagaac gcagagcacc cctggctaca tatttgggaa acgcatcata
      421 ctcttcctgt tcctcatgtc cgttgctggc atattcaact attacctcat cttctttttc
      481 ggaagtgact ttgaaaacta cataaagacg atctccacca ccatctcccc tctacttctc
      541 attccctaac tctctgctga atatggggtt ggtgttctca tctaatcaat acctacaagt
      601 catcataatt cagctcttga gagcattctg ctcttcttta gatggctgta aatctattgg
      661 ccatctgggc ttcacagctt gagttaacct tgcttttccg ggaacaaaat gatgtcatgt
      721 cagctccgcc ccttgaacat gaccgtggcc ccaaatttgc tattcccatg cattttgttt
      781 gtttcttcac ttatcctgtt ctctgaagat gttttgtgac caggtttgtg ttttcttaaa
      841 ataaaatgca gagacatgtt ttaagctga
//
