LOCUS       NM_001141               2697 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens arachidonate 15-lipoxygenase type B (ALOX15B),
            transcript variant d, mRNA.
ACCESSION   NM_001141
VERSION     NM_001141.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2697)
  AUTHORS   Benatzy,Y., Palmer,M.A., Lutjohann,D., Ohno,R.I., Kampschulte,N.,
            Schebb,N.H., Fuhrmann,D.C., Snodgrass,R.G. and Brune,B.
  TITLE     ALOX15B controls macrophage cholesterol homeostasis via lipid
            peroxidation, ERK1/2 and SREBP2
  JOURNAL   Redox Biol 72, 103149 (2024)
   PUBMED   38581859
  REMARK    GeneRIF: ALOX15B controls macrophage cholesterol homeostasis via
            lipid peroxidation, ERK1/2 and SREBP2.
REFERENCE   2  (bases 1 to 2697)
  AUTHORS   Kianfar,S., Salimi,V., Jahangirifard,A., Mirtajani,S.B.,
            Vaezi,M.A., Yavarian,J., Mokhtari-Azad,T. and Tavakoli-Yaraki,M.
  TITLE     15-lipoxygenase and cyclooxygenase expression profile and their
            related modulators in COVID-19 infection
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 197, 102587 (2023)
   PUBMED   37716021
  REMARK    GeneRIF: 15-lipoxygenase and cyclooxygenase expression profile and
            their related modulators in COVID-19 infection.
REFERENCE   3  (bases 1 to 2697)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2697)
  AUTHORS   Li,M.Y., Liu,L.Z., Li,W., Ng,C.S.H., Liu,Y., Kong,A.W.Y., Zhao,Z.,
            Wang,S., Qi,H., Jia,H., Yang,S., Du,J., Long,X., Ho,R.L.K.,
            Chak,E.C.W., Wan,I.Y.P., Mok,T.S.K., Underwood,M.J., Gali,N.K.,
            Ning,Z. and Chen,G.G.
  TITLE     Ambient fine particulate matter inhibits 15-lipoxygenases to
            promote lung carcinogenesis
  JOURNAL   J Exp Clin Cancer Res 38 (1), 359 (2019)
   PUBMED   31420013
  REMARK    GeneRIF: Low 15-LOX-2 expression is associated with lung
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2697)
  AUTHORS   Barooni,A.B., Ghorbani,M., Salimi,V., Alimohammadi,A.,
            Khamseh,M.E., Akbari,H., Imani,M., Nourbakhsh,M., Sheikhi,A.,
            Shirian,F.I., Ameri,M. and Tavakoli-Yaraki,M.
  TITLE     Up-regulation of 15-lipoxygenase enzymes and products in functional
            and non-functional pituitary adenomas
  JOURNAL   Lipids Health Dis 18 (1), 152 (2019)
   PUBMED   31288808
  REMARK    GeneRIF: ALOX15B expression and up-regulation in the functional and
            non-functional pituitary adenomas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2697)
  AUTHORS   Krieg,P., Marks,F. and Furstenberger,G.
  TITLE     A gene cluster encoding human epidermis-type lipoxygenases at
            chromosome 17p13.1: cloning, physical mapping, and expression
  JOURNAL   Genomics 73 (3), 323-330 (2001)
   PUBMED   11350124
REFERENCE   7  (bases 1 to 2697)
  AUTHORS   Jisaka,M., Kim,R.B., Boeglin,W.E. and Brash,A.R.
  TITLE     Identification of amino acid determinants of the positional
            specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2
  JOURNAL   J Biol Chem 275 (2), 1287-1293 (2000)
   PUBMED   10625675
REFERENCE   8  (bases 1 to 2697)
  AUTHORS   Kilty,I., Logan,A. and Vickers,P.J.
  TITLE     Differential characteristics of human 15-lipoxygenase isozymes and
            a novel splice variant of 15S-lipoxygenase
  JOURNAL   Eur J Biochem 266 (1), 83-93 (1999)
   PUBMED   10542053
REFERENCE   9  (bases 1 to 2697)
  AUTHORS   Brash,A.R., Boeglin,W.E. and Chang,M.S.
  TITLE     Discovery of a second 15S-lipoxygenase in humans
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6148-6152 (1997)
   PUBMED   9177185
REFERENCE   10 (bases 1 to 2697)
  AUTHORS   Sigal,E., Grunberger,D., Highland,E., Gross,C., Dixon,R.A. and
            Craik,C.S.
  TITLE     Expression of cloned human reticulocyte 15-lipoxygenase and
            immunological evidence that 15-lipoxygenases of different cell
            types are related
  JOURNAL   J Biol Chem 265 (9), 5113-5120 (1990)
   PUBMED   2318885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP327830.1, AF468051.1,
            CA405703.1, BC063647.1 and CA307212.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001141.2.
            
            Summary: This gene encodes a member of the lipoxygenase family of
            structurally related nonheme iron dioxygenases involved in the
            production of fatty acid hydroperoxides. The encoded protein
            converts arachidonic acid exclusively to
            15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic
            acid less effectively. This gene is located in a cluster of related
            genes and a pseudogene that spans approximately 100 kilobases on
            the short arm of chromosome 17. Alternatively spliced transcript
            variants encoding different isoforms have been described. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (d) represents the longest
            transcript and encodes the longest isoform (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063647.1, SRR1803613.32624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380183.9/ ENSP00000369530.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                BP327830.1         30-126
            98-801              AF468051.1         1-704
            802-815             CA405703.1         615-628
            816-2063            BC063647.1         791-2038
            2064-2691           CA307212.1         1-628               c
            2692-2697           BC063647.1         2667-2672
FEATURES             Location/Qualifiers
     source          1..2697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2697
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /note="arachidonate 15-lipoxygenase type B"
                     /db_xref="GeneID:247"
                     /db_xref="HGNC:HGNC:434"
                     /db_xref="MIM:603697"
     exon            1..244
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2128
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /EC_number="1.13.11.33"
                     /note="isoform d is encoded by transcript variant d;
                     arachidonate 15-lipoxygenase, second type; arachidonate
                     omega(6) lipoxygenase; linoleate 13-lipoxygenase 15-LOb;
                     15S-lipoxygenase; arachidonate 15-lipoxygenase 2;
                     15-LOX-B; arachidonate 15-lipoxygenase type II;
                     polyunsaturated fatty acid lipoxygenase ALOX15B"
                     /codon_start=1
                     /product="polyunsaturated fatty acid lipoxygenase ALOX15B
                     isoform d"
                     /protein_id="NP_001132.2"
                     /db_xref="CCDS:CCDS11128.1"
                     /db_xref="GeneID:247"
                     /db_xref="HGNC:HGNC:434"
                     /db_xref="MIM:603697"
                     /translation="MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKE
                     FTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHL
                     LFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPH
                     CLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFN
                     FRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGT
                     SLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLS
                     QTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQL
                     PHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLN
                     YSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDREL
                     QAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAW
                     MPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYP
                     DEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI"
     exon            245..464
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..546
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..669
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..773
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            774..946
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1093
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1297
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1384
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1554
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1676
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1777
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1948
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2697
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2678..2683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /note="hexamer: AATAAA"
     polyA_site      2697
                     /gene="ALOX15B"
                     /gene_synonym="15-LOX-2"
                     /note="major polyA site"
ORIGIN      
        1 agtggcaata accaggggca ataaccaggc gtgtcccagg ggggagcccc gctctgcagc
       61 cctgtgcgcc gtagagagct ggacttaggc tggcagcatg gccgagttca gggtcagggt
      121 gtccaccgga gaagccttcg gggctggcac atgggacaaa gtgtctgtca gcatcgtggg
      181 gacccgggga gagagccccc cactgcccct ggacaatctc ggcaaggagt tcactgcggg
      241 cgctgaggag gacttccagg tgacgctccc ggaggacgta ggccgagtgc tgctgctgcg
      301 cgtgcacaag gcgcccccag tgctgcccct gctggggccc ctggccccgg atgcctggtt
      361 ctgccgctgg ttccagctga caccgccgcg gggcggccac ctcctcttcc cctgctacca
      421 gtggctggag ggggcgggga ccctggtgct gcaggagggt acagccaagg tgtcctgggc
      481 agaccaccac cctgtgctcc agcaacagcg ccaggaggag cttcaggccc ggcaggagat
      541 gtaccagtgg aaggcttaca acccaggttg gcctcactgc ctggatgaaa agacagtgga
      601 agacttggag ctcaatatca aatactccac agccaagaat gccaactttt atctacaggc
      661 tggctctgct tttgcagaga tgaaaatcaa ggggttgctg gaccgcaagg ggctctggag
      721 gagtctgaat gagatgaaaa ggatcttcaa cttccggagg accccagcag ctgagcacgc
      781 atttgagcac tggcaggagg acgccttctt cgcctcccag ttcctgaatg gtctcaaccc
      841 tgtcctgatc cgccgctgtc actacctccc aaagaacttc cccgtcactg atgccatggt
      901 ggcctcagtg ttgggtcctg ggaccagctt gcaggctgag ctagagaagg gctccctgtt
      961 cttggtggat cacggcatcc tctctggcat ccagaccaat gtcattaatg ggaagcctca
     1021 gttctctgcg gccccaatga ccctgctata ccagagccca ggctgcgggc cgctgctgcc
     1081 tctcgccatc cagctcagcc agacccccgg cccaaacagc cccatcttcc tgcccactga
     1141 tgacaagtgg gactggttgc tggccaagac ctgggtgcgc aatgccgagt tctccttcca
     1201 tgaggccctc acgcacctgc tgcactcaca tctgctgcct gaggtcttca ccctggctac
     1261 cctgcgtcag ctgccccact gccaccctct cttcaagctg ctgatcccgc acacccgata
     1321 caccctgcac atcaacacac tcgcccggga gctgcttatc gtgccagggc aggtggtgga
     1381 caggtccaca ggcatcggca ttgaaggctt ctctgagttg atacagagga acatgaagca
     1441 gctgaactat tctctcctgt gtctgcctga ggatatccgg acccgaggag ttgaagacat
     1501 cccaggctac tactaccgtg atgatgggat gcagatctgg ggtgcagtgg aacgctttgt
     1561 ctctgaaatc atcggtatct actacccaag tgatgagtct gtccaagatg acagagagct
     1621 ccaggcctgg gtcagagaga tcttctccaa gggcttccta aaccaggaga gctcaggtat
     1681 accctcctca ctggagaccc gggaagccct ggtgcagtat gtcaccatgg tgatattcac
     1741 ctgctccgcc aagcatgcgg ctgtcagtgc agggcagttt gactcctgtg cttggatgcc
     1801 caacctgcca cccagcatgc agctgccacc acccacctcc aaaggcctgg caacatgcga
     1861 gggcttcata gccaccctcc cacctgtcaa tgccacatgt gatgtcatcc ttgctctctg
     1921 gttgctgagc aaggagcctg gagaccaaag gcccctgggc acctatccgg atgagcactt
     1981 cacagaggag gcccctcggc ggagcatcgc caccttccag agccgcctgg cccagatctc
     2041 gaggggcatc caggagcgga accagggcct ggtgctgccc tacacctacc tagaccctcc
     2101 cctcatcgag aacagcgtct ccatctaaat cccaggggaa cacaggccca gatgacatcc
     2161 ctttgaccac atcgctctag gataactggc acccagagaa aaggactcct cagaaaaaac
     2221 aggcccccat gtgcctctcc tgggacaacc agactctgta actcaccccc accaccatac
     2281 acacacacaa aaacagaaac aaaatcaaaa cagagaaagc agaaaatcta ccaagaacag
     2341 agtctcagga cagaaccact gagtcttttg gaggctccaa gcctcaaagt gcccgcagag
     2401 cccaccttga gggttttgct agttggtttt gttttgcgtt ttacagccgt ggggggaagc
     2461 acataatccc gccccagggc ccactagcat ccactgattg gaccttatgg tcacccaact
     2521 caaggacagc caccaagaag tggctgccaa agagactggg cgcagtggct catgcccata
     2581 atcccagcac tttgggagat ggaggcggga aaatcatttg aggtcagaag ttcaaggcca
     2641 gcctggacga catagcgaga ctccacctct accaaaaaat aaaaattaaa aaacaaa
//
